Why should you book Kissimmee, FL to Key West, FL buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of Lynx Central Florida Transport to find the best option for your trip from Kissimmee, FL to Key West, FL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Journey information
Overview: Bus from Kissimmee, FL to Key West, FL
Buses from Kissimmee, FL to Key West, FL run on average 3 times per day, taking around 8h 45m. Cheap bus tickets for this journey start at $136 (€110) if you book in advance.
The earliest bus runs at 10:00, the last at 17:00. The fastest bus covers the 259 miles (418 km) distance in 20h 30m.
Distance 259 miles (418 km) |
Average bus duration 8h 45m |
Cheapest ticket price $136 (€110) |
Buses per day 3 |
Fastest bus 20h 30m |
First bus 10:00 |
Last bus 17:00 |
Cheapest month Aug |
Cheapest day Thu |
High season Jul - Sep |
Low season Jul - Sep |
Bus providers: Greyhound, Lynx Central Florida Transport from Kissimmee, FL to Key West, FLYou can travel by bus between Kissimmee, FL to Key West, FL with Greyhound, Lynx Central Florida Transport for as low as $136 (€110). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
Lynx Central Florida Transport
FAQs: Bus from Kissimmee, FL to Key West, FL
Find answers to the most common questions about traveling from Kissimmee, FL to Key West, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Key West, FL, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Ernest Hemingway Home and Museum, the former residence of the famous author featuring guided tours and a colony of six-toed cats
- Key West Butterfly and Nature Conservatory, a lush habitat housing hundreds of butterflies and exotic birds
- Fort Zachary Taylor Historic State Park, a Civil War-era fort offering beach access, snorkeling, and picnic areas
- Mallory Square, a waterfront plaza known for its nightly sunset celebrations and street performances
- Key West Lighthouse and Keeper's Quarters Museum, offering panoramic views of the island and insights into maritime history.
- Duval Street, stroll along the vibrant street lined with shops, bars, and restaurants
- Dry Tortugas National Park, visit the remote park known for its historic fort and snorkeling opportunities
- Southernmost Point Buoy, take a photo at the iconic landmark marking the southernmost point in the continental USA
- Key West Ghost and Mysteries Tour, embark on a guided tour exploring the haunted history of the island
- Fury Water Adventures, enjoy a variety of water sports including snorkeling, parasailing, and sunset cruises.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Kissimmee, FL to Key West, FL
Most popular bus connections from Kissimmee, FL
More options for your journey from Kissimmee, FL to Key West, FL
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