Travel Information
Compare bus, train, and flight for Lyon to Prague
Omio recommends booking the flight as it is the most popular option from Lyon to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $60. For those with little time consider booking a flight which can get you there in 2h 38m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.9 - 2.1kg. The ticket price range depends on the travel mode: a bus costs an average of $60, and a train costs an average of $284.
Distance: 534 miles (860 km)
Compare flight with
Most popular Flight | Bus | Train |
|---|---|---|
$195 Average price | $88 Average price Cheapest | $319 Average price |
5h 38m Average total duration Fastest 2h 38m Onboard + 3h 0m Additional time* | 16h 49m Average total duration 16h 19m Onboard + 30m Additional time* | 12h 54m Average total duration 12h 24m Onboard + 30m Additional time* |
2.6 - 5.2kg CO2 emissions | 0.9 - 2.1kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular airline | ![]() Most popular bus company | ![]() Most popular train company |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Travel optionsfrom Lyon to Prague
How to get from Lyon to Prague by train, bus or flight.
Our recommendation
The best way to travel from Lyon to Prague is by taking a bus because it’s the best combination of price and speed.
FlixBus10:00 PM17h25Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)3:25 PMPraha, ÚAN Florenc$1051One-way0 transfers
Cheapest
FlixBus · FlixBus1:05 PM23h35Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)12:40 PMPrague, Central Train Station$991One-way1 transfer
Fastest
U244911:55 PM1h45Lyon Saint Exupery Airport3:40 PMPrague Vaclav Havel Airport$1761One-way0 transfers
Other options
TGV 9583+
ICE 1229 · Bus EV · 383510:01 AM21h20Lyon Part Dieu7:21 AMPrague hlavní nádraží$3161One-way5 transfers
TGV 9583+
ICE 2517 · S1 · 2801810:01 AM22h09Lyon Part Dieu8:10 AMPrague hlavní nádraží$3551One-way4 transfers
FlixBus10:00 PM18h10Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)4:10 PMPraha, Černý Most$1051One-way0 transfers
FlixBus · FlixBus2:15 PM22h30Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)12:45 PMPraha, Na Knížecí$1031One-way1 transfer
FlixBus · FlixBus12:15 PM19h15Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)7:30 AMPraha, M. Horákové (Hradčanská)$1001One-way1 transfer
LO348 · LO5237:20 PM13h55Lyon Saint Exupery Airport9:15 AMPrague Vaclav Havel Airport$2831One-way1 transfer
SN3588+
SN28151:10 PM9h15Lyon Saint Exupery Airport10:25 PMPrague Vaclav Havel Airport$4521One-way1 transfer
VY1221+
FR 30399:50 AM11h25Lyon Saint Exupery Airport9:15 PMPrague Vaclav Havel Airport$4621One-way1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Apr 15
Apr 16
Apr 17
Apr 18
Apr 19
Apr 20
Apr 21
Apr 22
Apr 23
Apr 24
Apr 25
Apr 26
Apr 27
Apr 28
Apr 29
Apr 30
May 01
May 02
May 03
May 04
May 05
More than 1,000 travel companies trust us to sell their tickets all in one place.
FAQs: Travel from Lyon to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Lyon to Prague.

This is compared to other travel options from Lyon to Prague:
A flight is $4 (€3) less than a bus for this route with tickets for a bus from Lyon to Prague costing on average $60 (€47).
A flight is $229 (€182) less than a train for this route with tickets for a train from Lyon to Prague costing on average $284 (€226).
Other travel options to Prague take longer:
Train takes on average 13h 18m.
Bus takes on average 12h 30m.
- Around 36 flights per day.
- Around 12 buses per day.
- Around 1 trains per day.
However, we recommend checking specific travel dates for your route between Lyon and Prague as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Lyon Saint Exupery Airport and arrive in Prague Vaclav Havel Airport.
- Trains mostly depart from Lyon Part Dieu and arrive in Prague hlavní nádraží.
- Buses mostly depart from Lyon, Perrache Bus Station and arrive in Praha, ÚAN Florenc.
- Travel with TGV to go to Prague by train.
- Travel with FlixBus, BlaBlaCar Bus to go to Prague by bus.
- Travel with Volotea, easyJet, Lufthansa, Lufthansa Cityline, KLM, Brussels Airlines, Air France, Air Dolomiti, Austrian Airlines, Eurowings, LOT Polish Airlines, Vueling Airlines, Amelia International, Air Baltic, Amelia, Cityjet to go to Prague by flight.
- 6 direct buses per day with FlixBus, BlaBlaCar Bus.
- 1 direct flights per day with Volotea, easyJet.
Travelling from Lyon to Prague: related information
Here are some other resources that might have the information you need

