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Nov 28
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$160skywest airlines
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$85Greyhound
$157gojet airlines
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$59Greyhound
$158skywest airlines
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$28Amtrak
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$159envoy air
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$28Amtrak
$45Greyhound
$165skywest airlines
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$28Amtrak
$42Greyhound
$158envoy air
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$158envoy air
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$42Greyhound
$78American Airlines
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$28Amtrak
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$42Greyhound
$68American Airlines
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$91American Airlines
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$67American Airlines
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Dec 13
$27Amtrak
$41Greyhound
$77American Airlines
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$66envoy air
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Dec 15
$28Amtrak
$40Greyhound
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Dec 16
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$68American Airlines
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Dec 17
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Dec 18
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Travel Tips

Flights from Chicago to St. Louis, MO
Take a flight to St. Louis, MO easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Chicago to St. Louis, MO.
FAQs
What is the distance between Chicago and St. Louis, MO by plane?
The distance between Chicago and St. Louis, MO by plane is approximately 259 miles (418 km).
What time is the earliest flight from Chicago to St. Louis, MO? What time is the last flight from Chicago to St. Louis, MO?
You can take the first flight from Chicago to St. Louis, MO at 1: 30 PM. The last flight from Chicago to St. Louis, MO that you can take departs at 9: 35 PM. Omio shows you the latest flight from Chicago to St. Louis, MO schedule to help you book the best departure time for this route.