- Must visit
Muhammad Ali Center
Museum and archive exploring Muhammad Ali's life, boxing career, and humanitarian legacy through immersive exhibits.
Cheapest price on Oct 01
$64
Average ticket price on Oct 01
$64
Fastest journey on Oct 01
12 h 55 m
Average journey duration on Oct 01
12 h 55 m
Buses on Oct 01
1
Distance
523 km
The best way to find a cheap bus ticket from Roanoke, VA to Louisville, KY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Roanoke, VA to Louisville, KY will cost around $64 if you buy it on the day, but the cheapest tickets can be found for only $64.
It's difficult to get from Roanoke, VA to Louisville, KY without transferring at least once.
·
· | Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:45PM | Arrival Time 01:40AM | Duration 12h55 | Departure days Thu | Cheapest price $64 |
Operator Greyhound USA | Departure Time 12:50PM | Arrival Time 02:55AM | Duration 14h05 | Departure days Mon, Wed, Fri, Sat, Sun | Cheapest price $168 |
The table below shows live departures for Roanoke, VA to Louisville, KY buses for today, Wednesday, September 30. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:50 PM Roanoke, VA | 14h05 | 2:55 AM Louisville, KY | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Roanoke, VA to Louisville, KY run on average 1 times per day, taking around 11h 17m. Cheap bus tickets for this journey start at $88 if you book in advance.
The earliest bus runs at 12:50, the last at 14:20. The fastest bus covers the 324 miles (523 km) distance in 11h 15m.
Distance 324 miles (523 km) |
Average bus duration 11h 17m |
Cheapest ticket price $88 |
Buses per day 1 |
Fastest bus 11h 15m |
First bus 12:50 PM |
Last bus 2:20 PM |
Cheapest Month Jul |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Oct - Dec |
Discover the best of Louisville, KY — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Louisville, KY trip today.
Museum and archive exploring Muhammad Ali's life, boxing career, and humanitarian legacy through immersive exhibits.
Interactive museum at Churchill Downs covering racing history, Kentucky Derby traditions, and access to select track areas.
Regional art museum in the Speed family mansion area with global collections, modern works, and a sculpture garden.
Revitalized riverfront park with lawns, play areas, public art, and easy access to downtown trails and the Big Four Bridge.
Historic district known for dense Victorian architecture, local shops, and pleasant walking streets near Central Park.
Olmsted-designed urban park with scenic loops, woodlands, picnic areas, and a popular walking route around the reservoir.
Hot Brown is an open-faced turkey sandwich with bacon, tomato, and Mornay sauce, created at Louisville's Brown Hotel and closely tied to the city's dining history.
Benedictine is a Louisville sandwich spread made from cucumber and cream cheese. It is a local tea-room classic, often served on sandwiches or crackers.
Derby Pie is a Louisville dessert tart with chocolate chips and walnuts in a buttery crust, long associated with Derby season and local celebrations.
Refined restaurant in NuLu focused on seasonal American cooking with a thoughtful dining room and strong bourbon-friendly menu.
Longstanding local bakery and cafe best known for Derby Pie and other Louisville sweets in a casual, old-school setting.
Classic German-American beer hall atmosphere with house beers, sausages, schnitzel, and a long-running place in Louisville dining culture.
Moderate for U.S. city breaks: hotels and dining are mid-priced, while transit is limited so many visitors budget extra for rideshares or car hire.
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts for small tips.
Find answers to the most common questions about traveling from Roanoke, VA to Louisville, KY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Louisville, KY, this guide helps you travel smarter and with confidence.

Most Roanoke, VA to Louisville, KY buses use the Roanoke, Third Street Station to Louisville, W Broadway (Greyhound Bus Station) station pair. Use this guide to compare Roanoke, VA and Louisville, KY bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Roanoke, Third Street Station has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Roanoke, Third Street Station. ATMs are available at Roanoke, Third Street Station.
Ticket office support is available at Roanoke, Third Street Station.
Available at Roanoke, Third Street Station: Parking, Taxis, WC.
Accessibility facilities are available at Roanoke, Third Street Station: Station is wheelchair accessible.
Louisville, W Broadway (Greyhound Bus Station) is 1 km from Louisville city centre. Public transport options include:
Louisville, W Broadway (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Vending machines and nearby fast food restaurants.
Free WiFi available in the waiting area. ATMs are aTMs available inside the station.
Ticket office support is available at Louisville, W Broadway (Greyhound Bus Station).
Available at Louisville, W Broadway (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Louisville, W Broadway (Greyhound Bus Station): Wheelchair accessible entrances and facilities.
Here are some other resources that might have the information you need