- Must visit
Musée des Beaux-Arts de Lyon
Major fine arts museum in a former abbey on Place des Terreaux, known for strong collections from antiquity to modern art.
Omio recommends booking the flight as it is the most popular option from Palermo to Lyon among Omio's users. If you are prioritising price take the bus with prices starting from $80. For those with little time consider booking a flight which can get you there in 2h 35m. The ticket price range depends on the travel mode: a bus costs an average of $80, and a flight costs an average of $26.
Distance: 684 miles (1102 km)
| Train | Most popular Flight | Bus | Driving |
|---|---|---|---|
$207 Average price | $287 Average price | $166 Average price Cheapest | $325 Average price (fuel + tolls) |
21h 53m Average total duration 21h 23m Onboard + 30m Additional time* | 5h 35m Average total duration Fastest 2h 35m Onboard + 3h 0m Additional time* | 29h 5m Average total duration 28h 35m Onboard + 30m Additional time* | 21h 12m Average total duration (door-to-door) |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Palermo to Lyon:
A bus is $41 (€33) less than a train for this route with tickets for a train from Palermo to Lyon costing on average $207 (€169).
A bus is $121 (€99) less than a flight for this route with tickets for a flight from Palermo to Lyon costing on average $287 (€234).
Other travel options to Lyon take longer:
Train takes on average 21h 23m.
Bus takes on average 28h 35m.
Tickets start at around $207 (€169) compared to roughly $325 (€265) in fuel and tolls — a saving of about $118 (€96). The journey takes 21h 23m versus 21h 12m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Palermo to Lyon trains for today, Friday, June 12. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:25 PM Palermo | 24h07 | 7:32 PM Lyon | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare bus, flight, and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Palermo to Lyon run on average 1 times per day, taking around 21h 23m. Cheap train tickets for this journey start at $168 (€137) but you can travel from only $26 (€21) by flight.
The earliest train runs at 05:46, the last at 21:10. The fastest train covers the 684 miles (1102 km) distance in 24h 7m.
Distance 684 miles (1102 km) |
Average train duration 21h 23m |
Cheapest ticket price $168 (€137) |
Trains per day 1 |
Fastest train 24h 7m |
First train 5:46 AM |
Last train 9:10 PM |
Cheapest Month Oct |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Mon |
Least Busy Day Mon |
Best time to book 42 days |
Discover the best of Lyon — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lyon trip today.
Major fine arts museum in a former abbey on Place des Terreaux, known for strong collections from antiquity to modern art.
Excellent museum on Roman Lyon with mosaics, inscriptions, and artifacts beside the ancient theaters on Fourvière hill.
Striking science and society museum at the meeting of the Rhône and Saône, famous for immersive displays and architecture.
The city's atmospheric old quarter with Renaissance lanes, traboules, courtyards, and a strong UNESCO heritage feel.
One of Europe's largest open squares and a key central meeting point in Lyon's Presqu'île.
Large urban park with lake, botanical spaces, greenhouses, and broad paths for walking and relaxing.
Light dumplings traditionally made with pike and baked in a rich Nantua crayfish sauce, a classic specialty of Lyonnais cuisine.
A warm salad of frisee lettuce, lardons, croutons, and a poached egg, emblematic of Lyon's hearty bouchon cooking.
Pork sausage baked inside a soft brioche loaf, a festive and traditional Lyonnais dish often served in bouchons.
An iconic fine-dining restaurant with deep Lyon culinary heritage, serving elegant cuisine in a prestigious setting.
A respected modern bouchon offering refined takes on Lyonnais classics in a warm and polished setting.
A historic bouchon known for classic Lyonnais dishes, convivial service, and a traditional, bustling atmosphere.
Moderate by French standards: bakeries and lunch deals are good value, while central hotels and dinner spots cost more.
Service is included by law. Rounding up or leaving 5-10% for very good restaurant service is appreciated, not required. Round up taxis; small change is fine in cafés and bars.
Official public transport app
Lyon Part-Dieu -> Bellecour, Lyon
Find answers to the most common questions about traveling from Palermo to Lyon by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lyon, this guide helps you travel smarter and with confidence.

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