- Must visit
Bowers Museum
Major Orange County museum campus with art exhibitions, family programs, and rotating contemporary and historical shows.
Flights from Denver, CO to Santa Ana, CA depart on average 83 times per day, taking around 5h 23m. Cheap flight tickets for this journey start at $138 but you can travel from only $100 by bus.
There are 6 flights per day. The earliest flight runs at 05:00, the last at 22:40. The fastest flight covers the 823 miles (1325 km) distance in 2h 25m. July is the cheapest month to fly.
Distance 823 miles (1325 km) |
Average flight duration 5h 23m |
Cheapest ticket price $138 |
Flights per day 83 |
Direct flights 6 |
Fastest flight 2h 25m |
First flight 5:00 AM |
Last flight 10:40 PM |
Cheapest Month Jul |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Oct - Dec |
Cheapest price on Sep 20
$93
Average ticket price on Sep 20
$117
Fastest journey on Sep 20
2 h 36 m
Average journey duration on Sep 20
11 h 32 m
Flights on Sep 20
2
Distance
1325 km
The best way to find a cheap flight ticket from Denver, CO to Santa Ana, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Denver, CO to Santa Ana, CA will cost around $117 if you buy it on the day, but the cheapest tickets can be found for only $93.
On Sun, Sep 20, we found 2 flights from Denver, CO to Santa Ana, CA, including 2 direct services.
On Sun, Sep 20 the direct flights cover the 1325 km distance in an average of 11 h 32 m but if you time it right, some flights will get you there in just 2 h 36 m .
On Sun, Sep 20 the longest flights will take 20 h 27 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Omio recommends booking the bus as it is the most popular option from Denver, CO to Santa Ana, CA among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $146 For those with little time, consider booking a flight, which has an average total journey time of 7h 23m. Average ticket prices depend on the travel mode: a bus costs an average of $146, while a flight costs an average of $759.
Distance: 823 miles (1325 km)
| Flight | Most popular Bus | Train | Driving |
|---|---|---|---|
$759 Average price | $146 Average price Cheapest | $208 Average price (fuel + tolls) | |
7h 23m Average total duration Fastest 5h 23m Onboard + 2h 0m Additional time* | 29h 52m Average total duration 29h 22m Onboard + 30m Additional time* | 14h 51m Average total duration (door-to-door) | |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Denver, CO to Santa Ana, CA:
A bus is $613 less than a flight for this route with tickets for a flight from Denver, CO to Santa Ana, CA costing on average $759.
Other travel options to Santa Ana, CA take longer:
Bus takes on average 29h 22m.
The table below shows live departures for Denver, CO to Santa Ana, CA flights for today, Saturday, September 19. You can also manually refresh the results below to see updated flight journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 3:49 PM Denver, CO | 2h36 | 6:25 PM Santa Ana, CA | 0 transfersDirect | |
| Sunday, September 20 | |||||
![]() | 4:29 AM Denver, CO | 20h27 | 12:56 AM Santa Ana, CA | 0 transfersDirect | |
This is the last flight of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of Santa Ana, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Santa Ana, CA trip today.
Major Orange County museum campus with art exhibitions, family programs, and rotating contemporary and historical shows.
Hands-on science museum with interactive exhibits, a Discovery Cube, and family-friendly learning in downtown Santa Ana.
Small local museum preserving Orange County aviation and aerospace history with artifacts, photos, and volunteer-led interpretation.
Walkable downtown district with historic buildings, murals, shops, galleries, and regular arts and community events.
Lively pedestrian-friendly arts corridor known for galleries, murals, boutiques, and monthly art-focused street activity.
Historic neighborhood of preserved early 20th-century homes, ideal for architecture walks and seasonal house tours.
Find answers to the most common questions about traveling from Denver, CO to Santa Ana, CA by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Santa Ana, CA, this guide helps you travel smarter and with confidence.

Most Denver, CO to Santa Ana, CA flights use the Denver International Airport to John Wayne Airport airport pair. Use this guide to compare Denver, CO and Santa Ana, CA airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Denver International Airport is 18 km from Denver city centre. Public transport options include:
Denver International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food options include: Various restaurants in Jeppesen terminal and concourses, including American and intertiol cuisine.
Free Wi-Fi available throughout the airport. ATMs are located throughout the terminal and concourses.
Lost and found is available at the station.
Available at Denver International Airport: Parking, Taxis, WC.
Available at Denver International Airport: Car Rental.
Accessibility facilities are available at Denver International Airport: Elevators, ramps.
Nearby hotels include Westin Hotel connected to the terminal..
John Wayne Airport is 3 km from Santa Ana city centre. Public transport options include:
John Wayne Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food options include: Located in terminals; options include fast food and sit-down restaurants like McDold's and Ruby's Diner
Free Wi-Fi available throughout the airport. ATMs are located in all terminals.
Lost and found is available at the station.
Available at John Wayne Airport: Parking, Taxis, WC.
Available at John Wayne Airport: Car Rental.
Accessibility facilities are available at John Wayne Airport: Elevators, ramps.
Nearby hotels include Hotels within walking distance, Hilton Irvine/Orange County Airport..
Here are some other resources that might have the information you need