- Must visit
National Museum
Prague’s principal museum on Wenceslas Square, known for its grand Neo-Renaissance building and broad natural history, history, and culture collections.
Cheapest price
$49
Average price
$64
Fastest journey
9 h 58 m
Average duration
11 h
Buses per day
27
Distance
553 km
The best way to find a cheap bus ticket from Düsseldorf to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Düsseldorf to Prague will cost around $64 if you buy it on the day, but the cheapest tickets can be found for only $49.
Of the 27 buses that leave Düsseldorf for Prague on Sat, Jun 20, 7 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Jun 20 the direct buses cover the 553 km distance in an average of 11 h but if you time it right, some buses will get you there in just 9 h 58 m .
On Sat, Jun 20 the slowest buses will take 11 h 35 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
(Amsterdam -> Prague)
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
(Amsterdam -> Prague)
FlixBus
FlixBus · FlixBus
FlixBus · FlixBus
FlixBus · FlixBusOmio recommends booking the train as it is the most popular option from Düsseldorf to Prague among Omio's users. If you are prioritising price take the bus with prices starting from $36. For those with little time consider booking a flight which can get you there in 2h 7m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.5kg. The ticket price range depends on the travel mode: a bus costs an average of $36, and a flight costs an average of $75.
Distance: 343 miles (553 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$57 Average price Cheapest | $92 Average price | $227 Average price | $143 Average price (fuel + tolls) |
10h 36m Average total duration 10h 6m Onboard + 30m Additional time* | 9h 45m Average total duration 9h 15m Onboard + 30m Additional time* | 5h 7m Average total duration Fastest 2h 7m Onboard + 3h 0m Additional time* | 7h 48m Average total duration (door-to-door) |
0.6 - 1.4kg CO2 emissions | 0.2 - 0.5kg CO2 emissions Lowest | 1.7 - 3.3kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Düsseldorf to Prague:
A bus is $35 (€28) less than a train for this route with tickets for a train from Düsseldorf to Prague costing on average $92 (€75).
A bus is $170 (€139) less than a flight for this route with tickets for a flight from Düsseldorf to Prague costing on average $227 (€186).
Other travel options to Prague take longer:
Train takes on average 9h 15m.
Bus takes on average 10h 6m.
Tickets start at around $57 (€47) compared to roughly $143 (€117) in fuel and tolls — a saving of about $86 (€70). The journey takes 10h 6m versus 7h 48m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus, BlaBlaCar, Infobus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:30AM | Arrival Time 01:05PM | Duration 11h35 | Departure days Everyday | Cheapest price $41 |
Operator FlixBus | Departure Time 03:45AM | Arrival Time 05:35PM | Duration 13h50 | Departure days Everyday | Cheapest price $42 |
Operator FlixBus | Departure Time 07:15AM | Arrival Time 07:10PM | Duration 11h55 | Departure days Everyday | Cheapest price $41 |
Operator FlixBus | Departure Time 07:30AM | Arrival Time 07:10PM | Duration 11h40 | Departure days Everyday | Cheapest price $44 |
Operator BlaBlaCar Bus | Departure Time 08:15AM | Arrival Time 09:45AM | Duration 25h30 | Departure days Mon, Fri | Cheapest price $166 |
Operator FlixBus | Departure Time 08:38AM | Arrival Time 10:25PM | Duration 13h47 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $42 |
Operator FlixBus | Departure Time 09:15AM | Arrival Time 09:10PM | Duration 11h55 | Departure days Everyday | Cheapest price $43 |
Operator FlixBus | Departure Time 09:27AM | Arrival Time 12:25AM | Duration 14h58 | Departure days Mon, Sat | Cheapest price $62 |
Operator FlixBus | Departure Time 10:15AM | Arrival Time 12:25AM | Duration 14h10 | Departure days Mon, Tue, Wed, Fri, Sat | Cheapest price $41 |
Operator BlaBlaCar | Departure Time 01:00PM | Arrival Time 08:10PM | Duration 7h10 | Departure days Fri | Cheapest price $53 |
Operator FlixBus | Departure Time 02:00PM | Arrival Time 02:50AM | Duration 12h50 | Departure days Mon, Tue, Wed, Thu, Fri, Sat | Cheapest price $41 |
Operator BlaBlaCar | Departure Time 04:10PM | Arrival Time 11:40PM | Duration 7h30 | Departure days Fri | Cheapest price $40 |
Operator FlixBus | Departure Time 04:38PM | Arrival Time 07:15AM | Duration 14h37 | Departure days Fri | Cheapest price $113 |
Operator FlixBus | Departure Time 04:45PM | Arrival Time 07:00AM | Duration 14h15 | Departure days Mon, Tue, Fri, Sat, Sun | Cheapest price $42 |
Operator BlaBlaCar | Departure Time 05:40PM | Arrival Time 01:20AM | Duration 7h40 | Departure days Sat | Cheapest price $69 |
Operator FlixBus | Departure Time 06:20PM | Arrival Time 07:30AM | Duration 13h10 | Departure days Everyday | Cheapest price $40 |
Operator RegioJet a.s. | Departure Time 06:50PM | Arrival Time 04:48AM | Duration 9h58 | Departure days Everyday | Cheapest price $36 |
Operator FlixBus | Departure Time 10:35PM | Arrival Time 10:05AM | Duration 11h30 | Departure days Everyday | Cheapest price $40 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 10:10AM | Duration 10h40 | Departure days Everyday | Cheapest price $41 |
Operator FlixBus | Departure Time 11:59PM | Arrival Time 02:00PM | Duration 14h01 | Departure days Mon, Tue, Wed, Fri, Sat, Sun | Cheapest price $41 |
The table below shows live departures for Düsseldorf to Prague buses for today, Friday, June 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus | 7:15 AM Düsseldorf, ZOB am Hbf | 11h55 | 7:10 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 7:15 AM Düsseldorf, ZOB am Hbf | 12h45 | 8:00 PM Praha, M. Horákové (Hradčanská) | 1 transfer | |
FlixBus · FlixBus | 7:15 AM Düsseldorf, ZOB am Hbf | 15h10 | 10:25 PM Praha, Černý Most | 1 transfer | |
FlixBus | 7:30 AM Düsseldorf, ZOB am Hbf | 12h05 | 7:35 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus | 7:30 AM Düsseldorf, ZOB am Hbf | 11h40 | 7:10 PM Praha, Na Knížecí | 0 transfersDirect | |
FlixBus · FlixBus | 7:30 AM Düsseldorf, ZOB am Hbf | 12h20 | 7:50 PM Praha, Zličín | 1 transfer | |
50457 · 30512 | 8:15 AM Düsseldorf, ZOB am Hbf | 25h30 | 9:45 AM Praha, ÚAN Florenc | 1 transfer | |
FlixTrain+ FlixBus | 8:38 AM Düsseldorf Hbf | 13h47 | 10:25 PM Praha, Černý Most | 1 transfer | |
FlixTrain+ FlixBus · FlixBus | 8:38 AM Düsseldorf Hbf | 15h27 | 12:05 AM Praha, Na Knížecí | 2 transfers | |
FlixBus | 9:15 AM Düsseldorf, ZOB am Hbf | 11h55 | 9:10 PM Praha, Na Knížecí | 0 transfersDirect | |
FlixBus | 9:15 AM Düsseldorf, ZOB am Hbf | 12h15 | 9:30 PM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 10:15 AM Düsseldorf, ZOB am Hbf | 14h10 | 12:25 AM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 2:00 PM Düsseldorf, ZOB am Hbf | 12h50 | 2:50 AM Prague, Central Train Station | 1 transfer | |
FlixTrain+ FlixBus | 4:38 PM Düsseldorf Hbf | 14h37 | 7:15 AM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus | 4:45 PM Düsseldorf, ZOB am Hbf | 14h15 | 7:00 AM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 6:20 PM Düsseldorf, ZOB am Hbf | 12h35 | 6:55 AM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus · FlixBus | 6:20 PM Düsseldorf, ZOB am Hbf | 14h10 | 8:30 AM Praha, Zličín | 2 transfers | |
FlixBus · FlixBus | 6:20 PM Düsseldorf, ZOB am Hbf | 14h35 | 8:55 AM Praha, Na Knížecí | 1 transfer | |
(Amsterdam -> Prague) | 6:50 PM Düsseldorf, ZOB am Hbf | 9h58 | 4:48 AM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 10:35 PM Düsseldorf, ZOB am Hbf | 11h30 | 10:05 AM Praha, Na Knížecí | 1 transfer | |
FlixBus · FlixBus | 10:35 PM Düsseldorf, ZOB am Hbf | 12h45 | 11:20 AM Prague, Central Train Station | 1 transfer | |
FlixBus | 11:30 PM Düsseldorf, ZOB am Hbf | 10h40 | 10:10 AM Praha, ÚAN Florenc | 0 transfersDirect | |
FlixBus · FlixBus | 11:30 PM Düsseldorf, ZOB am Hbf | 12h00 | 11:30 AM Prague, Central Train Station | 1 transfer | |
FlixBus · FlixBus | 11:59 PM Düsseldorf, ZOB am Hbf | 12h01 | 12:00 PM Prague, Central Train Station | 1 transfer | |
| Saturday, June 20 | |||||
FlixBus · FlixBus | 1:30 AM Düsseldorf, ZOB am Hbf | 11h15 | 12:45 PM Praha, Na Knížecí | 1 transfer | |
FlixBus · FlixBus | 1:30 AM Düsseldorf, ZOB am Hbf | 11h35 | 1:05 PM Praha, ÚAN Florenc | 1 transfer | |
FlixBus · FlixBus | 3:45 AM Düsseldorf, ZOB am Hbf | 13h50 | 5:35 PM Praha, M. Horákové (Hradčanská) | 1 transfer | |
FlixBus · FlixBus | 3:45 AM Düsseldorf, ZOB am Hbf | 14h10 | 5:55 PM Praha, ÚAN Florenc | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Buses from Düsseldorf to Prague run on average 23 times per day, taking around 10h 6m. Cheap bus tickets for this journey start at $36 (€30) if you book in advance.
There are 6 buses per day. The earliest bus runs at 00:10, the last at 23:50. The fastest bus covers the 343 miles (553 km) distance in 9h 55m.
Distance 343 miles (553 km) |
Average bus duration 10h 6m |
Cheapest ticket price $36 (€30) |
Buses per day 23 |
Direct buses 6 |
Fastest bus 9h 55m |
First bus 12:10 AM |
Last bus 11:50 PM |
Cheapest Month Jul |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Thu |
Least Busy Day Mon |
Best time to book 70 days |
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Prague’s principal museum on Wenceslas Square, known for its grand Neo-Renaissance building and broad natural history, history, and culture collections.
A significant museum complex preserving Jewish history and heritage through synagogues, ceremonial objects, and exhibitions in Josefov.
A highly regarded design museum with glass, ceramics, fashion, graphics, and decorative arts in a historic building near the Old Town.
Prague’s ceremonial heart, surrounded by historic facades, churches, and major landmarks; essential for first-time visitors.
A picturesque historic district below Prague Castle with baroque streets, embassies, gardens, and a romantic atmosphere.
A major boulevard-like square central to modern Czech history, shopping, and public life, anchored by the National Museum.
Marinated beef sirloin with creamy root-vegetable sauce, bread dumplings, cranberry, and whipped cream. It is one of the best-known classic Czech festive dishes.
Roast pork served with dumplings and braised cabbage. This is a cornerstone of traditional Czech home-style cooking and pub menus.
Czech-style goulash is usually a rich beef stew with onions, paprika, and bread dumplings. It is a hearty staple often eaten in historic Prague pubs.
Established traditional restaurant known for duck, old-Bohemian recipes, and elegant historic interiors. A strong choice for a refined Czech meal.
Well-known Old Town restaurant offering polished Czech classics and seasonal dishes in a stylish but approachable atmosphere.
A famous modern Czech beer hall serving classic dishes, fresh Pilsner, and dependable traditional cooking in a lively central setting.
Moderate by European standards. Beer, transit, and casual meals are good value; central hotels cost more.
About 10% in restaurants for good service, often rounded up. Tip taxis modestly by rounding up. No tip needed for counter service, though small change is appreciated.
Official public transport app
Praha Hlavní Nádraží, Prague -> Václavské Náměstí, Prague
Find answers to the most common questions about traveling from Düsseldorf to Prague by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

Most Düsseldorf to Prague buses use the Düsseldorf, ZOB am Hbf to Praha, ÚAN Florenc station pair, with some services arriving at Praha, Hlavní Nádraží. Use this guide to compare Düsseldorf and Prague bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Düsseldorf, ZOB am Hbf is 1 km from Düsseldorf city centre. Public transport options include:
Düsseldorf, ZOB am Hbf has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria im ZOB (in the station), Brauerei Schumacher (0.5 km), Pizzeria Trattoria Romantica (0.7 km).
Free Wi-Fi. ATMs are located near the main entrance and throughout the station.
Ticket office support is available at Düsseldorf, ZOB am Hbf.
Available at Düsseldorf, ZOB am Hbf: Parking, Taxis, WC.
Accessibility facilities are available at Düsseldorf, ZOB am Hbf: Elevators, ramps.
Praha, ÚAN Florenc is 1 km from Prague city centre. Public transport options include:
Praha, ÚAN Florenc has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Florenc (in the station), Bistro Florenc (0.2 km), Restaurace U Rozvařilů (0.5 km).
Free Wi-Fi. ATMs are located inside the station, offering multiple currency options.
Ticket office support is available at Praha, ÚAN Florenc.
Available at Praha, ÚAN Florenc: Parking, Taxis, WC.
Accessibility facilities are available at Praha, ÚAN Florenc: Elevators, ramps.
Praha, Hlavní Nádraží is 1 km from Prague city centre. Public transport options include:
Praha, Hlavní Nádraží has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Czech Bistro (in the station), Fast Food Express (in the station), Bohemian Café (0.2 km).
Free Wi-Fi. ATMs are located near the main entrance and ticketing area.
Ticket office support is available at Praha, Hlavní Nádraží.
Available at Praha, Hlavní Nádraží: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Hlavní Nádraží: Elevators, ramps.
Praha, Na Knížecí is 2 km from Prague city centre. Public transport options include:
Praha, Na Knížecí has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, and WC.
Food options include: Café Na Knížecí (in the station), Bistro Praha (0.2 km), Restaurace U Knížete (0.5 km).
Free Wi-Fi. ATMs are located near the entrance.
Available at Praha, Na Knížecí: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Na Knížecí: Elevators, ramps.
Here are some other resources that might have the information you need