- Must visit
Centro Botín
Leading modern and contemporary art center by Renzo Piano, renowned for exhibitions, architecture, and exceptional bay views.
The best way to find a cheap bus ticket from Lyon to Santander is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lyon to Santander will cost around $77 if you buy it on the day, but the cheapest tickets can be found for only $49.
On Mon, Nov 02, we found 5 buses from Lyon to Santander, including 5 direct services.
On Mon, Nov 02 the direct buses cover the 730 km distance in an average of 19 h 39 m but if you time it right, some buses will get you there in just 19 h 20 m .
On Mon, Nov 02 the slowest buses will take 20 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Lyon to Santander run on average 3 times per day, taking around 16h 54m. Cheap bus tickets for this journey start at $10 (€9) if you book in advance.
The earliest bus runs at 01:00, the last at 20:50. The fastest bus covers the 453 miles (730 km) distance in 13h 20m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Lyon to Santander.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Alsa | Departure Time 03:15AM | Arrival Time 11:15PM | Duration 20h00 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $58 |
Operator Alsa | Departure Time 04:10AM | Arrival Time 12:15AM | Duration 20h05 | Departure days Tue, Wed, Thu | Cheapest price $59 |
Operator Alsa | Departure Time 04:15AM | Arrival Time 12:15AM | Duration 20h00 | Departure days Mon, Tue, Thu, Fri | Cheapest price $47 |
Operator Alsa | Departure Time 04:40AM | Arrival Time 12:15AM | Duration 19h35 | Departure days Mon, Wed, Thu, Fri, Sat | Cheapest price $53 |
Operator Alsa | Departure Time 05:15AM | Arrival Time 01:15AM | Duration 20h00 | Departure days Sun | Cheapest price $59 |
Operator Alsa | Departure Time 09:30AM | Arrival Time 06:30AM | Duration 21h00 | Departure days Tue, Thu | Cheapest price $48 |
Operator FlixBus | Departure Time 12:00PM | Arrival Time 07:20AM | Duration 19h20 | Departure days Mon, Fri | Cheapest price $91 |
Operator FlixBus | Departure Time 01:00PM | Arrival Time 08:20AM | Duration 19h20 | Departure days Mon, Fri | Cheapest price $136 |
Operator FlixBus | Departure Time 01:15PM | Arrival Time 07:20AM | Duration 18h05 | Departure days Thu | Cheapest price $102 |
Operator FlixBus | Departure Time 01:50PM | Arrival Time 07:20AM | Duration 17h30 | Departure days Wed | Cheapest price $82 |
Operator FlixBus | Departure Time 02:15PM | Arrival Time 08:20AM | Duration 18h05 | Departure days Sat | Cheapest price $92 |
Operator FlixBus | Departure Time 03:50PM | Arrival Time 09:20AM | Duration 17h30 | Departure days Sun | Cheapest price $144 |
The table below shows live departures for Lyon to Santander buses for today, Sunday, November 1. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Normal · Normal | 5:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 20h00 | 1:15 AM Santander, Estación de Autobuses | 1 transfer | |
FlixBus · FlixBus | 3:50 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 17h30 | 9:20 AM Santander, Estación de Autobuses | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Lyon to Santander with Alsa, FlixBus, and BlaBlaCar Bus. Overnight buses available on this route with Alsa, FlixBus, and BlaBlaCar Bus. Regional buses available on this route with Alsa. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Santander — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Santander trip today.
Leading modern and contemporary art center by Renzo Piano, renowned for exhibitions, architecture, and exceptional bay views.
Excellent maritime museum covering Cantabrian seafaring, ecology, fishing, and naval history with aquariums and family-friendly displays.
Art museum focused on Cantabrian and Spanish painting, offering a compact but rewarding overview in a central historic setting.
Iconic peninsula park with palace grounds, beaches, mini-zoo area, and scenic walking routes. One of Santander’s essential outings.
Elegant seafront promenade linking gardens, monuments, and bay views. Ideal for a first walk through central Santander.
Dramatic headland viewpoint with cliffs, lighthouse scenery, and walking trails. A favorite for sunsets and Atlantic panoramas.
Cantabrian anchovies cured in salt or olive oil. Santander is famous for high-quality bocarte landed on this coast and served as a prized tapa.
Fresh hake with green sauce, usually with garlic, parsley, fish stock, peas and clams. A classic northern coastal dish tied to local fishing traditions.
Mountain stew from Cantabria with white beans, collard greens and pork products. Hearty inland cooking that is iconic across the region.
Refined Michelin-starred dining focused on seasonal Cantabrian products. Elegant setting and creative tasting menus with strong local identity.
Well-known dining room specializing in grilled fish and Cantabrian seafood. Smart but relaxed atmosphere with a strong local reputation.
Established seafood restaurant known for fresh fish, shellfish and classic Santander cooking. Traditional atmosphere near the seafront.
Moderate for Spain. Hotels and dining are usually cheaper than Madrid or Barcelona, while local transit and casual meals stay fairly affordable for tourists.
Tipping is modest. Round up or leave 5-10% in restaurants for good service, small change in cafes, and round up taxi fares.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Santander.
Find answers to the most common questions about traveling from Lyon to Santander by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Santander, this guide helps you travel smarter and with confidence.

Most Lyon to Santander buses use the Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) to Santander, Estación de Autobuses station pair. Use this guide to compare Lyon and Santander bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) is 2 km from Lyon city centre. Public transport options include:
Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland). ATMs are available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland).
Ticket office support is available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland).
Available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland): Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland): Station is accessible for passengers with reduced mobility.
Lyon, Gare Routière de Perrache is 1 km from Lyon city centre. Public transport options include:
Lyon, Gare Routière de Perrache has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Café de la Gare (in the station), Le Bistrot de Lyon (0.5 km), Brasserie Georges (0.6 km).
Free Wi-Fi. ATMs are located near the main entrance.
Ticket office support is available at Lyon, Gare Routière de Perrache.
Available at Lyon, Gare Routière de Perrache: Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Gare Routière de Perrache: Elevators, ramps.
Lyon, Gare Perrache is 1 km from Lyon city centre. Public transport options include:
Lyon, Gare Perrache has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Café de la Gare (in the station), Bistro Lyonnais (0.2 km), Fast Food Express (0.3 km).
Free Wi-Fi. ATMs are located near the main entrance and in the shopping area.
Ticket office support is available at Lyon, Gare Perrache.
Available at Lyon, Gare Perrache: Parking, Taxis, WC.
Accessibility facilities are available at Lyon, Gare Perrache: Elevators, ramps.