The cheapest and fastest buses from Roanoke, VA to Louisville, KY
Cheapest price
$311
Average price
$311
Fastest journey
14 h 25 m
Average duration
14 h 25 m
Buses per day
1
Distance
523 km
The best way to find a cheap bus ticket from Roanoke, VA to Louisville, KY is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Roanoke, VA to Louisville, KY will cost around $311 if you buy it on the day, but the cheapest tickets can be found for only $311.
It's difficult to get from Roanoke, VA to Louisville, KY without transferring at least once.


Travel Information
Compare bus for Roanoke, VA to Louisville, KY
Omio recommends booking the bus as it is the most popular option from Roanoke, VA to Louisville, KY among Omio's users. If you are prioritising price take the bus with prices starting from €87. For those with little time consider booking a flight which can get you there in 6h 36m. The ticket price range depends on the travel mode: a bus costs an average of €87, and a flight costs an average of €323.
Distance: 324 miles (523 km)
Compare bus with
Most popular Bus | Flight |
|---|---|
€121 Average price Cheapest | €323 Average price |
13h 10m Average total duration 12h 40m Onboard + 30m Additional time* | 9h 36m Average total duration Fastest 6h 36m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options |
Live departures
Roanoke, VA to Louisville, KY bus times
The table below shows live departures for Roanoke, VA to Louisville, KY buses for tomorrow, Friday, November 7. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:35 PM Roanoke, VA | 14h25 | 3:00 AM Louisville, KY | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Roanoke, VA to Louisville, KY by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Nov 07
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Journey information
Overview: Bus from Roanoke, VA to Louisville, KY
Buses from Roanoke, VA to Louisville, KY run on average 1 times per day, taking around 12h 40m. Cheap bus tickets for this journey start at $106 (€87) if you book in advance.
The earliest bus runs at 12:50, the last at 14:20. The fastest bus covers the 324 miles (523 km) distance in 12h 40m.
Distance 324 miles (523 km) |
Average bus duration 12h 40m |
Cheapest ticket price $106 (€87) |
Buses per day 1 |
Fastest bus 12h 40m |
First bus 12:50 |
Last bus 14:20 |
Bus providers: Greyhound from Roanoke, VA to Louisville, KYYou can travel by bus between Roanoke, VA to Louisville, KY with Greyhound for as low as $106 (€87). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
FAQs: Bus from Roanoke, VA to Louisville, KY
Find answers to the most common questions about traveling from Roanoke, VA to Louisville, KY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Louisville, KY, this guide helps you travel smarter and with confidence.

- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
To find the cheapest bus tickets for your trip from Roanoke, VA to Louisville, KY, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- Greyhound
- $15 per additional bag.
popular bus stations
Popular bus stations from Roanoke, VA to Louisville, KY
Most popular bus connections from Roanoke, VA
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