Travel Information
Compare train, bus, and flight for Syracuse, NY to St. Louis, MO
Omio recommends booking the train as it is the most popular option from Syracuse, NY to St. Louis, MO among Omio's users. If you are prioritising price take the train with prices starting from €289. For those with little time consider booking a train which can get you there in 18h 23m. The ticket price range depends on the travel mode: a train costs an average of €289, and a bus costs an average of €312.
Distance: 794 miles (1278 km)
Compare train with
Most popular Train | Bus |
|---|---|
€289 Average price Cheapest | €352 Average price |
18h 53m Average total duration Fastest 18h 23m Onboard + 30m Additional time* | 29h 17m Average total duration 28h 47m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Syracuse, NY to St. Louis, MO train times
The table below shows live departures for Syracuse, NY to St. Louis, MO trains for today, Saturday, December 20. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 10:05 PM Syracuse, NY | 21h02 | 7:07 PM St. Louis, MO | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Syracuse, NY to St. Louis, MO by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Syracuse to St. Louis trains with Omio?
Amtrak operates all train services from Syracuse to St. Louis. Omio is the only official third party seller for Amtrak tickets.
Why book with Omio vs Amtrak?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Amtrak with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Syracuse to St. Louis.
Why book with Omio over Trainline and Rail Europe?
- Official reseller: Amtrak tickets can only be bought on Omio or Amtrak's website as Omio is the only official third party seller for Amtrak tickets. Trainline, RailEurope, and Rail.Ninja do not sell Amtrak tickets as they are not official sellers.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Syracuse to St. Louis.
Journey information
Overview: Train from Syracuse, NY to St. Louis, MO
Trains from Syracuse, NY to St. Louis, MO run on average 4 times per day, taking around 18h 23m. Cheap train tickets for this journey start at $360 (€289) if you book in advance.
The earliest train runs at 06:35, the last at 22:05. The fastest train covers the 794 miles (1278 km) distance in 21h 2m.
Distance 794 miles (1278 km) |
Average train duration 18h 23m |
Cheapest ticket price $360 (€289) |
Trains per day 4 |
Fastest train 21h 2m |
First train 06:35 |
Last train 22:05 |
Train companies: Amtrak from Syracuse, NY to St. Louis, MO trainsAmtrak trains will get you between Syracuse, NY and St. Louis, MO from $360 (€289). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
FAQs: Trains from Syracuse, NY to St. Louis, MO
Find answers to the most common questions about traveling from Syracuse, NY to St. Louis, MO by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Syracuse, NY to St. Louis, MO
- 6:00 AM - 10:00 PM Monday - Sunday
- Parking is available at the station.
- Dinosaur Bar-B-Que
- The Mission Restaurant
- Outside the main entrance.
- $1
- Embassy Suites by Hilton Syracuse
- Comfort Inn & Suites Airport
- Best Western Syracuse Downtown Hotel and Suites
- Located in the main hall
- Enterprise
- Located in the main hall
- Free
- Hall 1: main entrance, ticket office, and waiting area
- Hall 2: platforms for Amtrak and bus services
- Bus: Centro Bus Service
- Taxi: Available outside the station
- 5:30 AM - 10:00 PM Monday - Sunday
- Free
- Parking is available on-site with both short-term and long-term options.
- Landry's Seafood House
- The Station Grille
- Outside the main entrance.
- Ramps, restrooms.
- $1
- St. Louis Union Station Hotel, Curio Collection by Hilton
- Courtyard St. Louis Downtown West
- Drury Inn St. Louis at Union Station
- Located in the main hall
- Avis
- Enterprise
- Hertz
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-4 for Amtrak and regional trains
- Hall 2: MetroLink connections
- MetroLink: Red Line, Blue Line
- Bus: Several lines available including 40, 94, 97
More options for your journey from Syracuse, NY to St. Louis, MO
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