Travel Information
Compare bus, train, and flight for San Diego, CA to South San Francisco, CA
Omio recommends booking the flight as it is the most popular option from San Diego, CA to South San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from €60. For those with little time consider booking a flight which can get you there in 1h 32m. The ticket price range depends on the travel mode: a bus costs an average of €60, and a flight costs an average of €125.
Distance: 451 miles (727 km)
Compare bus with
| Bus | Most popular Flight | Train |
|---|---|---|
€60 Average price Cheapest | €125 Average price | €96 Average price |
14h 9m Average total duration 13h 39m Onboard + 30m Additional time* | 4h 32m Average total duration Fastest 1h 32m Onboard + 3h 0m Additional time* | 14h 56m Average total duration 14h 26m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Compare prices and tickets San Diego, CA to South San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from San Diego, CA to South San Francisco, CA
Buses from San Diego, CA to South San Francisco, CA run on average 30 times per day, taking around 13h 39m. Cheap bus tickets for this journey start at $75 (€60) if you book in advance.
There are 4 buses per day. The earliest bus runs at 04:01, the last at 23:25. The fastest bus covers the 451 miles (727 km) distance in 13h 39m.
Distance 451 miles (727 km) |
Average bus duration 13h 39m |
Cheapest ticket price $75 (€60) |
Buses per day 30 |
Direct buses 4 |
Fastest bus 13h 39m |
First bus 04:01 |
Last bus 23:25 |
FAQs: Bus from San Diego, CA to South San Francisco, CA
Find answers to the most common questions about traveling from San Diego, CA to South San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.

To find the cheapest bus tickets for your trip from San Diego, CA to South San Francisco, CA, follow these tips:
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Popular bus stations from San Diego, CA to South San Francisco, CA
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