- Must visit
Pinacoteca di Brera
One of Milan’s premier art museums, known for Italian masterpieces by Raphael, Caravaggio, and Mantegna in the historic Brera district.
Cheapest price
$149
Average price
$152
Fastest journey
21 h 15 m
Average duration
22 h 25 m
Trains per day
3
Distance
889 km
The best way to find a cheap train ticket from Palermo to Milan Centrale is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Palermo to Milan Centrale will cost around $152 if you buy it on the day, but the cheapest tickets can be found for only $149.
Of the 3 trains that leave Palermo for Milan Centrale on Mon, Jun 01, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, Jun 01 the direct trains cover the 889 km distance in an average of 22 h 25 m but if you time it right, some trains will get you there in just 21 h 15 m .
On Mon, Jun 01 the slowest trains will take 23 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.






Omio recommends booking the train as it is the most popular option from Palermo to Milan Centrale among Omio's users. If you are prioritising price take the ferry with prices starting from $75. For those with little time consider booking a flight which can get you there in 1h 47m. The ticket price range depends on the travel mode: a ferry costs an average of $75, and a train costs an average of $59.
Distance: 552 miles (889 km)
Most popular Train | Flight | Bus | Ferry | Driving |
|---|---|---|---|---|
$144 Average price | $105 Average price | $110 Average price | $89 Average price Cheapest | $123 Average price (fuel + tolls) |
16h 20m Average total duration 15h 50m Onboard + 30m Additional time* | 4h 47m Average total duration Fastest 1h 47m Onboard + 3h 0m Additional time* | 19h 26m Average total duration 18h 56m Onboard + 30m Additional time* | 22h 22m Average total duration 21h 22m Onboard + 1h 0m Additional time* | 25h 49m Average total duration (door-to-door) |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | ![]() Most popular ferry company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Palermo to Milan Centrale:
A ferry is $16 (€13) less than a flight for this route with tickets for a flight from Palermo to Milan Centrale costing on average $105 (€85).
A ferry is $21 (€17) less than a bus for this route with tickets for a bus from Palermo to Milan Centrale costing on average $110 (€89).
A ferry is $55 (€44) less than a train for this route with tickets for a train from Palermo to Milan Centrale costing on average $144 (€116).
Other travel options to Milan Centrale take longer:
Train takes on average 15h 50m.
Bus takes on average 18h 56m.
Ferry takes on average 21h 22m.
You'll arrive about 9h 59m sooner (15h 50m by train vs 25h 49m by car). Tickets start at around $144 (€116) compared to roughly $123 (€99) in fuel and tolls — so you're paying a bit more, but getting hours of your day back, a city-centre arrival, and the freedom to work or relax instead of drive.
Direct services run with Intercity Notte.
Driving makes more sense if you're travelling as a group (where fuel costs split several ways), want to stop along the way, or need a car once you arrive.
The table below shows live departures for Palermo to Milan Centrale trains for today, Sunday, May 31. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
InterCityNotte 1954+ FRECCIAROSSA 9612 | 6:48 PM Palermo Centrale | 16h10 | 10:58 AM Milan Centrale | 1 transfer | |
InterCityNotte 1958+ Intercity 588 · Intercity 608 | 9:10 PM Palermo Centrale | 20h35 | 5:45 PM Milan Centrale | 2 transfers | |
InterCityNotte 1958+ FRECCIAROSSA 9520 | 9:10 PM Palermo Centrale | 15h40 | 12:50 PM Milan Centrale | 1 transfer | |
InterCityNotte 1958+ FRECCIAROSSA 9520 · FRECCIAROSSA 9620 | 9:10 PM Palermo Centrale | 15h14 | 12:24 PM Milan Centrale | 2 transfers | |
InterCityNotte 1958+ Intercity 590 | 9:10 PM Palermo Centrale | 22h15 | 7:25 PM Milan Centrale | 1 transfer | |
![]() | 10:55 AM Palermo | 21h15 | 8:10 AM Milan Centrale | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Palermo to Milan Centrale run on average 7 times per day, taking around 15h 50m. Cheap train tickets for this journey start at $59 (€48) but you can travel from only $21 (€17) by flight.
There are 1 trains per day. The earliest train runs at 06:05, the last at 19:25. The fastest train covers the 552 miles (889 km) distance in 13h 55m.
Distance 552 miles (889 km) |
Average train duration 15h 50m |
Cheapest ticket price $59 (€48) |
Trains per day 7 |
Direct trains 1 |
Fastest train 13h 55m |
First train 6:05 AM |
Last train 7:25 PM |
Cheapest Month Feb |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Mon |
Least Busy Day Wed |
Discover the best of Milano Centrale — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Milano Centrale trip today.
One of Milan’s premier art museums, known for Italian masterpieces by Raphael, Caravaggio, and Mantegna in the historic Brera district.
The museum site hosting Leonardo da Vinci’s Last Supper at Santa Maria delle Grazie, one of Milan’s most sought-after cultural visits.
A leading museum of 20th-century Italian art overlooking Piazza del Duomo, with strong Futurist and modern collections.
Milan’s main square and the city’s symbolic heart, ideal for first-time visitors, landmark views, and people-watching.
A charming historic neighborhood of narrow streets, elegant buildings, galleries, and boutiques, popular for strolling and atmosphere.
Milan’s canal-side area known for scenic walks, bridges, and lively urban character, especially photogenic in the evening.
Creamy saffron risotto, the signature dish of Milan, prized for its rich flavor and golden color.
Breaded veal cutlet fried in butter, a classic Milanese main course with a crisp exterior and tender meat.
Braised veal shanks, often served with risotto, loved in Milan for its deep, slow-cooked flavor.
Elegant fine-dining venue at Excelsior Hotel Gallia near Milano Centrale, known for upscale Italian cuisine.
Established Michelin-starred restaurant celebrated for creative vegetarian cuisine and a distinctive fine-dining experience.
Well-known modern Milanese restaurant serving refined Lombard classics in a stylish, contemporary setting.
Generally pricier than many Italian cities, especially near the station. Budget eats are manageable, but hotels and sit-down dining cost more.
Service is often included or covered by a coperto charge. Tipping is not mandatory, but rounding up or leaving EUR 1-2 at cafes and 5-10% at restaurants for good service is appreciated.
Official public transport app
Milano Centrale, Milan -> Duomo di Milano, Milan
Find answers to the most common questions about traveling from Palermo to Milan Centrale by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Milan Centrale, this guide helps you travel smarter and with confidence.

Here are some other resources that might have the information you need