- Must visit
Paolo Orsi Regional Archaeological Museum
Sicily’s most important archaeological museum, with major collections from prehistoric to Greek and Roman Syracuse. A key stop for understanding the city’s ancient history.
Cheapest price
$45
Average price
$49
Fastest journey
14 h 35 m
Average duration
14 h 35 m
Buses per day
2
Distance
456 km
The best way to find a cheap bus ticket from Brindisi to Syracuse is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Brindisi to Syracuse will cost around $49 if you buy it on the day, but the cheapest tickets can be found for only $45.
Of the 2 buses that leave Brindisi for Syracuse on Sat, Jun 20, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Jun 20 the direct buses cover the 456 km distance in an average of 14 h 35 m but if you time it right, some buses will get you there in just 14 h 35 m .
On Sat, Jun 20 the slowest buses will take 14 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Omio recommends booking the train as it is the most popular option from Brindisi to Syracuse among Omio's users. If you are prioritising price take the train with prices starting from $34. For those with little time consider booking a bus which can get you there in 14h 35m. The ticket price range depends on the travel mode: a train costs an average of $34, and a bus costs an average of $41.
Distance: 283 miles (456 km)
| Bus | Most popular Train |
|---|---|
$70 Average price | $68 Average price Cheapest |
15h 5m Average total duration Fastest 14h 35m Onboard + 30m Additional time* | 15h 15m Average total duration 14h 45m Onboard + 30m Additional time* |
Direct Options | Direct Options |
This is compared to other travel options from Brindisi to Syracuse:
A train is $2 (€2) less than a bus for this route with tickets for a bus from Brindisi to Syracuse costing on average $70 (€57).
Other travel options to Syracuse take longer:
Train takes on average 14h 45m.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 04:05AM | Arrival Time 06:40PM | Duration 14h35 | Departure days Tue, Thu, Sat | Cheapest price $52 |
Operator FlixBus | Departure Time 05:05AM | Arrival Time 07:40PM | Duration 14h35 | Departure days Thu, Fri, Sat | Cheapest price $45 |
Operator FlixBus | Departure Time 06:00AM | Arrival Time 08:40PM | Duration 14h40 | Departure days Wed | Cheapest price $81 |
Operator FlixBus | Departure Time 07:20AM | Arrival Time 08:40PM | Duration 13h20 | Departure days Sun | Cheapest price $77 |
The table below shows live departures for Brindisi to Syracuse buses for tomorrow, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 4:05 AM Brindisi | 14h35 | 6:40 PM Syracuse | 0 transfersDirect | |
![]() | 5:05 AM Brindisi | 14h35 | 7:40 PM Syracuse | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Brindisi to Syracuse run on average 2 times per day, taking around 14h 35m. Cheap bus tickets for this journey start at $41 (€34) but you can travel from only $34 (€28) by train.
The earliest bus runs at 05:17, the last at 22:40. The fastest bus covers the 283 miles (456 km) distance in 14h 35m.
Distance 283 miles (456 km) |
Average bus duration 14h 35m |
Cheapest ticket price $41 (€34) |
Buses per day 2 |
Fastest bus 14h 35m |
First bus 5:17 AM |
Last bus 10:40 PM |
Cheapest Month Jan |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Oct - Dec |
Busiest Day Wed |
Least Busy Day Wed |
Best time to book 14 days |
Discover the best of Syracuse — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Syracuse trip today.
Sicily’s most important archaeological museum, with major collections from prehistoric to Greek and Roman Syracuse. A key stop for understanding the city’s ancient history.
An art museum in a historic palace on Ortigia, known for Sicilian medieval and Renaissance works, including Antonello da Messina’s Annunciation.
An interactive museum with models and reconstructions of inventions linked to Leonardo and Archimedes. Popular with families and visitors exploring Ortigia.
The historic heart of Syracuse, packed with sea views, Baroque lanes, markets, and major landmarks. The top area for walking, photography, and atmosphere.
Syracuse’s most celebrated square, framed by elegant Baroque buildings and the cathedral. A classic must-see and especially beautiful in the evening.
A freshwater spring beside the sea, linked to Greek myth and lined with papyrus plants. One of Ortigia’s most photographed corners.
A local pasta preparation often made with tomatoes, garlic, olive oil, breadcrumbs, and sometimes anchovies, reflecting the simple coastal flavors of Syracuse.
Traditional Sicilian pasta with sardines, wild fennel, pine nuts, and raisins; a classic sweet-savory dish widely associated with eastern Sicily.
Swordfish cooked in a rich sauce with tomatoes, capers, olives, and onions, showcasing the seafood traditions of the Ionian coast.
Popular casual spot celebrated for Sicilian sandwiches, boards, and regional products, with a convivial atmosphere in Ortigia.
Established Ortigia restaurant known for refined Sicilian cuisine, fresh seafood, and an elegant atmosphere in a historic setting.
Established Ortigia venue offering creative Sicilian dishes with strong vegetarian and vegan options in a stylish contemporary space.
Moderate by Italian standards. Casual dining is affordable, while Ortigia hotels and seafood restaurants cost more in peak season.
Service is often included or modest. Tipping is not required, but leaving EUR 1-2 at cafes or 5-10% in restaurants for good service is appreciated. Round up taxis.
Official public transport app
Syracuse, Corso Gelone (Gelone est 2) -> Siracusa Railway Station
Find answers to the most common questions about traveling from Brindisi to Syracuse by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Syracuse, this guide helps you travel smarter and with confidence.

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