Travel Information
Compare bus, train, and flight for Philadelphia, PA to South San Francisco, CA
Omio recommends booking the bus as it is the most popular option from Philadelphia, PA to South San Francisco, CA among Omio's users. If you are prioritising price take the flight with prices starting from €212. For those with little time consider booking a flight which can get you there in 10h 13m. The ticket price range depends on the travel mode: a flight costs an average of €212, and a train costs an average of €367.
Distance: 2519 miles (4054 km)
Compare bus with
Most popular Bus | Flight | Train |
|---|---|---|
€292 Average price | €290 Average price Cheapest | €458 Average price |
67h 5m Average total duration 66h 35m Onboard + 30m Additional time* | 13h 13m Average total duration Fastest 10h 13m Onboard + 3h 0m Additional time* | 87h 14m Average total duration 86h 44m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets Philadelphia, PA to South San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Philadelphia, PA to South San Francisco, CA
Buses from Philadelphia, PA to South San Francisco, CA run on average 26 times per day, taking around 66h 35m. Cheap bus tickets for this journey start at $240 (€192) if you book in advance.
The earliest bus runs at 11:10, the last at 22:30. The fastest bus covers the 2519 miles (4054 km) distance in 69h 55m.
Distance 2519 miles (4054 km) |
Average bus duration 66h 35m |
Cheapest ticket price $240 (€192) |
Buses per day 26 |
Fastest bus 69h 55m |
First bus 11:10 |
Last bus 22:30 |
Bus providers: Greyhound from Philadelphia, PA to South San Francisco, CAYou can travel by bus between Philadelphia, PA to South San Francisco, CA with Greyhound for as low as $240 (€192). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Philadelphia, PA to South San Francisco, CA
Find answers to the most common questions about traveling from Philadelphia, PA to South San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Philadelphia, PA to South San Francisco, CA, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Philadelphia, PA to South San Francisco, CA
Most popular bus connections from Philadelphia, PA
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