The cheapest and fastest buses from Chicago, IL to South San Francisco, CA
Cheapest price on Oct 08
€487
Average ticket price on Oct 08
€487
Fastest journey on Oct 08
2 d 1 h 20 m
Average journey duration on Oct 08
2 d 1 h 20 m
Buses on Oct 08
1
Distance
2987 km
The best way to find a cheap bus ticket from Chicago, IL to South San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Chicago, IL to South San Francisco, CA will cost around €487 if you buy it on the day, but the cheapest tickets can be found for only €487.
It's difficult to get from Chicago, IL to South San Francisco, CA without transferring at least 3 times.
12:01 PM49h20Chicago, IL1:21 PMSouth San Francisco, CA€4871One-way3 transfers
12:01 PM49h20Chicago, IL1:21 PMSouth San Francisco, CA€4871One-way3 transfers
Journey information
Overview: Bus from Chicago, IL to South San Francisco, CA
Buses from Chicago, IL to South San Francisco, CA run on average 3 times per day, taking around 52h 44m. Cheap bus tickets for this journey start at €207 but you can travel from only €165 by flight.
The earliest bus runs at 06:30, the last at 23:25. The fastest bus covers the 1856 miles (2987 km) distance in 48h 30m.
Distance 1856 miles (2987 km) |
Average bus duration 52h 44m |
Cheapest ticket price €207 |
Buses per day 3 |
Fastest bus 48h 30m |
First bus 6:30 AM |
Last bus 11:25 PM |
Cheapest Month Jul |
Cheapest Day Thu |
High Season Apr - Jun |
Low Season Jul - Sep |
Chicago, IL to South San Francisco, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 04:10AM | Arrival Time 01:40PM | Duration 57h30 | Departure days Mon | Cheapest price €142 |
Operator Greyhound USA | Departure Time 12:01PM | Arrival Time 01:21PM | Duration 49h20 | Departure days Tue, Wed, Thu, Fri | Cheapest price €487 |
Operator Greyhound | Departure Time 05:01PM | Arrival Time 01:05AM | Duration 56h04 | Departure days Sat | Cheapest price €165 |
Operator Greyhound | Departure Time 05:25PM | Arrival Time 07:25PM | Duration 50h00 | Departure days Sat | Cheapest price €237 |
Live departures
Chicago, IL to South San Francisco, CA bus times
The table below shows live departures for Chicago, IL to South San Francisco, CA buses for today, Wednesday, October 7. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:01 PM Chicago, IL | 49h36 | 1:37 PM South San Francisco, CA | 3 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book Chicago, IL to South San Francisco, CA buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Chicago, IL to South San Francisco, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Chicago, IL to South San Francisco, CA.
Bus providers: Greyhound from Chicago, IL to South San Francisco, CAYou can travel by bus between Chicago, IL to South San Francisco, CA with Greyhound for as low as €165. When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Chicago, IL to South San Francisco, CA
Find answers to the most common questions about traveling from Chicago, IL to South San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Chicago, IL to South San Francisco, CA
Most Chicago, IL to South San Francisco, CA buses use the Chicago, Greyhound Bus Station to San Francisco, Townsend Street / 5th Street station pair. Use this guide to compare Chicago, IL and South San Francisco, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Which Chicago, IL station do buses to South San Francisco, CA leave from?
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Chicago, Greyhound Bus Station bus station facilities and services
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Snack shop and vending machines available
Wi-Fi and ATMs
Free Wi-Fi in waiting area. ATMs are located near entrance.
Tickets and information
Ticket office support is available at Chicago, Greyhound Bus Station.
Parking, taxis and toilets
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Chicago, Union Station (Amtrak) bus station facilities and services
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options are available inside the station.
Wi-Fi and ATMs
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Tickets and information
Ticket office support is available at Chicago, Union Station (Amtrak).
Parking, taxis and toilets
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Most popular bus connections from Chicago, IL
More options for your journey from Chicago, IL to South San Francisco, CA
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