- Must visit
Ernest Hemingway Home and Museum
The Ernest Hemingway Home and Museum lets visitors tour the writer's residence, gardens, and rooms tied to his Key West years.
Cheapest price on Sep 19
€234
Average ticket price on Sep 19
€234
Fastest journey on Sep 19
1 d 19 h
Average journey duration on Sep 19
1 d 19 h
Buses on Sep 19
1
Distance
1806 km
The best way to find a cheap bus ticket from Harrisburg, PA to Key West, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Harrisburg, PA to Key West, FL will cost around €234 if you buy it on the day, but the cheapest tickets can be found for only €234.
On Sat, Sep 19, we found 1 buses from Harrisburg, PA to Key West, FL, including 1 direct services.
On Sat, Sep 19 the direct buses cover the 1806 km distance in an average of 1 d 19 h but if you time it right, some buses will get you there in just 1 d 19 h .
On Sat, Sep 19 the slowest buses will take 1 d 19 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Omio recommends booking the bus as it is the most popular option from Harrisburg, PA to Key West, FL among Omio's users. If you are prioritising price, take the bus, with an average ticket price of €227 For those with little time, consider booking a bus, which has an average total journey time of 33h 30m. Average ticket prices depend on the travel mode: a bus costs an average of €227, while a bus costs an average of €227.
Distance: 1122 miles (1806 km)
Most popular Bus | Driving |
|---|---|
€227 Average price Cheapest | €222 Average price (fuel + tolls) |
33h 30m Average total duration Fastest 33h 0m Onboard + 30m Additional time* | 20h 2m Average total duration (door-to-door) |
![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
This is compared to other travel options from Harrisburg, PA to Key West, FL:
A bus is €420 less than a flight for this route with tickets for a flight from Harrisburg, PA to Key West, FL costing on average €647.
Other travel options to Key West, FL take longer:
Bus takes on average 33h 0m.
Tickets start at around €227 compared to roughly €222 in fuel and tolls — a saving of about €-4.89. The journey takes 33h 0m versus 20h 2m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 12:30PM | Arrival Time 01:02PM | Duration 48h32 | Departure days Wed, Thu, Fri | Cheapest price €213 |
Operator Greyhound | Departure Time 06:30PM | Arrival Time 01:30PM | Duration 43h00 | Departure days Sat | Cheapest price €234 |
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Harrisburg, PA to Key West, FL run on average 1 times per day, taking around 33h 0m. Cheap bus tickets for this journey start at €227 if you book in advance.
The earliest bus runs at 12:30, the last at 12:30. The fastest bus covers the 1122 miles (1806 km) distance in 33h 0m.
Distance 1122 miles (1806 km) |
Average bus duration 33h 0m |
Cheapest ticket price €227 |
Buses per day 1 |
Fastest bus 33h 0m |
First bus 12:30 PM |
Last bus 12:30 PM |
Cheapest Month Apr |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Oct - Dec |
Discover the best of Key West, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Key West, FL trip today.
The Ernest Hemingway Home and Museum lets visitors tour the writer's residence, gardens, and rooms tied to his Key West years.
The Key West Butterfly and Nature Conservatory features a glass habitat with butterflies, birds, and tropical plants in a calm setting.
The Key West Museum of Art and History at the Custom House presents island history, art, and rotating exhibitions in a grand landmark building.
Duval Street is Key West's main historic thoroughfare, lined with shops, galleries, and lively architecture across the old town.
Mallory Square is a waterfront plaza known for harbor views, public space, and easy access to the historic seaport district.
Fort Zachary Taylor Historic State Park combines a coastal fort, walking paths, shaded grounds, and one of the island's best natural beaches.
Find answers to the most common questions about traveling from Harrisburg, PA to Key West, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Key West, FL, this guide helps you travel smarter and with confidence.

Most Harrisburg, PA to Key West, FL buses use the Harrisburg, Market St (Bus Station) to Key West, South Roosevelt Boulevard (Key West International Airport) station pair. Use this guide to compare Harrisburg, PA and Key West, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Harrisburg, Market St (Bus Station) is 1 km from Harrisburg city centre. Public transport options include:
Harrisburg, Market St (Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free WiFi inside the station. ATMs are available at Harrisburg, Market St (Bus Station).
Ticket office support is available at Harrisburg, Market St (Bus Station).
Available at Harrisburg, Market St (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Harrisburg, Market St (Bus Station): Wheelchair accessible with ramps.
Key West, South Roosevelt Boulevard (Key West International Airport) is 2 km from Key West city centre. Public transport options include:
Key West, South Roosevelt Boulevard (Key West International Airport) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Key West, South Roosevelt Boulevard (Key West International Airport). ATMs are available at Key West, South Roosevelt Boulevard (Key West International Airport).
Ticket office support is available at Key West, South Roosevelt Boulevard (Key West International Airport).
Available at Key West, South Roosevelt Boulevard (Key West International Airport): Parking, Taxis, WC.
Accessibility facilities are available at Key West, South Roosevelt Boulevard (Key West International Airport): The station is wheelchair accessible.
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