- Must visit
International Civil Rights Center & Museum
Major museum preserving the Woolworth sit-in site. Essential for understanding Greensboro's role in the American civil rights movement.
Omio recommends booking the bus as it is the most popular option from Des Moines, IA to Greensboro, NC among Omio's users. If you are prioritising price take the bus with prices starting from $138. For those with little time consider booking a flight which can get you there in 4h 31m. The ticket price range depends on the travel mode: a bus costs an average of $138, and a flight costs an average of $290.
Distance: 834 miles (1343 km)
Most popular Bus | Flight | Driving |
|---|---|---|
$140 Average price Cheapest | $290 Average price | $209 Average price (fuel + tolls) |
30h 9m Average total duration 29h 39m Onboard + 30m Additional time* | 7h 31m Average total duration Fastest 4h 31m Onboard + 3h 0m Additional time* | 15h 30m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Des Moines, IA to Greensboro, NC:
A bus is $150 (€121) less than a flight for this route with tickets for a flight from Des Moines, IA to Greensboro, NC costing on average $290 (€234).
Other travel options to Greensboro, NC take longer:
Bus takes on average 29h 39m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 08:05AM | Arrival Time 12:30PM | Duration 27h25 | Departure days Mon, Fri, Sun | Cheapest price $127 |
Operator FlixBus | Departure Time 09:20AM | Arrival Time 08:10PM | Duration 33h50 | Departure days Mon, Fri, Sun | Cheapest price $237 |
Operator Greyhound | Departure Time 09:45AM | Arrival Time 01:10AM | Duration 38h25 | Departure days Mon, Fri, Sun | Cheapest price $243 |
Buses from Des Moines, IA to Greensboro, NC run on average 4 times per day, taking around 29h 39m. Cheap bus tickets for this journey start at $138 (€111) if you book in advance.
The earliest bus runs at 02:15, the last at 23:05. The fastest bus covers the 834 miles (1343 km) distance in 29h 0m.
Distance 834 miles (1343 km) |
Average bus duration 29h 39m |
Cheapest ticket price $138 (€111) |
Buses per day 4 |
Fastest bus 29h 0m |
First bus 2:15 AM |
Last bus 11:05 PM |
Cheapest Month Oct |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Oct - Dec |
Discover the best of Greensboro, NC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greensboro, NC trip today.
Major museum preserving the Woolworth sit-in site. Essential for understanding Greensboro's role in the American civil rights movement.
Leading regional art museum with American and international works, rotating exhibitions, and a sculpture collection near downtown.
Free city museum covering Greensboro's people, industries, and major events. A strong introduction to local history in the historic center.
Greensboro's main downtown street lined with shops, theaters, murals, and historic buildings. Best for strolling and city atmosphere.
Large urban park known for walking trails, sports fields, and the Bog Garden nearby. A versatile green space popular with locals.
Raised boardwalk through wetlands with shade, birds, and calm views. It is a peaceful local favorite for an easy nature walk.
North Carolina barbecue here often means slow-smoked pork with a tangy vinegar-based sauce, a Piedmont staple tied to family cookouts and old-school BBQ joints.
Barbecue slaw is a crisp cabbage slaw dressed with vinegar and ketchup, commonly piled on BBQ sandwiches across the Piedmont for bite and tang.
A classic Southern side of finely ground corn simmered until creamy. In Greensboro, it often appears with shrimp, gravy, or breakfast plates.
Historic fine-dining restaurant serving upscale Southern cuisine and steaks in an elegant clubhouse atmosphere near downtown.
Well-known local spot for hearty Southern breakfasts, biscuits, pancakes, and diner classics in a friendly, busy atmosphere.
Established venue for refined Southern and New American dishes, craft cocktails, and a polished but relaxed neighborhood feel.
Moderate for U.S. city breaks; hotels and dining are usually lower than major hubs, while car use can add to visitor costs.
Tip 18-20% at restaurants, 15-20% for taxis, and $1-2 per drink or café order if table service is provided.
Find answers to the most common questions about traveling from Des Moines, IA to Greensboro, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greensboro, NC, this guide helps you travel smarter and with confidence.

Most Des Moines, IA to Greensboro, NC buses use the Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) to Greensboro, E Washington St (Greyhound Bus Station) station pair. Use this guide to compare Des Moines, IA and Greensboro, NC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) is 3 km from Des Moines city centre. Public transport options include:
Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.). ATMs are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Ticket office support is available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.).
Available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Parking, Taxis, WC.
Accessibility facilities are available at Des Moines, E Euclid Ave (Clark Lift Of Des Moines, Inc.): Wheelchair accessible buses available.
Greensboro, E Washington St (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Greensboro, E Washington St (Greyhound Bus Station). ATMs are available at Greensboro, E Washington St (Greyhound Bus Station).
Ticket office support is available at Greensboro, E Washington St (Greyhound Bus Station).
Available at Greensboro, E Washington St (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Greensboro, E Washington St (Greyhound Bus Station): Wheelchair accessible entrance and facilities available.
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