Travel Information
Compare flight and bus for Southampton to Brussels
Omio recommends booking the flight as it is the most popular option from Southampton to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from €85. For those with little time consider booking a flight which can get you there in 2h 0m. The ticket price range depends on the travel mode: a bus costs an average of €85, and a flight costs an average of €140.
Distance: 251 miles (404 km)
Compare bus with
| Bus | Most popular Flight |
|---|---|
€85 Average price Cheapest | €218 Average price |
12h 30m Average total duration 12h 0m Onboard + 30m Additional time* | 5h 0m Average total duration Fastest 2h 0m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Compare prices and tickets Southampton to Brussels by flight or bus
Compare flight and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Southampton to Brussels
Buses from Southampton to Brussels run on average 2 times per day, taking around 12h 0m. Cheap bus tickets for this journey start at $104 (€85) if you book in advance.
The earliest bus runs at 02:00, the last at 23:40. The fastest bus covers the 251 miles (404 km) distance in 12h 0m.
Distance 251 miles (404 km) |
Average bus duration 12h 0m |
Cheapest ticket price $104 (€85) |
Buses per day 2 |
Fastest bus 12h 0m |
First bus 02:00 |
Last bus 23:40 |
FAQs: Bus from Southampton to Brussels
Find answers to the most common questions about traveling from Southampton to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

- Grand Place, a UNESCO World Heritage site known for its opulent guildhalls and vibrant flower market
- Atomium, an iconic structure and museum offering panoramic views of the city
- Manneken Pis, a famous bronze statue symbolizing the irreverent spirit of Brussels
- Royal Palace of Brussels, the official palace of the Belgian king with impressive architecture and gardens
- Magritte Museum, dedicated to the works of surrealist artist René Magritte, featuring an extensive collection of his paintings and drawings.
- Explore the vibrant Marolles district, known for its eclectic mix of antique shops and street art
- Enjoy a leisurely stroll through the picturesque Parc du Cinquantenaire, home to impressive arches and museums
- Sample Belgian chocolates at one of the city's renowned chocolatiers
- Discover the lively atmosphere of the Saint-Géry district, filled with trendy bars and cafes
- Attend a performance at the historic La Monnaie opera house, showcasing world-class productions.
To find the cheapest bus tickets for your trip from Southampton to Brussels, follow these tips:
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