The cheapest and fastest buses from Milan to Syracuse
Cheapest price
$62
Average price
$85
Fastest journey
20 h 40 m
Average duration
22 h 42 m
Buses per day
3
Distance
1061 km
The best way to find a cheap bus ticket from Milan to Syracuse is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Milan to Syracuse will cost around $85 if you buy it on the day, but the cheapest tickets can be found for only $62.
It's difficult to get from Milan to Syracuse without transferring at least once.
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBusTravel Information
Compare bus, train, and flight for Milan to Syracuse
Omio recommends booking the train as it is the most popular option from Milan to Syracuse among Omio's users. If you are prioritising price take the flight with prices starting from €14. For those with little time consider booking a flight which can get you there in 1h 50m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.3 - 1.0kg. The ticket price range depends on the travel mode: a flight costs an average of €14, and a train costs an average of €60.
Distance: 659 miles (1061 km)
Compare bus with
| Bus | Most popular Train | Flight |
|---|---|---|
€102 Average price | €127 Average price | €91 Average price Cheapest |
21h 42m Average total duration 21h 12m Onboard + 30m Additional time* | 15h 10m Average total duration 14h 40m Onboard + 30m Additional time* | 4h 50m Average total duration Fastest 1h 50m Onboard + 3h 0m Additional time* |
1.1 - 2.6kg CO2 emissions | 0.3 - 1.0kg CO2 emissions Lowest | 3.2 - 6.4kg CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Milan to Syracuse Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:55PM | Arrival Time 09:35AM | Duration 20h40 | Departure days Mon, Sun | Cheapest price $62 |
Operator FlixBus | Departure Time 08:35PM | Arrival Time 08:40PM | Duration 24h05 | Departure days Mon, Sun | Cheapest price $96 |
Operator FlixBus | Departure Time 09:20PM | Arrival Time 08:40PM | Duration 23h20 | Departure days Mon, Sun | Cheapest price $96 |
Live departures
Milan to Syracuse bus times
The table below shows live departures for Milan to Syracuse buses for today, Sunday, November 30. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 11:55 AM Milano, Autostazione Lampugnano | 20h40 | 8:35 AM Syracuse, Corso Umberto I | 1 transfer | |
FlixBus · FlixBus | 7:35 PM Milano, Autostazione Lampugnano | 24h05 | 7:40 PM Syracuse, Corso Umberto I | 1 transfer | |
FlixBus · FlixBus | 8:20 PM Milano, San Donato - Settore B (Viale Giuseppe Impastato) | 23h20 | 7:40 PM Syracuse, Corso Umberto I | 1 transfer | |
| Monday, December 1 | |||||
![]() | 10:55 AM Milan | 20h40 | 7:35 AM Syracuse | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Milan to Syracuse by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Dec 01
Dec 02
Dec 03
Dec 04
Dec 05
Dec 06
Dec 07
Journey information
Overview: Bus from Milan to Syracuse
Buses from Milan to Syracuse run on average 3 times per day, taking around 21h 12m. Cheap bus tickets for this journey start at $47 (€38) but you can travel from only $18 (€14) by flight.
The earliest bus runs at 04:20, the last at 21:50. The fastest bus covers the 659 miles (1061 km) distance in 20h 40m.
Distance 659 miles (1061 km) |
Average bus duration 21h 12m |
Cheapest ticket price $47 (€38) |
Buses per day 3 |
Fastest bus 20h 40m |
First bus 04:20 |
Last bus 21:50 |
Bus providers: FlixBus from Milan to SyracuseYou can travel by bus between Milan to Syracuse with FlixBus for as low as $18 (€14). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Milan to Syracuse
Find answers to the most common questions about traveling from Milan to Syracuse by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Syracuse, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Itabus
- Assistance
- Dedicated seating areas
- Accessible restrooms.
- Neapolis Archaeological Park, a historical site featuring the Greek Theatre and Roman Amphitheatre
- Ortigia Island, the historical heart of Syracuse known for its Baroque architecture and charming streets
- Syracuse Cathedral, a stunning cathedral built on the remains of a Greek temple
- Temple of Apollo, one of the oldest Doric temples in Sicily, offering insight into ancient Greek architecture
- Castello Maniace, a 13th-century castle offering panoramic views of the sea and city.
- Ear of Dionysius, experience the unique acoustics of this limestone cave
- Aretusa Fountain, admire the legendary freshwater spring surrounded by papyrus plants
- Explore the vibrant local markets, where you can taste and purchase fresh Sicilian produce
- Take a boat tour around Ortigia Island, offering a unique perspective of the city from the water
- Enjoy a traditional Sicilian cooking class, learning to make local dishes with fresh ingredients.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Itabus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
To find the cheapest bus tickets for your trip from Milan to Syracuse, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Itabus
- One carry-on bag up to 10kg and one checked bag up to 20kg.
- FlixBus
- Additional luggage can be purchased for a fee.
- Itabus
- 5€ per additional bag.
- FlixBus
- Small pets in carriers allowed
- Guide dogs travel for free.
- Itabus
- Small pets allowed in carriers
- Larger pets must be leashed and muzzled.
popular bus stations
Popular bus stations from Milan to Syracuse
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Milano (in the station)
- Trattoria San Donato (0.5 km)
- Burger House (0.7 km).
- Available outside the station.
- Elevators, ramps
- Available in the station.
- Metro: M3 Bus: 121, 132, 133
- 06:00-23:00
- Free Wi-Fi
- Cafeteria Lampugnano (in the station)
- Trattoria Milano (0.5 km)
- Pizza Express (0.7 km).
- Available outside the station.
- Elevators, ramps
- Available in the station.
- Metro: M1 Bus: 68, 78, 80
- 06:00-22:00
- Free Wi-Fi
- Cafeteria Italiana (in the station)
- Fast Food Express (in the station)
- Trattoria Milano (0.5 km).
- Available outside the station.
- Elevators, ramps
- Available in the station.
- Bus: 121, 132 Metro: M3
More options for your journey from Milan to Syracuse
Here are some other resources that might have the information you need


