- Must visit
Musée des Beaux-Arts de Lyon
Major fine arts museum in a former abbey, with strong collections from antiquity to modern art. A core cultural stop in Lyon.
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The cheapest and fastest buses from Santander to Lyon
Showing times, prices and bookable tickets for Oct 07
Cheapest price on Oct 07
$109
Average ticket price on Oct 07
$109
Fastest journey on Oct 07
22 h 40 m
Average journey duration on Oct 07
22 h 40 m
Buses on Oct 07
1
Distance
730 km
Cheap tickets
The best way to find a cheap bus ticket from Santander to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santander to Lyon will cost around $109 if you buy it on the day, but the cheapest tickets can be found for only $109.
Fast buses
It's difficult to get from Santander to Lyon without transferring at least 2 times.
FlixBus · FlixBus · FlixBus6:50 PM22h40Santander, Estación de Autobuses5:30 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1091One-way2 transfers
- FlixBus · FlixBus · FlixBus6:50 PM22h40Santander, Estación de Autobuses5:30 PMLyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)$1091One-way2 transfers
Journey information
Overview: Bus from Santander to Lyon
Spain
France
Buses from Santander to Lyon run on average 4 times per day, taking around 16h 1m. Cheap bus tickets for this journey start at $10 (€8) if you book in advance.
The earliest bus runs at 00:55, the last at 23:35. The fastest bus covers the 453 miles (730 km) distance in 13h 9m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 453 miles (730 km) |
Average bus duration 16h 1m |
Cheapest ticket price $10 (€8) |
Buses per day 4 |
Fastest bus 13h 9m |
First bus 12:55 AM |
Last bus 11:35 PM |
Cheapest Month Dec |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Fri |
Least Busy Day Fri |
Best time to book 14 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Santander to Lyon Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Alsa | Departure Time 07:00AM | Arrival Time 02:05AM | Duration 19h05 | Departure days Fri | Cheapest price $62 |
Operator Alsa | Departure Time 08:00AM | Arrival Time 03:55AM | Duration 19h55 | Departure days Fri | Cheapest price $55 |
Operator FlixBus | Departure Time 08:25AM | Arrival Time 12:25AM | Duration 40h00 | Departure days Mon | Cheapest price $99 |
Operator Alsa | Departure Time 09:00AM | Arrival Time 04:05AM | Duration 19h05 | Departure days Tue | Cheapest price $49 |
Operator FlixBus | Departure Time 04:50PM | Arrival Time 02:25PM | Duration 21h35 | Departure days Mon, Fri, Sat, Sun | Cheapest price $121 |
Operator Alsa | Departure Time 05:00PM | Arrival Time 09:14AM | Duration 16h14 | Departure days Fri | Cheapest price $43 |
Operator FlixBus | Departure Time 05:50PM | Arrival Time 03:25PM | Duration 21h35 | Departure days Sat, Sun | Cheapest price $76 |
Operator FlixBus | Departure Time 06:50PM | Arrival Time 10:50AM | Duration 16h00 | Departure days Tue, Wed, Thu | Cheapest price $97 |
Operator Alsa | Departure Time 07:45PM | Arrival Time 05:15PM | Duration 21h30 | Departure days Sun | Cheapest price $64 |
Live departures
Santander to Lyon bus times
The table below shows live departures for Santander to Lyon buses for tomorrow, Wednesday, October 7. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus · FlixBus · FlixBus | 6:50 PM Santander, Estación de Autobuses | 22h40 | 5:30 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book Santander to Lyon buses with Omio?
Alsa as well as BlaBlaCar Bus, FlixBus, Internorte, KLR and more offer buses services from Santander to Lyon.
Omio is an official ticket reseller for all your travel options from Santander to Lyon.
Why book with Omio vs Alsa?
- Compare with other providers: On Omio, you can not only buy tickets for Alsa, but also compare tickets for the likes of BlaBlaCar Bus, FlixBus, Internorte or KLR to find the best option for your trip from Santander to Lyon.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Alsa with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Santander to Lyon.
Why book with Omio over Checkmybus, Rome2rio or Busbud?
- Compare with other providers: On Omio, you can also compare tickets for the likes of BlaBlaCar Bus, FlixBus, Internorte or KLR to find the best option for your trip from Santander to Lyon.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Santander to Lyon.
Bus providers: Alsa, BlaBlaCar Bus, FlixBus, Internorte, KLR from Santander to LyonYou can travel by bus between Santander to Lyon with Alsa, BlaBlaCar Bus, FlixBus, Internorte, KLR for as low as $10 (€8). When you search for schedules and tickets, Omio will show you the best journey
Alsa
About
Alsa is the main provider of bus travel in Spain and a subsidiary of the UK’s National Express. It operates an extensive network of regional, national, and international routes, transporting more than 300 million passengers annually. Alsa’s modern fleet offers varying levels of comfort and amenities. The standard Alsa Normal buses include free Wi-Fi, onboard bathrooms, footrests, and entertainment. For a more premium experience, Alsa Supra, Alsa Eurobus, and Alsa Premium services provide enhanced comfort and luxury features.
Luggage & cancellation policy
Average Alsa Duration
13h 9m
Cheapest Alsa Price
$34 (€28)
Alsa frequency
2 a day
Luggage included
One carry-on bag up to 10kg and one checked bag up to 25kg.
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 48 hours before departure for a partial refund. Changes allowed for a fee.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Accessible seating.
Bikes
Bikes are allowed for an additional fee; must be packed.
Pets
Small pets allowed in carriers; larger pets must travel in the hold.
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
14h 5m
Cheapest FlixBus Price
$62 (€51)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
BlaBlaCar Bus
About
BlaBlaCar Bus (formerly known as Ouibus or iDBUS) is a long-distance coach company operating in 10 European countries and connecting over 300 destinations. A subsidiary of the French carpooling company BlaBlaCar, it offers comfortable travel with standard amenities such as air conditioning, toilets, USB and power outlets for charging devices, extra legroom, and adjustable seats. Free Wi-Fi is available on select routes. BlaBlaCar Bus offers only a Standard ticket type, which allows passengers to bring one carry-on bag and up to two checked bags per person.
Luggage & cancellation policy
Average BlaBlaCar Bus Duration
13h 16m
Cheapest BlaBlaCar Bus Price
$10 (€8)
BlaBlaCar Bus frequency
1 a day
Luggage included
One carry-on bag up to 7kg and one checked bag up to 20kg.
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 30 minutes before departure for a refund in the form of a voucher.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Accessible seating options.
Bikes
Bikes are allowed; additional fees may apply.
KLR
About
KLR Bus is a Ukrainian carrier offering comfortable and safe international bus transportation since 2012. Serving over 100 cities across more than 15 European countries, including Germany, Poland, and Spain, KLR Bus operates a modern fleet equipped with amenities such as air conditioning, Wi-Fi, and onboard restrooms. Passengers can conveniently book tickets online and enjoy features like real-time bus tracking and electronic tickets accessible via the KLR-Bus mobile app. The company is committed to providing affordable travel options, with special offers and discounts available to app users.
Luggage & cancellation policy
Average KLR Duration
14h 35m
Cheapest KLR Price
$44 (€37)
KLR frequency
1 a day
Luggage included
Each passenger is allowed one checked bag with a maximum weight of 20 kg and one personal bag free of charge.
Additional luggage
Additional luggage is subject to extra fees based on weight and size.
Luggage storage
Luggage is stored in the bus's luggage compartment.
Cancellation Policy
No refunds are allowed; changes can be made with a fee if done at least 96 hours before departure.
Refund
No refunds are allowed under any circumstances.
Unaccompagned minor
Children under 12 must travel with an adult; those under 16 require parental consent.
Amenities on board the bus
Toilets
Internorte
Luggage & cancellation policy
Average Internorte Duration
13h 59m
Cheapest Internorte Price
$95 (€79)
Internorte frequency
1 a day
Complete guide to Lyon
Things to do in Lyon
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
- Must visit
Musée Cinéma et Miniature
Museum of cinema miniatures and film props in Vieux Lyon. Popular for detailed sets, special-effects history, and family-friendly exhibits.
- Must visit
Musée des Confluences
Excellent free natural history and ethnography museum with fossils, animals, and global cultures. A strong local favorite, especially for families.
- Must visit
Vieux Lyon
Renaissance quarter with cobbled lanes, traboules, courtyards, and major monuments. Essential for atmosphere, history, and walking exploration.
- Must visit
Presqu'île
Central peninsula between the Rhône and Saône, packed with elegant streets, squares, shopping, and many of Lyon’s classic city views.
- Must visit
La Croix-Rousse
Historic silk-workers’ hill district with stairways, murals, markets, and hidden passageways. Great for local character and city panoramas.
Quenelles De Brochet
Pike dumplings in a rich crayfish sauce. A Lyon classic from traditional bouchons, prized for its delicate fish texture and luxurious sauce.
Salade Lyonnaise
Crisp salad of frisée, bacon lardons, croutons, and a poached egg. A staple Lyonnaise bistro dish that reflects the city's hearty cooking style.
- Vegetarian
- Gluten-free
Cervelle De Canut
Slow-cooked onions with vinegar, often served warm or chilled. This old Lyonnais side dish is traditional in bouchons and pairs well with charcuterie.
L'Auberge Du Pont De Collonges
Refined dining by Paul Bocuse, known for polished French cuisine and iconic Lyon dishes in an elegant, historic dining room.
Le Musée
Well-known traditional bouchon in Vieux Lyon, praised for generous Lyonnais specialties and a lively old-city atmosphere.
Café Comptoir Abel
Historic bouchon near Place Bellecour serving quenelles, salade lyonnaise, and classic regional fare in a warm traditional setting.
Euro (€)
Moderate for Western Europe: hotels and dining are mid-priced, while public transport is good value for visitors.
Average meal costs
- Budget
- €8-15 for fast food or a simple lunch.
- Mid-range
- €20-35 per person for a meal.
- Fine dining
- €70+ per person for upscale restaurants.
- Coffee
- €2.50-4 for coffee or cappuccino.
Tipping culture
Service is usually included. Round up or leave 5-10% for great restaurant service. Round up taxi fares; small change is fine in cafes.
FAQs: Bus from Santander to Lyon
Find answers to the most common questions about traveling from Santander to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Santander to Lyon can start from as little as $10 (€8) when you book in advance. The average bus ticket price for Santander to Lyon is $75 (€63) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Santander to Lyon is 13h 9m to travel the 453 miles (730 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Santander to Lyon leaves at 12:55 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Santander to Lyon leaves at 11:35 PM.
There are 4 buses a day from Santander to Lyon which require at least one change with Alsa, BlaBlaCar Bus, FlixBus, Internorte, KLR. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Santander to Lyon, you can count on Alsa, BlaBlaCar Bus, FlixBus, Internorte, KLR for the best way to get you to Lyon. You can also check all possible bus companies who offer a service between Santander and Lyon and compare the amenities they offer before buying a bus ticket.
When departing from Santander , you have various bus station options to start your journey from including Santander, Estación de Autobuses . When arriving in Lyon , you can end your journey in bus stations like Lyon, Perrache Bus Station, Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland), Lyon, St Exupéry Aéroport, Givors, Plaza Jean Berry .Passengers board the bus most frequently from Santander, Estación de Autobuses, which is located around away from the city centre, and they get off the bus at Lyon, Perrache Bus Station, located 1 away from the city centre.
It's helpful to compare your options as there are 3 ways to travel between Santander and Lyon including taking a train, bus, and flight.
Yes, the following accessibility options are available when taking the bus from Santander to Lyon:
- Alsa
- Assistance
- Priority boarding
- Accessible seating.
- BlaBlaCar Bus
- Assistance
- Priority boarding
- Accessible seating options.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Santander to Lyon for bus company Alsa, BlaBlaCar Bus, FlixBus, KLR.
Whether you can cancel your bus ticket from Santander to Lyon depends on the bus companies:
- Alsa
- You can cancel your ticket up to 48 hours before departure for a partial refund. Changes allowed for a fee.
- BlaBlaCar Bus
- You can cancel your ticket up to 30 minutes before departure for a refund in the form of a voucher.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Alsa, BlaBlaCar Bus, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Santander to Lyon.
Yes, the following luggage options are included when booking a bus ticket from Santander to Lyon:
- Alsa
- One carry-on bag up to 10kg and one checked bag up to 25kg.
- BlaBlaCar Bus
- One carry-on bag up to 7kg and one checked bag up to 20kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Santander to Lyon:
- Alsa
- Additional luggage can be purchased for a fee.
- BlaBlaCar Bus
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Santander to Lyon. The following conditions apply:
- Alsa
- Small pets allowed in carriers
- larger pets must travel in the hold.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Santander to Lyon with the following bus company: Alsa, BlaBlaCar Bus, FlixBus
Yes, there are USB plugs on board the bus from Santander to Lyon with the following bus company: Alsa, BlaBlaCar Bus, FlixBus.
Yes, there is Wifi on board the bus from Santander to Lyon with the following bus company: Alsa, BlaBlaCar Bus, FlixBus.
France uses the euro (EUR) as its currency. Travelers generally find it convenient to use cards for most transactions, especially in cities and larger establishments, but carrying some cash is advisable for small vendors, markets, and rural areas where card acceptance may be limited.
In Lyon, travelers should be cautious of pickpocketing, especially in crowded areas like public transport, popular tourist spots, and markets. Common scams include distraction techniques and fake charity collectors. It's advisable to keep valuables secure and be wary of overly friendly strangers offering unsolicited help. Avoid unlicensed taxi services to prevent overcharging. Staying alert in busy zones ensures a safer visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Santander to Lyon
Most Santander to Lyon buses use the Santander, Estación de Autobuses to Lyon, Gare Routière de Perrache station pair, with some services arriving at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland). Use this guide to compare Santander and Lyon bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Santander
Arrival bus stations in Lyon
Santander, Estación de AutobusesSantander Bus Station, Calle Navas de Tolosa 2, 39002
Which Lyon station do buses from Santander arrive at?
Buses from Santander to Lyon most often arrive at Lyon, Gare Routière de Perrache. Some services arrive at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland), so check your ticket before travel to confirm your Lyon arrival station.
Lyon, Gare Routière de Perrache13 Cours de Verdun, 69002 Lyon, France
City-centre transport
Getting to Lyon, Gare Routière de Perrache from Lyon city centre
Lyon, Gare Routière de Perrache is 1 km from Lyon city centre. Public transport options include:
TrainTer · 5m · $1 · every ~5 min
Lyon, Gare Routière de Perrache bus station facilities and services
Lyon, Gare Routière de Perrache has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food and drink
Food options include: Café de la Gare (in the station), Le Bistrot de Lyon (0.5 km), Brasserie Georges (0.6 km).
Wi-Fi and ATMs
Free Wi-Fi. ATMs are located near the main entrance.
Tickets and information
Ticket office support is available at Lyon, Gare Routière de Perrache.
Parking, taxis and toilets
Available at Lyon, Gare Routière de Perrache: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Lyon, Gare Routière de Perrache: Elevators, ramps.
Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland)52 Av. Tony Garnier, 69007 Lyon, France
City-centre transport
Getting to Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) from Lyon city centre
Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) is 2 km from Lyon city centre. Public transport options include:
BusN734 · 15m · $1
Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) bus station facilities and services
Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland). ATMs are available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland).
Tickets and information
Ticket office support is available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland).
Parking, taxis and toilets
Available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland): Station is accessible for passengers with reduced mobility.
Lyon, St Exupéry AéroportLyon St Exupéry Aéroport, 69125 Colombier-Saugnieu, France
City-centre transport
Getting to Lyon, St Exupéry Aéroport from Lyon city centre
Lyon, St Exupéry Aéroport is 2 km from Lyon city centre. Public transport options include:
TrainRx · 29m · $19 · every ~8 min
BusS766, 776, 787, N760, N1759, 1776, 1624, N746, 1779, S1736, 1606, 1787, 1676 · 38m · $2 · every ~1 min
Lyon, St Exupéry Aéroport bus station facilities and services
Lyon, St Exupéry Aéroport has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Lyon, St Exupéry Aéroport. ATMs are available at Lyon, St Exupéry Aéroport.
Tickets and information
Ticket office support is available at Lyon, St Exupéry Aéroport.
Parking, taxis and toilets
Available at Lyon, St Exupéry Aéroport: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Lyon, St Exupéry Aéroport: Access ramps and services available.
More options for your journey from Santander to Lyon
Here are some other resources that might have the information you need
Most popular buses to and from Lyon and Santander
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