- Must visit
Saint Louis Art Museum
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
The best way to find a cheap bus ticket from Springfield, MA to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Springfield, MA to St. Louis, MO will cost around $301 if you buy it on the day, but the cheapest tickets can be found for only $300.
It's difficult to get from Springfield, MA to St. Louis, MO without transferring at least once.

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Buses from Springfield, MA to St. Louis, MO run on average 4 times per day, taking around 26h 20m. Cheap bus tickets for this journey start at $102 if you book in advance.
The earliest bus runs at 02:00, the last at 23:30. The fastest bus covers the 955 miles (1538 km) distance in 24h 15m.
Distance 955 miles (1538 km) |
Average bus duration 26h 20m |
Cheapest ticket price $102 |
Buses per day 4 |
Fastest bus 24h 15m |
First bus 2:00 AM |
Last bus 11:30 PM |
Cheapest Month Mar |
Cheapest Day Wed |
High Season Jan - Mar |
Low Season Jul - Sep |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Springfield, MA to St. Louis, MO.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 03:25AM | Arrival Time 12:55PM | Duration 33h30 | Departure days Thu | Cheapest price $153 |
Operator Greyhound | Departure Time 03:35AM | Arrival Time 12:55PM | Duration 33h20 | Departure days Sat | Cheapest price $230 |
Operator Flixbus USA | Departure Time 04:15AM | Arrival Time 07:55AM | Duration 27h40 | Departure days Sat | Cheapest price $300 |
Operator Greyhound | Departure Time 04:25AM | Arrival Time 01:55PM | Duration 33h30 | Departure days Thu, Fri | Cheapest price $236 |
Operator Greyhound | Departure Time 08:15AM | Arrival Time 12:55PM | Duration 28h40 | Departure days Mon | Cheapest price $235 |
Operator Flixbus USA | Departure Time 12:45PM | Arrival Time 11:25PM | Duration 34h40 | Departure days Tue | Cheapest price $302 |
Operator Flixbus USA | Departure Time 04:00PM | Arrival Time 11:25PM | Duration 31h25 | Departure days Sun | Cheapest price $300 |
Operator FlixBus | Departure Time 08:00PM | Arrival Time 04:20AM | Duration 32h20 | Departure days Thu | Cheapest price $217 |
Operator Greyhound | Departure Time 09:40PM | Arrival Time 04:20AM | Duration 30h40 | Departure days Thu | Cheapest price $238 |
Operator Flixbus USA | Departure Time 11:25PM | Arrival Time 07:55AM | Duration 32h30 | Departure days Tue, Sun | Cheapest price $300 |
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of St. Louis, MO — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis, MO trip today.
Vast art museum in Forest Park with global collections from antiquity to modern works and strong free general admission.
Leading history museum covering St. Louis, Missouri, and national stories through rotating exhibitions in Forest Park.
Interactive science museum with hands-on exhibits, planetarium, and family-friendly displays near Forest Park.
Lively downtown riverfront district with trails, views of the Arch, public art, and access to major historic sites.
Large urban park with trails, lakes, zoo access, and major museums, ideal for walking between top attractions.
Beloved neighborhood park with formal lily ponds, pavilions, and one of the city's most photographed landscapes.
A thin, cracker-like crust pizza cut into squares and topped with Provel cheese, a St. Louis original loved for its distinct texture and tangy flavor.
Crisp, breaded ravioli said to be born on The Hill, usually served with marinara. It is a signature St. Louis Italian-American appetizer.
Sticky butter cake with a dense base and gooey sweet top. A longtime St. Louis bakery favorite often enjoyed for breakfast or dessert.
Refined contemporary restaurant with tasting menus and strong national acclaim. Elegant fine dining focused on seasonal Midwestern ingredients.
Beloved frozen custard stand serving concretes and sundaes since 1929. Casual, nostalgic, and one of the city's iconic dessert stops.
Popular smokehouse known for St. Louis barbecue, especially ribs, brisket, and pork steak, in a polished but relaxed atmosphere.
Moderate for U.S. city breaks: hotels and dining are reasonable, transit is limited, and attractions often cost less than in larger U.S. tourist cities.
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in St. Louis, MO.
Find answers to the most common questions about traveling from Springfield, MA to St. Louis, MO by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

Most Springfield, MA to St. Louis, MO buses use the Springfield, Union Station (Frank B Murray St) to St. Louis, S 15th St (Civic center) station pair. Use this guide to compare Springfield, MA and St. Louis, MO bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Springfield, Union Station (Frank B Murray St) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Fast food options available on site.
Free WiFi available in the waiting area. ATMs are aTM is located in the main hall.
Ticket office support is available at Springfield, Union Station (Frank B Murray St).
Available at Springfield, Union Station (Frank B Murray St): Parking, Taxis, WC.
Accessibility facilities are available at Springfield, Union Station (Frank B Murray St): Wheelchair accessible with ramps and elevators.
St. Louis, S 15th St (Civic center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at St. Louis, S 15th St (Civic center). ATMs are available at St. Louis, S 15th St (Civic center).
Ticket office support is available at St. Louis, S 15th St (Civic center).
Available at St. Louis, S 15th St (Civic center): Parking, Taxis, WC.
Accessibility facilities are available at St. Louis, S 15th St (Civic center): Wheelchair accessible routes available.
Check bus stations information for Springfield, MA and St. Louis, MO, including where buses depart and arrive on this route.
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