Travel Information
Compare train, bus, and flight for Lyon to Mainz
Omio recommends booking the train as it is the most popular option from Lyon to Mainz among Omio's users. If you are prioritising price, take the bus, with an average ticket price of CHF70 For those with little time, consider booking a flight, which has an average total journey time of 4h 34m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.2 - 0.5kg. Average ticket prices depend on the travel mode: a bus costs an average of CHF70, while a flight costs an average of CHF453.
Distance: 333 miles (536 km)
Compare train with
Most popular Train | Bus | Flight |
|---|---|---|
CHF114 Average price | CHF70 Average price Cheapest | CHF453 Average price |
6h 35m Average total duration 6h 5m Onboard + 30m Additional time* | 12h 40m Average total duration 12h 10m Onboard + 30m Additional time* | 4h 34m Average total duration Fastest 2h 34m Onboard + 2h 0m Additional time* |
0.2 - 0.5kg CO2 emissions Lowest | 0.5 - 1.3kg CO2 emissions | 1.6 - 3.2kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Lyon to Mainz
How to get from Lyon to Mainz by train, bus or flight.
Our recommendation
The best way to travel from Lyon to Mainz is by taking a bus because it’s the best combination of price and speed.
4:20 AM13h25Lyon5:45 PMMainzCHF461One-way0 transfers
Cheapest
4:20 AM13h25Lyon5:45 PMMainzCHF461One-way0 transfers
Fastest
4:20 AM13h25Lyon5:45 PMMainzCHF461One-way0 transfers
Other options
1:20 AM15h30Lyon4:50 PMMainzCHF481One-way0 transfers
12:15 PM16h25Lyon4:40 AMMainzCHF481One-way0 transfers
4:05 PM18h10Lyon10:15 AMMainzCHF751One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Lyon to Mainz
Travel to Mainz easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Lyon to Mainz.

This is compared to other travel options from Lyon to Mainz:
A bus is CHF57 less than a train for this route with tickets for a train from Lyon to Mainz costing on average CHF114.
A bus is CHF131 less than a flight for this route with tickets for a flight from Lyon to Mainz costing on average CHF189.
Other travel options to Mainz take longer:
Train takes on average 6h 35m.
Bus takes on average 13h 47m.
- Around 21 flights per day.
- Around 5 buses per day.
- Around 1 trains per day.
However, we recommend checking specific travel dates for your route between Lyon and Mainz as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Lyon Saint Exupery Airport and arrive in Frankfurt am Main Airport.
- Trains mostly depart from Lyon Part Dieu and arrive in Mainz Hbf.
- Buses mostly depart from Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) and arrive in Mainz, Binger Schlag (Kurzzeitparkplatz).
- Travel with Lufthansa to go to Mainz by flight.
- Travel with FlixBus, BlaBlaCar Bus, Sindbad to go to Mainz by bus.
- Travel with TGV, SNCF | TGV INOUI to go to Mainz by train.
- 4 direct flights per day with Lufthansa.
Travelling from Lyon to Mainz: related information
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