- Must visit
The Children's Museum of Indianapolis
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Buses from Lafayette, LA to Indianapolis, IN run on average 10 times per day, taking around 25h 3m. Cheap bus tickets for this journey start at $90 if you book in advance.
The earliest bus runs at 02:00, the last at 23:55. The fastest bus covers the 737 miles (1187 km) distance in 20h 55m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Lafayette, LA to Indianapolis, IN.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 12:20AM | Arrival Time 09:45AM | Duration 33h25 | Departure days Thu | Cheapest price $240 |
Operator Greyhound | Departure Time 10:25PM | Arrival Time 01:25AM | Duration 27h00 | Departure days Wed | Cheapest price $206 |
Operator FlixBus | Departure Time 11:55PM | Arrival Time 02:25AM | Duration 26h30 | Departure days Fri | Cheapest price $158 |
Buses from Lafayette, LA to Indianapolis, IN with Greyhound and FlixBus. Overnight buses available on this route with Greyhound and FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Indianapolis, IN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Indianapolis, IN trip today.
World-class children's museum with science, history, dinosaurs, sports, and immersive exhibits. One of Indianapolis's signature attractions for all ages.
Leading art museum set on the Newfields campus, with major collections from Europe, Asia, Africa, and America plus temporary exhibitions.
Museum and restored home of the 23rd U.S. president. Guided visits reveal politics, domestic life, and architecture from the late 1800s.
Pedestrian-friendly downtown canal lined with museums, public art, and boats. Ideal for a scenic walk and one of the city's most popular areas.
Historic city center surrounding the Soldiers and Sailors Monument. A signature urban space for architecture, events, and classic downtown views.
Popular cultural trail linking downtown districts with public art, bike lanes, and green streetscape design. Perfect for exploring the city on foot.
Indiana pork tenderloin sandwich is a breaded, fried cutlet served on a bun, often comically oversized. It is a beloved statewide classic common in Indianapolis pubs and diners.
Sugar cream pie is Indiana's state pie, made with cream, sugar, and nutmeg. Its simple farm-pantry origins make it a traditional Hoosier dessert tied closely to local identity.
Shrimp cocktail in Indianapolis style features chilled shrimp with very spicy tomato-horseradish sauce. St. Elmo made this fiery version a city dining icon.
Established fine-dining restaurant serving seasonal Midwestern cuisine with polished service. Known for refined plates and a warm, contemporary atmosphere.
Historic downtown steakhouse famous for aged steaks and the city's iconic fiery shrimp cocktail. Classic, upscale atmosphere with longstanding local prestige.
Long-running Indianapolis institution known for classic steaks, seafood, and old-school service. A traditional downtown choice with historic local character.
Moderate for a U.S. city: hotels and dining are mid-range, while transit is limited so many visitors use rideshare or rental cars.
Tip 18-20% at restaurants, $1-$2 per drink at bars, and 10-15% for taxis. Small cafe tips are appreciated but optional.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Indianapolis, IN.
Find answers to the most common questions about traveling from Lafayette, LA to Indianapolis, IN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Indianapolis, IN, this guide helps you travel smarter and with confidence.

Most Lafayette, LA to Indianapolis, IN buses use the Lafayette, Lee Ave (Greyhound Bus Station) to Indianapolis, Illinois St (Greyhound Bus Station) station pair. Use this guide to compare Lafayette, LA and Indianapolis, IN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Lafayette, Lee Ave (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Lafayette, Lee Ave (Greyhound Bus Station). ATMs are available at Lafayette, Lee Ave (Greyhound Bus Station).
Ticket office support is available at Lafayette, Lee Ave (Greyhound Bus Station).
Available at Lafayette, Lee Ave (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Lafayette, Lee Ave (Greyhound Bus Station): Ramp access available.
Lafayette, TA Travel center is 3 km from Lafayette city centre. Public transport options include:
Lafayette, TA Travel center has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: There is a fast-food restaurant at the station.
Free Wi-Fi is available in the waiting area. ATMs are an ATM is available near the main entrance.
Ticket office support is available at Lafayette, TA Travel center.
Available at Lafayette, TA Travel center: Parking, Taxis, WC.
Accessibility facilities are available at Lafayette, TA Travel center: The station is wheelchair accessible.
Indianapolis, Illinois St (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Fast food outlets are available.
Free Wi-Fi is available throughout the station. ATMs are aTM is located near the entrance.
Ticket office support is available at Indianapolis, Illinois St (Greyhound Bus Station).
Available at Indianapolis, Illinois St (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Indianapolis, Illinois St (Greyhound Bus Station): The station is wheelchair accessible.
Check bus stations information for Lafayette, LA and Indianapolis, IN, including where buses depart and arrive on this route.