The cheapest and fastest buses from Santander to Lyon
Cheapest price
$87
Average price
$87
Fastest journey
19 h 55 m
Average duration
1 d 6 h 20 m
Buses per day
2
Distance
730 km
The best way to find a cheap bus ticket from Santander to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santander to Lyon will cost around $87 if you buy it on the day, but the cheapest tickets can be found for only $87.
Of the 2 buses that leave Santander for Lyon on Mon, Feb 23, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, Feb 23 the direct buses cover the 730 km distance in an average of 1 d 6 h 20 m but if you time it right, some buses will get you there in just 19 h 55 m .
On Mon, Feb 23 the slowest buses will take 1 d 16 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare bus and flight for Santander to Lyon
Omio recommends booking the bus as it is the most popular option from Santander to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from €25. For those with little time consider booking a flight which can get you there in 2h 43m. The ticket price range depends on the travel mode: a bus costs an average of €25, and a flight costs an average of €60.
Distance: 453 miles (730 km)
Compare bus with
Most popular Bus | Flight |
|---|---|
€55 Average price Cheapest | €166 Average price |
15h 30m Average total duration 15h 0m Onboard + 30m Additional time* | 5h 43m Average total duration Fastest 2h 43m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options |
Santander to Lyon Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Alsa | Departure Time 09:00AM | Arrival Time 05:15AM | Duration 20h15 | Departure days Fri | Cheapest price $56 |
Operator Alsa | Departure Time 06:00PM | Arrival Time 10:14AM | Duration 16h14 | Departure days Fri | Cheapest price $134 |
Operator FlixBus | Departure Time 06:50PM | Arrival Time 10:50AM | Duration 16h00 | Departure days Wed, Fri, Sat, Sun | Cheapest price $93 |
Operator Alsa | Departure Time 08:45PM | Arrival Time 06:15PM | Duration 21h30 | Departure days Sun | Cheapest price $67 |
Live departures
Santander to Lyon bus times
The table below shows live departures for Santander to Lyon buses for today, Sunday, February 22. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets | |
|---|---|---|---|---|---|---|
Normal · Normal | 7:45 PM Santander, Estación de Autobuses | 21h30 | 5:15 PM Lyon, Perrache Bus Station | 1 transfer | ||
| Monday, February 23 | ||||||
![]() | 8:00 AM Santander | 19h55 | 3:55 AM Lyon | 0 transfersDirect | ||
![]() | 8:25 AM Santander | 40h45 | 1:10 AM Lyon | 0 transfersDirect | ||
This is the last bus of the day. | ||||||
Find all the dates and times for this journey
Compare prices and tickets Santander to Lyon by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 23
Feb 24
Feb 25
Feb 26
Feb 27
Feb 28
Mar 01
Why should you book Santander to Lyon buses with Omio?
Why book with Omio vs Alsa?
- Compare with other providers: On Omio, you can not only buy tickets for Alsa, but also compare tickets for the likes of BlaBlaCar Bus or FlixBus to find the best option for your trip from Santander to Lyon.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Alsa with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Santander to Lyon.
Why book with Omio over Checkmybus, Rome2rio or Busbud?
- Compare with other providers: On Omio, you can also compare tickets for the likes of BlaBlaCar Bus or FlixBus to find the best option for your trip from Santander to Lyon.
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Santander to Lyon.
Journey information
Overview: Bus from Santander to Lyon
Buses from Santander to Lyon run on average 2 times per day, taking around 15h 0m. Cheap bus tickets for this journey start at $31 (€25) if you book in advance.
The earliest bus runs at 00:55, the last at 23:35. The fastest bus covers the 453 miles (730 km) distance in 15h 55m.
Distance 453 miles (730 km) |
Average bus duration 15h 0m |
Cheapest ticket price $31 (€25) |
Buses per day 2 |
Fastest bus 15h 55m |
First bus 00:55 |
Last bus 23:35 |
Bus providers: Alsa, BlaBlaCar Bus, FlixBus from Santander to LyonYou can travel by bus between Santander to Lyon with Alsa, BlaBlaCar Bus, FlixBus for as low as $31 (€25). When you search for schedules and tickets, Omio will show you the best journey
Alsa
FlixBus
BlaBlaCar Bus
FAQs: Bus from Santander to Lyon
Find answers to the most common questions about traveling from Santander to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

- Alsa
- Assistance
- Priority boarding
- Accessible seating.
- BlaBlaCar Bus
- Assistance
- Priority boarding
- Accessible seating options.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Basilica of Notre-Dame de Fourvière, a stunning 19th-century basilica offering panoramic views of the city
- Vieux Lyon, a UNESCO World Heritage site known for its Renaissance architecture and narrow cobblestone streets
- Parc de la Tête d'Or, a large urban park featuring a zoo, botanical garden, and lake
- Musée des Confluences, a modern science and anthropology museum with innovative exhibits
- Place Bellecour, one of Europe's largest open squares, ideal for shopping and dining.
- Les Halles de Lyon Paul Bocuse, a renowned indoor market offering gourmet food and local specialties
- Take a river cruise on the Rhône and Saône for a unique view of the city
- Explore the traboules, secret passageways in Vieux Lyon
- Attend a performance at the Opéra de Lyon, known for its diverse program
- Visit the Institut Lumière, dedicated to the history of cinema.
- Alsa
- You can cancel your ticket up to 48 hours before departure for a partial refund. Changes allowed for a fee.
- BlaBlaCar Bus
- You can cancel your ticket up to 30 minutes before departure for a refund in the form of a voucher.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Alsa
- One carry-on bag up to 10kg and one checked bag up to 25kg.
- BlaBlaCar Bus
- One carry-on bag up to 7kg and one checked bag up to 20kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Alsa
- Additional luggage can be purchased for a fee.
- BlaBlaCar Bus
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
- Alsa
- Small pets allowed in carriers
- larger pets must travel in the hold.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Santander to Lyon
- 06:00-23:00
- Free Wi-Fi
- Café de la Gare (in the station)
- Le Bistrot de Lyon (0.5 km)
- Brasserie Georges (0.6 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: C19, C20, 31, 46, 49, 55, 60, S1 Metro: A Tram: T1, T2
Most popular bus connections from Santander
More options for your journey from Santander to Lyon
Here are some other resources that might have the information you need

