The cheapest and fastest buses from Lucerne to Prague
Cheapest price
$81
Average price
$123
Fastest journey
11 h 5 m
Average duration
14 h 9 m
Buses per day
16
Distance
562 km
The best way to find a cheap bus ticket from Lucerne to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lucerne to Prague will cost around $123 if you buy it on the day, but the cheapest tickets can be found for only $81.
Of the 16 buses that leave Lucerne for Prague on Sun, Mar 22, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Mar 22 the direct buses cover the 562 km distance in an average of 14 h 9 m but if you time it right, some buses will get you there in just 11 h 5 m .
On Sun, Mar 22 the slowest buses will take 16 h 20 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
(Milan -> Prague)
(Milan -> Prague)
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
(Milan -> Prague)
(Milan -> Prague)
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBusTravel Information
Compare bus, train, and flight for Lucerne to Prague
Omio recommends booking the train as it is the most popular option from Lucerne to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $49. For those with little time consider booking a flight which can get you there in 1h 56m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $49, and a flight costs an average of $87.
Distance: 349 miles (562 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
$81 Average price Cheapest | $149 Average price | $227 Average price |
13h 1m Average total duration 12h 31m Onboard + 30m Additional time* | 12h 14m Average total duration 11h 44m Onboard + 30m Additional time* | 4h 56m Average total duration Fastest 1h 56m Onboard + 3h 0m Additional time* |
0.6 - 1.4kg CO2 emissions | 0.2 - 0.5kg CO2 emissions Lowest | 1.7 - 3.4kg CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Lucerne to Prague Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:15AM | Arrival Time 08:35PM | Duration 18h20 | Departure days Sun | Cheapest price $126 |
Operator FlixBus | Departure Time 04:25AM | Arrival Time 09:30PM | Duration 17h05 | Departure days Sun | Cheapest price $119 |
Operator FlixBus | Departure Time 07:15AM | Arrival Time 03:15AM | Duration 20h00 | Departure days Sun | Cheapest price $205 |
Operator FlixBus | Departure Time 03:35PM | Arrival Time 11:30AM | Duration 19h55 | Departure days Thu, Fri, Sun | Cheapest price $90 |
Operator FlixBus | Departure Time 04:35PM | Arrival Time 08:55AM | Duration 16h20 | Departure days Thu, Fri, Sun | Cheapest price $96 |
Operator Regiojet | Departure Time 07:20PM | Arrival Time 06:28AM | Duration 11h08 | Departure days Sun | Cheapest price $81 |
Live departures
Lucerne to Prague bus times
The table below shows live departures for Lucerne to Prague buses for today, Saturday, March 21. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:15 AM Lucerne | 23h00 | 5:15 AM Prague | 0 transfersDirect | |
![]() | 3:10 PM Lucerne | 19h20 | 10:30 AM Prague | 0 transfersDirect | |
![]() | 3:20 PM Lucerne | 16h35 | 7:55 AM Prague | 0 transfersDirect | |
![]() | 3:35 PM Lucerne | 18h00 | 9:35 AM Prague | 0 transfersDirect | |
| Sunday, March 22 | |||||
FlixBus · FlixBus · FlixBus | 1:15 AM Luzern, Landenburgstrasse (Busparkplatz) | 18h20 | 7:35 PM Praha, ÚAN Florenc | 2 transfers | |
FlixBus · FlixBus · FlixBus | 1:15 AM Luzern, Landenburgstrasse (Busparkplatz) | 18h05 | 7:20 PM Praha, Na Knížecí | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Lucerne to Prague by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 22
Mar 23
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Mar 25
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Mar 27
Mar 28
Mar 29
Mar 30
Mar 31
Apr 01
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Why should you book Lucerne to Prague buses with Omio?
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Lucerne to Prague.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Lucerne to Prague.
Journey information
Overview: Bus from Lucerne to Prague
Buses from Lucerne to Prague run on average 13 times per day, taking around 12h 31m. Cheap bus tickets for this journey start at $49 (€40) if you book in advance.
The earliest bus runs at 01:30, the last at 23:50. The fastest bus covers the 349 miles (562 km) distance in 11h 8m.
Distance 349 miles (562 km) |
Average bus duration 12h 31m |
Cheapest ticket price $49 (€40) |
Buses per day 13 |
Fastest bus 11h 8m |
First bus 01:30 |
Last bus 23:50 |
Bus providers: FlixBus from Lucerne to PragueYou can travel by bus between Lucerne to Prague with FlixBus for as low as $49 (€40). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Lucerne to Prague
Find answers to the most common questions about traveling from Lucerne to Prague by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Prague Castle, a historic complex and the official office of the Czech president offering panoramic city views
- Charles Bridge, a 14th-century stone bridge adorned with statues and connecting the Old Town with Lesser Town
- Old Town Square, a vibrant historic square featuring the Astronomical Clock and Gothic churches
- St. Vitus Cathedral, a stunning Gothic cathedral known for its impressive architecture and stained glass windows
- The Jewish Quarter, a historic area with preserved synagogues and the Old Jewish Cemetery.
- Petrin Hill, a lush park providing panoramic views of the city and home to the Petrin Tower and Mirror Maze
- Explore the vibrant nightlife in the Vinohrady district, known for its trendy bars and cafes
- Take a boat cruise on the Vltava River to see Prague's landmarks from a different perspective
- Visit the National Museum to delve into Czech history and culture
- Enjoy a classical music concert in one of Prague's historic churches or concert halls.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Lucerne to Prague
- 00:00-23:59
- Free Wi-Fi
- Czech Bistro (in the station)
- Fast Food Express (in the station)
- Bohemian Café (0.2 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 135, 175, 207 Metro: C Train: All major s
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Florenc (in the station)
- Bistro Florenc (0.2 km)
- Restaurace U Rozvařilů (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 133, 135, 175, 207 Metro: B, C
- Free Wi-Fi
- Café Na Knížecí (in the station)
- Bistro Praha (0.2 km)
- Restaurace U Knížete (0.5 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 137, 176, 191 Metro: B
Most popular bus connections from Lucerne
More options for your journey from Lucerne to Prague
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