The cheapest and fastest buses from Harrisburg, PA to Key West, FL
Cheapest price
$265
Average price
$265
Fastest journey
2 d 32 m
Average duration
2 d 32 m
Buses per day
1
Distance
1806 km
The best way to find a cheap bus ticket from Harrisburg, PA to Key West, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to Key West, FL will cost around $265 if you buy it on the day, but the cheapest tickets can be found for only $265.
It's difficult to get from Harrisburg, PA to Key West, FL without transferring at least 4 times.
12:30 PM48h32Harrisburg, PA1:02 PMKey West, FL$2651One-way4 transfers
12:30 PM48h32Harrisburg, PA1:02 PMKey West, FL$2651One-way4 transfers
Live departures
Harrisburg, PA to Key West, FL bus times
The table below shows live departures for Harrisburg, PA to Key West, FL buses for tomorrow, Wednesday, May 6. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:30 PM Harrisburg, PA | 48h32 | 1:02 PM Key West, FL | 4 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Harrisburg, PA to Key West, FL by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Harrisburg, PA to Key West, FL
Take a bus from Harrisburg, PA to Key West, FL and enjoy the approximately 1122 miles (1806 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
Distance 1122 miles (1806 km) |
High Season Apr - Jun |
Low Season Oct - Dec |
FAQs: Bus from Harrisburg, PA to Key West, FL
Find answers to the most common questions about traveling from Harrisburg, PA to Key West, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Key West, FL, this guide helps you travel smarter and with confidence.

- Ernest Hemingway Home and Museum, the former residence of the famous author featuring guided tours and a colony of six-toed cats
- Key West Butterfly and Nature Conservatory, a lush habitat housing hundreds of butterflies and exotic birds
- Fort Zachary Taylor Historic State Park, a Civil War-era fort offering beach access, snorkeling, and picnic areas
- Mallory Square, a waterfront plaza known for its nightly sunset celebrations and street performances
- Key West Lighthouse and Keeper's Quarters Museum, offering panoramic views of the island and insights into maritime history.
- Duval Street, stroll along the vibrant street lined with shops, bars, and restaurants
- Dry Tortugas National Park, visit the remote park known for its historic fort and snorkeling opportunities
- Southernmost Point Buoy, take a photo at the iconic landmark marking the southernmost point in the continental USA
- Key West Ghost and Mysteries Tour, embark on a guided tour exploring the haunted history of the island
- Fury Water Adventures, enjoy a variety of water sports including snorkeling, parasailing, and sunset cruises.
popular bus stations
Popular bus stations from Harrisburg, PA to Key West, FL
Most popular bus connections from Harrisburg, PA
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