MILAN to ISERNIA train from $33 (€26) with Frecciarossa

2,000+ travel companies

Scan to get our free app

Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.

App Store

4.9

42K ratings

Google Play

4.6

136K reviews

The cheapest and fastest trains from Milan to Isernia

Showing times and prices for Aug 06

Cheapest price

$98

Average price

$130

Fastest journey

5 h 50 m

Average duration

5 h 59 m

Trains per day

Distance

592 km

Cheap tickets

The best way to find a cheap train ticket from Milan to Isernia is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Milan to Isernia will cost around $130 if you buy it on the day, but the cheapest tickets can be found for only $98.

Fast trains

It's difficult to get from Milan to Isernia without transferring at least once.

Intercity 583+Regionale 12663 · treno 23369 effettuato con bus CB708
6:05 AM10h50
Milan Centrale
4:55 PMIsernia station
$981One-way
2 transfers
Intercity 583+treno 5196 effettuato con bus CB910
6:05 AM13h15
Milan Centrale
7:20 PMIsernia station
$1031One-way
1 transfer
FRECCIAROSSA 9539+treno 23425 effettuato con bus CB714
1:10 PM6h45
Milan Centrale
7:55 PMIsernia station
$1341One-way
1 transfer
FRECCIAROSSA 9601+treno 23365 effettuato con bus CB704
5:20 AM6h05
Milan Centrale
11:25 AMIsernia station
$1341One-way
1 transfer
FRECCIAROSSA 9637+Regionale Veloce 4106 · treno 23425 effettuato con bus CB714
1:58 PM5h57
Milan Centrale
7:55 PMIsernia station
$1341One-way
2 transfers

Travel Information

Compare train, bus, and flight for Milan to Isernia

Omio recommends booking the train as it is the most popular option from Milan to Isernia among Omio's users. If you are prioritising price take the bus with prices starting from $33. For those with little time consider booking a flight which can get you there in 1h 20m. The ticket price range depends on the travel mode: a bus costs an average of $33, and a flight costs an average of $36.

Distance: 367 miles (592 km)

Compare train with

Most popular Train	Bus	Flight	Driving
$89 Average price	$53 Average price Cheapest	$99 Average price	$220 Average price (fuel + tolls)
7h 45m Average total duration 7h 15m Onboard + 30m Additional time*	12h 3m Average total duration 11h 33m Onboard + 30m Additional time*	4h 20m Average total duration Fastest 1h 20m Onboard + 3h 0m Additional time*	7h 39m Average total duration (door-to-door)
Most popular train company	Most popular bus company	Most popular airline	Your own car or car rental
Direct Options	Direct Options	Direct Options	Direct Options

The cheapest way to travel from Milan to Isernia is a bus with an average price of $53 (€43).

This is compared to other travel options from Milan to Isernia:

A bus is $36 (€29) less than a train for this route with tickets for a train from Milan to Isernia costing on average $89 (€73).

A bus is $46 (€37) less than a flight for this route with tickets for a flight from Milan to Isernia costing on average $99 (€81).

The fastest way to travel from Milan to Isernia is by flight with an average journey time of 1h 20m.

Other travel options to Isernia take longer:

Train takes on average 7h 15m.

Bus takes on average 11h 33m.

It's helpful to compare your options as there are 3 ways to travel between Milan and Isernia including taking a train, bus, and flight.

We recommend using the train as it is the most popular way to get from Milan to Isernia among Omio's users.

Take the train. On this route, it beats driving on both time and money.

The journey is about 24m faster (7h 15m by train vs 7h 39m by car) and roughly $131 (€107) cheaper once you factor in fuel and tolls ($89 (€73) vs $220 (€179)). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.

Driving is still worth considering if you want to stop along the way or need a car once you arrive.

Live departures

Milan to Isernia train times

The table below shows live departures for Milan to Isernia trains for today, Wednesday, August 5. You can also manually refresh the results below to see updated train journeys.

Last updated at

Provider	Departs	Duration	Arrives	Transfers
9931+treno 23379 effettuato con bus CB712	On time 11:40 AM Milan Centrale	10h55	10:35 PM Isernia station	1 transfer
9931+Regionale 12631 · Autobus RM114	On time 11:40 AM Milan Centrale	9h15	8:55 PM Isernia station	2 transfers
9931+Regionale Veloce 4106 · treno 23425 effettuato con bus CB714	On time 11:40 AM Milan Centrale	8h15	7:55 PM Isernia station	2 transfers
FRECCIAROSSA 9627+treno 5196 effettuato con bus CB910	11:58 AM Milan Centrale	7h22	7:20 PM Isernia station	1 transfer
9981+Regionale 12631 · Autobus RM114	On time 12:20 PM Milan Centrale	8h35	8:55 PM Isernia station	2 transfers
9981+treno 23379 effettuato con bus CB712	On time 12:20 PM Milan Centrale	10h15	10:35 PM Isernia station	1 transfer
9981+Regionale Veloce 4106 · treno 23425 effettuato con bus CB714	On time 12:20 PM Milan Centrale	7h35	7:55 PM Isernia station	2 transfers
9935+treno 23379 effettuato con bus CB712	On time 12:40 PM Milan Centrale	9h55	10:35 PM Isernia station	1 transfer
9935+Regionale 12631 · Autobus RM114	On time 12:40 PM Milan Centrale	8h15	8:55 PM Isernia station	2 transfers
9935+Regionale Veloce 4106 · treno 23425 effettuato con bus CB714	On time 12:40 PM Milan Centrale	7h15	7:55 PM Isernia station	2 transfers
FRECCIAROSSA 9539+treno 23425 effettuato con bus CB714	1:10 PM Milan Centrale	6h45	7:55 PM Isernia station	1 transfer
9983+Regionale Veloce 4106 · treno 23425 effettuato con bus CB714	1:20 PM Milan Centrale	6h35	7:55 PM Isernia station	2 transfers
9983+treno 23379 effettuato con bus CB712	1:20 PM Milan Centrale	9h15	10:35 PM Isernia station	1 transfer
9983+Regionale 12631 · Autobus RM114	1:20 PM Milan Centrale	7h35	8:55 PM Isernia station	2 transfers
9939+Regionale 12631 · Autobus RM114	On time 1:40 PM Milan Centrale	7h15	8:55 PM Isernia station	2 transfers
9939+treno 23379 effettuato con bus CB712	On time 1:40 PM Milan Centrale	8h55	10:35 PM Isernia station	1 transfer
9939+FRECCIAROSSA 8323+treno 23495 effettuato con bus CB912	On time 1:40 PM Milan Centrale	8h05	9:45 PM Isernia station	2 transfers
FRECCIAROSSA 9637+Regionale Veloce 4106 · treno 23425 effettuato con bus CB714	1:58 PM Milan Centrale	5h57	7:55 PM Isernia station	2 transfers
FRECCIAROSSA 9543+treno 23495 effettuato con bus CB912	2:10 PM Milan Centrale	7h35	9:45 PM Isernia station	1 transfer
FRECCIAROSSA 9639 · FRECCIAROSSA 8323+treno 23495 effettuato con bus CB912	2:30 PM Milan Centrale	7h15	9:45 PM Isernia station	2 transfers
8143+treno 23379 effettuato con bus CB712	2:40 PM Milan Centrale	7h55	10:35 PM Isernia station	1 transfer
9987+treno 23379 effettuato con bus CB712	On time 3:15 PM Milan Centrale	7h20	10:35 PM Isernia station	1 transfer
9947+treno 23379 effettuato con bus CB712	3:40 PM Milan Centrale	6h55	10:35 PM Isernia station	1 transfer
9989+treno 23379 effettuato con bus CB712	4:15 PM Milan Centrale	6h20	10:35 PM Isernia station	1 transfer
FRECCIAROSSA 9647+treno 23379 effettuato con bus CB712	4:30 PM Milan Centrale	6h05	10:35 PM Isernia station	1 transfer
FRECCIAROSSA 9601+treno 23365 effettuato con bus CB704	5:20 AM Milan Centrale	6h05	11:25 AM Isernia station	1 transfer
Intercity 583+Regionale 12663 · treno 23369 effettuato con bus CB708	6:05 AM Milan Centrale	10h50	4:55 PM Isernia station	2 transfers
Intercity 583+treno 5196 effettuato con bus CB910	6:05 AM Milan Centrale	13h15	7:20 PM Isernia station	1 transfer
FRECCIAROSSA 9607+treno 5190 effettuato con bus CB906	7:00 AM Milan Centrale	7h10	2:10 PM Isernia station	1 transfer
FRECCIAROSSA 9617+treno 23367 effettuato con bus CB706	9:35 AM Milan Centrale	5h50	3:25 PM Isernia station	1 transfer
FRECCIAROSSA 9623+treno 23369 effettuato con bus CB708	10:58 AM Milan Centrale	5h57	4:55 PM Isernia station	1 transfer
This is the last train of the day.

Find all the dates and times for this journey

Compare prices and tickets Milan to Isernia by train, bus, or flight

Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Thu
Aug 06

Fri
Aug 07

Sat
Aug 08

Sun
Aug 09

Mon
Aug 10

Tue
Aug 11

Wed
Aug 12

Why should you book Milan to Isernia trains with Omio?

Frecciarossa as well as Italo or Intercity offer trains services from Milan to Isernia.

Omio is an official ticket reseller for all your travel options from Milan to Isernia.

Why book with Omio vs Frecciarossa?

Compare with other providers: On Omio, you can not only buy tickets for Frecciarossa, but also compare tickets for the likes of Italo or Intercity to find the best option for your trip from Milan to Isernia.
Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Compare all your options: Omio allows you to compare Frecciarossa with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Milan to Isernia.

Why book with Omio over Raileurope?

Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Milan to Isernia.

Journey information

Overview: Train from Milan to Isernia

Italy

Trains from Milan to Isernia run on average 11 times per day, taking around 7h 15m. Cheap train tickets for this journey start at $45 (€37) but you can travel from only $33 (€26) by bus.

The earliest train runs at 04:40, the last at 22:45. The fastest train covers the 367 miles (592 km) distance in 4h 33m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.

Price information

Cheapest alternative travel mode

Bus from $33 (€26)

Distance

367 miles (592 km)

Average train duration

7h 15m

Cheapest ticket price

$45 (€37)

Trains per day

Fastest train

4h 33m

First train

4:40 AM

Last train

10:45 PM

Cheapest Month

Sep

Cheapest Day

Wed

High Season

Jul - Sep

Low Season

Apr - Jun

Busiest Day

Tue

Least Busy Day

Tue

Best time to book

3 days

Price information

Cheapest alternative travel mode

Bus from $33 (€26)

Train companies: Frecciarossa, Italo, Intercity from Milan to Isernia trainsFrecciarossa, Italo, Intercity trains will get you between Milan and Isernia from $33 (€26). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.

Frecciarossa

About

Step on board a Frecciarossa train and relax as you travel across Italy. Trenitalia’s Frecciarossa high-speed trains make around 200 connections across the country each day and are renowned for their comfort, speed, and reduced environmental impact. Reaching speeds of up to 186 mph (300 km/h), they connect major destinations such as Rome, Florence, Milan, Venice, and Naples quickly and efficiently. When booking your Frecciarossa journey, you can choose between four classes: Standard, Premium, Business, and Executive. While each class offers different levels of comfort, all provide free Wi-Fi access, power outlets, air conditioning, bathrooms, luggage storage, onboard entertainment, and restaurant and bar services. Ticket options include Super Economy, Economy, and Base, making it easy to find the right balance of comfort and price for your trip.

Luggage & cancellation policy

Average Duration

5h 54m

Cheapest Price

$127 (€104)

Frecciarossa frequency

2 a day

Luggage included

1 carry-on bag and 1 suitcase per passenger

Luggage storage

Overhead racks, dedicated luggage areas at carriage ends, under seats

Cancellation Policy

Refund policy depends on ticket type

Refund

Full refund provided for canceled trains

Amenities on board the train

Wifi

Food sold onboard

Restaurant car with full meals, bar service with snacks and beverages, at-seat service in Executive class

Seat reservation

Included in Executive class, optional fee for other classes

Toilets

USB plugs

Accessibility

Wheelchair spaces, accessible toilets, assistance service available

Pets

Small pets in carriers travel free, larger dogs require paid ticket and muzzle, service animals free

Quiet zone

Learn more about Frecciarossa

Italo

About

Italo is Italy’s private high-speed train service operated by Nuovo Trasporto Viaggiatori (NTV), connecting major cities such as Rome, Milan, Naples, Florence, Turin, Bologna, and Salerno. Its fleet includes the Italo AGV 575, capable of speeds up to 186 mph (300 km/h), and the eco-friendly Italo EVO, which reaches up to 150 mph (250 km/h). Passengers can choose from four classes — Smart, Comfort, Prima, and Club Executive — all offering modern amenities such as free Wi-Fi, power outlets, reclining leather seats, footrests, bathrooms, snack machines, and Italo Live entertainment with movies, music, and games. Italo offers three fare types — Low Cost, Economy, and Flex — providing different levels of price and flexibility. Popular routes include Rome–Milan, Rome–Florence, and Milan–Turin, making Italo a fast, comfortable, and convenient way to travel around Italy.

Luggage & cancellation policy

Average Duration

4h 33m

Cheapest Price

$119 (€97)

Italo frequency

1 a day

Luggage included

2 pieces of hand luggage (max 55x35x25cm) and 1 piece of luggage (max 75x53x30cm)

Luggage storage

Overhead racks and designated luggage areas between seats

Cancellation Policy

Cancellation possible according to ticket conditions

Refund

Full refund provided for canceled trains

Amenities on board the train

Wifi

Food sold onboard

Snack bar service available in most trains with drinks and light refreshments. Welcome service in Prima and Club Executive classes

Seat reservation

Included in Prima and Club Executive. Optional extra cost in Smart and Comfort

Toilets

USB plugs

Accessibility

Wheelchair spaces and assistance available for passengers with reduced mobility

Pets

Small pets in carriers travel free. Larger dogs require paid ticket and muzzle. Guide dogs travel free

Quiet zone

Learn more about Italo

Intercity

About

Trenitalia Intercity is a high-speed train service operated by the Italian national railway company, Trenitalia. It operates throughout the country, with services running from early morning to late evening. The Intercity trains come in two types: the Intercity Plus, which is the fastest and most comfortable, and the Intercity, which is slightly slower but still offers a comfortable journey. Onboard facilities include air conditioning, power sockets, Wi-Fi, and a bar service. There are several ticket types available, including Standard, Super Economy, and Business. The most popular routes for Trenitalia Intercity are from Rome to Milan, Naples to Florence, and Turin to Venice.

Luggage & cancellation policy

Average Duration

10h 35m

Cheapest Price

$45 (€37)

Luggage included

2 pieces of luggage up to 30kg total

Luggage storage

Overhead racks and designated luggage areas at end of carriages

Cancellation Policy

According to ticket conditions

Refund

Full refund provided

Amenities on board the train

Wifi

Food sold onboard

Restaurant car with hot meals and snacks, trolley service in some trains. But do not count on the presence of a buffet car. So if having access to food and drink on the train is important to you, it’s best to bring your own refreshments onboard.

Seat reservation

Seat reservation included in ticket price for most routes

Toilets

USB plugs

Accessibility

Wheelchair spaces and accessible toilets available

Pets

Small pets in carriers allowed free, larger dogs require paid ticket

Quiet zone

Complete guide to Isernia

Things to do in Isernia

Discover the best of Isernia — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Isernia trip today.

Must visit

Museo Nazionale del Paleolitico di Isernia

Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.

View on map Visit website

Recommended

Museo Archeologico di Santa Maria delle Monache

Archaeological area museum presenting finds from the ancient settlement. A strong companion visit to the cathedral and Roman remains.

View on map Visit website

Recommended

Complesso Monumentale di Santa Maria delle Monache

Exhibition venue in a historic setting, often used for local heritage displays. Good for visitors interested in community-focused culture.

View on map Visit website

Euro (€)

Moderate for Italy. Hotels and dining are usually cheaper than Rome or Florence, while local buses and coffee remain low-cost for most travelers.

Average meal costs

Budget: €8-12 for fast food or a simple meal.
Mid-range: €20-35 per person for a restaurant meal.
Fine dining: €50+ per person for upscale dining.
Coffee: €1.20-2.50 for espresso or cappuccino.

Tipping culture

Tipping is modest. Service may be included. Round up or leave 5-10% at restaurants for good service; round up taxi fares; small change is enough at cafes.

FAQs: Trains from Milan to Isernia

Find answers to the most common questions about traveling from Milan to Isernia by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Isernia, this guide helps you travel smarter and with confidence.

Train ticket prices from Milan to Isernia can vary. The cheapest ticket starts at $45 (€37), while the average price is around $89 (€73).

The train from Milan to Isernia takes 4h 33m and runs 11 per day.

The first train from Milan to Isernia leaves at 4:40 AM.

The distance by train from Milan to Isernia is 367 miles (592 km).

The last train from Milan to Isernia leaves at 10:45 PM.

Yes, there is a high-speed train from Milan to Isernia.

There is no direct train service currently available from Milan to Isernia.

Unfortunately, there is no night train available from Milan to Isernia.

The train station in Milan that goes to Isernia is Milan Centrale, which connects to Isernia station.

The cheapest way to get from Milan to Isernia is by bus, with a cost of around $33 (€26).

The train journey from Milan to Isernia offers diverse scenery, including views of the Italian countryside, rolling hills, and charming towns, providing a picturesque travel experience.

A day trip from Milan to Isernia is not feasible as the journey takes 4h 33m. The distance is 367 miles (592 km). There are 11 trains available per day.

Two to three days are ideal to explore Isernia, allowing time to visit historical sites, enjoy local cuisine, and experience the surrounding nature.

Yes, you can take the train from Milan to Isernia.

Since both Milan and Isernia are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.

Popular day trips by train from Isernia include Naples, Venafro, Caserta, Cassino, Bojano.

We recommend using the train as it is the most popular way to get from Milan to Isernia among Omio's users.

Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.

Yes, rail passes such as the Eurail Italy Pass and Interrail Italy Pass are valid on most trains operated by Trenitalia and Italo within Italy, including regional, intercity, and high-speed trains, though some restrictions and seat reservation fees may apply.

Italy uses the euro (EUR) as its currency. Travelers generally find it convenient to use cards for most payments, especially in cities and larger establishments, but carrying some cash is advisable for small shops, markets, and rural areas where card acceptance may be limited.

In Isernia, travelers should be cautious of petty theft, especially in crowded areas and near transportation hubs. It is advisable to stay vigilant with personal belongings and avoid accepting unsolicited offers from strangers. There are no widespread reports of specific scams targeting visitors, but standard travel precautions apply, such as using official taxi services and verifying ticket purchases to ensure safety and avoid fraud.

Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular train stations

Popular train stations from Milan to Isernia

Most Milan to Isernia trains use the Milano Centrale to Isernia station pair. Use this guide to compare Milan and Isernia train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.

Departure train stations in Milan

Arrival train stations in Isernia

Which Milan station do trains to Isernia leave from?

Trains from Milan to Isernia leave from Milano Centrale. The station is 1 miles (3 km) from Milan city centre at Piazza Duca d'Aosta, 1, 20124 Milan, Italy.

Milano CentralePiazza Duca d'Aosta, 1, 20124 Milan, Italy+39 892021 Wifi

City-centre transport

Getting to Milano Centrale from Milan city centre

Milano Centrale is 2 km from Milan city centre. Public transport options include:

TrainRe51 · 11m · $2 · every ~5 min

BusNm3 · 9m · $2 · every ~1 min

60 · 31m · $2 · every ~10 min

Tram9 · 27m · $2 · every ~16 min

Subway3 · 11m · $2 · every ~25 min

Milano Centrale train station facilities and services

Milano Centrale has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.

Food and drink

Food options include: Venchi, Panzera Coffee, Burger King, Bar Motta, Caffè Napoli, VyTA Boulangerie, Spontini, Starbucks, Dispensa Emilia, McDonald's, & many more

Wi-Fi and ATMs

Free WiFi in the station. ATMs are there are ATMs in various locations around the station.

Tickets and information

The ticket office is open Mon - Sun: 05:50 - 22:20. Information desks are located next to the ticket office on the ground floor in the shopping gallery.

Luggage and lost property

Luggage storage is provided by KiPoint and located on the ground floor, on the side of Piazza Luigi di Savoia. It is open every day from 06:00 to 23:00.

Parking, taxis and toilets

Available at Milano Centrale: Parking, Taxis, WC.

Bike and car services

Available at Milano Centrale: Bike Parking, Bike Rental, Car Rental.

Accessibility

Accessibility facilities are available at Milano Centrale: Station is wheelchair accessible, has elevators and the Sala Blu, Trenitalia's office of assistance for disabled travelers, is next to Platform 4.

Shops, hotels and contact

Nearby hotels include Glam Hotel Milano, NYX MIlan, iQ Hotel Milano.

More about Milano Centrale

Milano RogoredoVia G Battista Cassinis 76, Milan, 20139, Italy+39 02 7740 4318 Wifi

City-centre transport

Getting to Milano Rogoredo from Milan city centre

Milano Rogoredo is 5 km from Milan city centre. Public transport options include:

TrainRe, 2363, 2375, 2391, 2399, 3013, 3017, 3025, 3029, 3033, 3037, 3041, 3045, 3057, 3067, 3069, 3073, 3077, 33375 · 8m · $1 · every ~1 min

S1, S2, S13, S12 · 13m · $2 · every ~13 min

BusNm3 · 15m · $2 · every ~1 min

Bus · 28m

Subway3 · 10m · $2 · every ~25 min

Milano Rogoredo train station facilities and services

Milano Rogoredo has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.