- Must visit
Museo Nazionale del Paleolitico di Isernia
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
The best way to find a cheap train ticket from Termoli to Isernia is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Termoli to Isernia will cost around $42 if you buy it on the day, but the cheapest tickets can be found for only $42.
On Wed, Nov 04, we found 1 trains from Termoli to Isernia, including 1 direct services.
On Wed, Nov 04 the direct trains cover the 76 km distance in an average of 6 h 17 m but if you time it right, some trains will get you there in just 6 h 17 m .
On Wed, Nov 04 the slowest trains will take 6 h 17 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Trains from Termoli to Isernia run on average 1 times per day, taking around 4h 44m. Cheap train tickets for this journey start at $36 but you can travel from only $15 by bus.
The earliest train runs at 05:21, the last at 19:26. The fastest train covers the 47 miles (76 km) distance in 4h 15m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Termoli to Isernia.
The table below shows live departures for Termoli to Isernia trains for tomorrow, Wednesday, November 4. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 6:47 AM Termoli | 6h17 | 1:04 PM Isernia | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Trains from Termoli to Isernia with Intercity and Frecciarossa. High-speed trains available on this route with Frecciarossa. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Isernia — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Isernia trip today.
Major Paleolithic museum beside the renowned prehistoric site. Essential for understanding early human settlement in Europe.
Archaeological area museum presenting finds from the ancient settlement. A strong companion visit to the cathedral and Roman remains.
Exhibition venue in a historic setting, often used for local heritage displays. Good for visitors interested in community-focused culture.
Main historic street lined with palaces, churches, and shops. The best walk for absorbing Isernia's old-town atmosphere.
The historic center preserves medieval lanes, arches, and layered architecture. Ideal for slow exploration and local street photography.
Central square near the cathedral and Fontana Fraterna. A practical starting point for discovering the city's key monuments.
Fresh pasta sheets layered with rich pork ragù, mozzarella, and caciocavallo. A Sunday and feast-day classic in Molise with deep family tradition.
Small handmade cavatelli pasta, often served with tomato sauce, pork, or seasonal vegetables. It is one of Molise’s best-known home-style staples.
Rustic soup of field greens, potatoes, beans, and cornbread or stale bread. A traditional peasant dish from the Isernia area, especially in colder months.
Established restaurant known for Molisan cooking, handmade pasta, and local meats in a refined but welcoming setting.
Well-regarded traditional venue serving regional specialties, grilled meats, and classic local dishes in a rustic atmosphere.
Casual, popular spot for pizza and southern Italian dishes, suited to an easy meal with locals and families.
Moderate for Italy. Hotels and dining are usually cheaper than Rome or Florence, while local buses and coffee remain low-cost for most travelers.
Tipping is modest. Service may be included. Round up or leave 5-10% at restaurants for good service; round up taxi fares; small change is enough at cafes.
Official public transport app
Isernia Railway Station -> Piazza Andrea d'Isernia
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Isernia.
Find answers to the most common questions about traveling from Termoli to Isernia by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Isernia, this guide helps you travel smarter and with confidence.

Most Termoli to Isernia trains use the Termoli to Isernia station pair. Use this guide to compare Termoli and Isernia train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Termoli is 1 km from Termoli city centre. Public transport options include:
Termoli has practical services for this route, including Wifi, Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Information Desk, and Luggage Carts.
Food options include: Da Nicolino, Spirito Divino
Free.
Ticket office support is available at Termoli. Information desks are located in the main hall.
Luggage storage is available at Termoli. Lost and found is available at the station.
Available at Termoli: Parking, Taxis, WC.
Available at Termoli: Bike Parking.
Accessibility facilities are available at Termoli: Ramps.
Nearby hotels include Hotel Santa Lucia, Hotel Mistral, Hotel Meridiano.
Isernia has practical services for this route, including Wifi, Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Information Desk, and Luggage Carts.
Food options include: Pasta e Pizza, Ristorante da Adriano
Free.
Ticket office support is available at Isernia. Information desks are located in the main hall.
Luggage storage is available at Isernia. Lost and found is available at the station.
Available at Isernia: Parking, Taxis, WC.
Available at Isernia: Bike Parking.
Accessibility facilities are available at Isernia: Ramps.
Nearby hotels include Grand Hotel Europa, Hotel Ristorante Sayonara, Hotel La Tequila.
Check train stations information for Termoli and Isernia, including where trains depart and arrive on this route.