Travel Information
Compare bus and train for Syracuse to Palermo
Omio recommends booking the bus as it is the most popular option from Syracuse to Palermo among Omio's users. If you are prioritising price take the train with prices starting from $25. For those with little time consider booking a bus which can get you there in 3h 34m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.2kg. The ticket price range depends on the travel mode: a train costs an average of $25, and a bus costs an average of $20.
Distance: 126 miles (204 km)
Compare bus with
Most popular Bus | Train |
|---|---|
$34 Average price | $26 Average price Cheapest |
4h 4m Average total duration Fastest 3h 34m Onboard + 30m Additional time* | 5h 38m Average total duration 5h 8m Onboard + 30m Additional time* |
0.2 - 0.5kg CO2 emissions | 0.1 - 0.2kg CO2 emissions Lowest |
![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Syracuse to Palermo
How to get from Syracuse to Palermo by train, bus or flight.
Our recommendation
The best way to travel from Syracuse to Palermo is by taking a train because it’s the best combination of price and speed.
Regionale 22112 · Regionale Veloce 55132:13 PM4h19Syracuse station6:32 PMPalermo Centrale$251One-way1 transfer
Cheapest
Regionale 22112 · Regionale Veloce 55132:13 PM4h19Syracuse station6:32 PMPalermo Centrale$251One-way1 transfer
Fastest
Regionale 22112 · Regionale Veloce 55132:13 PM4h19Syracuse station6:32 PMPalermo Centrale$251One-way1 transfer
Other options
Regionale 5388 · Regionale Veloce 55193:42 PM4h50Syracuse station8:32 PMPalermo Centrale$251One-way1 transfer
Regionale 5500 · Regionale Veloce 55035:32 AM5h00Syracuse station10:32 AMPalermo Centrale$251One-way1 transfer
FlixBus · FlixBus7:15 AM8h00Syracuse, Corso Umberto I3:15 PMPalermo, Via Tommaso Fazello (Terminal Bus)$331One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Syracuse to Palermo
Travel to Palermo easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Syracuse to Palermo.

This is compared to other travel options from Syracuse to Palermo:
A bus is $5 (€4) less than a train for this route with tickets for a train from Syracuse to Palermo costing on average $25 (€20).
Other travel options to Palermo take longer:
Train takes on average 4h 13m.
- Around 10 trains per day.
- Around 6 buses per day.
However, we recommend checking specific travel dates for your route between Syracuse and Palermo as scheduled services by bus and train can vary by season or day of the week.
- Trains mostly depart from Syracuse station and arrive in Palermo Centrale.
- Buses mostly depart from Syracuse, Corso Umberto I and arrive in Palermo, Via Tommaso Fazello (Terminal Bus).
- Travel with Interbus S.p.A., Alibus, Infobus, FlixBus, BlaBlaCar to go to Palermo by bus.
- Travel with Regionale, Intercity to go to Palermo by train.
- 3 direct buses per day with Interbus S.p.A., BlaBlaCar.
Travelling from Syracuse to Palermo: related information
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