4.9
4.6
Travel Information
Compare bus, train, and flight for San Diego, CA to South San Francisco, CA
Omio recommends booking the flight as it is the most popular option from San Diego, CA to South San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from $67. For those with little time consider booking a flight which can get you there in 3h 24m. The ticket price range depends on the travel mode: a bus costs an average of $67, and a flight costs an average of $115.
Distance: 451 miles (727 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
$78 Average price Cheapest | $191 Average price | $88 Average price | $100 Average price (fuel + tolls) |
14h 9m Average total duration 13h 39m Onboard + 30m Additional time* | 6h 24m Average total duration Fastest 3h 24m Onboard + 3h 0m Additional time* | 14h 33m Average total duration 14h 3m Onboard + 30m Additional time* | 8h 3m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from San Diego, CA to South San Francisco, CA:
A bus is $11 (€9) less than a train for this route with tickets for a train from San Diego, CA to South San Francisco, CA costing on average $88 (€73).
A bus is $113 (€93) less than a flight for this route with tickets for a flight from San Diego, CA to South San Francisco, CA costing on average $191 (€157).
Other travel options to South San Francisco, CA take longer:
Bus takes on average 13h 39m.
Train takes on average 14h 3m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
San Diego, CA to South San Francisco, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Amtrak | Departure Time 06:10AM | Arrival Time 07:30PM | Duration 13h20 | Departure days Tue | Cheapest price $126 |
Operator Amtrak | Departure Time 03:01PM | Arrival Time 04:40AM | Duration 13h39 | Departure days Mon | Cheapest price $72 |
Operator Amtrak | Departure Time 04:01PM | Arrival Time 05:40AM | Duration 13h39 | Departure days Sat | Cheapest price $72 |
Operator Amtrak | Departure Time 11:01PM | Arrival Time 12:45PM | Duration 13h44 | Departure days Fri, Sat, Sun | Cheapest price $67 |
Compare prices and tickets San Diego, CA to South San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jul 08
Jul 09
Jul 10
Jul 11
Jul 12
Jul 13
Jul 14
Journey information
Overview: Bus from San Diego, CA to South San Francisco, CA
USAUSA
Buses from San Diego, CA to South San Francisco, CA run on average 14 times per day, taking around 13h 39m. Cheap bus tickets for this journey start at $67 (€55) if you book in advance.
There are 2 buses per day. The earliest bus runs at 04:01, the last at 23:25. The fastest bus covers the 451 miles (727 km) distance in 13h 20m.
Distance 451 miles (727 km) |
Average bus duration 13h 39m |
Cheapest ticket price $67 (€55) |
Buses per day 14 |
Direct buses 2 |
Fastest bus 13h 20m |
First bus 4:01 AM |
Last bus 11:25 PM |
Cheapest Month Feb |
Cheapest Day Sun |
High Season Apr - Jun |
Low Season Jul - Sep |
FAQs: Bus from San Diego, CA to South San Francisco, CA
Find answers to the most common questions about traveling from San Diego, CA to South San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.
popular bus stations
Popular bus stations from San Diego, CA to South San Francisco, CA
Most San Diego, CA to South San Francisco, CA buses use the San Diego, Congress Street (Old Town Park) to San Francisco, Transit Center Bay 29 station pair. Use this guide to compare San Diego, CA and South San Francisco, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Getting to San Diego, Congress Street (Old Town Park) from San Diego city centre
Getting to San Diego, San Ysidro Transit Center from San Diego city centre
More options for your journey from San Diego, CA to South San Francisco, CA
Here are some other resources that might have the information you need
Most popular buses to and from South San Francisco, CA and San Diego, CA
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
