Chicago, IL to South San Francisco, CA bus

Sat, Feb 14
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FlixBus
Costa Verde
Alsa
BlaBlaCar Bus
Rede Expressos
1,000+ travel companies
FlixBus
Costa Verde
Alsa
BlaBlaCar Bus
Rede Expressos
1,000+ travel companies
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Travel Information

Compare bus, train, and flight for Chicago, IL to South San Francisco, CA

Omio recommends booking the train as it is the most popular option from Chicago, IL to South San Francisco, CA among Omio's users. If you are prioritising price take the flight with prices starting from €223. For those with little time consider booking a flight which can get you there in 19h 22m. The ticket price range depends on the travel mode: a flight costs an average of €223, and a train costs an average of €1103.

Distance: 1856 miles (2987 km)

Compare bus with

Bus
Most popular
Train
Flight

€428

Average price

€1103

Average price

€223

Average price

Cheapest

58h 15m

Average total duration

57h 45m

Onboard

+

30m

Additional time*

53h 26m

Average total duration

52h 56m

Onboard

+

30m

Additional time*

22h 22m

Average total duration

Fastest

19h 22m

Onboard

+

3h 0m

Additional time*

Direct Options

Direct Options

Direct Options

Journey information

Overview: Bus from Chicago, IL to South San Francisco, CA

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Buses from Chicago, IL to South San Francisco, CA run on average 10 times per day, taking around 57h 45m. Cheap bus tickets for this journey start at $542 (€428) but you can travel from only $283 (€223) by flight.

The earliest bus runs at 06:30, the last at 23:25. The fastest bus covers the 1856 miles (2987 km) distance in 57h 45m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $283 (€223)
Distance
1856 miles (2987 km)
Average bus duration
57h 45m
Cheapest ticket price
$542 (€428)
Buses per day
10
Fastest bus
57h 45m
First bus
06:30
Last bus
23:25
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $283 (€223)

FAQs: Bus from Chicago, IL to South San Francisco, CA

Find answers to the most common questions about traveling from Chicago, IL to South San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Chicago, IL to South San Francisco, CA can start from as little as $542 (€428) when you book in advance. The average bus ticket price for Chicago, IL to South San Francisco, CA is $542 (€428) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Chicago, IL to South San Francisco, CA is 57h 45m to travel the 1856 miles (2987 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Chicago, IL to South San Francisco, CA leaves at 6:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Chicago, IL to South San Francisco, CA leaves at 11:25 PM.
A trip to South San Francisco, CA from Chicago, IL is worth doing but not as a day trip with a journey time of 57h 45m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Chicago, IL to South San Francisco, CA is October.
It's helpful to compare your options as there are 3 ways to travel between Chicago, IL and South San Francisco, CA including taking a bus, train, and flight.
No, the bus from Chicago, IL to South San Francisco, CA has no accessibility options.
No, there are no bathrooms on board the bus from Chicago, IL to South San Francisco, CA.
No, bikes are not allowed on board the bus from Chicago, IL to South San Francisco, CA.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Chicago, IL to South San Francisco, CA.
No, luggage for the bus from Chicago, IL to South San Francisco, CA needs to be booked in addition.
No, there are no additional luggage options for the bus from Chicago, IL to South San Francisco, CA.
Unfortunately, pets are not allowed on the bus from Chicago, IL to South San Francisco, CA.
No, there are no USB plugs on board the bus from Chicago, IL to South San Francisco, CA.
No, there is no WiFi on board the bus from Chicago, IL to South San Francisco, CA.

popular bus stations

Popular bus stations from Chicago, IL to South San Francisco, CA

Chicago
South San Francisco
Chicago, Greyhound Bus Station
information
Chicago, Union Station (Amtrak)
information

More options for your journey from Chicago, IL to South San Francisco, CA

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