Milan to Isernia train with Frecciarossa

Fri, May 08
+ Add return
Frecciarossa
Italo
Intercity
Regionale
Deutsche Bahn
2,000+ travel companies
Frecciarossa
Italo
Intercity
Regionale
Deutsche Bahn
2,000+ travel companies
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The cheapest and fastest trains from Milan to Isernia

Showing times and prices for May 08

Cheapest price

$74

Average price

$87

Fastest journey

11 h 55 m

Average duration

12 h 26 m

Trains per day

4

Distance

592 km

Cheap tickets

The best way to find a cheap train ticket from Milan to Isernia is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Milan to Isernia will cost around $87 if you buy it on the day, but the cheapest tickets can be found for only $74.

Fast trains

Of the 4 trains that leave Milan for Isernia on Fri, May 08, 4 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.

On Fri, May 08 the direct trains cover the 592 km distance in an average of 12 h 26 m but if you time it right, some trains will get you there in just 11 h 55 m .

On Fri, May 08 the slowest trains will take 13 h 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

  • Intercity
    5:05 AM13h25
    Milan
    6:30 PMIsernia
    $741One-way
    0 transfers
  • Intercity Notte
    7:50 PM12h00
    Milan
    7:50 AMIsernia
    $831One-way
    0 transfers
  • Intercity
    4:25 AM11h55
    Milan
    4:20 PMIsernia
    $911One-way
    0 transfers
  • Intercity
    7:05 PM12h22
    Milan
    7:27 AMIsernia
    $1021One-way
    0 transfers

Travel Information

Compare train, bus, and flight for Milan to Isernia

Omio recommends booking the train as it is the most popular option from Milan to Isernia among Omio's users. If you are prioritising price take the bus with prices starting from $33. For those with little time consider booking a flight which can get you there in 1h 20m. The ticket price range depends on the travel mode: a bus costs an average of $33, and a train costs an average of $46.

Distance: 367 miles (592 km)

Compare train with

Most popular
Train
Bus
Flight
Driving

$86

Average price

$62

Average price

Cheapest

$74

Average price

$225

Average price

(fuel + tolls)

7h 46m

Average total duration

7h 16m

Onboard

+

30m

Additional time*

11h 14m

Average total duration

10h 44m

Onboard

+

30m

Additional time*

4h 20m

Average total duration

Fastest

1h 20m

Onboard

+

3h 0m

Additional time*

7h 39m

Average total duration

(door-to-door)

Frecciarossa

Most popular train company

FlixBus

Most popular bus company

Malta Air

Most popular airline

Your own car or car rental

Direct Options

Direct Options

Direct Options

Direct Options

The cheapest way to travel from Milan to Isernia is a bus with an average price of $62 (€50).

This is compared to other travel options from Milan to Isernia:

A bus is $12 (€10) less than a flight for this route with tickets for a flight from Milan to Isernia costing on average $74 (€59).

A bus is $24 (€19) less than a train for this route with tickets for a train from Milan to Isernia costing on average $86 (€68).

The fastest way to travel from Milan to Isernia is by flight with an average journey time of 1h 20m.

Other travel options to Isernia take longer:

Train takes on average 7h 16m.

Bus takes on average 10h 44m.

It's helpful to compare your options as there are 3 ways to travel between Milan and Isernia including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from Milan to Isernia among Omio's users.
Take the train. On this route, it beats driving on both time and money.

The journey is about 23m faster (7h 16m by train vs 7h 39m by car) and roughly $140 (€112) cheaper once you factor in fuel and tolls ($86 (€68) vs $225 (€180)). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.

Driving is still worth considering if you want to stop along the way or need a car once you arrive.

Live departures

Milan to Isernia train times

The table below shows live departures for Milan to Isernia trains for today, Thursday, May 7. You can also manually refresh the results below to see updated train journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
trenitaliaint4:25 AM Milan
11h55
4:20 PM Isernia0 transfersDirect

This is the last train of the day.

Find all the dates and times for this journey

Compare prices and tickets Milan to Isernia by train, bus, or flight

Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Fri
May 08
Sat
May 09
Sun
May 10
Mon
May 11
Tue
May 12
Wed
May 13
Thu
May 14

Why should you book Milan to Isernia trains with Omio?

Frecciarossa as well as Italo or Intercity offer trains services from Milan to Isernia.
Omio is an official ticket reseller for all your travel options from Milan to Isernia.

Why book with Omio vs Frecciarossa?

  • Compare with other providers: On Omio, you can not only buy tickets for Frecciarossa, but also compare tickets for the likes of Italo or Intercity to find the best option for your trip from Milan to Isernia.
  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Frecciarossa with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Milan to Isernia.

Why book with Omio over Raileurope?

  • Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Milan to Isernia.

Journey information

Overview: Train from Milan to Isernia

ItalyItaly
ItalyItaly
Icon of train

Trains from Milan to Isernia run on average 11 times per day, taking around 7h 16m. Cheap train tickets for this journey start at $46 (€37) but you can travel from only $22 (€17) by flight.

The earliest train runs at 04:40, the last at 22:45. The fastest train covers the 367 miles (592 km) distance in 4h 23m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $22 (€17)
Distance
367 miles (592 km)
Average train duration
7h 16m
Cheapest ticket price
$46 (€37)
Trains per day
11
Fastest train
4h 23m
First train
4:40 AM
Last train
10:45 PM
Cheapest Month
Mar
Cheapest Day
Wed
High Season
Jul - Sep
Low Season
Apr - Jun
Busiest Day
Wed
Least Busy Day
Wed
Best time to book
3 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $22 (€17)

Train companies: Frecciarossa, Italo, Intercity from Milan to Isernia trainsFrecciarossa, Italo, Intercity trains will get you between Milan and Isernia from $22 (€17). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.

Frecciarossa

About
Step on board a Frecciarossa train and relax as you travel across Italy. Trenitalia’s Frecciarossa high-speed trains make around 200 connections across the country each day and are renowned for their comfort, speed, and reduced environmental impact. Reaching speeds of up to 186 mph (300 km/h), they connect major destinations such as Rome, Florence, Milan, Venice, and Naples quickly and efficiently. When booking your Frecciarossa journey, you can choose between four classes: Standard, Premium, Business, and Executive. While each class offers different levels of comfort, all provide free Wi-Fi access, power outlets, air conditioning, bathrooms, luggage storage, onboard entertainment, and restaurant and bar services. Ticket options include Super Economy, Economy, and Base, making it easy to find the right balance of comfort and price for your trip.
Luggage & cancellation policy
Average Duration
5h 43m
Cheapest Price
$155 (€124)
Frecciarossa frequency
3 a day
Luggage included
1 carry-on bag and 1 suitcase per passenger
Luggage storage
Overhead racks, dedicated luggage areas at carriage ends, under seats
Cancellation Policy
Refund policy depends on ticket type
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with full meals, bar service with snacks and beverages, at-seat service in Executive class
Seat reservation
Included in Executive class, optional fee for other classes
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible toilets, assistance service available
Pets
Small pets in carriers travel free, larger dogs require paid ticket and muzzle, service animals free
Quiet zone
Learn more about Frecciarossa

Italo

About
Italo is Italy’s private high-speed train service operated by Nuovo Trasporto Viaggiatori (NTV), connecting major cities such as Rome, Milan, Naples, Florence, Turin, Bologna, and Salerno. Its fleet includes the Italo AGV 575, capable of speeds up to 186 mph (300 km/h), and the eco-friendly Italo EVO, which reaches up to 150 mph (250 km/h). Passengers can choose from four classes — Smart, Comfort, Prima, and Club Executive — all offering modern amenities such as free Wi-Fi, power outlets, reclining leather seats, footrests, bathrooms, snack machines, and Italo Live entertainment with movies, music, and games. Italo offers three fare types — Low Cost, Economy, and Flex — providing different levels of price and flexibility. Popular routes include Rome–Milan, Rome–Florence, and Milan–Turin, making Italo a fast, comfortable, and convenient way to travel around Italy.
Luggage & cancellation policy
Average Duration
4h 23m
Cheapest Price
$56 (€45)
Italo frequency
2 a day
Luggage included
2 pieces of hand luggage (max 55x35x25cm) and 1 piece of luggage (max 75x53x30cm)
Luggage storage
Overhead racks and designated luggage areas between seats
Cancellation Policy
Cancellation possible according to ticket conditions
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Snack bar service available in most trains with drinks and light refreshments. Welcome service in Prima and Club Executive classes
Seat reservation
Included in Prima and Club Executive. Optional extra cost in Smart and Comfort
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for passengers with reduced mobility
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle. Guide dogs travel free
Quiet zone
Learn more about Italo

Intercity

About
Trenitalia Intercity is a high-speed train service operated by the Italian national railway company, Trenitalia. It operates throughout the country, with services running from early morning to late evening. The Intercity trains come in two types: the Intercity Plus, which is the fastest and most comfortable, and the Intercity, which is slightly slower but still offers a comfortable journey. Onboard facilities include air conditioning, power sockets, Wi-Fi, and a bar service. There are several ticket types available, including Standard, Super Economy, and Business. The most popular routes for Trenitalia Intercity are from Rome to Milan, Naples to Florence, and Turin to Venice.
Luggage & cancellation policy
Average Duration
10h 35m
Cheapest Price
$46 (€37)
Luggage included
2 pieces of luggage up to 30kg total
Luggage storage
Overhead racks and designated luggage areas at end of carriages
Cancellation Policy
According to ticket conditions
Refund
Full refund provided
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with hot meals and snacks, trolley service in some trains. But do not count on the presence of a buffet car. So if having access to food and drink on the train is important to you, it’s best to bring your own refreshments onboard.
Seat reservation
Seat reservation included in ticket price for most routes
Toilets
USB plugs
Accessibility
Wheelchair spaces and accessible toilets available
Pets
Small pets in carriers allowed free, larger dogs require paid ticket
Quiet zone

FAQs: Trains from Milan to Isernia

Find answers to the most common questions about traveling from Milan to Isernia by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Isernia, this guide helps you travel smarter and with confidence.

FAQs
Train ticket prices from Milan to Isernia can vary. The cheapest ticket starts at $46 (€37), while the average price is around $86 (€68).
The train from Milan to Isernia takes 4h 23m and runs 11 per day.
The first train from Milan to Isernia leaves at 4:40 AM.
The distance by train from Milan to Isernia is 367 miles (592 km).
The last train from Milan to Isernia leaves at 10:45 PM.
Yes, there is a high-speed train from Milan to Isernia.
There is no direct train service currently available from Milan to Isernia.
Unfortunately, there is no night train available from Milan to Isernia.
The train station in Milan that goes to Isernia is Milan Centrale, which connects to Isernia station.
The cheapest way to get from Milan to Isernia is by flight, with a cost of around $22 (€17).
The train journey from Milan to Isernia offers diverse scenery, including views of the Italian countryside, rolling hills, and charming towns, providing a picturesque travel experience.
A day trip from Milan to Isernia is not feasible as the journey takes 4h 23m. The distance is 367 miles (592 km). There are 11 trains available per day.
Two to three days are ideal to explore Isernia, allowing time to visit historical sites, enjoy local cuisine, and experience the surrounding nature.
Yes, you can take the train from Milan to Isernia.
Since both Milan and Isernia are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
Popular day trips by train from Isernia include Naples, Venafro, Caserta, Cassino, Bojano.
We recommend using the train as it is the most popular way to get from Milan to Isernia among Omio's users.
Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.
Yes, rail passes such as the Eurail Italy Pass and Interrail Italy Pass are valid on most trains operated by Trenitalia and Italo within Italy, including regional, intercity, and high-speed trains, though some restrictions and seat reservation fees may apply.
Italy uses the euro (EUR) as its currency. Travelers generally find it convenient to use cards for most payments, especially in cities and larger establishments, but carrying some cash is advisable for small shops, markets, and rural areas where card acceptance may be limited.
In Isernia, travelers should be cautious of petty theft, especially in crowded areas and near transportation hubs. It is advisable to stay vigilant with personal belongings and avoid accepting unsolicited offers from strangers. There are no widespread reports of specific scams targeting visitors, but standard travel precautions apply, such as using official taxi services and verifying ticket purchases to ensure safety and avoid fraud.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular train stations

Popular train stations from Milan to Isernia

Milan
Isernia
The major train station for departures in Milan is Milano Centrale. Find all the information you need to know about services, amenities and connections at Milano Centrale for your trip from Milan to Isernia.
Milano CentraleWifiLockersParkingDiningATMTaxisAccessibilityWCHotelTicket OfficeBike ParkingBike RentalCar RentalInformation Desk
Amenities at train station
WifiWifi
LockersLockers
ParkingParking
DiningDining
ATMATM
TaxisTaxis
AccessibilityAccessibility
WCWC
HotelHotel
Ticket OfficeTicket Office
Bike ParkingBike Parking
Bike RentalBike Rental
Car RentalCar Rental
Information DeskInformation Desk
information
address
Address
Piazza Duca d'Aosta, 1, 20124 Milan, Italy
phone
Phone Number
ticketOfficeHours
Ticket Office Hours
  • Mon - Sun: 05:50 - 22:20
ticketOfficeHours
Distance to city center
2 km
Wifi
Wifi
  • Free WiFi in the station.
Lockers
Lockers
  • Provided by KiPoint and located on the ground floor, on the side of Piazza Luigi di Savoia. It is open every day from 06:00 to 23:00.
Dining
Dining
  • Venchi
  • Panzera Coffee
  • Burger King
  • Bar Motta
  • Caffè Napoli
  • VyTA Boulangerie
  • Spontini
  • Starbucks
  • Dispensa Emilia
  • McDonald's
  • & many more
Accessibility
Accessibility
  • Station is wheelchair accessible, has elevators and the Sala Blu, Trenitalia's office of assistance for disabled travelers, is next to Platform 4.
Hotel
Hotel
  • Glam Hotel Milano
  • NYX MIlan
  • iQ Hotel Milano
Ticket Office
Ticket Office
  • Mon - Sun: 05:50 - 22:20
Information Desk
Information Desk
  • Located next to the ticket office on the ground floor in the shopping gallery.
Public transit options for Milano Centrale
  • Metro lines: M2 (green), M3 (yellow)
  • Tram lines: 1
  • Bus lines: 5, 9, 10, 42, 81, 87, 152, 728, N26, NM2, NM3, Air Bus, Orio Shuttle
  • Train lines: FR, FB, EC, Thello, XP2, R28, IC, ICN, RV, R, Regio, Italo
Milano RogoredoWifiLockersParkingDiningATMTaxisAccessibilityWCHotelLost and Found OfficeTicket OfficeBike ParkingCar RentalInformation DeskLuggage Carts
Amenities at train station
WifiWifi
LockersLockers
ParkingParking
DiningDining
ATMATM
TaxisTaxis
AccessibilityAccessibility
WCWC
HotelHotel
Lost and Found OfficeLost and Found Office
Ticket OfficeTicket Office
Bike ParkingBike Parking
Car RentalCar Rental
Information DeskInformation Desk
Luggage CartsLuggage Carts
information
address
Address
Via G Battista Cassinis 76, Milan, 20139, Italy
phone
Phone Number
ticketOfficeHours
Ticket Office Hours
  • 6:00 AM - 10:00 PM Monday - Sunday
ticketOfficeHours
Distance to city center
5 km
platformCount
Number of platforms
8
Wifi
Wifi
  • Free
Parking
Parking
  • The car park is open 7 days a week, 24 hours a day. Access is available from Via G Battista Cassinis.
Dining
Dining
  • Ristorante Pizzeria Il Moro
  • Osteria La Piola
Taxis
Taxis
  • Outside the main entrance.
Accessibility
Accessibility
  • Elevators, ramps.
WC
WC
  • €1
Hotel
Hotel
  • Starhotels Business Palace
  • Hotel Mistral
  • Hotel Brenta Milano
Lost and Found Office
Lost and Found Office
  • Located in the main hall
Car Rental
Car Rental
  • Avis
Information Desk
Information Desk
  • Located in the main hall
Luggage Carts
Luggage Carts
  • Free
Station Plan
  • Hall 1: main entrance, platforms 1-8 for trains to various destinations
  • Hall 2: metro connections
Public transit options for Milano Rogoredo
  • Metro: Line M3
  • Bus: Several lines available
  • Train: Regional and high-speed services
Milano Porta GaribaldiWifiParkingDiningATMTaxisAccessibilityWCHotelBike ParkingBike Rental
Amenities at train station
WifiWifi
ParkingParking
DiningDining
ATMATM
TaxisTaxis
AccessibilityAccessibility
WCWC
HotelHotel
Bike ParkingBike Parking
Bike RentalBike Rental
information
address
Address
Piazza Sigmund Freud, 1, Milan, Italy
phone
Phone Number
ticketOfficeHours
Distance to city center
2 km
Wifi
Wifi
  • Free Wi-Fi in the station.
Dining
Dining
  • Caffeteria Panni Caldi
  • Princi
  • Burgez
  • Bricco Café
  • U! Come tu mi vuoi
  • Autogrill
  • Culto
Accessibility
Accessibility
  • Accessible facilities such as ticket machines, toilets, and ramps and additional assistance as needed from 07:45 to 22:30.
Hotel
Hotel
  • Hotel NH Milano Palazzo Moscova
  • AC Hotel by Marriott Milano
  • Tocq Hotel
Public transit options for Milano Porta Garibaldi
  • Metro lines: M2, M5
  • Bus lines: 43, 56, 70, 94
  • Train lines: R21, R31, S1, S11, S2, S5, S7, S8

More options for your journey from Milan to Isernia

Here are some other resources that might have the information you need

Tickets and more information for trains to Milan
Tickets and more information for trains to Isernia

Most popular train connections to Isernia

Train Rome - Isernia
Train Naples - Isernia
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