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Antwerp and Brussels are so close together (45 kilometers) that flying isn't an option, and Belgians tend not to travel between cities by bus. That leaves the country's excellent train network as the only option. That's not a problem though, as SNCB operates a regular service between the two cities that takes just over an hour to reach Brussels. Alternatives could include renting a car, taxis or a car pool firm like Bla Bla Car.
Return trips from Brussels to Antwerp are also available.
Catching the train is the only realistic way to travel between Antwerp and Brussels, and it is fast, comfortable and convenient. All trains from Antwerp to Brussels are operated by SNCB, the Belgian national rail firm, and the fastest services take only 46 minutes to reach their destination. Timetables start at 4:35 a.m. and continue until after midnight, with at least one train per hour to choose from. Not all trains are express services, however, so check before you book to make sure you catch the fastest possible connection. All trains depart from Antwerp Centraal, which is right in the center of town, next to the city zoo. If you are arriving by plane, there is also a stop at Antwerpen-Berchem, which is served by Antwerp to Brussels trains. When you get to Brussels, all trains terminate at Brussels-Midi. From there, you can catch a further train to Brussels Centraal, or take a cab to Grand Place - which is in the middle of downtown Brussels. There are also onward rail connections to Brussels Airport, and Eurostar services to London or Paris.