Travel Information
Compare train, bus, and flight for Lyon to Mainz
Omio recommends booking the train as it is the most popular option from Lyon to Mainz among Omio's users. If you are prioritising price take the bus with prices starting from $47. For those with little time consider booking a flight which can get you there in 1h 58m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $47, and a flight costs an average of $116.
Distance: 333 miles (536 km)
Compare train with
Most popular Train | Bus | Flight |
|---|---|---|
$125 Average price | $70 Average price Cheapest | $245 Average price |
6h 32m Average total duration 6h 2m Onboard + 30m Additional time* | 11h 27m Average total duration 10h 57m Onboard + 30m Additional time* | 4h 58m Average total duration Fastest 1h 58m Onboard + 3h 0m Additional time* |
0.2 - 0.5kg CO2 emissions Lowest | 0.5 - 1.3kg CO2 emissions | 1.6 - 3.2kg CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Lyon to Mainz
How to get from Lyon to Mainz by train, bus or flight.
Our recommendation
The best way to travel from Lyon to Mainz is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus2:15 PM16h25Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)6:40 AMMainz, Binger Schlag (Kurzzeitparkplatz)$861One-way1 transfer
Cheapest
FlixBus · FlixBus2:15 PM16h25Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)6:40 AMMainz, Binger Schlag (Kurzzeitparkplatz)$861One-way1 transfer
Fastest
LH10772:35 PM1h25Lyon Saint Exupery Airport4:00 PMFrankfurt am Main Airport$4121One-way0 transfers
Other options
TGV 9583+
ICE 71010:01 AM6h14Lyon Part Dieu4:15 PMMainz Hbf$1361One-way1 transfer
FlixBus · FlixBus · FlixBus10:00 PM21h30Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)7:30 PMMainz, Binger Schlag (Kurzzeitparkplatz)$871One-way2 transfers
FlixBus · FlixBus1:40 AM20h30Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)10:10 PMMainz, Binger Schlag (Kurzzeitparkplatz)$871One-way1 transfer
BA363 · BA9029:45 PM12h05Lyon Saint Exupery Airport9:50 AMFrankfurt am Main Airport$1891One-way1 transfer
BA357 · BA9081:35 PM6h10Lyon Saint Exupery Airport7:45 PMFrankfurt am Main Airport$2791One-way1 transfer
BA357 · BA9101:35 PM9h00Lyon Saint Exupery Airport10:35 PMFrankfurt am Main Airport$2791One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Lyon to Mainz
Travel to Mainz easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Lyon to Mainz.

This is compared to other travel options from Lyon to Mainz:
A bus is $21 (€17) less than a train for this route with tickets for a train from Lyon to Mainz costing on average $68 (€55).
A bus is $69 (€55) less than a flight for this route with tickets for a flight from Lyon to Mainz costing on average $116 (€93).
Other travel options to Mainz take longer:
Train takes on average 5h 17m.
Bus takes on average 13h 25m.
- Around 22 flights per day.
- Around 6 buses per day.
- Around 1 trains per day.
However, we recommend checking specific travel dates for your route between Lyon and Mainz as scheduled services by train, bus, and flight can vary by season or day of the week.
- Trains mostly depart from Lyon Part Dieu and arrive in Mainz Hbf.
- Flights mostly depart from Lyon Saint Exupery Airport and arrive in Dusseldorf Airport.
- Buses mostly depart from Lyon, Perrache Bus Station and arrive in Mainz, Binger Schlag (Kurzzeitparkplatz).
- Travel with Lufthansa, Lufthansa Cityline to go to Mainz by flight.
- Travel with TGV, SNCF, TGV INOUI to go to Mainz by train.
- Travel with FlixBus, BlaBlaCar to go to Mainz by bus.
- 4 direct flights per day with Lufthansa.
- 0 direct buses per day with BlaBlaCar.
Travelling from Lyon to Mainz: related information
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