Travel Information
Compare train, bus, and flight for Avignon to Brussels
Omio recommends booking the train as it is the most popular option from Avignon to Brussels among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $101 For those with little time, consider booking a flight, which has an average total journey time of 3h 45m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.2 - 0.7kg. Average ticket prices depend on the travel mode: a bus costs an average of $101, while a flight costs an average of $130.
Distance: 477 miles (768 km)
Compare train with
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$103 Average price | $101 Average price Cheapest | $130 Average price | $263 Average price (fuel + tolls) |
5h 2m Average total duration 4h 32m Onboard + 30m Additional time* | 14h 8m Average total duration 13h 38m Onboard + 30m Additional time* | 3h 45m Average total duration Fastest 1h 45m Onboard + 2h 0m Additional time* | 9h 38m Average total duration (door-to-door) |
0.2 - 0.7kg CO2 emissions Lowest | 0.8 - 1.9kg CO2 emissions | 2.3 - 4.6kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Avignon to Brussels
Compare the available ways to get from Avignon to Brussels, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Avignon to Brussels:
A bus is $3 less than a train for this route with tickets for a train from Avignon to Brussels costing on average $103.
A bus is $29 less than a flight for this route with tickets for a flight from Avignon to Brussels costing on average $130.
Other travel options to Brussels take longer:
Train takes on average 5h 2m.
Bus takes on average 14h 8m.
The journey is about 5h 6m faster (4h 32m by train vs 9h 38m by car) and roughly $160 cheaper once you factor in fuel and tolls ($103 vs $263). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
Travel optionsfrom Avignon to Brussels
How to get from Avignon to Brussels by train, bus or flight.
Our recommendation
The best way to travel from Avignon to Brussels is by taking a bus because it’s the best combination of price and speed.
5808 · 165710:20 PM 13h40 Le Pontet, Avignon Gare de Bus (Ave. Charles de Gaulle) 12:00 PM Brussels, Brussels South (Gare du Midi) $49 1 One-way 1 transfer
Cheapest
5808 · 165710:20 PM 13h40 Le Pontet, Avignon Gare de Bus (Ave. Charles de Gaulle) 12:00 PM Brussels, Brussels South (Gare du Midi) $49 1 One-way 1 transfer
Fastest
98683:49 PM 4h55 Avignon TGV 8:44 PM Brussels-Midi $207 1 One-way 0 transfers
Other options
6124+
93874:41 PM 5h03 Avignon TGV 9:44 PM Brussels-Midi $132 1 One-way 1 transfer
6122+
93873:41 PM 6h03 Avignon TGV 9:44 PM Brussels-Midi $132 1 One-way 1 transfer
98825:49 PM 5h07 Avignon TGV 10:56 PM Brussels-Midi $134 1 One-way 0 transfers
FlixBus · FlixBus1:25 AM 15h20 Le Pontet, Avignon Gare de Bus (Ave. Charles de Gaulle) 4:45 PM Schaerbeek, Bd Roi Albert II (Bruxelles Gare Du Nord) $71 1 One-way 1 transfer
FlixBus · FlixBus · FlixBus7:00 PM 18h40 Le Pontet, Avignon Gare de Bus (Ave. Charles de Gaulle) 1:40 PM Brussels, Brussels South (Gare du Midi) $72 1 One-way 2 transfers
FlixBus · FlixBus2:55 PM 17h20 Le Pontet, Avignon Gare de Bus (Ave. Charles de Gaulle) 8:15 AM Brussels, Brussels South (Gare du Midi) $72 1 One-way 1 transfer
879527+
LH2261+
LH56308:48 AM 8h22 Avignon Centre 5:10 PM Brussels Airport $213 1 One-way 2 transfers
879539+
KL1470 · KL170712:52 PM 9h28 Avignon Centre 10:20 PM Brussels Airport $473 1 One-way 2 transfers
879533+
KL1470 · KL170711:53 AM 10h27 Avignon Centre 10:20 PM Brussels Airport $473 1 One-way 2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Avignon to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Avignon to Brussels.

This is compared to other travel options from Avignon to Brussels:
A bus is $3 less than a train for this route with tickets for a train from Avignon to Brussels costing on average $103.
A bus is $29 less than a flight for this route with tickets for a flight from Avignon to Brussels costing on average $130.
Other travel options to Brussels take longer:
Train takes on average 5h 2m.
Bus takes on average 14h 8m.
- Around 28 trains per day.
- Around 9 buses per day.
- Around 1 flights per day.
However, we recommend checking specific travel dates for your route between Avignon and Brussels as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Beziers Cap d'Agde Airport and arrive in Brussels South Charleroi Airport.
- Trains mostly depart from Avignon TGV and arrive in Brussels-Midi.
- Buses mostly depart from Le Pontet, Avignon Gare de Bus (Ave. Charles de Gaulle) and arrive in Brussels, Brussels South (Gare du Midi).
- Travel with Ryanair to go to Brussels by flight.
- Travel with FlixBus, BlaBlaCar Bus to go to Brussels by bus.
- Travel with SNCF | TGV INOUI, Eurostar, TER to go to Brussels by train.
- 1 direct flights per day with Ryanair.
- 2 direct trains per day with SNCF | TGV INOUI.
Travelling from Avignon to Brussels: related information
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