The cheapest and fastest buses from San Diego, CA to South San Francisco, CA
Cheapest price
$73
Average price
$100
Fastest journey
13 h 20 m
Average duration
13 h 30 m
Buses per day
2
Distance
727 km
The best way to find a cheap bus ticket from San Diego, CA to South San Francisco, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Diego, CA to South San Francisco, CA will cost around $100 if you buy it on the day, but the cheapest tickets can be found for only $73.
Of the 2 buses that leave San Diego, CA for South San Francisco, CA on Mon, May 18, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, May 18 the direct buses cover the 727 km distance in an average of 13 h 30 m but if you time it right, some buses will get you there in just 13 h 20 m .
On Mon, May 18 the slowest buses will take 13 h 39 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
3:01 PM13h39San Diego, CA4:40 AMSouth San Francisco, CA$731One-way0 transfers
6:10 AM13h20San Diego, CA7:30 PMSouth San Francisco, CA$1281One-way0 transfers
6:10 AM13h20San Diego, CA7:30 PMSouth San Francisco, CA$1281One-way0 transfers
3:01 PM13h39San Diego, CA4:40 AMSouth San Francisco, CA$731One-way0 transfers
Travel Information
Compare bus, train, and flight for San Diego, CA to South San Francisco, CA
Omio recommends booking the train as it is the most popular option from San Diego, CA to South San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from $68. For those with little time consider booking a flight which can get you there in 3h 24m. The ticket price range depends on the travel mode: a bus costs an average of $68, and a flight costs an average of $117.
Distance: 451 miles (727 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$79 Average price Cheapest | $90 Average price | $194 Average price | $102 Average price (fuel + tolls) |
14h 9m Average total duration 13h 39m Onboard + 30m Additional time* | 14h 33m Average total duration 14h 3m Onboard + 30m Additional time* | 6h 24m Average total duration Fastest 3h 24m Onboard + 3h 0m Additional time* | 8h 3m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from San Diego, CA to South San Francisco, CA:
A bus is $11 (€9) less than a train for this route with tickets for a train from San Diego, CA to South San Francisco, CA costing on average $90 (€73).
A bus is $115 (€93) less than a flight for this route with tickets for a flight from San Diego, CA to South San Francisco, CA costing on average $194 (€157).
Other travel options to South San Francisco, CA take longer:
Bus takes on average 13h 39m.
Train takes on average 14h 3m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
San Diego, CA to South San Francisco, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Amtrak | Departure Time 06:10AM | Arrival Time 07:30PM | Duration 13h20 | Departure days Tue | Cheapest price $128 |
Operator Amtrak | Departure Time 03:01PM | Arrival Time 04:40AM | Duration 13h39 | Departure days Mon | Cheapest price $73 |
Operator Amtrak | Departure Time 04:01PM | Arrival Time 05:40AM | Duration 13h39 | Departure days Sat | Cheapest price $74 |
Operator Amtrak | Departure Time 11:01PM | Arrival Time 12:45PM | Duration 13h44 | Departure days Fri, Sat, Sun | Cheapest price $68 |
Live departures
San Diego, CA to South San Francisco, CA bus times
The table below shows live departures for San Diego, CA to South San Francisco, CA buses for today, Sunday, May 17. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 11:01 PM San Diego, CA | 13h44 | 12:45 PM South San Francisco, CA | 0 transfersDirect | |
| Monday, May 18 | |||||
![]() | 6:10 AM San Diego, CA | 13h20 | 7:30 PM South San Francisco, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Diego, CA to South San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
May 18
May 19
May 20
May 21
May 22
May 23
May 24
Journey information
Overview: Bus from San Diego, CA to South San Francisco, CA
Buses from San Diego, CA to South San Francisco, CA run on average 14 times per day, taking around 13h 39m. Cheap bus tickets for this journey start at $68 (€55) if you book in advance.
There are 2 buses per day. The earliest bus runs at 04:01, the last at 23:25. The fastest bus covers the 451 miles (727 km) distance in 13h 20m.
Distance 451 miles (727 km) |
Average bus duration 13h 39m |
Cheapest ticket price $68 (€55) |
Buses per day 14 |
Direct buses 2 |
Fastest bus 13h 20m |
First bus 4:01 AM |
Last bus 11:25 PM |
Cheapest Month Feb |
Cheapest Day Sun |
High Season Apr - Jun |
Low Season Jul - Sep |
FAQs: Bus from San Diego, CA to South San Francisco, CA
Find answers to the most common questions about traveling from San Diego, CA to South San Francisco, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.

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Popular bus stations from San Diego, CA to South San Francisco, CA
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