Travel Information
Compare bus, train, and flight for Prague to Wiesloch
Omio recommends booking the train as it is the most popular option from Prague to Wiesloch among Omio's users. If you are prioritising price take the bus with prices starting from €20. For those with little time consider booking a flight which can get you there in 4h 34m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.1 - 0.4kg. The ticket price range depends on the travel mode: a bus costs an average of €20, and a flight costs an average of €81.
Distance: 261 miles (421 km)
Compare train with
Most popular Train | Bus | Flight |
|---|---|---|
€41 Average price | €29 Average price Cheapest | €150 Average price |
8h 8m Average total duration 7h 38m Onboard + 30m Additional time* | 7h 18m Average total duration 6h 48m Onboard + 30m Additional time* | 7h 34m Average total duration Fastest 4h 34m Onboard + 3h 0m Additional time* |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.1kg CO2 emissions | 1.3 - 2.5kg CO2 emissions |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare prices and tickets Prague to Wiesloch by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Prague to Wiesloch trains with Omio?
Deutsche Bahn operates all train services from Prague to Wiesloch. Omio is the only official third party seller for Deutsche Bahn tickets.
Why book with Omio vs Deutsche Bahn?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Deutsche Bahn with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Prague to Wiesloch.
Why book with Omio over Trainline and Rail Europe?
- Official reseller: Deutsche Bahn tickets can only be bought on Omio or Deutsche Bahn's website as Omio is the only official third party seller for Deutsche Bahn tickets. Trainline, RailEurope, and Rail.Ninja do not sell Deutsche Bahn tickets as they are not official sellers.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Prague to Wiesloch.
Journey information
Overview: Train from Prague to Wiesloch
Trains from Prague to Wiesloch run on average 14 times per day, taking around 7h 38m. Cheap train tickets for this journey start at $41 (€33) but you can travel from only $25 (€20) by bus.
The earliest train runs at 01:09, the last at 22:59. The fastest train covers the 261 miles (421 km) distance in 8h 53m.
Distance 261 miles (421 km) |
Average train duration 7h 38m |
Cheapest ticket price $41 (€33) |
Trains per day 14 |
Fastest train 8h 53m |
First train 01:09 |
Last train 22:59 |
Train companies: Deutsche Bahn from Prague to Wiesloch trainsDeutsche Bahn trains will get you between Prague and Wiesloch from $25 (€20). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Deutsche Bahn
A Bordrestaurant (restaurant car) where you can sit and eat.
A Bordbistro (bistro bar) with snacks, hot meals, and drinks to-go.
At-seat service in 1st class: staff will take your order and serve food/drinks directly to your seat.
Regional trains (RE / RB / S-Bahn):
No onboard catering.
You’re welcome to bring your own food and drinks.
Not included by default.
You can add a seat reservation when booking (recommended for busy routes).
Costs around €4.90 per seat (or €5.90 if booked separately later).
First Class:
Yes, always included in the ticket price.
Allowed for free if they can fit in a transport box (max. size: hand luggage).
Must stay in the box for the entire journey.
Large dogs:
Require a separate (paid) ticket — typically half the price of a regular second-class ticket.
Must be leashed and wear a muzzle while on the train.
Cannot sit on seats.
Assistance dogs:
Travel free of charge.
Do not need a muzzle or leash if medically not required.
Allowed to accompany the passenger at all times.
FAQs: Trains from Prague to Wiesloch
Find answers to the most common questions about traveling from Prague to Wiesloch by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Wiesloch, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Prague to Wiesloch
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- The car park is open 7 days a week, 24 hours a day. Access via Wilsonova Street.
- Restaurant Fantova Kavárna
- Sushi Time
- Outside the main entrance.
- Elevators, ramps.
- CZK 10
- Hotel Esplanade Prague
- Falkensteiner Hotel Maria Prag
- Hotel City Central
- Cost CZK 100
- Located in the main hall
- Located in the main hall
- Avis
- Europcar
- Hertz
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-7 for trains to Germany, Austria, Slovakia, and regional destinations
- Hall 2: Metro connections
- Metro: Line C
- Tram: Lines 5, 9, 26
- Bus: Several lines available
- Monday: 08:00 13:30 - 12:30 16:30
- Tuesday: 08:00 13:30 - 12:30 16:30
- Wednesday: 08:00 13:30 - 12:30 16:30
- Thursday: 08:00 13:30 - 12:30 16:30
- Friday: 08:00 13:30 - 12:30 16:30
- Döner
- Ristorante Negroamaro
- Subway
- Xia Pavillon
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