- Must visit
Musée des Confluences
A striking science and anthropology museum at the meeting of the Rhône and Saône, known for bold architecture and major permanent exhibitions.
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The cheapest and fastest buses from Santander to Lyon
Showing times and prices for May 25
Cheapest price
$102
Average price
$128
Fastest journey
21 h 35 m
Average duration
1 d 6 h 48 m
Buses per day
2
Distance
730 km
Cheap tickets
The best way to find a cheap bus ticket from Santander to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santander to Lyon will cost around $128 if you buy it on the day, but the cheapest tickets can be found for only $102.
Fast buses
Of the 2 buses that leave Santander for Lyon on Mon, May 25, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, May 25 the direct buses cover the 730 km distance in an average of 1 d 6 h 48 m but if you time it right, some buses will get you there in just 21 h 35 m .
On Mon, May 25 the slowest buses will take 1 d 16 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
8:25 AM40h00Santander12:25 AMLyon$1021One-way0 transfers- 4:50 PM21h35Santander2:25 PMLyon$1541One-way0 transfers
- 4:50 PM21h35Santander2:25 PMLyon$1541One-way0 transfers
- 8:25 AM40h00Santander12:25 AMLyon$1021One-way0 transfers
Travel Information
Compare train, bus, and flight for Santander to Lyon
Omio recommends booking the bus as it is the most popular option from Santander to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $44. For those with little time consider booking a flight which can get you there in 2h 45m. The ticket price range depends on the travel mode: a bus costs an average of $44, and a flight costs an average of $83.
Distance: 453 miles (730 km)
Compare bus with
Most popular Bus | Flight | Train | Driving |
|---|---|---|---|
$86 Average price Cheapest | $268 Average price | $190 Average price | $196 Average price (fuel + tolls) |
15h 36m Average total duration 15h 6m Onboard + 30m Additional time* | 5h 45m Average total duration Fastest 2h 45m Onboard + 3h 0m Additional time* | 23h 52m Average total duration 23h 22m Onboard + 30m Additional time* | 9h 42m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Santander to Lyon is a bus with an average price of $86 (€70).
This is compared to other travel options from Santander to Lyon:
A bus is $104 (€84) less than a train for this route with tickets for a train from Santander to Lyon costing on average $190 (€154).
A bus is $182 (€147) less than a flight for this route with tickets for a flight from Santander to Lyon costing on average $268 (€217).
The fastest way to travel from Santander to Lyon is by flight with an average journey time of 2h 45m.
Other travel options to Lyon take longer:
Bus takes on average 15h 6m.
Train takes on average 23h 22m.
It's helpful to compare your options as there are 3 ways to travel between Santander and Lyon including taking a train, bus, and flight.
We recommend using the bus as it is the most popular way to get from Santander to Lyon among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Santander to Lyon Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Alsa | Departure Time 07:00AM | Arrival Time 02:05AM | Duration 19h05 | Departure days Fri | Cheapest price $64 |
Operator Alsa | Departure Time 08:00AM | Arrival Time 03:55AM | Duration 19h55 | Departure days Fri | Cheapest price $57 |
Operator FlixBus | Departure Time 08:25AM | Arrival Time 12:25AM | Duration 40h00 | Departure days Mon | Cheapest price $102 |
Operator Alsa | Departure Time 09:00AM | Arrival Time 04:05AM | Duration 19h05 | Departure days Tue, Wed, Thu, Sun | Cheapest price $48 |
Operator FlixBus | Departure Time 04:50PM | Arrival Time 02:25PM | Duration 21h35 | Departure days Mon, Fri, Sat | Cheapest price $125 |
Operator Alsa | Departure Time 05:00PM | Arrival Time 09:14AM | Duration 16h14 | Departure days Fri | Cheapest price $44 |
Operator FlixBus | Departure Time 05:50PM | Arrival Time 09:50AM | Duration 16h00 | Departure days Sat | Cheapest price $120 |
Operator FlixBus | Departure Time 06:50PM | Arrival Time 10:50AM | Duration 16h00 | Departure days Tue, Wed, Thu, Sun | Cheapest price $88 |
Live departures
Santander to Lyon bus times
The table below shows live departures for Santander to Lyon buses for today, Sunday, May 24. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 Normal · Normal | 9:00 AM Santander, Estación de Autobuses | 19h05 | 4:05 AM Lyon, Perrache Bus Station | 1 transfer | |
| FlixBus · FlixBus | 6:50 PM Santander, Estación de Autobuses | 21h35 | 4:25 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Santander to Lyon by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mon
May 25
May 25
Tue
May 26
May 26
Wed
May 27
May 27
Thu
May 28
May 28
Fri
May 29
May 29
Sat
May 30
May 30
Sun
May 31
May 31
Why should you book Santander to Lyon buses with Omio?
Alsa as well as BlaBlaCar Bus or FlixBus offer buses services from Santander to Lyon.
Omio is an official ticket reseller for all your travel options from Santander to Lyon.
Why book with Omio vs Alsa?
- Compare with other providers: On Omio, you can not only buy tickets for Alsa, but also compare tickets for the likes of BlaBlaCar Bus or FlixBus to find the best option for your trip from Santander to Lyon.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Alsa with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Santander to Lyon.
Why book with Omio over Checkmybus, Rome2rio or Busbud?
- Compare with other providers: On Omio, you can also compare tickets for the likes of BlaBlaCar Bus or FlixBus to find the best option for your trip from Santander to Lyon.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Santander to Lyon.
Journey information
Overview: Bus from Santander to Lyon
Spain
France
Buses from Santander to Lyon run on average 2 times per day, taking around 15h 6m. Cheap bus tickets for this journey start at $44 (€36) if you book in advance.
The earliest bus runs at 00:55, the last at 23:35. The fastest bus covers the 453 miles (730 km) distance in 16h 0m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 453 miles (730 km) |
Average bus duration 15h 6m |
Cheapest ticket price $44 (€36) |
Buses per day 2 |
Fastest bus 16h 0m |
First bus 12:55 AM |
Last bus 11:35 PM |
Cheapest Month Dec |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Thu |
Least Busy Day Fri |
Best time to book 21 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: Alsa, BlaBlaCar Bus, FlixBus from Santander to LyonYou can travel by bus between Santander to Lyon with Alsa, BlaBlaCar Bus, FlixBus for as low as $44 (€36). When you search for schedules and tickets, Omio will show you the best journey
Alsa
About
Alsa is the main provider of bus travel in Spain and a subsidiary of the UK’s National Express. It operates an extensive network of regional, national, and international routes, transporting more than 300 million passengers annually. Alsa’s modern fleet offers varying levels of comfort and amenities. The standard Alsa Normal buses include free Wi-Fi, onboard bathrooms, footrests, and entertainment. For a more premium experience, Alsa Supra, Alsa Eurobus, and Alsa Premium services provide enhanced comfort and luxury features.
Luggage & cancellation policy
Average Duration
16h 14m
Cheapest Price
$44 (€36)
Alsa frequency
1 a day
Luggage included
One carry-on bag up to 10kg and one checked bag up to 25kg.
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 48 hours before departure for a partial refund. Changes allowed for a fee.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Accessible seating.
Bikes
Bikes are allowed for an additional fee; must be packed.
Pets
Small pets allowed in carriers; larger pets must travel in the hold.
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
16h 0m
Cheapest Price
$62 (€50)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
BlaBlaCar Bus
About
BlaBlaCar Bus (formerly known as Ouibus or iDBUS) is a long-distance coach company operating in 10 European countries and connecting over 300 destinations. A subsidiary of the French carpooling company BlaBlaCar, it offers comfortable travel with standard amenities such as air conditioning, toilets, USB and power outlets for charging devices, extra legroom, and adjustable seats. Free Wi-Fi is available on select routes. BlaBlaCar Bus offers only a Standard ticket type, which allows passengers to bring one carry-on bag and up to two checked bags per person.
Luggage & cancellation policy
BlaBlaCar Bus frequency
1 a day
Luggage included
One carry-on bag up to 7kg and one checked bag up to 20kg.
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 30 minutes before departure for a refund in the form of a voucher.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Accessible seating options.
Bikes
Bikes are allowed; additional fees may apply.
Complete guide to Lyon
Things to do in Lyon
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
- Must visit
Museum of Fine Arts of Lyon
One of France’s leading fine arts museums, housed in a former abbey with strong collections from antiquity to modern art.
- Recommended
Lugdunum Museum and Roman Theatres
Archaeological museum on Fourvière Hill with Roman mosaics, inscriptions, and access to the adjacent ancient theatres.
- Must visit
Place Bellecour
One of Europe’s largest open squares, a central meeting point and starting place for exploring Lyon.
- Must visit
Parc de la Tête d'Or
Lyon’s flagship urban park with a lake, botanical gardens, rose garden, and broad walking paths.
- Must visit
La Presqu'île
The central peninsula between the Rhône and Saône, packed with shopping streets, squares, and grand architecture.
Quenelles De Brochet
Light dumplings traditionally made with pike and served with a rich Nantua crayfish sauce, a classic of Lyonnais cooking.
Salade Lyonnaise
A warm salad with frisée, lardons, croutons, and a poached egg, widely associated with Lyon's bouchon tradition.
- Gluten-free
Andouillette
A robust sausage made from pork tripe, famous in Lyon for its strong flavor and served in many traditional bouchons.
La Mère Brazier
Historic fine-dining institution in Lyon, renowned for haute cuisine rooted in the legacy of Eugénie Brazier.
Le Bouchon Des Filles
Popular modern bouchon offering refined Lyonnais classics in a warm, intimate setting.
Café Des Fédérations
Classic bouchon known for traditional Lyonnais dishes, hearty set menus, and a lively, old-school atmosphere.
Euro
Moderate by French standards: bakeries and bouchons are reasonable, while hotels and fine dining cost more.
Average meal costs
- Budget
- EUR 10-15 for a sandwich, kebab, or lunch deal.
- Mid-range
- EUR 20-35 per person at a casual restaurant.
- Fine dining
- EUR 70+ per person at upscale restaurants.
- Coffee
- EUR 2.50-4 for an espresso or cappuccino.
Tipping culture
Service is included in restaurant bills. Leaving 5-10% for great service is appreciated but not required. Round up for taxis; small change for cafés is optional.
TCL: Itinéraires, Tickets
Get the appOfficial public transport app
Prices
- Single ticket
- 2.00 EUR
- Day pass
- 6.70 EUR
To the city center
Lyon Perrache Bus Station -> Lyon Part-Dieu Station
- Distance
- 4 km
- Travel time
- 15 min
- You can buy and validate tickets in the official TCL app, at ticket machines, or with contactless bank card on many services where available.
- A 24-hour pass is usually the best value if you plan several trips in one day across Metro, Tram, Bus, and Funicular.
FAQs: Bus from Santander to Lyon
Find answers to the most common questions about traveling from Santander to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Santander to Lyon can start from as little as $44 (€36) when you book in advance. The average bus ticket price for Santander to Lyon is $86 (€70) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Santander to Lyon is 16h 0m to travel the 453 miles (730 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Santander to Lyon leaves at 12:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Santander to Lyon leaves at 11:35 PM.
There are 2 buses a day from Santander to Lyon which require at least one change with Alsa, BlaBlaCar Bus, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Santander to Lyon, you can count on Alsa, BlaBlaCar Bus, FlixBus for the best way to get you to Lyon. You can also check all possible bus companies who offer a service between Santander and Lyon and compare the amenities they offer before buying a bus ticket.
When departing from Santander , you have various bus station options to start your journey from including Santander, Estación de Autobuses . When arriving in Lyon , you can end your journey in bus stations like Lyon, Perrache Bus Station, Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland), Lyon, St Exupéry Aéroport, Givors, Plaza Jean Berry .Passengers board the bus most frequently from Santander, Estación de Autobuses, which is located around 0 away from the city centre, and they get off the bus at Lyon, Perrache Bus Station, located 1 away from the city centre.
A trip to Lyon from Santander is worth doing but not as a day trip with a journey time of 16h 0m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Santander to Lyon is December.
It's helpful to compare your options as there are 3 ways to travel between Santander and Lyon including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from Santander to Lyon:
- Alsa
- Assistance
- Priority boarding
- Accessible seating.
- BlaBlaCar Bus
- Assistance
- Priority boarding
- Accessible seating options.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Santander to Lyon for bus company Alsa, BlaBlaCar Bus, FlixBus.
Some of the most interesting sights to explore in Lyon are:
- Basilica of Notre-Dame de Fourvière, a stunning 19th-century basilica offering panoramic views of the city
- Vieux Lyon, a UNESCO World Heritage site known for its Renaissance architecture and narrow cobblestone streets
- Parc de la Tête d'Or, a large urban park featuring a zoo, botanical garden, and lake
- Musée des Confluences, a modern science and anthropology museum with innovative exhibits
- Place Bellecour, one of Europe's largest open squares, ideal for shopping and dining.
The best things to do in Lyon include:
- Les Halles de Lyon Paul Bocuse, a renowned indoor market offering gourmet food and local specialties
- Take a river cruise on the Rhône and Saône for a unique view of the city
- Explore the traboules, secret passageways in Vieux Lyon
- Attend a performance at the Opéra de Lyon, known for its diverse program
- Visit the Institut Lumière, dedicated to the history of cinema.
Whether you can cancel your bus ticket from Santander to Lyon depends on the bus companies:
- Alsa
- You can cancel your ticket up to 48 hours before departure for a partial refund. Changes allowed for a fee.
- BlaBlaCar Bus
- You can cancel your ticket up to 30 minutes before departure for a refund in the form of a voucher.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Alsa, BlaBlaCar Bus, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Santander to Lyon.
Yes, the following luggage options are included when booking a bus ticket from Santander to Lyon:
- Alsa
- One carry-on bag up to 10kg and one checked bag up to 25kg.
- BlaBlaCar Bus
- One carry-on bag up to 7kg and one checked bag up to 20kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Santander to Lyon:
- Alsa
- Additional luggage can be purchased for a fee.
- BlaBlaCar Bus
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Santander to Lyon. The following conditions apply:
- Alsa
- Small pets allowed in carriers
- larger pets must travel in the hold.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Santander to Lyon with the following bus company: Alsa, BlaBlaCar Bus, FlixBus
Yes, there are USB plugs on board the bus from Santander to Lyon with the following bus company: Alsa, BlaBlaCar Bus, FlixBus.
Yes, there is Wifi on board the bus from Santander to Lyon with the following bus company: Alsa, BlaBlaCar Bus, FlixBus.
Since both Santander and Lyon are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
We recommend using the bus as it is the most popular way to get from Santander to Lyon among Omio's users.
France uses the euro (EUR) as its currency. Travelers generally find it convenient to use cards for most transactions, especially in cities and larger establishments, but carrying some cash is advisable for small vendors, markets, and rural areas where card acceptance may be limited.
In Lyon, travelers should be cautious of pickpocketing, especially in crowded areas like public transport, popular tourist spots, and markets. Common scams include distraction techniques and fake charity collectors. It's advisable to keep valuables secure and be wary of overly friendly strangers offering unsolicited help. Avoid unlicensed taxi services to prevent overcharging. Staying alert in busy zones ensures a safer visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Santander to Lyon
Santander
Lyon
The major bus station for departures in Santander is Santander, Estación de Autobuses. Find all the information you need to know about services, amenities and connections at Santander, Estación de Autobuses for your trip from Santander to Lyon.
Santander, Estación de Autobuses
information
The major bus station for arrivals in Lyon is Lyon, Gare Routière de Perrache. Find all the information you need to know about services, amenities and connections at Lyon, Gare Routière de Perrache for your trip to Lyon from Santander.
Lyon, Gare Routière de Perrache
Amenities at bus station
WifiParkingDiningATMTaxisAccessibilityWCTicket Officeinformation
Ticket Office Hours
- 06:00-23:00
Distance to city center
1 km
Car connection
Cours de VerdunWifi
- Free Wi-Fi
Dining
- Café de la Gare (in the station)
- Le Bistrot de Lyon (0.5 km)
- Brasserie Georges (0.6 km).
Taxis
- Available outside the main entrance.
Accessibility
- Elevators, ramps
WC
- Available in the station.
Public transit options for Lyon, Gare Routière de Perrache
- Bus: C19, C20, 31, 46, 49, 55, 60, S1 Metro: A Tram: T1, T2
Lyon, Avenue Tony Garnier (Gare routière de Lyon Gherlan)
information
Lyon, St Exupéry Aéroport
information
Most popular bus connections from Santander
More options for your journey from Santander to Lyon
Here are some other resources that might have the information you need
Most popular buses to and from Lyon and Santander
Most popular bus connections to Lyon
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