- Recommended
Spartanburg Science Center
Science and history museum with regional exhibits, a planetarium, and family-friendly programs in downtown Spartanburg.
Buses from Orlando, FL to Spartanburg, SC run on average 6 times per day, taking around 13h 47m. Cheap bus tickets for this journey start at NOK 920 but you can travel from only NOK 419 by flight.
The earliest bus runs at 04:45, the last at 23:40. The fastest bus covers the 444 miles (715 km) distance in 11h 15m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Orlando, FL to Spartanburg, SC.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 02:55AM | Arrival Time 11:45PM | Duration 20h50 | Departure days Sat | Cheapest price NOK 1,750 |
Operator FlixBus | Departure Time 06:45PM | Arrival Time 07:35AM | Duration 12h50 | Departure days Tue | Cheapest price NOK 854 |
Operator FlixBus | Departure Time 08:15PM | Arrival Time 04:40PM | Duration 20h25 | Departure days Sat | Cheapest price NOK 1,597 |
Buses from Orlando, FL to Spartanburg, SC with FlixBus and Greyhound. Overnight buses available on this route with FlixBus and Greyhound. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Spartanburg, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Spartanburg, SC trip today.
Science and history museum with regional exhibits, a planetarium, and family-friendly programs in downtown Spartanburg.
Art museum and gallery space on the Chapman Cultural Center campus, featuring rotating exhibitions and local artists.
Rail museum with historic locomotives, cars, and exhibits on regional railroad history near downtown Spartanburg.
Central downtown square with shops, public art, seating, and frequent events; a practical starting point for exploring Spartanburg.
Popular urban greenway for walking and cycling, linking downtown with parks, public art, and neighborhood views.
Large city park with trails, sports areas, gardens, and open space for a relaxed outdoor break close to downtown.
South Carolina-style pulled pork smoked low and slow, then finished with a tangy mustard barbecue sauce common across the Upstate and Midlands.
Pork shoulder smoked whole over wood, then chopped or pulled. It is a cornerstone of local barbecue culture in Spartanburg and the Upstate.
Stone-ground corn grits simmered until creamy, often served at breakfast or with seafood. Grits are a longstanding Southern staple in local homes and diners.
Upscale downtown restaurant focused on contemporary American dishes, steaks, and cocktails in a polished historic space.
Established Southern meat-and-three restaurant with fried chicken, vegetables, casseroles, and homestyle desserts in a simple setting.
Lively neighborhood restaurant serving burgers, sandwiches, salads, and broad craft beer selection in a relaxed downtown setting.
Moderate for a U.S. city. Hotels and dining are usually cheaper than major metros, but car use and limited transit can raise total trip costs.
Tip 18-20% at restaurants, 10-15% for taxis, and $1-2 per drink or cafe order if there is table service.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Spartanburg, SC.
Find answers to the most common questions about traveling from Orlando, FL to Spartanburg, SC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Spartanburg, SC, this guide helps you travel smarter and with confidence.

Most Orlando, FL to Spartanburg, SC buses use the Orlando, N John Young Pkwy (Greyhound Bus Station) to station pair. Use this guide to compare Orlando, FL and Spartanburg, SC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Orlando, N John Young Pkwy (Greyhound Bus Station) is 3 km from Orlando city centre. Public transport options include:
Orlando, N John Young Pkwy (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Orlando, N John Young Pkwy (Greyhound Bus Station). ATMs are available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Ticket office support is available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Available at Orlando, N John Young Pkwy (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Orlando, N John Young Pkwy (Greyhound Bus Station): The station is accessible for individuals with disabilities.