The cheapest and fastest buses from Brindisi to Siena
Cheapest price
$39
Average price
$62
Fastest journey
11 h 55 m
Average duration
13 h 57 m
Buses per day
3
Distance
622 km
The best way to find a cheap bus ticket from Brindisi to Siena is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Brindisi to Siena will cost around $62 if you buy it on the day, but the cheapest tickets can be found for only $39.
Of the 3 buses that leave Brindisi for Siena on Wed, Feb 04, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Feb 04 the direct buses cover the 622 km distance in an average of 13 h 57 m but if you time it right, some buses will get you there in just 11 h 55 m .
On Wed, Feb 04 the slowest buses will take 15 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.






Travel Information
Compare bus, train, and flight for Brindisi to Siena
Omio recommends booking the bus as it is the most popular option from Brindisi to Siena among Omio's users. If you are prioritising price take the bus with prices starting from €15. For those with little time consider booking a flight which can get you there in 2h 36m. The ticket price range depends on the travel mode: a bus costs an average of €15, and a flight costs an average of €28.
Distance: 386 miles (622 km)
Compare bus with
Most popular Bus | Train | Flight |
|---|---|---|
€40 Average price Cheapest | €84 Average price | €111 Average price |
11h 34m Average total duration 11h 4m Onboard + 30m Additional time* | 10h 25m Average total duration 9h 55m Onboard + 30m Additional time* | 5h 36m Average total duration Fastest 2h 36m Onboard + 3h 0m Additional time* |
Direct Options | Direct Options | Direct Options |
Brindisi to Siena Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Itabus | Departure Time 05:30AM | Arrival Time 06:30PM | Duration 13h00 | Departure days Sun | Cheapest price $47 |
Operator Marino Autolinee | Departure Time 05:35AM | Arrival Time 04:50PM | Duration 11h15 | Departure days Mon, Fri, Sun | Cheapest price $79 |
Operator FlixBus | Departure Time 09:55AM | Arrival Time 09:49PM | Duration 11h54 | Departure days Mon, Fri, Sun | Cheapest price $64 |
Operator FlixBus | Departure Time 10:35AM | Arrival Time 12:40AM | Duration 14h05 | Departure days Mon, Fri, Sun | Cheapest price $65 |
Operator Itabus | Departure Time 12:05PM | Arrival Time 01:04AM | Duration 12h59 | Departure days Fri, Sun | Cheapest price $24 |
Operator Marino Autolinee | Departure Time 08:50PM | Arrival Time 08:45AM | Duration 11h55 | Departure days Mon, Fri, Sun | Cheapest price $64 |
Operator FlixBus | Departure Time 09:30PM | Arrival Time 09:15AM | Duration 11h45 | Departure days Fri, Sun | Cheapest price $68 |
Operator Itabus | Departure Time 10:50PM | Arrival Time 10:50AM | Duration 12h00 | Departure days Mon, Fri, Sun | Cheapest price $36 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 03:00PM | Duration 15h30 | Departure days Mon, Fri | Cheapest price $68 |
Live departures
Brindisi to Siena bus times
The table below shows live departures for Brindisi to Siena buses for today, Tuesday, February 3. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:35 PM Brindisi | 15h45 | 6:20 AM Siena | 0 transfersDirect | |
![]() | 6:50 PM Brindisi | 11h55 | 6:45 AM Siena | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Brindisi to Siena by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 04
Feb 05
Feb 06
Feb 07
Feb 08
Feb 09
Feb 10
Why should you book Brindisi to Siena buses with Omio?
Why book with Omio vs Marino Autolinee?
- Compare with other providers: On Omio, you can not only buy tickets for Marino Autolinee, but also compare tickets for the likes of FlixBus to find the best option for your trip from Brindisi to Siena.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Marino Autolinee with all available travel options, which are bus, train and flight to ensure you get the best deal for traveling from Brindisi to Siena.
Why book with Omio over Checkmybus or Wanderu?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Brindisi to Siena.
- Multiple modes of transport: Omio allows you to compare travel options including bus, train and flight to find the ideal travel option from Brindisi to Siena.
Journey information
Overview: Bus from Brindisi to Siena
Buses from Brindisi to Siena run on average 12 times per day, taking around 11h 4m. Cheap bus tickets for this journey start at $19 (€15) if you book in advance.
There are 2 buses per day. The earliest bus runs at 00:05, the last at 23:39. The fastest bus covers the 386 miles (622 km) distance in 10h 35m.
Distance 386 miles (622 km) |
Average bus duration 11h 4m |
Cheapest ticket price $19 (€15) |
Buses per day 12 |
Direct buses 2 |
Fastest bus 10h 35m |
First bus 00:05 |
Last bus 23:39 |
Bus providers: Marino Autolinee, FlixBus from Brindisi to SienaYou can travel by bus between Brindisi to Siena with Marino Autolinee, FlixBus for as low as $19 (€15). When you search for schedules and tickets, Omio will show you the best journey
Marino Autolinee
FlixBus
FAQs: Bus from Brindisi to Siena
Find answers to the most common questions about traveling from Brindisi to Siena by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Siena, this guide helps you travel smarter and with confidence.

- Marino Autolinee
- Assistance
- Priority seating
- Accessible restrooms.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Piazza del Campo, a shell-shaped medieval square known for hosting the Palio horse race and surrounded by historic buildings
- Siena Cathedral, a stunning example of Italian Romanesque-Gothic architecture featuring intricate marble work and art by famous masters
- Palazzo Pubblico, a Gothic town hall with the Torre del Mangia offering panoramic views of the city
- Basilica of San Domenico, a large church housing relics of Saint Catherine of Siena and notable frescoes
- Santa Maria della Scala, a former hospital turned museum complex showcasing art and history exhibitions.
- Torre del Mangia, a tall tower offering panoramic views of the city and surrounding countryside
- Museo dell'Opera del Duomo, a museum housing an impressive collection of religious art and artifacts
- Fortezza Medicea, a historic fortress offering beautiful views and a peaceful park for relaxation
- Enoteca Italiana, a wine museum and tasting center where you can explore and enjoy Italian wines
- Take a cooking class to learn how to make traditional Tuscan dishes.
- Marino Autolinee
- You can cancel your ticket up to 24 hours before departure for a full refund. Cancellations within 24 hours incur a 50% fee.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Marino Autolinee
- One carry-on bag up to 10kg (55x40x20 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Marino Autolinee
- 10€ per additional bag up to 20 kg.
- FlixBus
- Additional luggage can be purchased for a fee.
- Marino Autolinee
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Brindisi to Siena
Most popular bus connections from Brindisi
More options for your journey from Brindisi to Siena
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