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Travel Information
Compare bus, train, and flight for San Diego, CA to South San Francisco, CA
Omio recommends booking the bus as it is the most popular option from San Diego, CA to South San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from €59. For those with little time consider booking a flight which can get you there in 2h 38m. The ticket price range depends on the travel mode: a bus costs an average of €59, and a flight costs an average of €94.
Distance: 451 miles (727 km)
Compare bus with
Most popular Bus | Flight | Train |
|---|---|---|
€59 Average price Cheapest | €180 Average price | €68 Average price |
14h 11m Average total duration 13h 41m Onboard + 30m Additional time* | 5h 38m Average total duration Fastest 2h 38m Onboard + 3h 0m Additional time* | 14h 29m Average total duration 13h 59m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
San Diego, CA to South San Francisco, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 11:55AM | Arrival Time 08:05AM | Duration 20h10 | Departure days Mon | Cheapest price $222 |
Operator Greyhound | Departure Time 03:25PM | Arrival Time 08:05AM | Duration 16h40 | Departure days Mon | Cheapest price $221 |
Operator Greyhound | Departure Time 03:55PM | Arrival Time 08:05AM | Duration 16h10 | Departure days Mon | Cheapest price $238 |
Operator Greyhound | Departure Time 04:15PM | Arrival Time 08:05AM | Duration 15h50 | Departure days Mon | Cheapest price $231 |
Operator Greyhound | Departure Time 07:00PM | Arrival Time 07:15AM | Duration 12h15 | Departure days Mon | Cheapest price $212 |
Operator Greyhound | Departure Time 07:35PM | Arrival Time 07:15AM | Duration 11h40 | Departure days Mon | Cheapest price $195 |
Operator Amtrak | Departure Time 10:10PM | Arrival Time 11:30AM | Duration 13h20 | Departure days Mon | Cheapest price $130 |
Live departures
San Diego, CA to South San Francisco, CA bus times
The table below shows live departures for San Diego, CA to South San Francisco, CA buses for today, Monday, February 16. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 FlixBus · FlixBus+ +FlixBus | 7:55 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 20h10 | 4:05 PM San Francisco, Townsend Street / 5th Street, CA | 3 transfers | |
| FlixBus · FlixBus+ | 7:55 PM San Diego, West Harbor Drive (The Headquarters at Seaport District), CA | 19h20 | 3:15 PM San Francisco, Transit Center Bay 29 | 2 transfers | |
| FlixBus++FlixBus | 11:25 PM San Diego, San Ysidro Transit Center | 16h40 | 4:05 PM San Francisco, Townsend Street / 5th Street, CA | 2 transfers | |
| FlixBus+ | 11:55 PM San Diego, Congress Street (Old Town Park), CA | 15h20 | 3:15 PM San Francisco, Transit Center Bay 29 | 1 transfer | |
| FlixBus++FlixBus | 11:55 PM San Diego, Congress Street (Old Town Park), CA | 16h10 | 4:05 PM San Francisco, Townsend Street / 5th Street, CA | 2 transfers | |
| FlixBus++FlixBus | 12:15 AM La Jolla, UCSD Health La Jolla Station, CA | 15h50 | 4:05 PM San Francisco, Townsend Street / 5th Street, CA | 2 transfers | |
| FlixBus+ | 12:15 AM La Jolla, UCSD Health La Jolla Station, CA | 15h00 | 3:15 PM San Francisco, Transit Center Bay 29 | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Diego, CA to South San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from San Diego, CA to South San Francisco, CA
USAUSA
Buses from San Diego, CA to South San Francisco, CA run on average 22 times per day, taking around 13h 41m. Cheap bus tickets for this journey start at $74 (€59) if you book in advance.
There are 3 buses per day. The earliest bus runs at 04:01, the last at 23:25. The fastest bus covers the 451 miles (727 km) distance in 13h 39m.
Distance 451 miles (727 km) |
Average bus duration 13h 41m |
Cheapest ticket price $74 (€59) |
Buses per day 22 |
Direct buses 3 |
Fastest bus 13h 39m |
First bus 04:01 |
Last bus 23:25 |
FAQs: Bus from San Diego, CA to South San Francisco, CA
Find answers to the most common questions about traveling from San Diego, CA to South San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.
popular bus stations
Popular bus stations from San Diego, CA to South San Francisco, CA
More options for your journey from San Diego, CA to South San Francisco, CA
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Most popular buses to and from South San Francisco, CA and San Diego, CA
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