Travel Information
Compare bus and train for Syracuse to Palermo
Omio recommends booking the bus as it is the most popular option from Syracuse to Palermo among Omio's users. If you are prioritising price take the train with prices starting from $24. For those with little time consider booking a bus which can get you there in 3h 31m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.2kg. The ticket price range depends on the travel mode: a train costs an average of $24, and a bus costs an average of $20.
Distance: 126 miles (204 km)
Compare bus with
Most popular Bus | Train |
|---|---|
$30 Average price | $25 Average price Cheapest |
4h 1m Average total duration Fastest 3h 31m Onboard + 30m Additional time* | 5h 30m Average total duration 5h 0m Onboard + 30m Additional time* |
0.2 - 0.5kg CO2 emissions | 0.1 - 0.2kg CO2 emissions Lowest |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Syracuse to Palermo:
A train is $5 (€4) less than a bus for this route with tickets for a bus from Syracuse to Palermo costing on average $30 (€25).
Other travel options to Palermo take longer:
Train takes on average 5h 0m.
Travel optionsfrom Syracuse to Palermo
How to get from Syracuse to Palermo by train, bus or flight.
Our recommendation
The best way to travel from Syracuse to Palermo is by taking a train because it’s the best combination of price and speed.
Regionale 22112 · Regionale 5513 · treno 5513 effettuato con bus PA3312:13 PM4h45Syracuse station6:58 PMPalermo Centrale$241One-way2 transfers
Cheapest
Regionale 22112 · Regionale 5513 · treno 5513 effettuato con bus PA3312:13 PM4h45Syracuse station6:58 PMPalermo Centrale$241One-way2 transfers
Fastest
FlixBus · FlixBus7:15 AM3h45Syracuse, Corso Umberto I11:00 AMPalermo, Via Tommaso Fazello (Terminal Bus)$451One-way1 transfer
Other options
Regionale 5388 · Regionale 5519 · treno 5519 effettuato con bus PA3333:42 PM5h16Syracuse station8:58 PMPalermo Centrale$241One-way2 transfers
Regionale 5500 · Regionale 5503 · treno 5503 effettuato con bus PA3255:35 AM5h23Syracuse station10:58 AMPalermo Centrale$241One-way2 transfers
Regionale 22112 · Regionale 53672:13 PM5h45Syracuse station7:58 PMPalermo Centrale$311One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Syracuse to Palermo
Travel to Palermo easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Syracuse to Palermo.

This is compared to other travel options from Syracuse to Palermo:
A train is $5 (€4) less than a bus for this route with tickets for a bus from Syracuse to Palermo costing on average $30 (€25).
Other travel options to Palermo take longer:
Train takes on average 5h 0m.
- Around 9 trains per day.
- Around 4 buses per day.
However, we recommend checking specific travel dates for your route between Syracuse and Palermo as scheduled services by bus and train can vary by season or day of the week.
- Trains mostly depart from Syracuse station and arrive in Palermo Centrale.
- Buses mostly depart from Syracuse, Corso Umberto I and arrive in Palermo, Via Tommaso Fazello (Terminal Bus).
- Ferries mostly depart from Port of Milazzo and arrive in Port of Palermo.
- Travel with Interbus S.p.A., Alibus, Infobus, FlixBus, BlaBlaCar to go to Palermo by bus.
- Travel with Regionale, Intercity to go to Palermo by train.
- 2 direct buses per day with Interbus S.p.A., BlaBlaCar.
Travelling from Syracuse to Palermo: related information
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