Chicago, IL to South San Francisco, CA train with Amtrak

Thu, Jun 18
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Amtrak
Regionale
Deutsche Bahn
iryo
Frecciarossa
2,000+ travel companies
Amtrak
Regionale
Deutsche Bahn
iryo
Frecciarossa
2,000+ travel companies
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Travel Information

Compare bus, train, and flight for Chicago, IL to South San Francisco, CA

Omio recommends booking the train as it is the most popular option from Chicago, IL to South San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from $174. For those with little time consider booking a flight which can get you there in 13h 0m. The ticket price range depends on the travel mode: a bus costs an average of $174, and a train costs an average of $160.

Distance: 1856 miles (2987 km)

Compare train with

Most popular
Train
Flight
Bus
Driving

$264

Average price

$227

Average price

$222

Average price

Cheapest

$433

Average price

(fuel + tolls)

53h 26m

Average total duration

52h 56m

Onboard

+

30m

Additional time*

16h 0m

Average total duration

Fastest

13h 0m

Onboard

+

3h 0m

Additional time*

55h 1m

Average total duration

54h 31m

Onboard

+

30m

Additional time*

31h 20m

Average total duration

(door-to-door)

Direct Options

Direct Options

Direct Options

Direct Options

The cheapest way to travel from Chicago, IL to South San Francisco, CA is a bus with an average price of $222 (€182).

This is compared to other travel options from Chicago, IL to South San Francisco, CA:

A bus is $5 (€4) less than a flight for this route with tickets for a flight from Chicago, IL to South San Francisco, CA costing on average $227 (€186).

A bus is $41 (€34) less than a train for this route with tickets for a train from Chicago, IL to South San Francisco, CA costing on average $264 (€215).

The fastest way to travel from Chicago, IL to South San Francisco, CA is by flight with an average journey time of 13h 0m.

Other travel options to South San Francisco, CA take longer:

Train takes on average 52h 56m.

Bus takes on average 54h 31m.

It's helpful to compare your options as there are 3 ways to travel between Chicago, IL and South San Francisco, CA including taking a bus, train, and flight.
We recommend using the train as it is the most popular way to get from Chicago, IL to South San Francisco, CA among Omio's users.
Take the train. It's the cheaper option, and the extra time on board is usually more relaxing than driving it.

Tickets start at around {cheapestPrice} compared to roughly {drivingPriceInCents} in fuel and tolls — a saving of about {savingsAmount}. The journey takes {durationInMinutes} versus {drivingDurationInMinutes} by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.

Direct services run with Amtrak.

Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.

Compare prices and tickets Chicago, IL to South San Francisco, CA by bus, train, or flight

Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

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Jun 18
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Journey information

Overview: Train from Chicago, IL to South San Francisco, CA

USAUSA
USAUSA
Icon of train

Trains from Chicago, IL to South San Francisco, CA run on average 10 times per day, taking around 52h 56m. Cheap train tickets for this journey start at $160 (€131) if you book in advance.

There are 1 trains per day. The earliest train runs at 06:55, the last at 21:41. The fastest train covers the 1856 miles (2987 km) distance in 52h 57m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
1856 miles (2987 km)
Average train duration
52h 56m
Cheapest ticket price
$160 (€131)
Trains per day
10
Direct trains
1
Fastest train
52h 57m
First train
6:55 AM
Last train
9:41 PM
Cheapest Month
Mar
Cheapest Day
Sun
High Season
Oct - Dec
Low Season
Jul - Sep
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Train companies: Amtrak from Chicago, IL to South San Francisco, CA trainsAmtrak trains will get you between Chicago, IL and South San Francisco, CA from $160 (€131). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.

Amtrak

About
Amtrak is the main passenger train operator in the United States, providing medium- and long-distance intercity services across 46 states and three Canadian provinces. Operating over 300 trains daily and serving more than 500 destinations, Amtrak connects cities and regions nationwide through routes such as the high-speed Acela in the Northeast Corridor, the scenic Coast Starlight along the West Coast, and the Empire Builder linking Chicago to the Midwest and the Pacific Northwest. Other notable services include the Northeast Regional, Keystone Service, and the unique Auto Train, which allows passengers to bring their cars onboard. Amtrak offers a variety of classes to suit different budgets and travel needs, including Coach, Business, First Class, and Sleeper Class with options like Roomettes, Bedrooms, and Bedroom Suites for overnight journeys. Ticket types include Saver, Value, Flexible, Business, and Premium. Onboard amenities vary by service but may include comfortable seating, Wi-Fi, power outlets, dining options, and lounge access on select trains. Popular routes include Washington, D.C.–Boston, San Diego–San Luis Obispo, San Jose–Sacramento, and Chicago–Seattle.
Luggage & cancellation policy
Average Duration
52h 57m
Cheapest Price
$160 (€131)
Amtrak frequency
10 a day
Luggage included
2 personal items and 2 carry-on bags included free
Luggage storage
Overhead racks, under seats, and designated luggage areas at end of cars
Cancellation Policy
Cancellation policies depend on ticket type and timing
Refund
Full refund if train is canceled by Amtrak
Amenities on board the train
Wifi
Food sold onboard
Café car with snacks, beverages, and light meals. Long-distance trains have full-service dining cars
Seat reservation
Included in ticket price for Business and First Class. Optional fee for Coach Class
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible restrooms, Red Cap assistance service, accessible platforms and stations
Pets
Small pets under 20 pounds allowed for $26 fee. Must be in carrier. Service animals travel free
Quiet zone

FAQs: Trains from Chicago, IL to South San Francisco, CA

Find answers to the most common questions about traveling from Chicago, IL to South San Francisco, CA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.

FAQs
Train ticket prices from Chicago, IL to South San Francisco, CA can vary. The cheapest ticket starts at $160 (€131), while the average price is around $264 (€215).
The train from Chicago, IL to South San Francisco, CA takes 52h 57m and runs 10 per day.
The distance by train from Chicago, IL to South San Francisco, CA is 1856 miles (2987 km).
The first train from Chicago, IL to South San Francisco, CA leaves at 6:55 AM.
The last train from Chicago, IL to South San Francisco, CA leaves at 9:41 PM.
There is no high speed train available from Chicago, IL to South San Francisco, CA.
Yes, there is a direct train from Chicago, IL to South San Francisco, CA. This service operates 1 times per day, provided by Amtrak.
Unfortunately, there is no night train available from Chicago, IL to South San Francisco, CA.
The cheapest way to get from Chicago, IL to South San Francisco, CA is by train, with a cost of around $160 (€131).
The train journey from Chicago, IL to South San Francisco, CA offers scenic views, particularly through the Rockies and Sierra Nevada mountains, showcasing diverse landscapes such as vast plains, lush forests, and rugged peaks.
A stay of 2 to 3 days in South San Francisco, CA, is generally sufficient to explore the area, including nearby attractions like Oyster Point Marina and the scenic views of the San Bruno Mountains.
Yes, you can take the train from Chicago, IL to South San Francisco, CA.
Since neither Chicago, IL nor South San Francisco, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Chicago, IL to South San Francisco, CA among Omio's users.
Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In South San Francisco, CA, travelers should be cautious of petty crimes such as pickpocketing and vehicle break-ins, especially in crowded or tourist-heavy areas. Common scams include overcharging by unlicensed taxi drivers or ride-share services, so it's advisable to use reputable transportation options. Staying aware of surroundings and securing personal belongings helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular train stations

Popular train stations from Chicago, IL to South San Francisco, CA

Most Chicago, IL to South San Francisco, CA trains use the Union Station to San Francisco, Mission Street (Chase Bank) station pair. Use this guide to compare Chicago, IL and South San Francisco, CA train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.

Departure train stations in Chicago
Arrival train stations in South San Francisco

Which Chicago, IL station do trains to South San Francisco, CA leave from?

Trains from Chicago, IL to South San Francisco, CA leave from Union Station. The station is 1 miles (3 km) from Chicago, IL city centre at 225 South Canal Street, Chicago, IL 60606, USA.
Union Station225 South Canal Street, Chicago, IL 60606, USA+1 800-872-7245WifiLockersParkingDiningATMTaxisAccessibilityWCHotelLoungeLost and Found OfficeTicket OfficeBike ParkingCar RentalInformation DeskLuggage Carts
City-centre transport

Getting to Union Station from Chicago city centre

Union Station is 3 km from Chicago city centre. Public transport options include:

Bus28, 151 · 7m · $4 · every ~13 min

Union Station train station facilities and services

Union Station has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.

Food and drink

Food options include: The Chicago Firehouse Restaurant, Lou Mitchell's

Wi-Fi and ATMs

Free. ATMs are available in the train station.

Tickets and information

Ticket office support is available at Union Station. Information desks are located in the main hall.

Luggage and lost property

Luggage storage is available at Union Station. Lost and found is available at the station.

Parking, taxis and toilets

Available at Union Station: Parking, Taxis, WC.

Bike and car services

Available at Union Station: Bike Parking, Car Rental.

Accessibility

Accessibility facilities are available at Union Station: Elevators, ramps, restrooms.

Shops, hotels and contact

Nearby hotels include The Kimpton Gray Hotel, JW Marriott Chicago, W Chicago - City Center.

More options for your journey from Chicago, IL to South San Francisco, CA

Here are some other resources that might have the information you need

Most popular train connections to South San Francisco, CA

HomeTrainsTrains in USAChicago, IL to South San Francisco, CA train

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