Journey information
Overview: Chicago, IL to South San Francisco, CA flight
Flights from Chicago, IL to South San Francisco, CA depart on average 95 times per day, taking around 6h 35m. Cheap flight tickets for this journey start at lei923 if you book in advance.
There are 14 flights per day. The earliest flight runs at 00:43, the last at 23:57. The fastest flight covers the 1856 miles (2987 km) distance in 4h 37m. July is the cheapest month to fly.
Distance 1856 miles (2987 km) |
Average flight duration 6h 35m |
Cheapest ticket price lei923 |
Flights per day 95 |
Direct flights 14 |
Fastest flight 4h 37m |
First flight 12:43 AM |
Last flight 11:57 PM |
Cheapest Month Jul |
Cheapest Day Thu |
High Season Apr - Jun |
Low Season Jul - Sep |
Travel Information
Compare bus, train, and flight for Chicago, IL to South San Francisco, CA
Omio recommends booking the train as it is the most popular option from Chicago, IL to South San Francisco, CA among Omio's users. If you are prioritising price, take the bus, with an average ticket price of lei1888 For those with little time, consider booking a flight, which has an average total journey time of 8h 35m. Average ticket prices depend on the travel mode: a bus costs an average of lei1888, while a train costs an average of lei5900.
Distance: 1856 miles (2987 km)
Compare flight with
| Flight | Most popular Train | Bus | Driving |
|---|---|---|---|
lei3368 Average price | lei5900 Average price | lei1888 Average price Cheapest | lei2008 Average price (fuel + tolls) |
8h 35m Average total duration Fastest 6h 35m Onboard + 2h 0m Additional time* | 56h 57m Average total duration 56h 27m Onboard + 30m Additional time* | 53h 14m Average total duration 52h 44m Onboard + 30m Additional time* | 31h 20m Average total duration (door-to-door) |
![]() Most popular airline | ![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Chicago, IL to South San Francisco, CA:
A bus is lei1481 less than a flight for this route with tickets for a flight from Chicago, IL to South San Francisco, CA costing on average lei3368.
A bus is lei4013 less than a train for this route with tickets for a train from Chicago, IL to South San Francisco, CA costing on average lei5900.
Other travel options to South San Francisco, CA take longer:
Bus takes on average 52h 44m.
Train takes on average 56h 27m.
Compare prices and tickets Chicago, IL to South San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Sep 23
FAQs: Chicago, IL to South San Francisco, CA Flight
Find answers to the most common questions about traveling from Chicago, IL to South San Francisco, CA by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.

popular airports
Popular airports from Chicago, IL to South San Francisco, CA
Most Chicago, IL to South San Francisco, CA flights use the O'Hare International Airport to San Francisco International Airport airport pair. Use this guide to compare Chicago, IL and South San Francisco, CA airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Which Chicago, IL airport do flights to South San Francisco, CA leave from?
Getting to O'Hare International Airport from Chicago city centre
O'Hare International Airport is 3 km from Chicago city centre. Public transport options include:
O'Hare International Airport airport facilities and services
O'Hare International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food and drink
Food options include: Restaurants are located in all terminals, offering a variety of cuisines including American and intertiol. Top options include Tortas Frontera and Publican Tavern.
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are located throughout all terminals.
Luggage and lost property
Lost and found is available at the station.
Parking, taxis and toilets
Available at O'Hare International Airport: Parking, Taxis, WC.
Bike and car services
Available at O'Hare International Airport: Car Rental.
Accessibility
Accessibility facilities are available at O'Hare International Airport: Elevators, ramps, toilets.
Shops, hotels and contact
Nearby hotels include Hotels such as Hilton Chicago O'Hare are located on airport grounds, with others like the Hyatt Regency nearby..
More options for your journey from Chicago, IL to South San Francisco, CA
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