Chicago, IL to South San Francisco, CA bus with Greyhound

Thu, Oct 08
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The cheapest and fastest buses from Chicago, IL to South San Francisco, CA

Showing times, prices and bookable tickets for Oct 08

Cheapest price on Oct 08

€487

Average ticket price on Oct 08

€487

Fastest journey on Oct 08

2 d 1 h 20 m

Average journey duration on Oct 08

2 d 1 h 20 m

Buses on Oct 08

1

Distance

2987 km

Cheap tickets

The best way to find a cheap bus ticket from Chicago, IL to South San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Chicago, IL to South San Francisco, CA will cost around €487 if you buy it on the day, but the cheapest tickets can be found for only €487.

Fast buses

It's difficult to get from Chicago, IL to South San Francisco, CA without transferring at least 3 times.

  • Greyhound USA
    12:01 PM49h20
    Chicago, IL
    1:21 PMSouth San Francisco, CA
    €4871One-way
    3 transfers

Journey information

Overview: Bus from Chicago, IL to South San Francisco, CA

USAUSA
USAUSA
Icon of bus

Buses from Chicago, IL to South San Francisco, CA run on average 3 times per day, taking around 52h 44m. Cheap bus tickets for this journey start at €207 but you can travel from only €165 by flight.

The earliest bus runs at 06:30, the last at 23:25. The fastest bus covers the 1856 miles (2987 km) distance in 48h 30m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from €165
Distance
1856 miles (2987 km)
Average bus duration
52h 44m
Cheapest ticket price
€207
Buses per day
3
Fastest bus
48h 30m
First bus
6:30 AM
Last bus
11:25 PM
Cheapest Month
Jul
Cheapest Day
Thu
High Season
Apr - Jun
Low Season
Jul - Sep
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from €165

Chicago, IL to South San Francisco, CA Bus Timetables

OperatorDeparture TimeArrival TimeDurationDeparture daysCheapest price
Operator
Greyhound
Departure Time
04:10AM
Arrival Time
01:40PM
Duration
57h30
Departure days
Mon
Cheapest price
€142
Operator
Greyhound USA
Departure Time
12:01PM
Arrival Time
01:21PM
Duration
49h20
Departure days
Tue, Wed, Thu, Fri
Cheapest price
€487
Operator
Greyhound
Departure Time
05:01PM
Arrival Time
01:05AM
Duration
56h04
Departure days
Sat
Cheapest price
€165
Operator
Greyhound
Departure Time
05:25PM
Arrival Time
07:25PM
Duration
50h00
Departure days
Sat
Cheapest price
€237

Live departures

Chicago, IL to South San Francisco, CA bus times

The table below shows live departures for Chicago, IL to South San Francisco, CA buses for today, Wednesday, October 7. You can also manually refresh the results below to see updated bus journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
Greyhound USA12:01 PM Chicago, IL
49h36
1:37 PM South San Francisco, CA3 transfers

This is the last bus of the day.

Find all the dates and times for this journey

Why should you book Chicago, IL to South San Francisco, CA buses with Omio?

Greyhound operates all buses services from Chicago, IL to South San Francisco, CA.
Omio is an official ticket reseller for all your travel options from Chicago, IL to South San Francisco, CA.

Why book with Omio vs Greyhound?

  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Chicago, IL to South San Francisco, CA.

Why book with Omio over Wanderu?

  • Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Chicago, IL to South San Francisco, CA.

Bus providers: Greyhound from Chicago, IL to South San Francisco, CAYou can travel by bus between Chicago, IL to South San Francisco, CA with Greyhound for as low as €165. When you search for schedules and tickets, Omio will show you the best journey

Greyhound

About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
48h 30m
Cheapest Greyhound Price
€207
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.

FAQs: Bus from Chicago, IL to South San Francisco, CA

Find answers to the most common questions about traveling from Chicago, IL to South San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.

FAQs
Cheap bus tickets from Chicago, IL to South San Francisco, CA can start from as little as €207 when you book in advance. The average bus ticket price for Chicago, IL to South San Francisco, CA is €337 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Chicago, IL to South San Francisco, CA is 48h 30m to travel the 1856 miles (2987 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Chicago, IL to South San Francisco, CA leaves at 6:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Chicago, IL to South San Francisco, CA leaves at 11:25 PM.
There are 3 buses a day from Chicago, IL to South San Francisco, CA which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Chicago, IL to South San Francisco, CA, you can count on Greyhound for the best way to get you to South San Francisco, CA. You can also check all possible bus companies who offer a service between Chicago, IL and South San Francisco, CA and compare the amenities they offer before buying a bus ticket.
When departing from Chicago, IL , you have various bus station options to start your journey from including Chicago, Greyhound Bus Station, Chicago, Union Station (Amtrak), IL . When arriving in South San Francisco, CA , you can end your journey in bus stations like San Francisco, Townsend Street / 5th Street, CA, San Francisco, Transit Center Bay 29 .Passengers board the bus most frequently from Chicago, Greyhound Bus Station, which is located around 1 miles (2 km) away from the city centre, and they get off the bus at San Francisco, Transit Center Bay 29, located 2 away from the city centre.
It's helpful to compare your options as there are 3 ways to travel between Chicago, IL and South San Francisco, CA including taking a bus, train, and flight.
Yes, the following accessibility options are available when taking the bus from Chicago, IL to South San Francisco, CA:
  • Greyhound
    • Assistance
    • Priority seating
    • Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Chicago, IL to South San Francisco, CA for bus company Greyhound.
Whether you can cancel your bus ticket from Chicago, IL to South San Francisco, CA depends on the bus companies:
  • Greyhound
    • You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Chicago, IL to South San Francisco, CA.
Yes, the following luggage options are included when booking a bus ticket from Chicago, IL to South San Francisco, CA:
  • Greyhound
    • One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from Chicago, IL to South San Francisco, CA:
  • Greyhound
    • $15 per additional bag.
Unfortunately, pets are not allowed on the bus from Chicago, IL to South San Francisco, CA.
You can reserve your seat on the bus from Chicago, IL to South San Francisco, CA with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from Chicago, IL to South San Francisco, CA with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from Chicago, IL to South San Francisco, CA with the following bus company: Greyhound.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In South San Francisco, CA, travelers should be cautious of petty crimes such as pickpocketing and vehicle break-ins, especially in crowded or tourist-heavy areas. Common scams include overcharging by unlicensed taxi drivers or ride-share services, so it's advisable to use reputable transportation options. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular bus stations

Popular bus stations from Chicago, IL to South San Francisco, CA

Most Chicago, IL to South San Francisco, CA buses use the Chicago, Greyhound Bus Station to San Francisco, Townsend Street / 5th Street station pair. Use this guide to compare Chicago, IL and South San Francisco, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.

Departure bus stations in Chicago
Arrival bus stations in South San Francisco

Which Chicago, IL station do buses to South San Francisco, CA leave from?

Buses from Chicago, IL to South San Francisco, CA leave from Chicago, Greyhound Bus Station. The station is 1 miles (3 km) from Chicago, IL city centre at 630 W Harrison St, Chicago, IL 60607, USA.
Chicago, Greyhound Bus Station630 W Harrison St, Chicago, IL 60607, USAWifiParkingDiningATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to Chicago, Greyhound Bus Station from Chicago city centre

Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:

Bus7 · 8m · €3 · every ~6 min

Chicago, Greyhound Bus Station bus station facilities and services

Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Food and drink

Food options include: Snack shop and vending machines available

Wi-Fi and ATMs

Free Wi-Fi in waiting area. ATMs are located near entrance.

Tickets and information

Ticket office support is available at Chicago, Greyhound Bus Station.

Parking, taxis and toilets

Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.

Chicago, Union Station (Amtrak)Chicago Union Station, 225 S Canal St, Chicago, IL 60606, USAWifiParkingDiningATMTaxisAccessibilityWCShowerTicket Office
City-centre transport

Getting to Chicago, Union Station (Amtrak) from Chicago city centre

Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:

Bus28, 151 · 7m · €3 · every ~13 min

Chicago, Union Station (Amtrak) bus station facilities and services

Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.

Food and drink

Food options include: Multiple dining options are available inside the station.

Wi-Fi and ATMs

Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.

Tickets and information

Ticket office support is available at Chicago, Union Station (Amtrak).

Parking, taxis and toilets

Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.

Accessibility

Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.

More options for your journey from Chicago, IL to South San Francisco, CA

Here are some other resources that might have the information you need

HomeBusesBuses in USAChicago, IL to South San Francisco, CA bus

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