- Must visit
Musée des Confluences
A major science and anthropology museum in a striking contemporary building at the confluence of the Rhône and Saône. One of Lyon’s signature cultural sites with strong temporary exhibitions.
Cheapest price
$51
Average price
$52
Fastest journey
9 h 35 m
Average duration
12 h 28 m
Buses per day
2
Distance
553 km
The best way to find a cheap bus ticket from Frankfurt am Main Airport to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Frankfurt am Main Airport to Lyon will cost around $52 if you buy it on the day, but the cheapest tickets can be found for only $51.
Of the 2 buses that leave Frankfurt am Main Airport for Lyon on Tue, Jun 02, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, Jun 02 the direct buses cover the 553 km distance in an average of 12 h 28 m but if you time it right, some buses will get you there in just 9 h 35 m .
On Tue, Jun 02 the slowest buses will take 15 h 20 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Omio recommends booking the bus as it is the most popular option from Frankfurt am Main Airport to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $34. For those with little time consider booking a flight which can get you there in 2h 12m. The ticket price range depends on the travel mode: a bus costs an average of $34, and a flight costs an average of $169.
Distance: 343 miles (553 km)
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$58 Average price Cheapest | $159 Average price | $300 Average price | $180 Average price (fuel + tolls) |
10h 27m Average total duration 9h 57m Onboard + 30m Additional time* | 6h 24m Average total duration 5h 54m Onboard + 30m Additional time* | 5h 12m Average total duration Fastest 2h 12m Onboard + 3h 0m Additional time* | 6h 30m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Frankfurt am Main Airport to Lyon:
A bus is $101 (€81) less than a train for this route with tickets for a train from Frankfurt am Main Airport to Lyon costing on average $159 (€128).
A bus is $242 (€195) less than a flight for this route with tickets for a flight from Frankfurt am Main Airport to Lyon costing on average $300 (€242).
Other travel options to Lyon take longer:
Train takes on average 5h 54m.
Bus takes on average 9h 57m.
Tickets start at around $58 (€47) compared to roughly $180 (€145) in fuel and tolls — a saving of about $123 (€99). The journey takes 9h 57m versus 6h 30m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, BlaBlaCar Bus, Infobus, BlaBlaCar.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:05AM | Arrival Time 03:25PM | Duration 15h20 | Departure days Mon, Tue | Cheapest price $44 |
Operator FlixBus | Departure Time 01:05AM | Arrival Time 12:40PM | Duration 11h35 | Departure days Sat | Cheapest price $59 |
Operator FlixBus | Departure Time 05:55AM | Arrival Time 08:50PM | Duration 14h55 | Departure days Sat | Cheapest price $58 |
Operator BlaBlaCar Bus | Departure Time 07:30AM | Arrival Time 06:45PM | Duration 11h15 | Departure days Wed | Cheapest price $54 |
Operator Alsa | Departure Time 07:30AM | Arrival Time 06:40PM | Duration 11h10 | Departure days Fri | Cheapest price $62 |
Operator BlaBlaCar Bus | Departure Time 08:30AM | Arrival Time 07:45PM | Duration 11h15 | Departure days Wed | Cheapest price $41 |
Operator FlixBus | Departure Time 08:55AM | Arrival Time 09:15PM | Duration 12h20 | Departure days Thu | Cheapest price $124 |
Operator FlixBus | Departure Time 10:55AM | Arrival Time 11:15PM | Duration 12h20 | Departure days Sat | Cheapest price $60 |
Operator BlaBlaCar Bus | Departure Time 11:25AM | Arrival Time 03:05AM | Duration 15h40 | Departure days Mon | Cheapest price $64 |
Operator FlixBus | Departure Time 03:50PM | Arrival Time 02:45AM | Duration 10h55 | Departure days Mon | Cheapest price $63 |
Operator FlixBus | Departure Time 04:00PM | Arrival Time 04:20AM | Duration 12h20 | Departure days Sat | Cheapest price $66 |
Operator BlaBlaCar Bus | Departure Time 05:00PM | Arrival Time 03:10AM | Duration 10h10 | Departure days Mon, Fri, Sun | Cheapest price $42 |
Operator FlixBus | Departure Time 05:50PM | Arrival Time 04:45AM | Duration 10h55 | Departure days Sat | Cheapest price $58 |
Operator BlaBlaCar Bus | Departure Time 06:00PM | Arrival Time 04:10AM | Duration 10h10 | Departure days Thu, Fri, Sun | Cheapest price $40 |
Operator FlixBus | Departure Time 06:30PM | Arrival Time 04:05AM | Duration 9h35 | Departure days Tue, Wed | Cheapest price $41 |
Operator FlixBus | Departure Time 06:40PM | Arrival Time 08:15AM | Duration 13h35 | Departure days Sat | Cheapest price $57 |
Operator BlaBlaCar Bus | Departure Time 07:00PM | Arrival Time 05:10AM | Duration 10h10 | Departure days Sat | Cheapest price $40 |
Operator FlixBus | Departure Time 07:30PM | Arrival Time 11:30AM | Duration 16h00 | Departure days Wed, Sat | Cheapest price $58 |
Operator FlixBus | Departure Time 10:05PM | Arrival Time 11:30AM | Duration 13h25 | Departure days Fri, Sun | Cheapest price $74 |
Operator FlixBus | Departure Time 11:05PM | Arrival Time 10:30AM | Duration 11h25 | Departure days Sat | Cheapest price $71 |
The table below shows live departures for Frankfurt am Main Airport to Lyon buses for today, Monday, June 1. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 11:25 AM Frankfurt am Main Airport | 15h40 | 3:05 AM Lyon | 0 transfersDirect | |
![]() | 3:50 PM Frankfurt am Main Airport | 10h55 | 2:45 AM Lyon | 0 transfersDirect | |
![]() | 5:00 PM Frankfurt am Main Airport | 10h10 | 3:10 AM Lyon | 0 transfersDirect | |
| Tuesday, June 2 | |||||
![]() | 12:05 AM Frankfurt am Main Airport | 15h20 | 3:25 PM Lyon | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Frankfurt am Main Airport to Lyon run on average 8 times per day, taking around 9h 57m. Cheap bus tickets for this journey start at $34 (€28) if you book in advance.
There are 2 buses per day. The earliest bus runs at 00:05, the last at 22:05. The fastest bus covers the 343 miles (553 km) distance in 9h 35m.
Distance 343 miles (553 km) |
Average bus duration 9h 57m |
Cheapest ticket price $34 (€28) |
Buses per day 8 |
Direct buses 2 |
Fastest bus 9h 35m |
First bus 12:05 AM |
Last bus 10:05 PM |
Cheapest Month Sep |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Mon |
Least Busy Day Tue |
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
A major science and anthropology museum in a striking contemporary building at the confluence of the Rhône and Saône. One of Lyon’s signature cultural sites with strong temporary exhibitions.
Lyon’s premier fine arts museum, housed in a former abbey near Place des Terreaux. Known for strong collections of painting, sculpture, antiquities, and decorative arts.
Museum of Roman Lyon paired with the city’s ancient theaters on Fourvière hill. A key stop for understanding Lugdunum, the Roman origins of Lyon.
Lyon’s atmospheric old quarter with Renaissance lanes, traboules, and riverfront views. It is the city’s classic strolling area and a top priority for first-time visitors.
One of Europe’s largest open squares and a central meeting point in Lyon. It is a practical orientation stop and a key place for city views toward Fourvière.
Lyon’s flagship urban park with broad walking paths, lake, botanical areas, and a zoo. It is one of the best places in the city for relaxation and scenic walks.
Light dumplings made with pike and panade, usually baked in a rich Nantua crayfish sauce. A classic Lyonnais bouchon specialty.
A traditional salad of frisée lettuce with lardons, croutons, and a poached egg. It is one of the city’s most iconic starter dishes.
Lyon’s famous sausage baked inside a soft brioche dough. It is a beloved charcuterie-based specialty found in many bouchons.
A landmark fine dining institution in Lyon, famed for historic prestige and elegant cuisine rooted in the city’s gastronomic heritage.
The city’s celebrated covered food market, ideal for sampling oysters, charcuterie, cheese, pastries, and many iconic Lyonnais products.
A respected traditional restaurant associated with chef Joseph Viola, celebrated for refined Lyonnais classics in a polished but welcoming setting.
Moderate for France: bakeries and bouchons are fair value, while central hotels and fine dining cost more.
Service is included by law. Leaving small change or 5-10% for great service is appreciated, not required. Round up for taxis.
Official public transport app
Lyon Perrache Bus Station, Lyon -> Lyon Part-Dieu Station, Lyon
Find answers to the most common questions about traveling from Frankfurt am Main Airport to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

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