The cheapest and fastest buses from Brindisi to Siena
Cheapest price
$38
Average price
$61
Fastest journey
11 h 55 m
Average duration
13 h 57 m
Buses per day
3
Distance
622 km
The best way to find a cheap bus ticket from Brindisi to Siena is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Brindisi to Siena will cost around $61 if you buy it on the day, but the cheapest tickets can be found for only $38.
Of the 3 buses that leave Brindisi for Siena on Wed, Nov 05, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Nov 05 the direct buses cover the 622 km distance in an average of 13 h 57 m but if you time it right, some buses will get you there in just 11 h 55 m .
On Wed, Nov 05 the slowest buses will take 15 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.






Travel Information
Compare bus, train, and flight for Brindisi to Siena
Omio recommends booking the bus as it is the most popular option from Brindisi to Siena among Omio's users. If you are prioritising price take the bus with prices starting from €15. For those with little time consider booking a flight which can get you there in 2h 36m. The ticket price range depends on the travel mode: a bus costs an average of €15, and a flight costs an average of €28.
Distance: 386 miles (622 km)
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
€40 Average price Cheapest | €84 Average price | €111 Average price |
11h 34m Average total duration 11h 4m Onboard + 30m Additional time* | 10h 25m Average total duration 9h 55m Onboard + 30m Additional time* | 5h 36m Average total duration Fastest 2h 36m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Brindisi to Siena bus times
The table below shows live departures for Brindisi to Siena buses for tomorrow, Wednesday, November 5. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:35 PM Brindisi | 15h45 | 6:20 AM Siena | 0 transfersDirect | |
![]() | 6:50 PM Brindisi | 11h55 | 6:45 AM Siena | 0 transfersDirect | |
![]() | 8:09 PM Brindisi | 14h11 | 10:20 AM Siena | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Brindisi to Siena by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Nov 05
Nov 06
Nov 07
Nov 08
Nov 09
Nov 10
Nov 11
Journey information
Overview: Bus from Brindisi to Siena
Distance 386 miles (622 km) |
Average bus duration 11h 4m |
Cheapest ticket price $18 (€15) |
Buses per day 12 |
Direct buses 2 |
Fastest bus 10h 35m |
First bus 00:05 |
Last bus 23:39 |
Key Takeaways
Train Ticket Prices
- Budget Options: Train tickets from Brindisi to Siena start from as low as $18 (€15) if booked well in advance.
- Standard Fares: Typically, trains cost $49 (€40) depending on the train type and class.
Bus providers: Marino Autolinee, FlixBus from Brindisi to SienaYou can travel by bus between Brindisi to Siena with Marino Autolinee, FlixBus for as low as $18 (€15). When you search for schedules and tickets, Omio will show you the best journey
Marino Autolinee
FlixBus
FAQs: Bus from Brindisi to Siena

Passengers board the bus most frequently from Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale), which is located around 0.6 miles (1 km) away from the city centre, and they get off the bus at Siena, Stazione FS (Piazzale Carlo Rosselli), located 1.5 miles (2.4 km) away from the city centre.
- Marino Autolinee
- Assistance
- Priority seating
- Accessible restrooms.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Piazza del Campo, a shell-shaped medieval square known for hosting the Palio horse race and surrounded by historic buildings
- Siena Cathedral, a stunning example of Italian Romanesque-Gothic architecture featuring intricate marble work and art by famous masters
- Palazzo Pubblico, a Gothic town hall with the Torre del Mangia offering panoramic views of the city
- Basilica of San Domenico, a large church housing relics of Saint Catherine of Siena and notable frescoes
- Santa Maria della Scala, a former hospital turned museum complex showcasing art and history exhibitions.
- Torre del Mangia, a tall tower offering panoramic views of the city and surrounding countryside
- Museo dell'Opera del Duomo, a museum housing an impressive collection of religious art and artifacts
- Fortezza Medicea, a historic fortress offering beautiful views and a peaceful park for relaxation
- Enoteca Italiana, a wine museum and tasting center where you can explore and enjoy Italian wines
- Take a cooking class to learn how to make traditional Tuscan dishes.
- Marino Autolinee
- You can cancel your ticket up to 24 hours before departure for a full refund. Cancellations within 24 hours incur a 50% fee.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
To find the cheapest bus tickets for your trip from Brindisi to Siena, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- Marino Autolinee
- One carry-on bag up to 10kg (55x40x20 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Marino Autolinee
- 10€ per additional bag up to 20 kg.
- FlixBus
- Additional luggage can be purchased for a fee.
- Marino Autolinee
- Small pets allowed in carriers
- Larger pets must be leashed and muzzled.
- FlixBus
- Small pets in carriers allowed
- Guide dogs travel for free.
popular bus stations
Popular bus stations from Brindisi to Siena
Most popular bus connections from Brindisi
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