- Recommended
Spartanburg Science Center
Science and history museum with regional exhibits, a planetarium, and family-friendly programs in downtown Spartanburg.
Buses from Jacksonville, FL to Spartanburg, SC run on average 2 times per day, taking around 10h 15m. Cheap bus tickets for this journey start at €78 if you book in advance.
The earliest bus runs at 03:40, the last at 21:45. The fastest bus covers the 319 miles (514 km) distance in 8h 20m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Jacksonville, FL to Spartanburg, SC.
Buses from Jacksonville, FL to Spartanburg, SC with FlixBus. Overnight buses available on this route with FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Spartanburg, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Spartanburg, SC trip today.
Science and history museum with regional exhibits, a planetarium, and family-friendly programs in downtown Spartanburg.
Art museum and gallery space on the Chapman Cultural Center campus, featuring rotating exhibitions and local artists.
Rail museum with historic locomotives, cars, and exhibits on regional railroad history near downtown Spartanburg.
Central downtown square with shops, public art, seating, and frequent events; a practical starting point for exploring Spartanburg.
Popular urban greenway for walking and cycling, linking downtown with parks, public art, and neighborhood views.
Large city park with trails, sports areas, gardens, and open space for a relaxed outdoor break close to downtown.
South Carolina-style pulled pork smoked low and slow, then finished with a tangy mustard barbecue sauce common across the Upstate and Midlands.
Pork shoulder smoked whole over wood, then chopped or pulled. It is a cornerstone of local barbecue culture in Spartanburg and the Upstate.
Stone-ground corn grits simmered until creamy, often served at breakfast or with seafood. Grits are a longstanding Southern staple in local homes and diners.
Upscale downtown restaurant focused on contemporary American dishes, steaks, and cocktails in a polished historic space.
Established Southern meat-and-three restaurant with fried chicken, vegetables, casseroles, and homestyle desserts in a simple setting.
Lively neighborhood restaurant serving burgers, sandwiches, salads, and broad craft beer selection in a relaxed downtown setting.
Moderate for a U.S. city. Hotels and dining are usually cheaper than major metros, but car use and limited transit can raise total trip costs.
Tip 18-20% at restaurants, 10-15% for taxis, and $1-2 per drink or cafe order if there is table service.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Spartanburg, SC.
Find answers to the most common questions about traveling from Jacksonville, FL to Spartanburg, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Spartanburg, SC, this guide helps you travel smarter and with confidence.

Most Jacksonville, FL to Spartanburg, SC buses use the Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St to station pair. Use this guide to compare Jacksonville, FL and Spartanburg, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St is 1 km from Jacksonville city centre. Public transport options include:
Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St. ATMs are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.
Ticket office support is available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St.
Available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Parking, Taxis, WC.
Accessibility facilities are available at Jacksonville, JTA Intercity Bus Terminal Bay 6 - 1111 W. Forsyth St: Wheelchair accessible entrances.