Travel Information
Compare bus for Prague to Wiesloch
Omio recommends booking the bus as it is the most popular option from Prague to Wiesloch among Omio's users. If you are prioritising price take the bus with prices starting from $48. For those with little time consider booking a bus which can get you there in 6h 48m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.4 - 1.1kg. The ticket price range depends on the travel mode: a bus costs an average of $48, and a bus costs an average of $48.
Distance: 261 miles (421 km)
Compare bus with
Most popular Bus | Driving |
|---|---|
$48 Average price Cheapest | $95 Average price (fuel + tolls) |
7h 18m Average total duration Fastest 6h 48m Onboard + 30m Additional time* | 5h 29m Average total duration (door-to-door) |
0.4 - 1.1kg CO2 emissions Lowest | - CO2 emissions |
![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Other travel options to Wiesloch take longer:
Train takes on average 7h 38m.
Compare prices and tickets Prague to Wiesloch by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Prague to Wiesloch trains with Omio?
Why book with Omio vs Deutsche Bahn?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Journey information
Overview: Train from Prague to Wiesloch
Take a train from Prague to Wiesloch and enjoy the approximately 261 miles (421 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest train runs at 01:09, the last at 22:59.
Distance 261 miles (421 km) |
Average train duration 7h 38m |
Trains per day 12 |
First train 1:09 AM |
Last train 10:59 PM |
Cheapest Month May |
Cheapest Day Mon |
High Season Jan - Mar |
Low Season Jul - Sep |
Train companies: Deutsche Bahn from Prague to Wiesloch trainsDeutsche Bahn trains will get you between Prague and Wiesloch from $48 (€39). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Deutsche Bahn
A Bordrestaurant (restaurant car) where you can sit and eat.
A Bordbistro (bistro bar) with snacks, hot meals, and drinks to-go.
At-seat service in 1st class: staff will take your order and serve food/drinks directly to your seat.
Regional trains (RE / RB / S-Bahn):
No onboard catering.
You’re welcome to bring your own food and drinks.
Not included by default.
You can add a seat reservation when booking (recommended for busy routes).
Costs around €4.90 per seat (or €5.90 if booked separately later).
First Class:
Yes, always included in the ticket price.
Allowed for free if they can fit in a transport box (max. size: hand luggage).
Must stay in the box for the entire journey.
Large dogs:
Require a separate (paid) ticket — typically half the price of a regular second-class ticket.
Must be leashed and wear a muzzle while on the train.
Cannot sit on seats.
Assistance dogs:
Travel free of charge.
Do not need a muzzle or leash if medically not required.
Allowed to accompany the passenger at all times.
FAQs: Trains from Prague to Wiesloch
Find answers to the most common questions about traveling from Prague to Wiesloch by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Wiesloch, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Prague to Wiesloch
Most Prague to Wiesloch trains use the Praha hlavní nádraží to Wiesloch-Walldorf station pair. Use this guide to compare Prague and Wiesloch train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Which Prague station do trains to Wiesloch leave from?
Getting to Praha hlavní nádraží from Prague city centre
Praha hlavní nádraží is 1 km from Prague city centre. Public transport options include:
Praha hlavní nádraží train station facilities and services
Praha hlavní nádraží has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, Information Desk, and Luggage Carts.
Food and drink
Food options include: Restaurant Fantova Kavárna, Sushi Time
Wi-Fi and ATMs
Free. ATMs are available in the train station.
Tickets and information
Ticket office support is available at Praha hlavní nádraží. Information desks are located in the main hall.
Luggage and lost property
Luggage storage is available at Praha hlavní nádraží. Lost and found is available at the station.
Parking, taxis and toilets
Available at Praha hlavní nádraží: Parking, Taxis, WC.
Bike and car services
Available at Praha hlavní nádraží: Bike Parking, Bike Rental, Car Rental.
Accessibility
Accessibility facilities are available at Praha hlavní nádraží: Elevators, ramps.
Shops, hotels and contact
Nearby hotels include Hotel Esplanade Prague, Falkensteiner Hotel Maria Prag, Hotel City Central.
Getting to Praha Masarykovo Nádraží from Prague city centre
Praha Masarykovo Nádraží train station facilities and services
Praha Masarykovo Nádraží has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, Information Desk, and Luggage Carts.
Food and drink
Food options include: Restaurant Kotleta, Café Imperial
Wi-Fi and ATMs
Free. ATMs are available in the train station.
Tickets and information
Ticket office support is available at Praha Masarykovo Nádraží. Information desks are located in the main hall.
Luggage and lost property
Luggage storage is available at Praha Masarykovo Nádraží. Lost and found is available at the station.
Parking, taxis and toilets
Available at Praha Masarykovo Nádraží: Parking, Taxis, WC.
Bike and car services
Available at Praha Masarykovo Nádraží: Bike Parking, Bike Rental, Car Rental.
Accessibility
Accessibility facilities are available at Praha Masarykovo Nádraží: Ramps.
Shops, hotels and contact
Nearby hotels include Hotel Kings Court, Grand Hotel Bohemia, Hotel Paris Prague.
Which Wiesloch station do trains from Prague arrive at?
Getting to Wiesloch-Walldorf from Wiesloch city centre
Wiesloch-Walldorf is 2 km from Wiesloch city centre. Public transport options include:
Wiesloch-Walldorf train station facilities and services
Wiesloch-Walldorf has practical services for this route, including Wifi, Lockers, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food and drink
Food options include: Döner, Ristorante Negroamaro, Subway, Xia Pavillon
Wi-Fi and ATMs
Wi-Fi is available at Wiesloch-Walldorf. ATMs are available at Wiesloch-Walldorf.
Tickets and information
Ticket office support is available at Wiesloch-Walldorf. Information desks are available at Wiesloch-Walldorf.
Luggage and lost property
Luggage storage is available at Wiesloch-Walldorf. Lost and found is available at the station.
Parking, taxis and toilets
Available at Wiesloch-Walldorf: Parking, Taxis, WC.
Bike and car services
Available at Wiesloch-Walldorf: Bike Parking, Bike Rental, Car Rental.
Accessibility
Accessibility facilities are available at Wiesloch-Walldorf.
More options for your journey from Prague to Wiesloch
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