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Travel Information
Compare bus, train, and flight for Chicago, IL to South San Francisco, CA
Omio recommends booking the train as it is the most popular option from Chicago, IL to South San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from €113. For those with little time consider booking a flight which can get you there in 7h 59m. The ticket price range depends on the travel mode: a bus costs an average of €113, and a train costs an average of €157.
Distance: 1856 miles (2987 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
€125 Average price Cheapest | €171 Average price | €143 Average price | €359 Average price (fuel + tolls) |
53h 26m Average total duration 52h 56m Onboard + 30m Additional time* | 53h 26m Average total duration 52h 56m Onboard + 30m Additional time* | 10h 59m Average total duration Fastest 7h 59m Onboard + 3h 0m Additional time* | 31h 20m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Chicago, IL to South San Francisco, CA:
A bus is €18 less than a flight for this route with tickets for a flight from Chicago, IL to South San Francisco, CA costing on average €143.
A bus is €46 less than a train for this route with tickets for a train from Chicago, IL to South San Francisco, CA costing on average €171.
Other travel options to South San Francisco, CA take longer:
Train takes on average 52h 56m.
Bus takes on average 52h 56m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Chicago, IL to South San Francisco, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 04:10AM | Arrival Time 01:40PM | Duration 57h30 | Departure days Mon | Cheapest price €142 |
Operator Greyhound USA | Departure Time 12:01PM | Arrival Time 01:21PM | Duration 49h20 | Departure days Tue, Wed, Thu, Fri | Cheapest price €487 |
Operator Greyhound | Departure Time 05:01PM | Arrival Time 01:05AM | Duration 56h04 | Departure days Sat | Cheapest price €165 |
Operator Greyhound | Departure Time 05:25PM | Arrival Time 07:25PM | Duration 50h00 | Departure days Sat | Cheapest price €237 |
Compare prices and tickets Chicago, IL to South San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Chicago, IL to South San Francisco, CA buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Chicago, IL to South San Francisco, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Chicago, IL to South San Francisco, CA.
Journey information
Overview: Bus from Chicago, IL to South San Francisco, CA
USAUSA
Buses from Chicago, IL to South San Francisco, CA run on average 10 times per day, taking around 52h 56m. Cheap bus tickets for this journey start at €113 if you book in advance.
The earliest bus runs at 06:30, the last at 23:25. The fastest bus covers the 1856 miles (2987 km) distance in 50h 24m.
Distance 1856 miles (2987 km) |
Average bus duration 52h 56m |
Cheapest ticket price €113 |
Buses per day 10 |
Fastest bus 50h 24m |
First bus 6:30 AM |
Last bus 11:25 PM |
Cheapest Month Jul |
Cheapest Day Thu |
High Season Apr - Jun |
Low Season Jul - Sep |
Bus providers: Greyhound from Chicago, IL to South San Francisco, CAYou can travel by bus between Chicago, IL to South San Francisco, CA with Greyhound for as low as €113. When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Chicago, IL to South San Francisco, CA
Find answers to the most common questions about traveling from Chicago, IL to South San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Chicago, IL to South San Francisco, CA
Most Chicago, IL to South San Francisco, CA buses use the Chicago, Greyhound Bus Station to San Francisco, Townsend Street / 5th Street station pair. Use this guide to compare Chicago, IL and South San Francisco, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Which Chicago, IL station do buses to South San Francisco, CA leave from?
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Chicago, Greyhound Bus Station bus station facilities and services
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Snack shop and vending machines available
Wi-Fi and ATMs
Free Wi-Fi in waiting area. ATMs are located near entrance.
Tickets and information
Ticket office support is available at Chicago, Greyhound Bus Station.
Parking, taxis and toilets
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Chicago, Union Station (Amtrak) bus station facilities and services
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options are available inside the station.
Wi-Fi and ATMs
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Tickets and information
Ticket office support is available at Chicago, Union Station (Amtrak).
Parking, taxis and toilets
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
Getting to Chicago, 95th Red Line Station from Chicago city centre
Chicago, 95th Red Line Station is 14 km from Chicago city centre. Public transport options include:
Chicago, 95th Red Line Station bus station facilities and services
Chicago, 95th Red Line Station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Chicago, 95th Red Line Station. ATMs are available at Chicago, 95th Red Line Station.
Tickets and information
Ticket office support is available at Chicago, 95th Red Line Station.
Parking, taxis and toilets
Available at Chicago, 95th Red Line Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, 95th Red Line Station: Wheelchair accessible entrances available.
Most popular bus connections from Chicago, IL
More options for your journey from Chicago, IL to South San Francisco, CA
Here are some other resources that might have the information you need
Most popular buses to and from South San Francisco, CA and Chicago, IL
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