The cheapest and fastest buses from Santander to Lyon
Cheapest price
$81
Average price
$88
Fastest journey
16 h
Average duration
19 h 8 m
Buses per day
3
Distance
730 km
The best way to find a cheap bus ticket from Santander to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santander to Lyon will cost around $88 if you buy it on the day, but the cheapest tickets can be found for only $81.
Of the 3 buses that leave Santander for Lyon on Thu, Jan 08, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Jan 08 the direct buses cover the 730 km distance in an average of 19 h 8 m but if you time it right, some buses will get you there in just 16 h .
On Thu, Jan 08 the slowest buses will take 21 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.






Travel Information
Compare bus and flight for Santander to Lyon
Omio recommends booking the bus as it is the most popular option from Santander to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from €40. For those with little time consider booking a flight which can get you there in 2h 43m. The ticket price range depends on the travel mode: a bus costs an average of €40, and a flight costs an average of €58.
Distance: 453 miles (730 km)
Compare bus with
Most popular Bus | Flight |
|---|---|
€87 Average price Cheapest | €330 Average price |
15h 9m Average total duration 14h 39m Onboard + 30m Additional time* | 5h 43m Average total duration Fastest 2h 43m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options |
Santander to Lyon Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Alsa | Departure Time 02:30AM | Arrival Time 05:15AM | Duration 26h45 | Departure days Wed, Sun | Cheapest price $49 |
Operator Alsa | Departure Time 06:00AM | Arrival Time 05:15AM | Duration 23h15 | Departure days Wed | Cheapest price $79 |
Operator Alsa | Departure Time 09:00AM | Arrival Time 04:55AM | Duration 19h55 | Departure days Wed, Sun | Cheapest price $51 |
Operator Alsa | Departure Time 10:00AM | Arrival Time 02:40PM | Duration 28h40 | Departure days Sun | Cheapest price $57 |
Operator Alsa | Departure Time 10:15AM | Arrival Time 02:40PM | Duration 28h25 | Departure days Sun | Cheapest price $57 |
Operator Alsa | Departure Time 11:00AM | Arrival Time 02:40PM | Duration 27h40 | Departure days Sun | Cheapest price $57 |
Operator Alsa | Departure Time 11:15AM | Arrival Time 02:40PM | Duration 27h25 | Departure days Sun | Cheapest price $57 |
Operator Alsa | Departure Time 12:00PM | Arrival Time 02:40PM | Duration 26h40 | Departure days Sun | Cheapest price $57 |
Operator Alsa | Departure Time 01:00PM | Arrival Time 02:40PM | Duration 25h40 | Departure days Sun | Cheapest price $65 |
Operator Alsa | Departure Time 02:00PM | Arrival Time 02:40PM | Duration 24h40 | Departure days Sun | Cheapest price $57 |
Operator Alsa | Departure Time 03:00PM | Arrival Time 02:40PM | Duration 23h40 | Departure days Sun | Cheapest price $57 |
Operator FlixBus | Departure Time 06:50PM | Arrival Time 10:45PM | Duration 27h55 | Departure days Wed | Cheapest price $103 |
Operator Alsa | Departure Time 08:45PM | Arrival Time 06:15PM | Duration 21h30 | Departure days Sun | Cheapest price $57 |
Live departures
Santander to Lyon bus times
The table below shows live departures for Santander to Lyon buses for tomorrow, Thursday, January 8. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:00 AM Santander | 19h55 | 2:55 AM Lyon | 0 transfersDirect | |
![]() | 4:50 PM Santander | 16h00 | 8:50 AM Lyon | 0 transfersDirect | |
![]() | 6:45 PM Santander | 21h30 | 4:15 PM Lyon | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Santander to Lyon by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jan 08
Jan 09
Jan 10
Jan 11
Jan 12
Jan 13
Jan 14
Journey information
Overview: Bus from Santander to Lyon
Buses from Santander to Lyon run on average 2 times per day, taking around 14h 39m. Cheap bus tickets for this journey start at $50 (€40) if you book in advance.
The earliest bus runs at 00:10, the last at 23:00. The fastest bus covers the 453 miles (730 km) distance in 13h 14m.
Distance 453 miles (730 km) |
Average bus duration 14h 39m |
Cheapest ticket price $50 (€40) |
Buses per day 2 |
Fastest bus 13h 14m |
First bus 00:10 |
Last bus 23:00 |
Bus providers: Alsa, FlixBus, BlaBlaCar Bus from Santander to LyonYou can travel by bus between Santander to Lyon with Alsa, FlixBus, BlaBlaCar Bus for as low as $50 (€40). When you search for schedules and tickets, Omio will show you the best journey
Alsa
FlixBus
BlaBlaCar Bus
FAQs: Bus from Santander to Lyon
Find answers to the most common questions about traveling from Santander to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

- Alsa
- Assistance
- Priority boarding
- Accessible seating.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Basilica of Notre-Dame de Fourvière, a stunning 19th-century basilica offering panoramic views of the city
- Vieux Lyon, a UNESCO World Heritage site known for its Renaissance architecture and narrow cobblestone streets
- Parc de la Tête d'Or, a large urban park featuring a zoo, botanical garden, and lake
- Musée des Confluences, a modern science and anthropology museum with innovative exhibits
- Place Bellecour, one of Europe's largest open squares, ideal for shopping and dining.
- Les Halles de Lyon Paul Bocuse, a renowned indoor market offering gourmet food and local specialties
- Take a river cruise on the Rhône and Saône for a unique view of the city
- Explore the traboules, secret passageways in Vieux Lyon
- Attend a performance at the Opéra de Lyon, known for its diverse program
- Visit the Institut Lumière, dedicated to the history of cinema.
- Alsa
- You can cancel your ticket up to 48 hours before departure for a partial refund. Changes allowed for a fee.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
To find the cheapest bus tickets for your trip from Santander to Lyon, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Alsa
- One carry-on bag up to 10kg and one checked bag up to 25kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Alsa
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
- Alsa
- Small pets allowed in carriers
- Larger pets must travel in the hold.
- FlixBus
- Small pets in carriers allowed
- Guide dogs travel for free.
popular bus stations
Popular bus stations from Santander to Lyon
- 06:00-23:00
- Free Wi-Fi
- Café de la Gare (in the station)
- Le Bistrot de Lyon (0.5 km)
- Brasserie Georges (0.6 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: C19, C20, 31, 46, 49, 55, 60, S1 Metro: A Tram: T1, T2
Most popular bus connections from Santander
More options for your journey from Santander to Lyon
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