The cheapest and fastest buses from Palermo to Siena
Cheapest price
$52
Average price
$67
Fastest journey
16 h 20 m
Average duration
17 h 38 m
Buses per day
2
Distance
603 km
The best way to find a cheap bus ticket from Palermo to Siena is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Palermo to Siena will cost around $67 if you buy it on the day, but the cheapest tickets can be found for only $52.
Of the 2 buses that leave Palermo for Siena on Thu, Nov 13, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Nov 13 the direct buses cover the 603 km distance in an average of 17 h 38 m but if you time it right, some buses will get you there in just 16 h 20 m .
On Thu, Nov 13 the slowest buses will take 18 h 55 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare train, bus, flight, and ferry for Palermo to Siena
Omio recommends booking the bus as it is the most popular option from Palermo to Siena among Omio's users. If you are prioritising price take the ferry with prices starting from €42. For those with little time consider booking a flight which can get you there in 1h 23m. The ticket price range depends on the travel mode: a ferry costs an average of €42, and a flight costs an average of €25.
Distance: 374 miles (603 km)
Compare bus with
Most popular Bus | Flight | Train | Ferry |
|---|---|---|---|
€78 Average price | €131 Average price | €119 Average price | €66 Average price Cheapest |
16h 54m Average total duration 16h 24m Onboard + 30m Additional time* | 4h 23m Average total duration Fastest 1h 23m Onboard + 3h 0m Additional time* | 15h 2m Average total duration 14h 32m Onboard + 30m Additional time* | 20h 50m Average total duration 19h 50m Onboard + 1h 0m Additional time* |
Direct Options | Direct Options | Direct Options | Direct Options |
Live departures
Palermo to Siena bus times
The table below shows live departures for Palermo to Siena buses for tomorrow, Thursday, November 13. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 9:10 AM Palermo | 18h55 | 4:05 AM Siena | 0 transfersDirect | |
![]() | 1:25 PM Palermo | 16h20 | 5:45 AM Siena | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Palermo to Siena by train, bus, flight, or ferry
Compare train, bus, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Nov 13
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Nov 19
Journey information
Overview: Bus from Palermo to Siena
Distance 374 miles (603 km) |
Average bus duration 16h 24m |
Cheapest ticket price $47 (€38) |
Buses per day 4 |
Direct buses 1 |
Fastest bus 16h 20m |
First bus 00:05 |
Last bus 23:39 |
Key Takeaways
Train Ticket Prices
- Budget Options: Train tickets from Palermo to Siena start from as low as $47 (€38) if booked well in advance.
- Standard Fares: Typically, trains cost $96 (€78) depending on the train type and class.
Bus providers: FlixBus, Itabus from Palermo to SienaYou can travel by bus between Palermo to Siena with FlixBus, Itabus for as low as $31 (€25). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Itabus
FAQs: Bus from Palermo to Siena
Find answers to the most common questions about traveling from Palermo to Siena by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Siena, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Itabus
- Assistance
- Dedicated seating areas
- Accessible restrooms.
- Piazza del Campo, a shell-shaped medieval square known for hosting the Palio horse race and surrounded by historic buildings
- Siena Cathedral, a stunning example of Italian Romanesque-Gothic architecture featuring intricate marble work and art by famous masters
- Palazzo Pubblico, a Gothic town hall with the Torre del Mangia offering panoramic views of the city
- Basilica of San Domenico, a large church housing relics of Saint Catherine of Siena and notable frescoes
- Santa Maria della Scala, a former hospital turned museum complex showcasing art and history exhibitions.
- Torre del Mangia, a tall tower offering panoramic views of the city and surrounding countryside
- Museo dell'Opera del Duomo, a museum housing an impressive collection of religious art and artifacts
- Fortezza Medicea, a historic fortress offering beautiful views and a peaceful park for relaxation
- Enoteca Italiana, a wine museum and tasting center where you can explore and enjoy Italian wines
- Take a cooking class to learn how to make traditional Tuscan dishes.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Itabus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
To find the cheapest bus tickets for your trip from Palermo to Siena, follow these tips:
Start your search now and compare ticket prices to find the best deal!
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Itabus
- One carry-on bag up to 10kg and one checked bag up to 20kg.
- FlixBus
- Additional luggage can be purchased for a fee.
- Itabus
- 5€ per additional bag.
- FlixBus
- Small pets in carriers allowed
- Guide dogs travel for free.
- Itabus
- Small pets allowed in carriers
- Larger pets must be leashed and muzzled.
popular bus stations
Popular bus stations from Palermo to Siena
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