- Must visit
Musée des Beaux-Arts de Lyon
Major fine arts museum in a former abbey, with strong collections from antiquity to modern art. A core cultural stop in Lyon.
Cheapest price
€177
Average price
€197
Fastest journey
20 h 15 m
Average duration
20 h 53 m
Buses per day
2
Distance
730 km
The best way to find a cheap bus ticket from Santander to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santander to Lyon will cost around €197 if you buy it on the day, but the cheapest tickets can be found for only €177.
It's difficult to get from Santander to Lyon without transferring at least once.
Normal · Normal
FlixBus · FlixBus
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FlixBus · FlixBusOmio recommends booking the bus as it is the most popular option from Santander to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from €39. For those with little time consider booking a flight which can get you there in 2h 45m. The ticket price range depends on the travel mode: a bus costs an average of €39, and a flight costs an average of €98.
Distance: 453 miles (730 km)
Most popular Bus | Flight | Train | Driving |
|---|---|---|---|
€69 Average price Cheapest | €264 Average price | €154 Average price | €161 Average price (fuel + tolls) |
15h 19m Average total duration 14h 49m Onboard + 30m Additional time* | 5h 45m Average total duration Fastest 2h 45m Onboard + 3h 0m Additional time* | 23h 52m Average total duration 23h 22m Onboard + 30m Additional time* | 9h 42m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Santander to Lyon:
A bus is €85 less than a train for this route with tickets for a train from Santander to Lyon costing on average €154.
A bus is €194 less than a flight for this route with tickets for a flight from Santander to Lyon costing on average €264.
Other travel options to Lyon take longer:
Bus takes on average 14h 49m.
Train takes on average 23h 22m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator KLR | Departure Time 02:30AM | Arrival Time 05:05PM | Duration 14h35 | Departure days Mon | Cheapest price €71 |
Operator Alsa | Departure Time 09:00AM | Arrival Time 05:15AM | Duration 20h15 | Departure days Tue, Wed, Thu, Fri, Sat, Sun | Cheapest price €50 |
Operator BlaBlaCar Bus | Departure Time 10:30AM | Arrival Time 10:05PM | Duration 35h35 | Departure days Wed | Cheapest price €92 |
Operator Alsa | Departure Time 02:45PM | Arrival Time 07:59AM | Duration 17h14 | Departure days Fri | Cheapest price €130 |
Operator Alsa | Departure Time 04:15PM | Arrival Time 07:59AM | Duration 15h44 | Departure days Fri | Cheapest price €130 |
Operator Alsa | Departure Time 05:00PM | Arrival Time 07:59AM | Duration 14h59 | Departure days Fri | Cheapest price €130 |
Operator FlixBus | Departure Time 06:55PM | Arrival Time 10:50AM | Duration 15h55 | Departure days Everyday | Cheapest price €128 |
The table below shows live departures for Santander to Lyon buses for today, Saturday, August 22. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 6:55 PM Santander, Estación de Autobuses | 15h55 | 10:50 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
| Sunday, August 23 | |||||
Normal · Normal | 9:00 AM Santander, Estación de Autobuses | 20h15 | 5:15 AM Lyon, Perrache Bus Station | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Santander to Lyon run on average 2 times per day, taking around 14h 49m. Cheap bus tickets for this journey start at €39 if you book in advance.
The earliest bus runs at 00:55, the last at 23:35. The fastest bus covers the 453 miles (730 km) distance in 13h 59m.
Distance 453 miles (730 km) |
Average bus duration 14h 49m |
Cheapest ticket price €39 |
Buses per day 2 |
Fastest bus 13h 59m |
First bus 12:55 AM |
Last bus 11:35 PM |
Cheapest Month Dec |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Thu |
Least Busy Day Tue |
Best time to book 21 days |
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
Major fine arts museum in a former abbey, with strong collections from antiquity to modern art. A core cultural stop in Lyon.
Museum of cinema miniatures and film props in Vieux Lyon. Popular for detailed sets, special-effects history, and family-friendly exhibits.
Excellent free natural history and ethnography museum with fossils, animals, and global cultures. A strong local favorite, especially for families.
Renaissance quarter with cobbled lanes, traboules, courtyards, and major monuments. Essential for atmosphere, history, and walking exploration.
Central peninsula between the Rhône and Saône, packed with elegant streets, squares, shopping, and many of Lyon’s classic city views.
Historic silk-workers’ hill district with stairways, murals, markets, and hidden passageways. Great for local character and city panoramas.
Pike dumplings in a rich crayfish sauce. A Lyon classic from traditional bouchons, prized for its delicate fish texture and luxurious sauce.
Crisp salad of frisée, bacon lardons, croutons, and a poached egg. A staple Lyonnaise bistro dish that reflects the city's hearty cooking style.
Slow-cooked onions with vinegar, often served warm or chilled. This old Lyonnais side dish is traditional in bouchons and pairs well with charcuterie.
Refined dining by Paul Bocuse, known for polished French cuisine and iconic Lyon dishes in an elegant, historic dining room.
Well-known traditional bouchon in Vieux Lyon, praised for generous Lyonnais specialties and a lively old-city atmosphere.
Historic bouchon near Place Bellecour serving quenelles, salade lyonnaise, and classic regional fare in a warm traditional setting.
Moderate for Western Europe: hotels and dining are mid-priced, while public transport is good value for visitors.
Service is usually included. Round up or leave 5-10% for great restaurant service. Round up taxi fares; small change is fine in cafes.
Find answers to the most common questions about traveling from Santander to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

Most Santander to Lyon buses use the Santander, Estación de Autobuses to Lyon, Gare Routière de Perrache station pair, with some services arriving at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland). Use this guide to compare Santander and Lyon bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Lyon, Gare Routière de Perrache is 1 km from Lyon city centre. Public transport options include:
Lyon, Gare Routière de Perrache has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Café de la Gare (in the station), Le Bistrot de Lyon (0.5 km), Brasserie Georges (0.6 km).
Free Wi-Fi. ATMs are located near the main entrance.
Ticket office support is available at Lyon, Gare Routière de Perrache.
Available at Lyon, Gare Routière de Perrache: Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Gare Routière de Perrache: Elevators, ramps.
Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) is 2 km from Lyon city centre. Public transport options include:
Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland). ATMs are available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland).
Ticket office support is available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland).
Available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland): Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland): Station is accessible for passengers with reduced mobility.
Lyon, St Exupéry Aéroport is 2 km from Lyon city centre. Public transport options include:
Lyon, St Exupéry Aéroport has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Lyon, St Exupéry Aéroport. ATMs are available at Lyon, St Exupéry Aéroport.
Ticket office support is available at Lyon, St Exupéry Aéroport.
Available at Lyon, St Exupéry Aéroport: Parking, Taxis, WC.
Accessibility facilities are available at Lyon, St Exupéry Aéroport: Access ramps and services available.
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