- Must visit
Antonino Salinas Regional Archaeological Museum
Palermo’s top museum displays Sicilian archaeology, including the famous Punic Stone and Selinunte finds, in a former convent complex.
Cheapest price
zł453
Average price
zł665
Fastest journey
21 h
Average duration
21 h 49 m
Buses per day
9
Distance
887 km
The best way to find a cheap bus ticket from Milan to Palermo is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Milan to Palermo will cost around zł665 if you buy it on the day, but the cheapest tickets can be found for only zł453.
Of the 9 buses that leave Milan for Palermo on Wed, Aug 05, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Aug 05 the direct buses cover the 887 km distance in an average of 21 h 49 m but if you time it right, some buses will get you there in just 21 h .
On Wed, Aug 05 the slowest buses will take 22 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
S121 · S201
S121 · S201
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus
FlixBus
S121 · S201
S121 · S201
FlixBus
FlixBus · FlixBus
FlixBus · FlixBusOmio recommends booking the flight as it is the most popular option from Milan to Palermo among Omio's users. If you are prioritising price take the ferry with prices starting from zł302. For those with little time consider booking a flight which can get you there in 1h 51m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.3 - 0.8kg. The ticket price range depends on the travel mode: a ferry costs an average of zł302, and a flight costs an average of zł79.
Distance: 551 miles (887 km)
| Bus | Most popular Flight | Train | Ferry |
|---|---|---|---|
zł410 Average price | zł561 Average price | zł561 Average price | zł329 Average price Cheapest |
20h 50m Average total duration 20h 20m Onboard + 30m Additional time* | 4h 51m Average total duration Fastest 1h 51m Onboard + 3h 0m Additional time* | 16h 38m Average total duration 16h 8m Onboard + 30m Additional time* | 21h 3m Average total duration 20h 3m Onboard + 1h 0m Additional time* |
0.9 - 2.2kg CO2 emissions | 2.7 - 5.3kg CO2 emissions | 0.3 - 0.8kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | ![]() Most popular ferry company |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Milan to Palermo:
A ferry is zł81 less than a bus for this route with tickets for a bus from Milan to Palermo costing on average zł410.
A ferry is zł232 less than a train for this route with tickets for a train from Milan to Palermo costing on average zł561.
A ferry is zł232 less than a flight for this route with tickets for a flight from Milan to Palermo costing on average zł561.
Other travel options to Palermo take longer:
Train takes on average 16h 8m.
Ferry takes on average 20h 3m.
Bus takes on average 20h 20m.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 07:50AM | Arrival Time 10:00AM | Duration 26h10 | Departure days Tue | Cheapest price zł311 |
Operator Itabus | Departure Time 08:00AM | Arrival Time 07:50AM | Duration 23h50 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price zł206 |
Operator FlixBus | Departure Time 08:20AM | Arrival Time 01:15PM | Duration 28h55 | Departure days Tue | Cheapest price zł389 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 11:00AM | Duration 25h20 | Departure days Thu | Cheapest price zł810 |
Operator Salemi | Departure Time 10:00AM | Arrival Time 07:45AM | Duration 21h45 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price zł453 |
Operator FlixBus | Departure Time 10:20AM | Arrival Time 03:15PM | Duration 28h55 | Departure days Wed, Thu, Fri, Sun | Cheapest price zł448 |
Operator Salemi | Departure Time 10:45AM | Arrival Time 07:45AM | Duration 21h00 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price zł453 |
Operator FlixBus | Departure Time 11:00AM | Arrival Time 12:55PM | Duration 25h55 | Departure days Tue | Cheapest price zł256 |
Operator FlixBus | Departure Time 12:00PM | Arrival Time 03:15PM | Duration 27h15 | Departure days Mon, Sat | Cheapest price zł845 |
Operator FlixBus | Departure Time 12:45PM | Arrival Time 11:00AM | Duration 22h15 | Departure days Mon, Wed, Fri, Sat, Sun | Cheapest price zł755 |
Operator FlixBus | Departure Time 01:05PM | Arrival Time 01:15PM | Duration 24h10 | Departure days Everyday | Cheapest price zł300 |
Operator FlixBus | Departure Time 02:30PM | Arrival Time 01:15PM | Duration 22h45 | Departure days Tue | Cheapest price zł652 |
Operator FlixBus | Departure Time 02:45PM | Arrival Time 03:15PM | Duration 24h30 | Departure days Mon | Cheapest price zł645 |
Operator FlixBus | Departure Time 03:15PM | Arrival Time 03:15PM | Duration 24h00 | Departure days Mon, Wed | Cheapest price zł645 |
Operator FlixBus | Departure Time 03:45PM | Arrival Time 05:20PM | Duration 25h35 | Departure days Tue | Cheapest price zł485 |
Operator FlixBus | Departure Time 04:40PM | Arrival Time 03:15PM | Duration 22h35 | Departure days Thu, Fri, Sat, Sun | Cheapest price zł696 |
Operator FlixBus | Departure Time 05:25PM | Arrival Time 03:15PM | Duration 21h50 | Departure days Thu, Fri, Sat, Sun | Cheapest price zł703 |
Operator FlixBus | Departure Time 05:45PM | Arrival Time 07:20PM | Duration 25h35 | Departure days Mon, Wed, Sat, Sun | Cheapest price zł604 |
Operator FlixBus | Departure Time 06:30PM | Arrival Time 07:20PM | Duration 24h50 | Departure days Mon, Wed, Sat, Sun | Cheapest price zł604 |
The table below shows live departures for Milan to Palermo buses for tomorrow, Wednesday, August 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
S121 · S201 | 10:00 AM Milano, Autostazione Lampugnano | 21h45 | 7:45 AM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 10:20 AM Milano, Milan Linate Airport | 28h55 | 3:15 PM Palermo, Via Tommaso Fazello (Terminal Bus) | 2 transfers | |
S121 · S201 | 10:45 AM Milano, San Donato M3 | 21h00 | 7:45 AM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
FlixBus · FlixBus | 12:45 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 22h15 | 11:00 AM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
FlixBus | 1:05 PM Milano, Autostazione Lampugnano | 21h55 | 11:00 AM Palermo, Via Tommaso Fazello (Terminal Bus) | 0 transfersDirect | |
FlixBus · FlixBus | 1:05 PM Milano, Autostazione Lampugnano | 22h10 | 11:15 AM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
FlixBus · FlixBus | 3:15 PM Milano, Autostazione Lampugnano | 24h00 | 3:15 PM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
FlixBus · FlixBus | 5:45 PM Milano, Autostazione Lampugnano | 25h35 | 7:20 PM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
FlixBus · FlixBus | 6:30 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 24h50 | 7:20 PM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Milan to Palermo run on average 6 times per day, taking around 20h 20m. Cheap bus tickets for this journey start at zł247 but you can travel from only zł79 by flight.
There are 1 buses per day. The earliest bus runs at 00:52, the last at 22:45. The fastest bus covers the 551 miles (887 km) distance in 21h 45m.
Distance 551 miles (887 km) |
Average bus duration 20h 20m |
Cheapest ticket price zł247 |
Buses per day 6 |
Direct buses 1 |
Fastest bus 21h 45m |
First bus 12:52 AM |
Last bus 10:45 PM |
Cheapest Month Mar |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Tue |
Least Busy Day Sat |
Best time to book 35 days |
Discover the best of Palermo — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Palermo trip today.
Palermo’s top museum displays Sicilian archaeology, including the famous Punic Stone and Selinunte finds, in a former convent complex.
Historic rooms and vivid majolica floors showcase aristocratic Palermo. Visit for decorative arts, period interiors and city history.
Housed in the grand Steri Palace, this museum presents the Sicilian Inquisition’s story through cells, graffiti and historical documents.
Palermo’s elegant main boulevard links major monuments, shops and theaters. Ideal for first walks and observing the city’s layered architecture.
This historic street cuts across the old center and hosts markets, churches and daily life. A lively route for exploring local Palermo.
A bustling old quarter famous for layered street life, churches and market culture. Best explored on foot for atmosphere and urban history.
Crisp fried rice ball stuffed with ragù, peas and caciocavallo. A Sicilian street food icon widely loved in Palermo.
Soft sesame-topped bun filled with spleen and lung, often with caciocavallo or ricotta. A classic Palermo street food with deep local roots.
Pasta with sardines, wild fennel, pine nuts and raisins. Its sweet-savory flavor reflects Palermo's Arab-Norman culinary heritage.
Refined Michelin-starred restaurant known for creative Sicilian tasting menus in an elegant, intimate setting.
Historic seafood restaurant near the port, praised for fresh catch, raw dishes and classic Palermo fish recipes.
Legendary no-frills street-food stop celebrated for pane con la milza and authentic local sandwiches loved by residents.
Moderate for Italy. Street food and local meals are affordable, while hotels in peak season cost more. Public transport is cheap, keeping overall tourist costs reasonable.
Service is often included or modest. Round up or leave 5-10% for great restaurant service. Taxis are usually rounded up. Small change is fine in cafes.
Bus trips to Milan and Palermo have a total duration of about 20 hours, including the passage over the Strait of Messina. Every day there are generally four journeys: two direct journeys and two routes with change, with a departure in the middle of the day and three evening journeys. The vehicles depart from the Bus Station of Lampugnano or the San Donato Bus Station, while the arrival station in Palermo is located in Piazza Cairoli.
The company that makes the direct trip is Bus Center, provides two trips a day and provides between services on board toilets and electrical outlets. The connection with gearbox is offered instead by the line Baltour.
The direct trip to Milan Palermo operated by Bus Center bus lines lasts from 19 to 22 hours. The change connection proposed by Baltour provides departures from the Bus Station of Lampugnano, with a journey time between 17 hours and 45 minutes and 18 hours and 30 minutes.
Two direct rides are scheduled each day, departing around 13:45 and 20:45. Coach services that make trips with change leave Milan in the evening with arrival in the next afternoon. A total of at least 25 connections are guaranteed each week.
Milan Palermo buses leave from Lampugnano Bus Station, which can be reached by metro, or from Piazzale San Donato Bus Station, which is connected to the city centre by the M3 underground. The terminus is in Palermo in Piazza Cairoli, connected to the rest of the city by several bus lines.
Find answers to the most common questions about traveling from Milan to Palermo by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Palermo, this guide helps you travel smarter and with confidence.

Most Milan to Palermo buses use the Milano, Autostazione Lampugnano to Palermo, Via Tommaso Fazello (Terminal Bus) station pair. Use this guide to compare Milan and Palermo bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Milano, Autostazione Lampugnano is 5 km from Milan city centre. Public transport options include:
Milano, Autostazione Lampugnano has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Lampugnano (in the station), Trattoria Milano (0.5 km), Pizza Express (0.7 km).
Free Wi-Fi. ATMs are located near the main entrance.
Ticket office support is available at Milano, Autostazione Lampugnano.
Available at Milano, Autostazione Lampugnano: Parking, Taxis, WC.
Accessibility facilities are available at Milano, Autostazione Lampugnano: Elevators, ramps.
Milano, San Donato - Settore B (Viale Giuseppe Impastato) is 6 km from Milan city centre. Public transport options include:
Milano, San Donato - Settore B (Viale Giuseppe Impastato) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Italiana (in the station), Fast Food Express (in the station), Trattoria Milano (0.5 km).
Free Wi-Fi. ATMs are located near the main entrance for cash withdrawals.
Ticket office support is available at Milano, San Donato - Settore B (Viale Giuseppe Impastato).
Available at Milano, San Donato - Settore B (Viale Giuseppe Impastato): Parking, Taxis, WC.
Accessibility facilities are available at Milano, San Donato - Settore B (Viale Giuseppe Impastato): Elevators, ramps.
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