- Must visit
Musée des Beaux-Arts de Lyon
Major fine arts museum in a former abbey on Place des Terreaux, known for strong collections from antiquity to modern art.
Flights from Santander to Lyon depart on average 5 times per day, taking around 2h 45m. Cheap flight tickets for this journey start at $82 (€67) but you can travel from only $44 (€36) by bus.
The earliest flight runs at 00:10, the last at 23:40. The fastest flight covers the 453 miles (730 km) distance in 4h 15m. November is the cheapest month to fly.
Distance 453 miles (730 km) |
Average flight duration 2h 45m |
Cheapest ticket price $82 (€67) |
Flights per day 5 |
Fastest flight 4h 15m |
First flight 12:10 AM |
Last flight 11:40 PM |
Cheapest Month Nov |
Cheapest Day Mon |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Thu |
Least Busy Day Fri |
Best time to book 21 days |
Cheapest price
$300
Average price
$373
Fastest journey
4 h 25 m
Average duration
9 h 23 m
Flights per day
2
Distance
730 km
The best way to find a cheap flight ticket from Santander to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santander to Lyon will cost around $373 if you buy it on the day, but the cheapest tickets can be found for only $300.
Of the 2 flights that leave Santander for Lyon onSun, Jun 21, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Jun 21 the direct flights cover the 730 km distance in an average of 9 h 23 m but if you time it right, some flights will get you there in just 4 h 25 m .
On Sun, Jun 21 the longest flights will take 14 h 20 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Omio recommends booking the bus as it is the most popular option from Santander to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $44. For those with little time consider booking a flight which can get you there in 2h 45m. The ticket price range depends on the travel mode: a bus costs an average of $44, and a flight costs an average of $82.
Distance: 453 miles (730 km)
| Flight | Most popular Bus | Train | Driving |
|---|---|---|---|
$265 Average price | $85 Average price Cheapest | $188 Average price | $194 Average price (fuel + tolls) |
5h 45m Average total duration Fastest 2h 45m Onboard + 3h 0m Additional time* | 15h 36m Average total duration 15h 6m Onboard + 30m Additional time* | 23h 52m Average total duration 23h 22m Onboard + 30m Additional time* | 9h 42m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Santander to Lyon:
A bus is $103 (€84) less than a train for this route with tickets for a train from Santander to Lyon costing on average $188 (€154).
A bus is $180 (€147) less than a flight for this route with tickets for a flight from Santander to Lyon costing on average $265 (€217).
Other travel options to Lyon take longer:
Bus takes on average 15h 6m.
Train takes on average 23h 22m.
The table below shows live departures for Santander to Lyon flights for today, Saturday, June 20. You can also manually refresh the results below to see updated flight journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 4:40 PM Santander | 4h15 | 8:55 PM Lyon | 0 transfersDirect | |
| Sunday, June 21 | |||||
![]() | 3:40 PM Santander | 4h25 | 8:05 PM Lyon | 0 transfersDirect | |
![]() | 4:25 PM Santander | 14h20 | 6:45 AM Lyon | 0 transfersDirect | |
This is the last flight of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
Major fine arts museum in a former abbey on Place des Terreaux, known for strong collections from antiquity to modern art.
Excellent museum on Roman Lyon with mosaics, inscriptions, and artifacts beside the ancient theaters on Fourvière hill.
Striking science and society museum at the meeting of the Rhône and Saône, famous for immersive displays and architecture.
The city's atmospheric old quarter with Renaissance lanes, traboules, courtyards, and a strong UNESCO heritage feel.
One of Europe's largest open squares and a key central meeting point in Lyon's Presqu'île.
Large urban park with lake, botanical spaces, greenhouses, and broad paths for walking and relaxing.
Light dumplings traditionally made with pike and baked in a rich Nantua crayfish sauce, a classic specialty of Lyonnais cuisine.
A warm salad of frisee lettuce, lardons, croutons, and a poached egg, emblematic of Lyon's hearty bouchon cooking.
Pork sausage baked inside a soft brioche loaf, a festive and traditional Lyonnais dish often served in bouchons.
An iconic fine-dining restaurant with deep Lyon culinary heritage, serving elegant cuisine in a prestigious setting.
A respected modern bouchon offering refined takes on Lyonnais classics in a warm and polished setting.
A historic bouchon known for classic Lyonnais dishes, convivial service, and a traditional, bustling atmosphere.
Moderate by French standards: bakeries and lunch deals are good value, while central hotels and dinner spots cost more.
Service is included by law. Rounding up or leaving 5-10% for very good restaurant service is appreciated, not required. Round up taxis; small change is fine in cafés and bars.
Official public transport app
Lyon Saint-Exupéry Airport, Lyon -> Lyon Part-Dieu, Lyon
Find answers to the most common questions about traveling from Santander to Lyon by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

Most Santander to Lyon flights use the Santander Airport to Lyon Saint Exupery Airport airport pair. Use this guide to compare Santander and Lyon airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Santander Airport is 4 km from Santander city centre. Public transport options include:
Santander Airport has practical services for this route, including Wifi, Shopping, Parking, ATM, Taxis, Accessibility, WC, Lounge, and Lost and Found Office.
Free Wi-Fi available throughout the airport. ATMs are located in the terminal.
Lost and found is available at the station.
Available at Santander Airport: Parking, Taxis, WC.
Accessibility facilities are available at Santander Airport: Elevators, ramps.
Lyon Saint Exupery Airport is 2 km from Lyon city centre. Public transport options include:
Lyon Saint Exupery Airport has practical services for this route, including Wifi, Shopping, Parking, ATM, Taxis, Accessibility, WC, Shower, Lounge, and Lost and Found Office.
Free Wi-Fi available throughout the airport. ATMs are located in all terminals 1 and 2.
Lost and found is available at the station.
Available at Lyon Saint Exupery Airport: Parking, Taxis, WC.
Accessibility facilities are available at Lyon Saint Exupery Airport: Elevators, ramps.
Here are some other resources that might have the information you need