- Must visit
The Charleston Museum
America’s first museum with natural history, decorative arts, and Charleston stories across several historic sites.
Cheapest price
$106
Average price
$106
Fastest journey
21 h 45 m
Average duration
21 h 45 m
Buses per day
1
Distance
614 km
The best way to find a cheap bus ticket from Seminole, FL to Charleston, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Seminole, FL to Charleston, SC will cost around $106 if you buy it on the day, but the cheapest tickets can be found for only $106.
Of the 1 buses that leave Seminole, FL for Charleston, SC on Fri, Aug 07, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Aug 07 the direct buses cover the 614 km distance in an average of 21 h 45 m but if you time it right, some buses will get you there in just 21 h 45 m .
On Fri, Aug 07 the slowest buses will take 21 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Omio recommends booking the train as it is the most popular option from Seminole, FL to Charleston, SC among Omio's users. If you are prioritising price take the bus with prices starting from $106. For those with little time consider booking a flight which can get you there in 2h 39m. The ticket price range depends on the travel mode: a bus costs an average of $106, and a flight costs an average of $170.
Distance: 381 miles (614 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$106 Average price Cheapest | $142 Average price | $291 Average price | $92 Average price (fuel + tolls) |
22h 15m Average total duration 21h 45m Onboard + 30m Additional time* | 14h 10m Average total duration 13h 40m Onboard + 30m Additional time* | 5h 39m Average total duration Fastest 2h 39m Onboard + 3h 0m Additional time* | 7h 24m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Seminole, FL to Charleston, SC:
A bus is $35 (€29) less than a train for this route with tickets for a train from Seminole, FL to Charleston, SC costing on average $142 (€115).
A bus is $185 (€150) less than a flight for this route with tickets for a flight from Seminole, FL to Charleston, SC costing on average $291 (€237).
Other travel options to Charleston, SC take longer:
Train takes on average 13h 40m.
Bus takes on average 21h 45m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:45AM | Arrival Time 10:30PM | Duration 21h45 | Departure days Fri | Cheapest price $106 |
The table below shows live departures for Seminole, FL to Charleston, SC buses for tomorrow, Thursday, August 6. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:45 AM Seminole, FL | 21h45 | 10:30 PM Charleston, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, flight, and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Seminole, FL to Charleston, SC run on average 2 times per day, taking around 21h 45m. Cheap bus tickets for this journey start at $106 (€86) if you book in advance.
The earliest bus runs at 00:45, the last at 00:45. The fastest bus covers the 381 miles (614 km) distance in 21h 45m.
Distance 381 miles (614 km) |
Average bus duration 21h 45m |
Cheapest ticket price $106 (€86) |
Buses per day 2 |
Fastest bus 21h 45m |
First bus 12:45 AM |
Last bus 12:45 AM |
Cheapest Month Mar |
Cheapest Day Thu |
High Season Jan - Mar |
Low Season Jul - Sep |
Discover the best of Charleston, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Charleston, SC trip today.
America’s first museum with natural history, decorative arts, and Charleston stories across several historic sites.
Leading Southern museum for contemporary art, known for bold exhibitions and strong local creative connections.
Powerful museum on Gadsden’s Wharf interpreting the African American journey and Charleston’s global significance.
Legendary waterfront promenade lined with antebellum homes, harbor breezes, and some of Charleston’s best views.
Historic defensive seawall and walk beside White Point Garden, ideal for sunset, mansions, and harbor panoramas.
Lively pedestrian-friendly market district known for crafts, architecture, and easy access to major downtown sights.
A Lowcountry rice dish with shrimp, sausage, or chicken simmered in rich broth. It reflects Charleston's Gullah Geechee and coastal cooking traditions.
Stone-ground grits cooked creamy and topped with local shrimp, often with bacon or gravy. It is one of Charleston's signature brunch and supper dishes.
A rich soup of blue crab, crab roe, cream, and sherry. This classic Charleston dish is closely tied to the city's historic seafood culture.
Historic fine-dining restaurant focused on seasonal Lowcountry cuisine. Known for polished Southern hospitality and dishes using regional ingredients.
Upscale seafood restaurant celebrated for local oysters and inventive Lowcountry dishes. Stylish, lively, and one of Charleston's best-known dining rooms.
Refined Southern restaurant in the Historic District, known for shrimp and grits, seafood, and polished service in an elegant setting.
Moderate for a US coastal city; hotels and dining in the historic district run higher, while transit is limited and many visitors rely on walking, rideshare, or car hire.
Tip 18-20% in restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip screens; small tips are appreciated but optional.
Find answers to the most common questions about traveling from Seminole, FL to Charleston, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Charleston, SC, this guide helps you travel smarter and with confidence.

Most Seminole, FL to Charleston, SC buses use the Saint Petersburg, Central Avenue N / Dr Martin Luther King St Jr to Charleston, Gaynor Avenue (Greyhound Bus Station) station pair. Use this guide to compare Seminole, FL and Charleston, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Charleston, Gaynor Avenue (Greyhound Bus Station) is 12 km from Charleston city centre. Public transport options include:
Charleston, Gaynor Avenue (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free Wi-Fi available. ATMs are available at Charleston, Gaynor Avenue (Greyhound Bus Station).
Ticket office support is available at Charleston, Gaynor Avenue (Greyhound Bus Station).
Available at Charleston, Gaynor Avenue (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Charleston, Gaynor Avenue (Greyhound Bus Station): Wheelchair accessible.