- Recommended
Spartanburg Science Center
Science and history museum with regional exhibits, a planetarium, and family-friendly programs in downtown Spartanburg.
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Journey information
Overview: Bus from Harrisburg, PA to Spartanburg, SC
USAUSA
Buses from Harrisburg, PA to Spartanburg, SC run on average 4 times per day, taking around 19h 9m. Cheap bus tickets for this journey start at $172 if you book in advance.
The earliest bus runs at 03:40, the last at 21:05. The fastest bus covers the 459 miles (740 km) distance in 15h 5m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 459 miles (740 km) |
Average bus duration 19h 9m |
Cheapest ticket price $172 |
Buses per day 4 |
Fastest bus 15h 5m |
First bus 3:40 AM |
Last bus 9:05 PM |
Cheapest Month Nov |
Cheapest Day Mon |
High Season Oct - Dec |
Low Season Jul - Sep |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Why should you book Harrisburg, PA to Spartanburg, SC buses with Omio?
Greyhound as well as FlixBus offer buses services from Harrisburg, PA to Spartanburg, SC.
Omio is an official ticket reseller for all your travel options from Harrisburg, PA to Spartanburg, SC.
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Harrisburg, PA to Spartanburg, SC.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Harrisburg, PA to Spartanburg, SC.
Bus providers: Greyhound, FlixBus from Harrisburg, PA to Spartanburg, SCYou can travel by bus between Harrisburg, PA to Spartanburg, SC with Greyhound, FlixBus for as low as $172. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
20h 55m
Cheapest FlixBus Price
$172
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
15h 5m
Cheapest Greyhound Price
$180
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Spartanburg, SC
Things to do in Spartanburg, SC
Discover the best of Spartanburg, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Spartanburg, SC trip today.
- Recommended
Spartanburg Art Museum
Art museum and gallery space on the Chapman Cultural Center campus, featuring rotating exhibitions and local artists.
- Recommended
Hub City Railroad Museum
Rail museum with historic locomotives, cars, and exhibits on regional railroad history near downtown Spartanburg.
- Must visit
Morgan Square
Central downtown square with shops, public art, seating, and frequent events; a practical starting point for exploring Spartanburg.
- Recommended
Mary Black Rail Trail
Popular urban greenway for walking and cycling, linking downtown with parks, public art, and neighborhood views.
- Recommended
Croft State Park
Large city park with trails, sports areas, gardens, and open space for a relaxed outdoor break close to downtown.
- Gluten-free
Mustard-Based Barbecue Pork
South Carolina-style pulled pork smoked low and slow, then finished with a tangy mustard barbecue sauce common across the Upstate and Midlands.
- Gluten-free
Whole Hog Barbecue
Pork shoulder smoked whole over wood, then chopped or pulled. It is a cornerstone of local barbecue culture in Spartanburg and the Upstate.
- Gluten-free
Southern Grits
Stone-ground corn grits simmered until creamy, often served at breakfast or with seafood. Grits are a longstanding Southern staple in local homes and diners.
The Peddler Steak House
Upscale downtown restaurant focused on contemporary American dishes, steaks, and cocktails in a polished historic space.
Mon Amie Morning Cafe
Established Southern meat-and-three restaurant with fried chicken, vegetables, casseroles, and homestyle desserts in a simple setting.
The Kennedy
Lively neighborhood restaurant serving burgers, sandwiches, salads, and broad craft beer selection in a relaxed downtown setting.
United States dollar ($)
Moderate for a U.S. city. Hotels and dining are usually cheaper than major metros, but car use and limited transit can raise total trip costs.
Average meal costs
- Budget
- $10-15 for fast food or casual lunch.
- Mid-range
- $18-35 per person for a sit-down meal.
- Fine dining
- $45+ per person for upscale dining.
- Coffee
- $3-5 for drip coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 10-15% for taxis, and $1-2 per drink or cafe order if there is table service.
FAQs: Bus from Harrisburg, PA to Spartanburg, SC
Find answers to the most common questions about traveling from Harrisburg, PA to Spartanburg, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Spartanburg, SC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Harrisburg, PA to Spartanburg, SC can start from as little as $172 when you book in advance. The average bus ticket price for Harrisburg, PA to Spartanburg, SC is $202 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Harrisburg, PA to Spartanburg, SC is 15h 5m to travel the 459 miles (740 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Harrisburg, PA to Spartanburg, SC leaves at 3:40 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Harrisburg, PA to Spartanburg, SC leaves at 9:05 PM.
There are 4 buses a day from Harrisburg, PA to Spartanburg, SC which require at least one change with Greyhound, FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Harrisburg, PA to Spartanburg, SC, you can count on Greyhound, FlixBus for the best way to get you to Spartanburg, SC. You can also check all possible bus companies who offer a service between Harrisburg, PA and Spartanburg, SC and compare the amenities they offer before buying a bus ticket.
Yes, you can take a between Harrisburg, PA and Spartanburg, SC.
Yes, the following accessibility options are available when taking the bus from Harrisburg, PA to Spartanburg, SC:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Harrisburg, PA to Spartanburg, SC for bus company Greyhound, FlixBus.
Whether you can cancel your bus ticket from Harrisburg, PA to Spartanburg, SC depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company Greyhound, FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Harrisburg, PA to Spartanburg, SC.
Yes, the following luggage options are included when booking a bus ticket from Harrisburg, PA to Spartanburg, SC:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Harrisburg, PA to Spartanburg, SC:
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Harrisburg, PA to Spartanburg, SC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Harrisburg, PA to Spartanburg, SC with the following bus company: Greyhound, FlixBus
Yes, there are USB plugs on board the bus from Harrisburg, PA to Spartanburg, SC with the following bus company: Greyhound, FlixBus.
Yes, there is Wifi on board the bus from Harrisburg, PA to Spartanburg, SC with the following bus company: Greyhound, FlixBus.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Spartanburg, SC, travelers should stay aware of common safety concerns such as petty theft and occasional vehicle break-ins, especially in parking areas near popular attractions. It’s advisable to avoid poorly lit or unfamiliar neighborhoods at night. Scams are not widespread but travelers should be cautious about unsolicited offers for transportation or tours, and only use licensed services to avoid overcharging or fraud. Staying alert and securing personal belongings can help ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
Most popular bus connections from Harrisburg, PA
More options for your journey from Harrisburg, PA to Spartanburg, SC
Here are some other resources that might have the information you need
Most popular buses to and from Spartanburg, SC and Harrisburg, PA
Most popular bus connections to Spartanburg, SC
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