- Recommended
Spartanburg Science Center
Science and history museum with regional exhibits, a planetarium, and family-friendly programs in downtown Spartanburg.
The best way to find a cheap bus ticket from Tampa, FL to Spartanburg, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Tampa, FL to Spartanburg, SC will cost around $150 if you buy it on the day, but the cheapest tickets can be found for only $124.
On Thu, Nov 05, we found 3 buses from Tampa, FL to Spartanburg, SC, including 3 direct services.
On Thu, Nov 05 the direct buses cover the 780 km distance in an average of 19 h 35 m but if you time it right, some buses will get you there in just 16 h 25 m .
On Thu, Nov 05 the slowest buses will take 21 h 10 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Tampa, FL to Spartanburg, SC run on average 5 times per day, taking around 16h 0m. Cheap bus tickets for this journey start at $96 but you can travel from only $52 by flight.
The earliest bus runs at 04:04, the last at 22:35. The fastest bus covers the 484 miles (780 km) distance in 14h 10m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Tampa, FL to Spartanburg, SC.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:35AM | Arrival Time 11:45PM | Duration 21h10 | Departure days Wed, Thu, Fri | Cheapest price $124 |
Operator FlixBus | Departure Time 03:35AM | Arrival Time 12:45AM | Duration 21h10 | Departure days Thu, Fri | Cheapest price $167 |
Operator Greyhound | Departure Time 03:10PM | Arrival Time 07:35AM | Duration 16h25 | Departure days Wed, Thu | Cheapest price $159 |
The table below shows live departures for Tampa, FL to Spartanburg, SC buses for tomorrow, Wednesday, November 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:35 AM Tampa, FL | 21h10 | 11:45 PM Spartanburg, SC | 0 transfersDirect | |
![]() | 3:35 AM Tampa, FL | 21h10 | 12:45 AM Spartanburg, SC | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Tampa, FL to Spartanburg, SC with Greyhound and FlixBus. Overnight buses available on this route with Greyhound and FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Spartanburg, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Spartanburg, SC trip today.
Science and history museum with regional exhibits, a planetarium, and family-friendly programs in downtown Spartanburg.
Art museum and gallery space on the Chapman Cultural Center campus, featuring rotating exhibitions and local artists.
Rail museum with historic locomotives, cars, and exhibits on regional railroad history near downtown Spartanburg.
Central downtown square with shops, public art, seating, and frequent events; a practical starting point for exploring Spartanburg.
Popular urban greenway for walking and cycling, linking downtown with parks, public art, and neighborhood views.
Large city park with trails, sports areas, gardens, and open space for a relaxed outdoor break close to downtown.
South Carolina-style pulled pork smoked low and slow, then finished with a tangy mustard barbecue sauce common across the Upstate and Midlands.
Pork shoulder smoked whole over wood, then chopped or pulled. It is a cornerstone of local barbecue culture in Spartanburg and the Upstate.
Stone-ground corn grits simmered until creamy, often served at breakfast or with seafood. Grits are a longstanding Southern staple in local homes and diners.
Upscale downtown restaurant focused on contemporary American dishes, steaks, and cocktails in a polished historic space.
Established Southern meat-and-three restaurant with fried chicken, vegetables, casseroles, and homestyle desserts in a simple setting.
Lively neighborhood restaurant serving burgers, sandwiches, salads, and broad craft beer selection in a relaxed downtown setting.
Moderate for a U.S. city. Hotels and dining are usually cheaper than major metros, but car use and limited transit can raise total trip costs.
Tip 18-20% at restaurants, 10-15% for taxis, and $1-2 per drink or cafe order if there is table service.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Spartanburg, SC.
Find answers to the most common questions about traveling from Tampa, FL to Spartanburg, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Spartanburg, SC, this guide helps you travel smarter and with confidence.

Most Tampa, FL to Spartanburg, SC buses use the Tampa, Marion Transit Center to station pair. Use this guide to compare Tampa, FL and Spartanburg, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Tampa, Marion Transit Center has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Tampa, Marion Transit Center. ATMs are available at Tampa, Marion Transit Center.
Ticket office support is available at Tampa, Marion Transit Center.
Available at Tampa, Marion Transit Center: Parking, Taxis, WC.
Accessibility facilities are available at Tampa, Marion Transit Center: Wheelchair accessible with ramps.
Tampa, USF Holly Drive (Central Plant) is 13 km from Tampa city centre. Public transport options include:
Tampa, USF Holly Drive (Central Plant) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Tampa, USF Holly Drive (Central Plant). ATMs are available at Tampa, USF Holly Drive (Central Plant).
Ticket office support is available at Tampa, USF Holly Drive (Central Plant).
Available at Tampa, USF Holly Drive (Central Plant): Parking, Taxis, WC.
Accessibility facilities are available at Tampa, USF Holly Drive (Central Plant): Wheelchair accessible facilities.