- Must visit
National Museum
Prague’s principal museum on Wenceslas Square, known for its grand Neo-Renaissance building and broad natural history, history, and culture collections.
Cheapest price
$77
Average price
$203
Fastest journey
11 h 10 m
Average duration
11 h 31 m
Trains per day
28
Distance
596 km
The best way to find a cheap train ticket from Luxembourg to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Luxembourg to Prague will cost around $203 if you buy it on the day, but the cheapest tickets can be found for only $77.
It's difficult to get from Luxembourg to Prague without transferring at least 3 times.
RE 5109 · ICE 1225 · 3571+
361
RE 5141 · 12551 · 12505 · ICE 1091
Bus 82110 · ICE 1091+
357
Bus 82126 · 4108 · ICE 370 · ICE 1653
Bus 82138 · 4118 · ICE 592 · RJ 479
Bus 82116 · 4146 · ICE 692 · IC 2443
Bus 82110 · ICE 1091 · ICE 694 · IC 2445
Bus 82118 · ICE 563 · 88617 · 3569
RE 5109 · 4102 · ICE 690 · IC 2441
RE 5119 · R 4263 · ICE 1655 · NJ 457Omio recommends booking the bus as it is the most popular option from Luxembourg to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $50. For those with little time consider booking a flight which can get you there in 2h 12m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $50, and a flight costs an average of $164.
Distance: 370 miles (596 km)
| Train | Most popular Bus | Flight | Driving |
|---|---|---|---|
$140 Average price | $71 Average price Cheapest | $289 Average price | $155 Average price (fuel + tolls) |
12h 4m Average total duration 11h 34m Onboard + 30m Additional time* | 11h 11m Average total duration 10h 41m Onboard + 30m Additional time* | 5h 12m Average total duration Fastest 2h 12m Onboard + 3h 0m Additional time* | 7h 6m Average total duration (door-to-door) |
0.2 - 0.5kg CO2 emissions Lowest | 0.6 - 1.5kg CO2 emissions | 1.8 - 3.6kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Luxembourg to Prague:
A bus is $69 (€56) less than a train for this route with tickets for a train from Luxembourg to Prague costing on average $140 (€114).
A bus is $218 (€177) less than a flight for this route with tickets for a flight from Luxembourg to Prague costing on average $289 (€234).
Other travel options to Prague take longer:
Bus takes on average 10h 41m.
Train takes on average 11h 34m.
Tickets start at around $140 (€114) compared to roughly $155 (€126) in fuel and tolls — a saving of about $15 (€12). The journey takes 11h 34m versus 7h 6m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Luxembourg to Prague trains for today, Friday, June 12. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
RE 5113 · R 4106 · ICE 598 · IC 2049 | On time 9:33 AM Luxembourg station | 11h52 | 9:25 PM Prague hlavní nádraží | 4 transfers | |
RE 5113 · 4106 · ICE 517+ 363 | On time 9:33 AM Luxembourg station | 12h49 | 10:22 PM Prague hlavní nádraží | 3 transfers | |
RE 5113 · 4106 · ICE 598 · IC 2049 | On time 9:33 AM Luxembourg station | 11h52 | 9:25 PM Prague hlavní nádraží | 4 transfers | |
RE 5117 · 4110 · ICE 596 · IC 2047 | On time 11:33 AM Luxembourg station | 11h58 | 11:31 PM Prague hlavní nádraží | 4 transfers | |
RE 5117 · R 4110 · ICE 596 · IC 2047 | On time 11:33 AM Luxembourg station | 11h58 | 11:31 PM Prague hlavní nádraží | 4 transfers | |
RE 5119 · R 4263 · ICE 1655 · NJ 457 | On time 12:33 PM Luxembourg station | 11h53 | 12:26 AM Prague hlavní nádraží | 3 transfers | |
Bus 82138 · 4118 · ICE 592 · RJ 479 | On time 4:05 PM Luxembourg station | 13h20 | 5:25 AM Prague hlavní nádraží | 3 transfers | |
Bus 82150 · 4122 · ICE 590 · 16501 | On time 6:10 PM Luxembourg station | 15h00 | 9:10 AM Prague hlavní nádraží | 6 transfers | |
RE 5133 · R 4132 · EC 459 | On time 7:33 PM Luxembourg station | 13h52 | 9:25 AM Prague hlavní nádraží | 2 transfers | |
Bus 82158 · 4132 · EC 459 | On time 8:05 PM Luxembourg station | 13h20 | 9:25 AM Prague hlavní nádraží | 2 transfers | |
Bus 82110 · ICE 1091 · ICE 694 · IC 2445 | On time 4:00 AM Luxembourg station | 11h14 | 3:14 PM Prague-Holešovice | 4 transfers | |
Bus 82110 · ICE 1091+ 357 | On time 4:00 AM Luxembourg station | 12h21 | 4:21 PM Prague hlavní nádraží | 2 transfers | |
R 5107 · ICE 25 · R 3567 · EC 359 | 6:10 AM Luxembourg station | 12h11 | 6:21 PM Prague hlavní nádraží | 3 transfers | |
Bus 82116 · 4146 · ICE 513+ 359 | On time 6:15 AM Luxembourg station | 12h06 | 6:21 PM Prague hlavní nádraží | 3 transfers | |
Bus 82116 · 4146 · ICE 692 · IC 2443 | On time 6:15 AM Luxembourg station | 11h10 | 5:25 PM Prague hlavní nádraží | 4 transfers | |
Bus 82118 · ICE 563+ 361 | On time 6:45 AM Luxembourg station | 13h36 | 8:21 PM Prague hlavní nádraží | 2 transfers | |
Bus 82118 · ICE 563 · 88617 · 3569 | On time 6:45 AM Luxembourg station | 11h36 | 6:21 PM Prague hlavní nádraží | 4 transfers | |
RE 5109 · 4102 · ICE 690 · IC 2441 | On time 7:33 AM Luxembourg station | 11h41 | 7:14 PM Prague-Holešovice | 4 transfers | |
RE 5109 · ICE 1225 · 3571+ 361 | On time 7:33 AM Luxembourg station | 12h48 | 8:21 PM Prague hlavní nádraží | 3 transfers | |
RE 5109 · ICE 1225 · R 3571 · EC 361 | On time 7:33 AM Luxembourg station | 12h48 | 8:21 PM Prague hlavní nádraží | 3 transfers | |
RE 5111 · R 4259 · ICE 1651 · rj 385 | On time 8:33 AM Luxembourg station | 12h52 | 9:25 PM Prague hlavní nádraží | 3 transfers | |
RE 5111 · 4259 · ICE 1651 · S1 | On time 8:33 AM Luxembourg station | 12h37 | 9:10 PM Prague hlavní nádraží | 5 transfers | |
RE 5111 · 4259 · ICE 1651 · RJ 385 | On time 8:33 AM Luxembourg station | 12h52 | 9:25 PM Prague hlavní nádraží | 3 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Luxembourg to Prague run on average 6 times per day, taking around 11h 34m. Cheap train tickets for this journey start at $73 (€59) but you can travel from only $50 (€41) by bus.
The earliest train runs at 00:30, the last at 23:54. The fastest train covers the 370 miles (596 km) distance in 11h 42m.
Distance 370 miles (596 km) |
Average train duration 11h 34m |
Cheapest ticket price $73 (€59) |
Trains per day 6 |
Fastest train 11h 42m |
First train 12:30 AM |
Last train 11:54 PM |
Cheapest Month Jul |
Cheapest Day Mon |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Wed |
Least Busy Day Sun |
Best time to book 63 days |
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Prague’s principal museum on Wenceslas Square, known for its grand Neo-Renaissance building and broad natural history, history, and culture collections.
A significant museum complex preserving Jewish history and heritage through synagogues, ceremonial objects, and exhibitions in Josefov.
A highly regarded design museum with glass, ceramics, fashion, graphics, and decorative arts in a historic building near the Old Town.
Prague’s ceremonial heart, surrounded by historic facades, churches, and major landmarks; essential for first-time visitors.
A picturesque historic district below Prague Castle with baroque streets, embassies, gardens, and a romantic atmosphere.
A major boulevard-like square central to modern Czech history, shopping, and public life, anchored by the National Museum.
Marinated beef sirloin with creamy root-vegetable sauce, bread dumplings, cranberry, and whipped cream. It is one of the best-known classic Czech festive dishes.
Roast pork served with dumplings and braised cabbage. This is a cornerstone of traditional Czech home-style cooking and pub menus.
Czech-style goulash is usually a rich beef stew with onions, paprika, and bread dumplings. It is a hearty staple often eaten in historic Prague pubs.
Established traditional restaurant known for duck, old-Bohemian recipes, and elegant historic interiors. A strong choice for a refined Czech meal.
Well-known Old Town restaurant offering polished Czech classics and seasonal dishes in a stylish but approachable atmosphere.
A famous modern Czech beer hall serving classic dishes, fresh Pilsner, and dependable traditional cooking in a lively central setting.
Moderate by European standards. Beer, transit, and casual meals are good value; central hotels cost more.
About 10% in restaurants for good service, often rounded up. Tip taxis modestly by rounding up. No tip needed for counter service, though small change is appreciated.
Official public transport app
Prague hlavní nádraží -> Old Town Square, Prague
Find answers to the most common questions about traveling from Luxembourg to Prague by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

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