- Must visit
Musée des Confluences
A major science and anthropology museum in a striking contemporary building at the confluence of the Rhône and Saône. One of Lyon’s signature cultural sites with strong temporary exhibitions.
Cheapest price
$59
Average price
$79
Fastest journey
10 h 45 m
Average duration
14 h 34 m
Buses per day
6
Distance
625 km
The best way to find a cheap bus ticket from Düsseldorf to Lyon is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Düsseldorf to Lyon will cost around $79 if you buy it on the day, but the cheapest tickets can be found for only $59.
Of the 6 buses that leave Düsseldorf for Lyon on Sat, May 30, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, May 30 the direct buses cover the 625 km distance in an average of 14 h 34 m but if you time it right, some buses will get you there in just 10 h 45 m .
On Sat, May 30 the slowest buses will take 16 h 50 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
50429 · 50617
FlixBus
50457 · 50107
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
50457 · 50107
50429 · 50617Omio recommends booking the bus as it is the most popular option from Düsseldorf to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $46. For those with little time consider booking a flight which can get you there in 2h 21m. The ticket price range depends on the travel mode: a bus costs an average of $46, and a flight costs an average of $81.
Distance: 388 miles (625 km)
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$71 Average price Cheapest | $266 Average price | $300 Average price | $193 Average price (fuel + tolls) |
12h 40m Average total duration 12h 10m Onboard + 30m Additional time* | 6h 51m Average total duration 6h 21m Onboard + 30m Additional time* | 5h 21m Average total duration Fastest 2h 21m Onboard + 3h 0m Additional time* | 8h 29m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Düsseldorf to Lyon:
A bus is $195 (€157) less than a train for this route with tickets for a train from Düsseldorf to Lyon costing on average $266 (€214).
A bus is $229 (€185) less than a flight for this route with tickets for a flight from Düsseldorf to Lyon costing on average $300 (€242).
Other travel options to Lyon take longer:
Train takes on average 6h 21m.
Bus takes on average 12h 10m.
Tickets start at around $71 (€57) compared to roughly $193 (€155) in fuel and tolls — a saving of about $122 (€98). The journey takes 12h 10m versus 8h 29m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, BlaBlaCar.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 03:45AM | Arrival Time 08:50PM | Duration 17h05 | Departure days Wed, Thu | Cheapest price $80 |
Operator FlixBus | Departure Time 07:15AM | Arrival Time 11:15PM | Duration 16h00 | Departure days Wed, Thu | Cheapest price $80 |
Operator FlixBus | Departure Time 07:55AM | Arrival Time 01:10AM | Duration 17h15 | Departure days Wed, Thu | Cheapest price $89 |
Operator BlaBlaCar Bus | Departure Time 08:15AM | Arrival Time 12:20AM | Duration 16h05 | Departure days Mon, Sat, Sun | Cheapest price $68 |
Operator FlixBus | Departure Time 08:38AM | Arrival Time 05:05AM | Duration 20h27 | Departure days Wed | Cheapest price $92 |
Operator FlixBus | Departure Time 09:27AM | Arrival Time 04:45AM | Duration 19h18 | Departure days Thu | Cheapest price $87 |
Operator BlaBlaCar Bus | Departure Time 10:40AM | Arrival Time 03:30AM | Duration 16h50 | Departure days Mon, Sat, Sun | Cheapest price $59 |
Operator BlaBlaCar | Departure Time 12:00PM | Arrival Time 09:00PM | Duration 9h00 | Departure days Tue | Cheapest price $96 |
Operator FlixBus | Departure Time 12:38PM | Arrival Time 06:00AM | Duration 17h22 | Departure days Wed, Thu | Cheapest price $87 |
Operator FlixBus | Departure Time 02:25PM | Arrival Time 04:45AM | Duration 14h20 | Departure days Everyday | Cheapest price $64 |
Operator FlixBus | Departure Time 04:38PM | Arrival Time 10:30AM | Duration 17h52 | Departure days Wed, Thu | Cheapest price $85 |
Operator FlixBus | Departure Time 05:25PM | Arrival Time 08:15AM | Duration 14h50 | Departure days Everyday | Cheapest price $59 |
Operator FlixBus | Departure Time 06:20PM | Arrival Time 10:30AM | Duration 16h10 | Departure days Wed, Thu | Cheapest price $85 |
Operator FlixBus | Departure Time 09:15PM | Arrival Time 12:50PM | Duration 15h35 | Departure days Wed, Thu | Cheapest price $80 |
Operator BlaBlaCar Bus | Departure Time 09:45PM | Arrival Time 02:40PM | Duration 16h55 | Departure days Everyday | Cheapest price $59 |
Operator FlixBus | Departure Time 11:00PM | Arrival Time 09:45AM | Duration 10h45 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $57 |
The table below shows live departures for Düsseldorf to Lyon buses for today, Friday, May 29. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
50449 · 94765 | 9:45 PM Düsseldorf, ZOB am Hbf | 16h55 | 2:40 PM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus | 11:00 PM Düsseldorf, ZOB am Hbf | 10h45 | 9:45 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 0 transfersDirect | |
| Saturday, May 30 | |||||
50457 · 50107 | 8:15 AM Düsseldorf, ZOB am Hbf | 16h05 | 12:20 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
50429 · 50617 | 10:40 AM Düsseldorf, ZOB am Hbf | 16h50 | 3:30 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 2:25 PM Düsseldorf, ZOB am Hbf | 14h20 | 4:45 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
FlixBus · FlixBus | 5:25 PM Düsseldorf, ZOB am Hbf | 14h50 | 8:15 AM Lyon, Avenue Tony Garnier (Gare routière de Lyon Gerland) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Düsseldorf to Lyon run on average 6 times per day, taking around 12h 10m. Cheap bus tickets for this journey start at $46 (€37) if you book in advance.
There are 1 buses per day. The earliest bus runs at 00:05, the last at 23:55. The fastest bus covers the 388 miles (625 km) distance in 10h 45m.
Distance 388 miles (625 km) |
Average bus duration 12h 10m |
Cheapest ticket price $46 (€37) |
Buses per day 6 |
Direct buses 1 |
Fastest bus 10h 45m |
First bus 12:05 AM |
Last bus 11:55 PM |
Cheapest Month Sep |
Cheapest Day Mon |
High Season Oct - Dec |
Low Season Apr - Jun |
Busiest Day Tue |
Least Busy Day Sat |
Best time to book 84 days |
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
A major science and anthropology museum in a striking contemporary building at the confluence of the Rhône and Saône. One of Lyon’s signature cultural sites with strong temporary exhibitions.
Lyon’s premier fine arts museum, housed in a former abbey near Place des Terreaux. Known for strong collections of painting, sculpture, antiquities, and decorative arts.
Museum of Roman Lyon paired with the city’s ancient theaters on Fourvière hill. A key stop for understanding Lugdunum, the Roman origins of Lyon.
Lyon’s atmospheric old quarter with Renaissance lanes, traboules, and riverfront views. It is the city’s classic strolling area and a top priority for first-time visitors.
One of Europe’s largest open squares and a central meeting point in Lyon. It is a practical orientation stop and a key place for city views toward Fourvière.
Lyon’s flagship urban park with broad walking paths, lake, botanical areas, and a zoo. It is one of the best places in the city for relaxation and scenic walks.
Light dumplings made with pike and panade, usually baked in a rich Nantua crayfish sauce. A classic Lyonnais bouchon specialty.
A traditional salad of frisée lettuce with lardons, croutons, and a poached egg. It is one of the city’s most iconic starter dishes.
Lyon’s famous sausage baked inside a soft brioche dough. It is a beloved charcuterie-based specialty found in many bouchons.
A landmark fine dining institution in Lyon, famed for historic prestige and elegant cuisine rooted in the city’s gastronomic heritage.
The city’s celebrated covered food market, ideal for sampling oysters, charcuterie, cheese, pastries, and many iconic Lyonnais products.
A respected traditional restaurant associated with chef Joseph Viola, celebrated for refined Lyonnais classics in a polished but welcoming setting.
Moderate for France: bakeries and bouchons are fair value, while central hotels and fine dining cost more.
Service is included by law. Leaving small change or 5-10% for great service is appreciated, not required. Round up for taxis.
Official public transport app
Lyon Perrache Bus Station, Lyon -> Lyon Part-Dieu Station, Lyon
Find answers to the most common questions about traveling from Düsseldorf to Lyon by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

Here are some other resources that might have the information you need