The cheapest and fastest buses from Philadelphia, PA to South San Francisco, CA
Cheapest price
$598
Average price
$621
Fastest journey
3 d 1 h 25 m
Average duration
3 d 4 h 50 m
Buses per day
2
Distance
4054 km
The best way to find a cheap bus ticket from Philadelphia, PA to South San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Philadelphia, PA to South San Francisco, CA will cost around $621 if you buy it on the day, but the cheapest tickets can be found for only $598.
Of the 2 buses that leave Philadelphia, PA for South San Francisco, CA on Fri, Apr 03, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Apr 03 the direct buses cover the 4054 km distance in an average of 3 d 4 h 50 m but if you time it right, some buses will get you there in just 3 d 1 h 25 m .
On Fri, Apr 03 the slowest buses will take 3 d 8 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
12:10 PM80h15Philadelphia, PA8:25 PMSouth San Francisco, CA$5981One-way0 transfers
7:00 PM73h25Philadelphia, PA8:25 PMSouth San Francisco, CA$6441One-way0 transfers
7:00 PM73h25Philadelphia, PA8:25 PMSouth San Francisco, CA$6441One-way0 transfers
12:10 PM80h15Philadelphia, PA8:25 PMSouth San Francisco, CA$5981One-way0 transfers
Travel Information
Compare bus, train, and flight for Philadelphia, PA to South San Francisco, CA
Omio recommends booking the bus as it is the most popular option from Philadelphia, PA to South San Francisco, CA among Omio's users. If you are prioritising price take the flight with prices starting from $214. For those with little time consider booking a flight which can get you there in 9h 45m. The ticket price range depends on the travel mode: a flight costs an average of $214, and a train costs an average of $451.
Distance: 2519 miles (4054 km)
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
$582 Average price | $1314 Average price | $304 Average price Cheapest |
67h 5m Average total duration 66h 35m Onboard + 30m Additional time* | 79h 54m Average total duration 79h 24m Onboard + 30m Additional time* | 12h 45m Average total duration Fastest 9h 45m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Philadelphia, PA to South San Francisco, CA bus times
The table below shows live departures for Philadelphia, PA to South San Francisco, CA buses for today, Thursday, April 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:00 PM Philadelphia, PA | 73h25 | 8:25 PM South San Francisco, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Philadelphia, PA to South San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Apr 03
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Apr 09
Why should you book Philadelphia, PA to South San Francisco, CA buses with Omio?
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Philadelphia, PA to South San Francisco, CA.
Why book with Omio over Wanderu?
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Philadelphia, PA to South San Francisco, CA.
Journey information
Overview: Bus from Philadelphia, PA to South San Francisco, CA
Buses from Philadelphia, PA to South San Francisco, CA run on average 17 times per day, taking around 66h 35m. Cheap bus tickets for this journey start at $245 (€200) but you can travel from only $214 (€174) by flight.
The earliest bus runs at 12:10, the last at 22:30. The fastest bus covers the 2519 miles (4054 km) distance in 69h 55m.
Distance 2519 miles (4054 km) |
Average bus duration 66h 35m |
Cheapest ticket price $245 (€200) |
Buses per day 17 |
Fastest bus 69h 55m |
First bus 12:10 PM |
Last bus 10:30 PM |
Bus providers: Greyhound from Philadelphia, PA to South San Francisco, CAYou can travel by bus between Philadelphia, PA to South San Francisco, CA with Greyhound for as low as $214 (€174). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Philadelphia, PA to South San Francisco, CA
Find answers to the most common questions about traveling from Philadelphia, PA to South San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Philadelphia, PA to South San Francisco, CA
Most popular bus connections from Philadelphia, PA
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