- Must visit
Museo Civico di Siena
The city museum inside Palazzo Pubblico, best known for Ambrogio Lorenzetti’s fresco cycle Allegory of Good and Bad Government. Essential for understanding Siena’s civic history and medieval art.
Cheapest price
$35
Average price
$55
Fastest journey
12 h
Average duration
12 h 20 m
Buses per day
3
Distance
622 km
The best way to find a cheap bus ticket from Brindisi to Siena is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Brindisi to Siena will cost around $55 if you buy it on the day, but the cheapest tickets can be found for only $35.
Of the 3 buses that leave Brindisi for Siena on Fri, Jun 19, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Jun 19 the direct buses cover the 622 km distance in an average of 12 h 20 m but if you time it right, some buses will get you there in just 12 h .
On Fri, Jun 19 the slowest buses will take 12 h 59 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.






Omio recommends booking the bus as it is the most popular option from Brindisi to Siena among Omio's users. If you are prioritising price take the bus with prices starting from $21. For those with little time consider booking a flight which can get you there in 1h 30m. The ticket price range depends on the travel mode: a bus costs an average of $21, and a train costs an average of $64.
Distance: 386 miles (622 km)
Most popular Bus | Flight | Train | Driving |
|---|---|---|---|
$44 Average price Cheapest | $72 Average price | $90 Average price | $211 Average price (fuel + tolls) |
11h 33m Average total duration 11h 3m Onboard + 30m Additional time* | 4h 30m Average total duration Fastest 1h 30m Onboard + 3h 0m Additional time* | 10h 25m Average total duration 9h 55m Onboard + 30m Additional time* | 7h 39m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Brindisi to Siena:
A bus is $27 (€22) less than a flight for this route with tickets for a flight from Brindisi to Siena costing on average $72 (€59).
A bus is $46 (€38) less than a train for this route with tickets for a train from Brindisi to Siena costing on average $90 (€74).
Other travel options to Siena take longer:
Train takes on average 9h 55m.
Bus takes on average 11h 3m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Itabus | Departure Time 03:30AM | Arrival Time 03:50PM | Duration 12h20 | Departure days Thu | Cheapest price $66 |
Operator Marino Autolinee | Departure Time 03:35AM | Arrival Time 02:50PM | Duration 11h15 | Departure days Mon | Cheapest price $65 |
Operator Itabus | Departure Time 04:30AM | Arrival Time 05:30PM | Duration 13h00 | Departure days Thu | Cheapest price $43 |
Operator Itabus | Departure Time 05:30AM | Arrival Time 05:50PM | Duration 12h20 | Departure days Sat, Sun | Cheapest price $77 |
Operator Marino Autolinee | Departure Time 05:35AM | Arrival Time 04:50PM | Duration 11h15 | Departure days Sat, Sun | Cheapest price $93 |
Operator FlixBus | Departure Time 07:20AM | Arrival Time 08:24PM | Duration 13h04 | Departure days Sat, Sun | Cheapest price $108 |
Operator FlixBus | Departure Time 07:55AM | Arrival Time 07:49PM | Duration 11h54 | Departure days Mon | Cheapest price $41 |
Operator FlixBus | Departure Time 09:55AM | Arrival Time 12:40AM | Duration 14h45 | Departure days Sun | Cheapest price $168 |
Operator Itabus | Departure Time 10:05AM | Arrival Time 11:04PM | Duration 12h59 | Departure days Mon, Wed, Thu | Cheapest price $25 |
Operator Itabus | Departure Time 11:05AM | Arrival Time 12:04AM | Duration 12h59 | Departure days Mon, Thu, Fri | Cheapest price $35 |
Operator Itabus | Departure Time 12:05PM | Arrival Time 01:04AM | Duration 12h59 | Departure days Sat, Sun | Cheapest price $84 |
Operator FlixBus | Departure Time 12:40PM | Arrival Time 12:40AM | Duration 12h00 | Departure days Sat | Cheapest price $112 |
Operator Marino Autolinee | Departure Time 01:40PM | Arrival Time 08:45AM | Duration 19h05 | Departure days Sat, Sun | Cheapest price $75 |
Operator FlixBus | Departure Time 04:20PM | Arrival Time 09:15AM | Duration 16h55 | Departure days Sun | Cheapest price $117 |
Operator Marino Autolinee | Departure Time 06:50PM | Arrival Time 06:45AM | Duration 11h55 | Departure days Wed | Cheapest price $71 |
Operator Marino Autolinee | Departure Time 08:50PM | Arrival Time 08:45AM | Duration 11h55 | Departure days Sat, Sun | Cheapest price $65 |
Operator Itabus | Departure Time 08:50PM | Arrival Time 08:50AM | Duration 12h00 | Departure days Mon, Fri | Cheapest price $48 |
Operator FlixBus | Departure Time 09:30PM | Arrival Time 09:15AM | Duration 11h45 | Departure days Sat, Sun | Cheapest price $89 |
Operator Itabus | Departure Time 09:50PM | Arrival Time 09:50AM | Duration 12h00 | Departure days Tue, Wed, Fri | Cheapest price $29 |
Operator Itabus | Departure Time 10:50PM | Arrival Time 10:50AM | Duration 12h00 | Departure days Sat, Sun | Cheapest price $72 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 02:50PM | Duration 15h20 | Departure days Sat, Sun | Cheapest price $82 |
The table below shows live departures for Brindisi to Siena buses for tomorrow, Friday, June 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 11:05 AM Brindisi | 12h59 | 12:04 AM Siena | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Brindisi to Siena run on average 11 times per day, taking around 11h 3m. Cheap bus tickets for this journey start at $21 (€17) if you book in advance.
There are 2 buses per day. The earliest bus runs at 00:05, the last at 23:39. The fastest bus covers the 386 miles (622 km) distance in 11h 15m.
Distance 386 miles (622 km) |
Average bus duration 11h 3m |
Cheapest ticket price $21 (€17) |
Buses per day 11 |
Direct buses 2 |
Fastest bus 11h 15m |
First bus 12:05 AM |
Last bus 11:39 PM |
Cheapest Month Mar |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Oct - Dec |
Busiest Day Tue |
Least Busy Day Mon |
Best time to book 77 days |
Discover the best of Siena — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Siena trip today.
The city museum inside Palazzo Pubblico, best known for Ambrogio Lorenzetti’s fresco cycle Allegory of Good and Bad Government. Essential for understanding Siena’s civic history and medieval art.
A vast former hospital turned museum complex with archaeological collections, frescoed halls, and major temporary exhibitions. One of Siena’s richest cultural sites and a local favorite beyond the Duo
The cathedral museum preserves original sculptures, stained glass, and masterpieces linked to Siena Cathedral. It is part of the Duomo complex and one of the city’s most rewarding art visits.
Siena’s shell-shaped main square is one of Italy’s greatest urban spaces and the home of the Palio. It is the city’s social heart and the first place most visitors should experience.
The cathedral square concentrates some of Siena’s most important monuments and dramatic architectural views. It is one of the city’s most photogenic areas.
One of Siena’s most elegant historic streets, lined with noble buildings, shops, and architectural details. It is ideal for slow walking between major sights.
Thick hand-rolled Tuscan pasta served with a garlicky tomato sauce made with aglione, a traditional local garlic variety.
A rustic Tuscan bread and tomato soup with olive oil and basil, closely associated with the Siena area and home cooking traditions.
A hearty Tuscan vegetable and bread soup, often made with beans and cavolo nero, traditional in Siena and across Tuscany.
Well-known traditional restaurant in a historic cellar setting, famous for Tuscan classics, pici, and warm atmospheric dining.
Established refined osteria near Piazza del Campo, known for elegant Tuscan cuisine, seasonal ingredients, and a polished intimate atmosphere.
Historic casual trattoria close to Piazza del Campo, appreciated for hearty Sienese dishes, generous portions, and classic local character.
Moderate by Italian standards. Cafes and simple meals are affordable, while tourist-center dining and hotels cost more.
Service is often included or covered by a coperto. Tipping is not required, but leaving EUR 1-2 at cafes or 5-10% for great restaurant service is appreciated. Round up taxis.
Official public transport app
Siena Stazione FS, Piazzale Carlo Rosselli, Siena -> Piazza del Campo, Siena
Find answers to the most common questions about traveling from Brindisi to Siena by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Siena, this guide helps you travel smarter and with confidence.

Most Brindisi to Siena buses use the Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) to Siena, Stazione FS (Piazzale Carlo Rosselli) station pair, with some services arriving at Siena, Siena/Viale Pietro Toselli. Use this guide to compare Brindisi and Siena bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need