Travel Information
Compare train, bus, and flight for Avignon to Brussels
Omio recommends booking the train as it is the most popular option from Avignon to Brussels among Omio's users. If you are prioritising price take the flight with prices starting from $23. For those with little time consider booking a flight which can get you there in 2h 21m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.7kg. The ticket price range depends on the travel mode: a flight costs an average of $23, and a train costs an average of $48.
Distance: 477 miles (768 km)
Compare train with
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$191 Average price | $79 Average price | $78 Average price Cheapest | $267 Average price (fuel + tolls) |
5h 15m Average total duration 4h 45m Onboard + 30m Additional time* | 13h 17m Average total duration 12h 47m Onboard + 30m Additional time* | 5h 21m Average total duration Fastest 2h 21m Onboard + 3h 0m Additional time* | 9h 38m Average total duration (door-to-door) |
0.2 - 0.7kg CO2 emissions Lowest | 0.8 - 1.9kg CO2 emissions | 2.3 - 4.6kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Avignon to Brussels:
A flight is $1 (€1) less than a bus for this route with tickets for a bus from Avignon to Brussels costing on average $79 (€65).
A flight is $113 (€92) less than a train for this route with tickets for a train from Avignon to Brussels costing on average $191 (€156).
Other travel options to Brussels take longer:
Train takes on average 4h 45m.
Bus takes on average 12h 47m.
Travel optionsfrom Avignon to Brussels
How to get from Avignon to Brussels by train, bus or flight.
Our recommendation
The best way to travel from Avignon to Brussels is by taking a bus because it’s the best combination of price and speed.
FlixBus · FlixBus · FlixBus12:15 AM15h30Le Pontet, Avignon Gare de Bus (Ave. Charles de Gaulle)3:45 PMBrussels, Brussels South (Gare du Midi)$1221One-way2 transfers
Cheapest
FlixBus · FlixBus · FlixBus12:15 AM15h30Le Pontet, Avignon Gare de Bus (Ave. Charles de Gaulle)3:45 PMBrussels, Brussels South (Gare du Midi)$1221One-way2 transfers
Fastest
6106+
94357:33 AM5h44Avignon TGV1:17 PMBrussels-Midi$3021One-way1 transfer
Other options
32956+
94871:47 PM7h57Avignon TGV9:44 PMBrussels-Midi$2851One-way1 transfer
32956+
94891:47 PM8h30Avignon TGV10:17 PMBrussels-Midi$2851One-way1 transfer
32956+
93891:47 PM8h30Avignon TGV10:17 PMBrussels-Midi$2851One-way1 transfer
5808 · 165710:20 PM13h40Le Pontet, Avignon Gare de Bus (Ave. Charles de Gaulle)12:00 PMBrussels, Brussels South (Gare du Midi)$1651One-way1 transfer
FlixBus · FlixBus3:35 PM16h40Le Pontet, Avignon Gare de Bus (Ave. Charles de Gaulle)8:15 AMBrussels, Brussels South (Gare du Midi)$1731One-way1 transfer
FlixBus · FlixBus · FlixBus3:25 AM20h05Le Pontet, Avignon Gare de Bus (Ave. Charles de Gaulle)11:30 PMBrussels, Brussels South (Gare du Midi)$1971One-way2 transfers
17703+
VY1509 · VY89802:51 PM18h54Avignon Centre9:45 AMBrussels Airport$3791One-way2 transfers
886569+
VY1509 · VY89801:55 PM19h50Avignon Centre9:45 AMBrussels Airport$3791One-way2 transfers
879641+
VY1509 · VY898012:54 PM20h51Avignon Centre9:45 AMBrussels Airport$3791One-way2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Avignon to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Avignon to Brussels.

This is compared to other travel options from Avignon to Brussels:
A flight is $1 (€1) less than a bus for this route with tickets for a bus from Avignon to Brussels costing on average $79 (€65).
A flight is $113 (€92) less than a train for this route with tickets for a train from Avignon to Brussels costing on average $191 (€156).
Other travel options to Brussels take longer:
Train takes on average 4h 45m.
Bus takes on average 12h 47m.
- Around 11 flights per day.
- Around 9 buses per day.
- Around 6 trains per day.
However, we recommend checking specific travel dates for your route between Avignon and Brussels as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Marseille Provence Airport and arrive in Brussels Airport.
- Trains mostly depart from Avignon TGV and arrive in Brussels-Midi.
- Buses mostly depart from Le Pontet, Avignon Gare de Bus (Ave. Charles de Gaulle) and arrive in Brussels, Brussels South (Gare du Midi).
- Travel with Ryanair, Malta Air, Brussels Airlines, Vueling, Lufthansa to go to Brussels by flight.
- Travel with BlaBlaCar Bus, FlixBus, BlaBlaCar, Alsa to go to Brussels by bus.
- Travel with TGV, SNCF | TGV INOUI, Eurostar to go to Brussels by train.
- 3 direct flights per day with Ryanair, Malta Air, Brussels Airlines.
- 0 direct buses per day with BlaBlaCar.
- 2 direct trains per day with TGV, SNCF | TGV INOUI, Eurostar.
Travelling from Avignon to Brussels: related information
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