- Must visit
Museo Civico
Siena’s main civic museum displays Lorenzetti’s frescoes and superb medieval art inside the historic town hall. It is essential for understanding the city.
The best way to find a cheap bus ticket from Brindisi to Siena is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Brindisi to Siena will cost around €38 if you buy it on the day, but the cheapest tickets can be found for only €22.
On Mon, Nov 02, we found 5 buses from Brindisi to Siena, including 5 direct services.
On Mon, Nov 02 the direct buses cover the 622 km distance in an average of 12 h 13 m but if you time it right, some buses will get you there in just 11 h 15 m .
On Mon, Nov 02 the slowest buses will take 12 h 59 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Brindisi to Siena run on average 11 times per day, taking around 10h 54m. Cheap bus tickets for this journey start at €9 if you book in advance.
There are 2 buses per day. The earliest bus runs at 00:05, the last at 23:39. The fastest bus covers the 386 miles (622 km) distance in 9h 44m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Brindisi to Siena.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Itabus | Departure Time 03:30AM | Arrival Time 03:50PM | Duration 12h20 | Departure days Thu | Cheapest price €54 |
Operator Marino Autolinee | Departure Time 03:35AM | Arrival Time 02:50PM | Duration 11h15 | Departure days Mon | Cheapest price €53 |
Operator Itabus | Departure Time 04:30AM | Arrival Time 05:30PM | Duration 13h00 | Departure days Thu | Cheapest price €36 |
Operator Itabus | Departure Time 05:30AM | Arrival Time 05:50PM | Duration 12h20 | Departure days Sun | Cheapest price €65 |
Operator Marino Autolinee | Departure Time 05:35AM | Arrival Time 04:50PM | Duration 11h15 | Departure days Sun | Cheapest price €55 |
Operator FlixBus | Departure Time 07:55AM | Arrival Time 07:49PM | Duration 11h54 | Departure days Mon | Cheapest price €34 |
Operator Itabus | Departure Time 10:05AM | Arrival Time 11:04PM | Duration 12h59 | Departure days Mon, Wed, Thu, Sat | Cheapest price €21 |
Operator Itabus | Departure Time 11:05AM | Arrival Time 12:04AM | Duration 12h59 | Departure days Mon, Thu, Fri, Sat | Cheapest price €28 |
Operator Itabus | Departure Time 12:05PM | Arrival Time 01:04AM | Duration 12h59 | Departure days Sun | Cheapest price €45 |
Operator FlixBus | Departure Time 12:40PM | Arrival Time 12:40AM | Duration 12h00 | Departure days Sun | Cheapest price €94 |
Operator Itabus | Departure Time 04:55PM | Arrival Time 09:20AM | Duration 16h25 | Departure days Sun | Cheapest price €43 |
Operator Marino Autolinee | Departure Time 06:50PM | Arrival Time 06:45AM | Duration 11h55 | Departure days Wed, Sat | Cheapest price €38 |
Operator Marino Autolinee | Departure Time 08:50PM | Arrival Time 08:45AM | Duration 11h55 | Departure days Sun | Cheapest price €48 |
Operator Itabus | Departure Time 08:50PM | Arrival Time 08:50AM | Duration 12h00 | Departure days Mon, Fri, Sat | Cheapest price €39 |
Operator FlixBus | Departure Time 09:30PM | Arrival Time 09:15AM | Duration 11h45 | Departure days Sun | Cheapest price €91 |
Operator Itabus | Departure Time 09:50PM | Arrival Time 09:50AM | Duration 12h00 | Departure days Tue, Wed, Fri, Sat | Cheapest price €24 |
Operator Itabus | Departure Time 10:50PM | Arrival Time 10:50AM | Duration 12h00 | Departure days Sun | Cheapest price €55 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 02:50PM | Duration 15h20 | Departure days Sun | Cheapest price €90 |
The table below shows live departures for Brindisi to Siena buses for today, Sunday, November 1. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
1120 · 2400 | 5:30 AM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 12h20 | 5:50 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 1 transfer | |
206 | 5:35 AM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 11h15 | 4:50 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 0 transfersDirect | |
1104 · 2494 | 12:05 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 12h59 | 1:04 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 1 transfer | |
FlixBus · FlixBus | 12:40 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 12h00 | 12:40 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 1 transfer | |
2214 · 1121 | 4:55 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 16h25 | 9:20 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 1 transfer | |
107 | 8:50 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 11h55 | 8:45 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 0 transfersDirect | |
FlixBus · FlixBus | 9:30 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 11h45 | 9:15 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 1 transfer | |
1108 · 2126 | 10:50 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 12h00 | 10:50 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 11:30 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 15h20 | 2:50 PM Siena, Siena/Viale Pietro Toselli | 2 transfers | |
FlixBus · FlixBus | 11:30 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 11h55 | 11:25 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 1 transfer | |
Find all the dates and times for this journey
Buses from Brindisi to Siena with FlixBus, Itabus, and Marino Autolinee. Overnight buses available on this route with FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Siena — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Siena trip today.
Siena’s main civic museum displays Lorenzetti’s frescoes and superb medieval art inside the historic town hall. It is essential for understanding the city.
This major museum complex occupies a former hospital and combines archaeology, frescoes, chapels, and underground spaces in a memorable setting.
The cathedral museum preserves sculptures, stained glass, and treasures from the Duomo complex, including close views of masterpieces and architecture.
Siena’s iconic shell-shaped square is the social and visual heart of the city, perfect for architecture, people-watching, and understanding the Palio.
This broad square in front of the cathedral frames some of Siena’s finest Gothic monuments and is a natural stop on any walking route.
The city’s main pedestrian street links major sights with shops and noble facades. It is ideal for a first walk through Siena’s historic core.
Thick rustic soup of bread, beans, cavolo nero and vegetables. A Tuscan staple in Siena, prized for peasant roots and deep, comforting flavor.
Dense vegetable and bread soup made with beans, tomato, onion, celery and stale bread. Traditional cucina povera, often linked to Sienese home cooking.
Hand-rolled thick spaghetti, usually served with rich garlic-forward tomato sauce or duck ragù. A classic Tuscan pasta common in Siena trattorie.
Popular central trattoria focused on pici, ribollita and other regional staples, offering a casual atmosphere near major sights.
Well-known osteria for classic Tuscan and Sienese dishes, with a cozy brick interior and strong local wine selection.
Elegant Michelin-starred restaurant near Piazza del Campo, known for refined Tuscan tasting menus and polished historic atmosphere.
Moderate for Italy: lodging and dining cost more than small towns, but transit is limited and many sights are walkable.
Service is often included or covered by coperto. Round up or leave 5-10% for great restaurant service; taxis are usually rounded up; cafés need no tip.
Official public transport app
Siena, Stazione FS (Piazzale Carlo Rosselli) -> Piazza del Campo, Siena
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Siena.
Find answers to the most common questions about traveling from Brindisi to Siena by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Siena, this guide helps you travel smarter and with confidence.

Most Brindisi to Siena buses use the Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) to Siena, Stazione FS (Piazzale Carlo Rosselli) station pair, with some services arriving at Siena, Siena/Viale Pietro Toselli. Use this guide to compare Brindisi and Siena bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Brindisi has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Cafes and small eateries nearby.
Wi-Fi is available at Brindisi. ATMs are available at Brindisi.
Ticket office support is available at Brindisi.
Available at Brindisi: Parking, Taxis, WC.
Accessibility facilities are available at Brindisi: Wheelchair ramps available.
Siena, Stazione FS (Piazzale Carlo Rosselli) is 1 km from Siena city centre. Public transport options include:
Siena, Stazione FS (Piazzale Carlo Rosselli) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Cafeteria and vending machines available.
Wi-Fi is available at Siena, Stazione FS (Piazzale Carlo Rosselli). ATMs are available at Siena, Stazione FS (Piazzale Carlo Rosselli).
Ticket office support is available at Siena, Stazione FS (Piazzale Carlo Rosselli).
Available at Siena, Stazione FS (Piazzale Carlo Rosselli): Parking, Taxis, WC.
Accessibility facilities are available at Siena, Stazione FS (Piazzale Carlo Rosselli): Wheelchair ramps are provided.
Siena, Siena/Viale Pietro Toselli is 1 km from Siena city centre. Public transport options include:
Siena, Siena/Viale Pietro Toselli has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Nearby cafes and fast food available.
Wi-Fi is available at Siena, Siena/Viale Pietro Toselli. ATMs are available at Siena, Siena/Viale Pietro Toselli.
Ticket office support is available at Siena, Siena/Viale Pietro Toselli.
Available at Siena, Siena/Viale Pietro Toselli: Parking, Taxis, WC.
Accessibility facilities are available at Siena, Siena/Viale Pietro Toselli: Ramps and accessible paths available.
Siena, P.za Gramsc has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Siena, P.za Gramsc. ATMs are available at Siena, P.za Gramsc.
Ticket office support is available at Siena, P.za Gramsc.
Available at Siena, P.za Gramsc: Parking, Taxis, WC.
Accessibility facilities are available at Siena, P.za Gramsc: The station is accessible with ramps and lowered curbs.