MILAN to ISERNIA train from $17 with Intercity

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The cheapest and fastest trains from Milan to Isernia

Showing times, prices and bookable tickets for Sep 20

Cheapest price on Sep 20

$45

Average ticket price on Sep 20

$69

Fastest journey on Sep 20

10 h 35 m

Average journey duration on Sep 20

11 h 15 m

Trains on Sep 20

Distance

592 km

Cheap tickets

The best way to find a cheap train ticket from Milan to Isernia is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Milan to Isernia will cost around $69 if you buy it on the day, but the cheapest tickets can be found for only $45.

Fast trains

On Sun, Sep 20, we found 3 trains from Milan to Isernia, including 3 direct services.

On Sun, Sep 20 the direct trains cover the 592 km distance in an average of 11 h 15 m but if you time it right, some trains will get you there in just 10 h 35 m .

On Sun, Sep 20 the slowest trains will take 12 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

5:05 AM10h35
Milan
3:40 PMIsernia
$451One-way
0 transfers
4:05 AM10h35
Milan
2:40 PMIsernia
$651One-way
0 transfers
5:20 AM12h35
Milan
5:55 PMIsernia
$981One-way
0 transfers

Travel Information

Compare train, bus, and flight for Milan to Isernia

Omio recommends booking the train as it is the most popular option from Milan to Isernia among Omio's users. If you are prioritising price, take the train, with an average ticket price of $37 For those with little time, consider booking a flight, which has an average total journey time of 4h 56m. Average ticket prices depend on the travel mode: a train costs an average of $37, while a flight costs an average of $503.

Distance: 367 miles (592 km)

Compare train with

Most popular Train	Flight	Bus	Driving
$37 Average price Cheapest	$503 Average price	$95 Average price	$222 Average price (fuel + tolls)
6h 38m Average total duration 6h 8m Onboard + 30m Additional time*	4h 56m Average total duration Fastest 2h 56m Onboard + 2h 0m Additional time*	12h 1m Average total duration 11h 31m Onboard + 30m Additional time*	7h 39m Average total duration (door-to-door)
Most popular train company	Most popular airline	Most popular bus company	Your own car or car rental
Direct Options	Direct Options	Direct Options	Direct Options

The cheapest way to travel from Milan to Isernia is a train with an average price of $37.

This is compared to other travel options from Milan to Isernia:

A train is $57 less than a bus for this route with tickets for a bus from Milan to Isernia costing on average $95.

A train is $466 less than a flight for this route with tickets for a flight from Milan to Isernia costing on average $503.

The fastest way to travel from Milan to Isernia is by flight with an average journey time of 2h 56m.

Other travel options to Isernia take longer:

Train takes on average 6h 8m.

Bus takes on average 11h 31m.

It's helpful to compare your options as there are 3 ways to travel between Milan and Isernia including taking a train, bus, and flight.

We recommend using the train as it is the most popular way to get from Milan to Isernia among Omio's users.

Take the train. On this route, it beats driving on both time and money.

The journey is about 1h 31m faster (6h 8m by train vs 7h 39m by car) and roughly $184 cheaper once you factor in fuel and tolls ($37 vs $222). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.

Driving is still worth considering if you want to stop along the way or need a car once you arrive.

Live departures

Milan to Isernia train times

The table below shows live departures for Milan to Isernia trains for today, Saturday, September 19. You can also manually refresh the results below to see updated train journeys.

Last updated at

Provider	Departs	Duration	Arrives	Transfers
	8:50 PM Milan	13h25	10:15 AM Isernia	0 transfersDirect
Sunday, September 20
	4:05 AM Milan	10h35	2:40 PM Isernia	0 transfersDirect
	5:05 AM Milan	10h35	3:40 PM Isernia	0 transfersDirect
	5:20 AM Milan	12h35	5:55 PM Isernia	0 transfersDirect
This is the last train of the day.

Find all the dates and times for this journey

Compare prices and tickets Milan to Isernia by train, bus, or flight

Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Sun
Sep 20

Mon
Sep 21

Tue
Sep 22

Wed
Sep 23

Thu
Sep 24

Fri
Sep 25

Sat
Sep 26

Why should you book Milan to Isernia trains with Omio?

Intercity as well as Frecciarossa, Italo, Intercity Notte and more offer trains services from Milan to Isernia.

Omio is the only official third party seller for Intercity tickets.

Why book with Omio vs Intercity?

Compare with other providers: On Omio, you can not only buy tickets for Intercity, but also compare tickets for the likes of Frecciarossa, Italo or Intercity Notte to find the best option for your trip from Milan to Isernia.
Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Compare all your options: Omio allows you to compare Intercity with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Milan to Isernia.

Journey information

Overview: Train from Milan to Isernia

Italy

Trains from Milan to Isernia run on average 54 times per day, taking around 6h 8m. Cheap train tickets for this journey start at $17 if you book in advance.

The earliest train runs at 04:40, the last at 22:45. The fastest train covers the 367 miles (592 km) distance in 4h 23m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.

Price information

Distance

367 miles (592 km)

Average train duration

6h 8m

Cheapest ticket price

$17

Trains per day

Fastest train

4h 23m

First train

4:40 AM

Last train

10:45 PM

Cheapest Month

Jul

Cheapest Day

Sun

High Season

Jul - Sep

Low Season

Jan - Mar

Busiest Day

Wed

Least Busy Day

Wed

Best time to book

3 days

Price information

Train companies: Italo, Frecciarossa, Intercity, Intercity Notte from Milan to Isernia trainsItalo, Frecciarossa, Intercity, Intercity Notte trains will get you between Milan and Isernia from $17. With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.

Italo

About

Italo is Italy’s private high-speed train service operated by Nuovo Trasporto Viaggiatori (NTV), connecting major cities such as Rome, Milan, Naples, Florence, Turin, Bologna, and Salerno. Its fleet includes the Italo AGV 575, capable of speeds up to 186 mph (300 km/h), and the eco-friendly Italo EVO, which reaches up to 150 mph (250 km/h). Passengers can choose from four classes — Smart, Comfort, Prima, and Club Executive — all offering modern amenities such as free Wi-Fi, power outlets, reclining leather seats, footrests, bathrooms, snack machines, and Italo Live entertainment with movies, music, and games. Italo offers three fare types — Low Cost, Economy, and Flex — providing different levels of price and flexibility. Popular routes include Rome–Milan, Rome–Florence, and Milan–Turin, making Italo a fast, comfortable, and convenient way to travel around Italy.

Luggage & cancellation policy

Average Italo Duration

4h 23m

Cheapest Italo Price

$17

Italo frequency

55 a day

Luggage included

2 pieces of hand luggage (max 55x35x25cm) and 1 piece of luggage (max 75x53x30cm)

Luggage storage

Overhead racks and designated luggage areas between seats

Cancellation Policy

Cancellation possible according to ticket conditions

Refund

Full refund provided for canceled trains

Amenities on board the train

Wifi

Food sold onboard

Snack bar service available in most trains with drinks and light refreshments. Welcome service in Prima and Club Executive classes

Seat reservation

Included in Prima and Club Executive. Optional extra cost in Smart and Comfort

Toilets

USB plugs

Accessibility

Wheelchair spaces and assistance available for passengers with reduced mobility

Pets

Small pets in carriers travel free. Larger dogs require paid ticket and muzzle. Guide dogs travel free

Quiet zone

Learn more about Italo

Frecciarossa

About

Step on board a Frecciarossa train and relax as you travel across Italy. Trenitalia’s Frecciarossa high-speed trains make around 200 connections across the country each day and are renowned for their comfort, speed, and reduced environmental impact. Reaching speeds of up to 186 mph (300 km/h), they connect major destinations such as Rome, Florence, Milan, Venice, and Naples quickly and efficiently. When booking your Frecciarossa journey, you can choose between four classes: Standard, Premium, Business, and Executive. While each class offers different levels of comfort, all provide free Wi-Fi access, power outlets, air conditioning, bathrooms, luggage storage, onboard entertainment, and restaurant and bar services. Ticket options include Super Economy, Economy, and Base, making it easy to find the right balance of comfort and price for your trip.

Luggage & cancellation policy

Average Frecciarossa Duration

5h 17m

Cheapest Frecciarossa Price

$78

Frecciarossa frequency

8 a day

Luggage included

1 carry-on bag and 1 suitcase per passenger

Luggage storage

Overhead racks, dedicated luggage areas at carriage ends, under seats

Cancellation Policy

Refund policy depends on ticket type

Refund

Full refund provided for canceled trains

Amenities on board the train

Wifi

Food sold onboard

Restaurant car with full meals, bar service with snacks and beverages, at-seat service in Executive class

Seat reservation

Included in Executive class, optional fee for other classes

Toilets

USB plugs

Accessibility

Wheelchair spaces, accessible toilets, assistance service available

Pets

Small pets in carriers travel free, larger dogs require paid ticket and muzzle, service animals free

Quiet zone

Learn more about Frecciarossa

Intercity

About

Trenitalia Intercity is a high-speed train service operated by the Italian national railway company, Trenitalia. It operates throughout the country, with services running from early morning to late evening. The Intercity trains come in two types: the Intercity Plus, which is the fastest and most comfortable, and the Intercity, which is slightly slower but still offers a comfortable journey. Onboard facilities include air conditioning, power sockets, Wi-Fi, and a bar service. There are several ticket types available, including Standard, Super Economy, and Business. The most popular routes for Trenitalia Intercity are from Rome to Milan, Naples to Florence, and Turin to Venice.

Luggage & cancellation policy

Average Intercity Duration

9h 21m

Cheapest Intercity Price

$49

Intercity frequency

2 a day

Luggage included

2 pieces of luggage up to 30kg total

Luggage storage

Overhead racks and designated luggage areas at end of carriages

Cancellation Policy

According to ticket conditions

Refund

Full refund provided

Amenities on board the train

Wifi

Food sold onboard

Restaurant car with hot meals and snacks, trolley service in some trains. But do not count on the presence of a buffet car. So if having access to food and drink on the train is important to you, it’s best to bring your own refreshments onboard.

Seat reservation

Seat reservation included in ticket price for most routes

Toilets

USB plugs

Accessibility

Wheelchair spaces and accessible toilets available

Pets

Small pets in carriers allowed free, larger dogs require paid ticket

Quiet zone

Intercity Notte

About

Intercity Notte is an Italian train service operated by Trenitalia. It runs overnight services between major cities in Italy, making it a great option for travelers looking to save time and money. The Intercity Notte offers two types of trains: the Frecciarossa Notte and the Frecciargento Notte. The Frecciarossa Notte is the fastest train, with speeds of up to 300 km/h, while the Frecciargento Notte is slightly slower but still offers a comfortable journey. Both trains offer a range of onboard facilities, including comfortable seating, air conditioning, and Wi-Fi. Trenitalia offers a range of ticket types, including Standard, Comfort, and Business. Standard tickets are the most affordable, while Comfort and Business tickets offer additional benefits such as priority boarding and access to the lounge. The most popular routes for Intercity Notte are Rome to Milan, Rome to Venice, and Milan to Venice. These routes offer travelers the chance to explore some of Italy's most iconic cities in a convenient and comfortable way.

Luggage & cancellation policy

Average Intercity Notte Duration

9h 26m

Cheapest Intercity Notte Price

$70

Intercity Notte frequency

1 a day

Luggage included

1 handbag and 1 suitcase included in ticket price

Luggage storage

Luggage racks above seats and at carriage ends

Cancellation Policy

Cancellation possible according to ticket type conditions

Refund

Full refund provided for canceled trains

Amenities on board the train

Wifi

Food sold onboard

Restaurant car with full dining service and bar

Seat reservation

Seat reservation included in ticket price

Toilets

USB plugs

Accessibility

Wheelchair spaces and assistance available for disabled passengers

Pets

Small pets in carriers travel free. Larger dogs require paid ticket and muzzle. Guide dogs free.

Quiet zone

Complete guide to Isernia

Things to do in Isernia

Discover the best of Isernia — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Isernia trip today.

Must visit

Museo Nazionale del Paleolitico di Isernia

Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.

View on map Visit website

Recommended

Museo Archeologico di Santa Maria delle Monache

Archaeological area museum presenting finds from the ancient settlement. A strong companion visit to the cathedral and Roman remains.

View on map Visit website

Recommended

Complesso Monumentale di Santa Maria delle Monache

Exhibition venue in a historic setting, often used for local heritage displays. Good for visitors interested in community-focused culture.

View on map Visit website

Euro (€)

Moderate for Italy. Hotels and dining are usually cheaper than Rome or Florence, while local buses and coffee remain low-cost for most travelers.

Average meal costs

Budget: €8-12 for fast food or a simple meal.
Mid-range: €20-35 per person for a restaurant meal.
Fine dining: €50+ per person for upscale dining.
Coffee: €1.20-2.50 for espresso or cappuccino.

Tipping culture

Tipping is modest. Service may be included. Round up or leave 5-10% at restaurants for good service; round up taxi fares; small change is enough at cafes.

FAQs: Trains from Milan to Isernia

Find answers to the most common questions about traveling from Milan to Isernia by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Isernia, this guide helps you travel smarter and with confidence.

Train ticket prices from Milan to Isernia can vary. The cheapest ticket starts at $17, while the average price is around $37.

The train from Milan to Isernia takes 4h 23m and runs 54 per day.

The distance by train from Milan to Isernia is 367 miles (592 km).

The first train from Milan to Isernia leaves at 4:40 AM.

The last train from Milan to Isernia leaves at 10:45 PM.

Yes, there is a high-speed train from Milan to Isernia.

There is no direct train service currently available from Milan to Isernia.

Yes, there is a night train from Milan to Isernia.

The train station in Milan that goes to Isernia is Milan Centrale, which connects to Isernia station.

The cheapest way to get from Milan to Isernia is by train, with a cost of around $17.

The train journey from Milan to Isernia offers diverse scenery, including views of the Italian countryside, rolling hills, and charming towns, providing a picturesque travel experience.

A day trip from Milan to Isernia is not feasible as the journey takes 4h 23m. The distance is 367 miles (592 km). There are 11 trains available per day.

Two to three days are ideal to explore Isernia, allowing time to visit historical sites, enjoy local cuisine, and experience the surrounding nature.

Yes, you can take the train from Milan to Isernia.

Since both Milan and Isernia are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.

Popular day trips by train from Isernia include Naples, Venafro, Caserta, Cassino, Bojano.

We recommend using the flight as it is the most popular way to get from Milan to Isernia among Omio's users.

Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.

Yes, rail passes such as the Eurail Italy Pass and Interrail Italy Pass are valid on most trains operated by Trenitalia and Italo within Italy, including regional, intercity, and high-speed trains, though some restrictions and seat reservation fees may apply.

Italy uses the euro (EUR) as its currency. Travelers generally find it convenient to use cards for most payments, especially in cities and larger establishments, but carrying some cash is advisable for small shops, markets, and rural areas where card acceptance may be limited.

In Isernia, travelers should be cautious of petty theft, especially in crowded areas and near transportation hubs. It is advisable to stay vigilant with personal belongings and avoid accepting unsolicited offers from strangers. There are no widespread reports of specific scams targeting visitors, but standard travel precautions apply, such as using official taxi services and verifying ticket purchases to ensure safety and avoid fraud.

Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular train stations

Popular train stations from Milan to Isernia

Most Milan to Isernia trains use the Milano Centrale to Isernia station pair. Use this guide to compare Milan and Isernia train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.

Departure train stations in Milan

Arrival train stations in Isernia

Which Milan station do trains to Isernia leave from?

Trains from Milan to Isernia leave from Milano Centrale. The station is 1 miles (3 km) from Milan city centre at Piazza Duca d'Aosta, 1, 20124 Milan, Italy.

Milano CentralePiazza Duca d'Aosta, 1, 20124 Milan, Italy+39 892021 Wifi

City-centre transport

Getting to Milano Centrale from Milan city centre

Milano Centrale is 2 km from Milan city centre. Public transport options include:

TrainRe51 · 11m · $2 · every ~5 min

BusNm3 · 9m · $2 · every ~1 min

60 · 31m · $2 · every ~10 min

Tram9 · 27m · $2 · every ~16 min

Subway3 · 11m · $2 · every ~25 min

Milano Centrale train station facilities and services

Milano Centrale has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.

Food and drink

Food options include: Venchi, Panzera Coffee, Burger King, Bar Motta, Caffè Napoli, VyTA Boulangerie, Spontini, Starbucks, Dispensa Emilia, McDonald's, & many more

Wi-Fi and ATMs

Free WiFi in the station. ATMs are there are ATMs in various locations around the station.

Tickets and information

The ticket office is open Mon - Sun: 05:50 - 22:20. Information desks are located next to the ticket office on the ground floor in the shopping gallery.

Luggage and lost property

Luggage storage is provided by KiPoint and located on the ground floor, on the side of Piazza Luigi di Savoia. It is open every day from 06:00 to 23:00.

Parking, taxis and toilets

Available at Milano Centrale: Parking, Taxis, WC.

Bike and car services

Available at Milano Centrale: Bike Parking, Bike Rental, Car Rental.

Accessibility

Accessibility facilities are available at Milano Centrale: Station is wheelchair accessible, has elevators and the Sala Blu, Trenitalia's office of assistance for disabled travelers, is next to Platform 4.

Shops, hotels and contact

Nearby hotels include Glam Hotel Milano, NYX MIlan, iQ Hotel Milano.

More about Milano Centrale

Milano RogoredoVia G Battista Cassinis 76, Milan, 20139, Italy+39 02 7740 4318 Wifi

City-centre transport

Getting to Milano Rogoredo from Milan city centre

Milano Rogoredo is 5 km from Milan city centre. Public transport options include:

TrainRe, 2363, 2375, 2391, 2399, 3013, 3017, 3025, 3029, 3033, 3037, 3041, 3045, 3057, 3067, 3069, 3073, 3077, 33375 · 8m · $1 · every ~1 min

S1, S2, S13, S12 · 13m · $2 · every ~13 min

BusNm3 · 15m · $2 · every ~1 min

Bus · 28m

Subway3 · 10m · $2 · every ~25 min

Milano Rogoredo train station facilities and services

Milano Rogoredo has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.