The cheapest and fastest buses from Lyon to Santander
Cheapest price
$63
Average price
$78
Fastest journey
18 h
Average duration
18 h 43 m
Buses per day
3
Distance
730 km
The best way to find a cheap bus ticket from Lyon to Santander is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lyon to Santander will cost around $78 if you buy it on the day, but the cheapest tickets can be found for only $63.
Of the 3 buses that leave Lyon for Santander on Sat, Mar 21, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Mar 21 the direct buses cover the 730 km distance in an average of 18 h 43 m but if you time it right, some buses will get you there in just 18 h .
On Sat, Mar 21 the slowest buses will take 20 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.






Travel Information
Compare bus and flight for Lyon to Santander
Omio recommends booking the bus as it is the most popular option from Lyon to Santander among Omio's users. If you are prioritising price take the bus with prices starting from $28. For those with little time consider booking a flight which can get you there in 2h 55m. The ticket price range depends on the travel mode: a bus costs an average of $28, and a flight costs an average of $62.
Distance: 453 miles (730 km)
Compare bus with
Most popular Bus | Flight |
|---|---|
$86 Average price Cheapest | $328 Average price |
15h 52m Average total duration 15h 22m Onboard + 30m Additional time* | 5h 55m Average total duration Fastest 2h 55m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options |
Live departures
Lyon to Santander bus times
The table below shows live departures for Lyon to Santander buses for today, Friday, March 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 1:00 PM Lyon | 19h20 | 8:20 AM Santander | 0 transfersDirect | |
| Saturday, March 21 | |||||
![]() | 4:10 AM Lyon | 20h05 | 12:15 AM Santander | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Lyon to Santander by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 21
Mar 22
Mar 23
Mar 24
Mar 25
Mar 26
Mar 27
Why should you book Lyon to Santander buses with Omio?
Why book with Omio vs Alsa?
- Compare with other providers: On Omio, you can not only buy tickets for Alsa, but also compare tickets for the likes of FlixBus, BlaBlaCar Bus or Union Ivkoni - Unibus to find the best option for your trip from Lyon to Santander.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Alsa with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Lyon to Santander.
Why book with Omio over Checkmybus, Rome2rio or Busbud?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus, BlaBlaCar Bus or Union Ivkoni - Unibus to find the best option for your trip from Lyon to Santander.
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Lyon to Santander.
Journey information
Overview: Bus from Lyon to Santander
Buses from Lyon to Santander run on average 2 times per day, taking around 15h 22m. Cheap bus tickets for this journey start at $28 (€23) if you book in advance.
The earliest bus runs at 00:10, the last at 23:00. The fastest bus covers the 453 miles (730 km) distance in 17h 35m.
Distance 453 miles (730 km) |
Average bus duration 15h 22m |
Cheapest ticket price $28 (€23) |
Buses per day 2 |
Fastest bus 17h 35m |
First bus 00:10 |
Last bus 23:00 |
Cheapest month Sep |
Cheapest day Wed |
High season Oct - Dec |
Low season Jan - Mar |
Busiest day Fri |
Least busy day Thu |
Best day to book ahead 35 days |
Bus providers: Alsa, FlixBus, BlaBlaCar Bus, Union Ivkoni - Unibus from Lyon to SantanderYou can travel by bus between Lyon to Santander with Alsa, FlixBus, BlaBlaCar Bus, Union Ivkoni - Unibus for as low as $28 (€23). When you search for schedules and tickets, Omio will show you the best journey
Alsa
FlixBus
BlaBlaCar Bus
Union Ivkoni - Unibus
FAQs: Bus from Lyon to Santander
Find answers to the most common questions about traveling from Lyon to Santander by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santander, this guide helps you travel smarter and with confidence.

- Alsa
- Assistance
- Priority boarding
- Accessible seating.
- BlaBlaCar Bus
- Assistance
- Priority boarding
- Accessible seating options.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Palacio de la Magdalena, a historic royal palace set on a peninsula offering stunning views and guided tours
- Centro Botín, a modern art center designed by Renzo Piano featuring exhibitions and cultural events
- Playa del Sardinero, a popular beach known for its golden sands and vibrant promenade
- Museo Marítimo del Cantábrico, a maritime museum showcasing marine life and naval history
- Jardines de Piquío, beautifully landscaped gardens offering a peaceful retreat with ocean views.
- Santander Cathedral, a Gothic-style cathedral with impressive architecture and historical significance
- Parque de Mataleñas, a scenic park ideal for hiking and enjoying nature
- Mercado de la Esperanza, a bustling market where you can experience local culture and cuisine
- Paseo de Pereda, a picturesque promenade perfect for a leisurely stroll along the waterfront
- Gran Casino del Sardinero, a historic casino offering entertainment and a glimpse into the city's glamorous past.
- Alsa
- You can cancel your ticket up to 48 hours before departure for a partial refund. Changes allowed for a fee.
- BlaBlaCar Bus
- You can cancel your ticket up to 30 minutes before departure for a refund in the form of a voucher.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Alsa
- One carry-on bag up to 10kg and one checked bag up to 25kg.
- BlaBlaCar Bus
- One carry-on bag up to 7kg and one checked bag up to 20kg.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Alsa
- Additional luggage can be purchased for a fee.
- BlaBlaCar Bus
- Additional luggage can be purchased for a fee.
- FlixBus
- Additional luggage can be purchased for a fee.
- Alsa
- Small pets allowed in carriers
- larger pets must travel in the hold.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Lyon to Santander
- 06:00-23:00
- Free Wi-Fi
- Café de la Gare (in the station)
- Le Bistrot de Lyon (0.5 km)
- Brasserie Georges (0.6 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: C19, C20, 31, 46, 49, 55, 60, S1 Metro: A Tram: T1, T2
Most popular bus connections from Lyon
More options for your journey from Lyon to Santander
Here are some other resources that might have the information you need

