Travel Information
Compare train, bus, and flight for Lyon to Mainz
Omio recommends booking the train as it is the most popular option from Lyon to Mainz among Omio's users. If you are prioritising price, take the bus, with an average ticket price of CHF 64 For those with little time, consider booking a flight, which has an average total journey time of 4h 40m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.2 - 0.5kg. Average ticket prices depend on the travel mode: a bus costs an average of CHF 64, while a flight costs an average of CHF 395.
Distance: 333 miles (536 km)
Compare train with
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
CHF 114 Average price | CHF 64 Average price Cheapest | CHF 395 Average price | CHF 146 Average price (fuel + tolls) |
6h 33m Average total duration 6h 3m Onboard + 30m Additional time* | 13h 13m Average total duration 12h 43m Onboard + 30m Additional time* | 4h 40m Average total duration Fastest 2h 40m Onboard + 2h 0m Additional time* | 6h 41m Average total duration (door-to-door) |
0.2 - 0.5kg CO2 emissions Lowest | 0.5 - 1.3kg CO2 emissions | 1.6 - 3.2kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Lyon to Mainz
Compare the available ways to get from Lyon to Mainz, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Lyon to Mainz:
A bus is CHF 51 less than a train for this route with tickets for a train from Lyon to Mainz costing on average CHF 114.
A bus is CHF 332 less than a flight for this route with tickets for a flight from Lyon to Mainz costing on average CHF 395.
Other travel options to Mainz take longer:
Train takes on average 6h 33m.
Bus takes on average 13h 13m.
The journey is about 38m faster (6h 3m by train vs 6h 41m by car) and roughly CHF 32 cheaper once you factor in fuel and tolls (CHF 114 vs CHF 146). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
Travel optionsfrom Lyon to Mainz
How to get from Lyon to Mainz by train, bus or flight.
Our recommendation
The best way to travel from Lyon to Mainz is by taking a bus because it’s the best combination of price and speed.

12:30 AM 19h40 Lyon 8:10 PM Mainz CHF 43 1 One-way 0 transfers
Cheapest

12:30 AM 19h40 Lyon 8:10 PM Mainz CHF 43 1 One-way 0 transfers
Fastest

8:30 AM 11h40 Lyon 8:10 PM Mainz CHF 60 1 One-way 0 transfers
Other options

1:25 AM 15h25 Lyon 4:50 PM Mainz CHF 47 1 One-way 0 transfers
4:05 PM 18h10 Lyon 10:15 AM Mainz CHF 49 1 One-way 0 transfers
4:25 AM 16h45 Lyon 9:10 PM Mainz CHF 56 1 One-way 0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Lyon to Mainz
Travel to Mainz easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Lyon to Mainz.

This is compared to other travel options from Lyon to Mainz:
A bus is CHF 51 less than a train for this route with tickets for a train from Lyon to Mainz costing on average CHF 114.
A bus is CHF 332 less than a flight for this route with tickets for a flight from Lyon to Mainz costing on average CHF 395.
Other travel options to Mainz take longer:
Train takes on average 6h 33m.
Bus takes on average 13h 13m.
- Around 30 flights per day.
- Around 3 buses per day.
- Around 1 trains per day.
However, we recommend checking specific travel dates for your route between Lyon and Mainz as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Lyon Saint Exupery Airport and arrive in Frankfurt am Main Airport.
- Trains mostly depart from Lyon Part Dieu and arrive in Mainz Hbf.
- Buses mostly depart from Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) and arrive in Mainz, Binger Schlag (Kurzzeitparkplatz).
- Travel with KLM, Lufthansa, Air France, Air Dolomiti, British Airways, Air Baltic, Austrian Airlines, Turkish Airlines, CitizenPlane, Lufthansa City Airlines, Lufthansa Cityline, KLM Cityhopper, Vueling to go to Mainz by flight.
- Travel with TGV to go to Mainz by train.
- Travel with FlixBus to go to Mainz by bus.
- 4 direct flights per day with Lufthansa, Air Dolomiti.
Travelling from Lyon to Mainz: related information
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