- Recommended
Museo Archeologico Provinciale Francesco Ribezzo
The city’s main archaeological museum, with finds from ancient Brundisium and the wider Salento area, including Roman and underwater archaeology.
Cheapest price
$92
Average price
$131
Fastest journey
11 h
Average duration
12 h 57 m
Buses per day
7
Distance
622 km
The best way to find a cheap bus ticket from Siena to Brindisi is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Siena to Brindisi will cost around $131 if you buy it on the day, but the cheapest tickets can be found for only $92.
Of the 7 buses that leave Siena for Brindisi on Fri, Jun 19, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Jun 19 the direct buses cover the 622 km distance in an average of 12 h 57 m but if you time it right, some buses will get you there in just 11 h .
On Fri, Jun 19 the slowest buses will take 15 h 30 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
1121
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
1121
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBus
FlixBus · FlixBus · FlixBusOmio recommends booking the bus as it is the most popular option from Siena to Brindisi among Omio's users. If you are prioritising price take the bus with prices starting from $25. For those with little time consider booking a train which can get you there in 8h 22m. The ticket price range depends on the travel mode: a bus costs an average of $25, and a train costs an average of $51.
Distance: 386 miles (622 km)
Most popular Bus | Train | Driving |
|---|---|---|
$50 Average price Cheapest | $91 Average price | $73 Average price (fuel + tolls) |
11h 32m Average total duration 11h 2m Onboard + 30m Additional time* | 8h 52m Average total duration Fastest 8h 22m Onboard + 30m Additional time* | 7h 22m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Siena to Brindisi:
A bus is $41 (€34) less than a train for this route with tickets for a train from Siena to Brindisi costing on average $91 (€74).
Other travel options to Brindisi take longer:
Train takes on average 8h 22m.
Bus takes on average 11h 2m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:45AM | Arrival Time 04:40PM | Duration 15h55 | Departure days Mon, Fri | Cheapest price $89 |
Operator FlixBus | Departure Time 06:50AM | Arrival Time 07:45PM | Duration 12h55 | Departure days Mon, Fri | Cheapest price $78 |
Operator FlixBus | Departure Time 07:00AM | Arrival Time 07:45PM | Duration 12h45 | Departure days Mon, Fri | Cheapest price $78 |
Operator FlixBus | Departure Time 07:10AM | Arrival Time 07:45PM | Duration 12h35 | Departure days Mon, Fri | Cheapest price $78 |
Operator Itabus | Departure Time 07:25AM | Arrival Time 06:25PM | Duration 11h00 | Departure days Tue, Wed, Sat, Sun | Cheapest price $25 |
Operator Itabus | Departure Time 08:25AM | Arrival Time 07:25PM | Duration 11h00 | Departure days Sat, Sun | Cheapest price $43 |
Operator FlixBus | Departure Time 08:45AM | Arrival Time 10:25PM | Duration 13h40 | Departure days Thu | Cheapest price $149 |
Operator Marino Autolinee | Departure Time 09:05AM | Arrival Time 08:10PM | Duration 11h05 | Departure days Wed | Cheapest price $99 |
Operator Itabus | Departure Time 09:25AM | Arrival Time 08:25PM | Duration 11h00 | Departure days Thu, Fri | Cheapest price $67 |
Operator FlixBus | Departure Time 10:35AM | Arrival Time 10:25PM | Duration 11h50 | Departure days Mon | Cheapest price $109 |
Operator FlixBus | Departure Time 10:45AM | Arrival Time 10:25PM | Duration 11h40 | Departure days Mon | Cheapest price $109 |
Operator FlixBus | Departure Time 10:55AM | Arrival Time 10:25PM | Duration 11h30 | Departure days Mon | Cheapest price $108 |
Operator Marino Autolinee | Departure Time 11:05AM | Arrival Time 10:10PM | Duration 11h05 | Departure days Mon | Cheapest price $67 |
Operator FlixBus | Departure Time 02:51PM | Arrival Time 06:10AM | Duration 15h19 | Departure days Mon, Thu | Cheapest price $99 |
Operator FlixBus | Departure Time 04:25PM | Arrival Time 04:10AM | Duration 11h45 | Departure days Tue | Cheapest price $80 |
Operator FlixBus | Departure Time 05:25PM | Arrival Time 06:15AM | Duration 12h50 | Departure days Wed | Cheapest price $51 |
Operator FlixBus | Departure Time 06:25PM | Arrival Time 06:10AM | Duration 11h45 | Departure days Mon, Thu | Cheapest price $76 |
Operator Marino Autolinee | Departure Time 06:30PM | Arrival Time 06:25AM | Duration 11h55 | Departure days Sun | Cheapest price $71 |
Operator FlixBus | Departure Time 06:40PM | Arrival Time 10:35AM | Duration 15h55 | Departure days Fri | Cheapest price $148 |
Operator FlixBus | Departure Time 06:45PM | Arrival Time 06:15AM | Duration 11h30 | Departure days Sat | Cheapest price $39 |
Operator Marino Autolinee | Departure Time 07:30PM | Arrival Time 07:25AM | Duration 11h55 | Departure days Tue, Wed | Cheapest price $62 |
Operator FlixBus | Departure Time 07:45PM | Arrival Time 07:15AM | Duration 11h30 | Departure days Mon, Thu | Cheapest price $77 |
Operator Marino Autolinee | Departure Time 08:30PM | Arrival Time 08:25AM | Duration 11h55 | Departure days Mon | Cheapest price $59 |
Operator FlixBus | Departure Time 09:25PM | Arrival Time 12:25PM | Duration 15h00 | Departure days Tue | Cheapest price $43 |
Operator FlixBus | Departure Time 10:25PM | Arrival Time 01:55PM | Duration 15h30 | Departure days Mon, Thu, Fri | Cheapest price $73 |
The table below shows live departures for Siena to Brindisi buses for today, Thursday, June 18. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 8:45 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 13h40 | 10:25 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 2 transfers | |
1121 | 9:25 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 11h00 | 8:25 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 0 transfersDirect | |
FlixBus · FlixBus · FlixBus | 2:51 PM Siena, Siena/Viale Pietro Toselli | 15h19 | 6:10 AM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 2 transfers | |
FlixBus · FlixBus | 6:25 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 11h45 | 6:10 AM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 1 transfer | |
FlixBus · FlixBus | 7:45 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 11h30 | 7:15 AM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 1 transfer | |
FlixBus · FlixBus · FlixBus | 10:25 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 15h30 | 1:55 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 2 transfers | |
| Friday, June 19 | |||||
FlixBus · FlixBus · FlixBus | 12:45 AM Siena, Stazione FS (Piazzale Carlo Rosselli) | 15h55 | 4:40 PM Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Siena to Brindisi run on average 13 times per day, taking around 11h 2m. Cheap bus tickets for this journey start at $25 (€20) if you book in advance.
There are 2 buses per day. The earliest bus runs at 00:05, the last at 23:39. The fastest bus covers the 386 miles (622 km) distance in 11h 0m.
Distance 386 miles (622 km) |
Average bus duration 11h 2m |
Cheapest ticket price $25 (€20) |
Buses per day 13 |
Direct buses 2 |
Fastest bus 11h 0m |
First bus 12:05 AM |
Last bus 11:39 PM |
Cheapest Month Feb |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Tue |
Least Busy Day Mon |
Best time to book 5 days |
Discover the best of Brindisi — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brindisi trip today.
The city’s main archaeological museum, with finds from ancient Brundisium and the wider Salento area, including Roman and underwater archaeology.
A historic palace used for exhibitions and cultural displays, also known for preserved Roman remains in its underground area.
Diocesan museum with sacred art, liturgical objects, paintings, and items linked to the religious history of Brindisi.
Brindisi’s best-known waterfront promenade, ideal for harbor views, evening walks, and seeing the city’s maritime character.
Atmospheric square around the cathedral, distinct from many Italian piazzas for its quiet, enclosed monumental setting.
Waterside staircase near the Roman Columns, a favorite photo spot and one of the city’s most recognizable viewpoints.
Handmade ear-shaped pasta with turnip greens, garlic, olive oil, and often chili. A classic Pugliese dish closely associated with everyday cooking in the region.
A rustic Puglian staple of pureed dried broad beans served with wild chicory. It is simple, traditional peasant food and one of the area’s most emblematic dishes.
A baked layered dish of rice, potatoes, and mussels with tomato, onion, and breadcrumbs. Popular across coastal Puglia and especially loved for family meals.
Well-regarded central restaurant known for polished Puglian cooking, seafood, and a refined but relaxed atmosphere near the historic center.
Popular casual venue in Brindisi for creative sandwiches, puccia, and quick local bites, with a lively informal atmosphere.
Established harbor-side dining spot focused on seafood and regional dishes, appreciated for its setting and classic local menu.
Generally moderate by Italian standards. Dining and coffee are reasonable, while hotels cost more in peak summer.
Service is often included or modest. Locals may round up or leave EUR 1-2 at cafes, 5-10% at restaurants for good service, and round up taxi fares.
Official public transport app
Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale), Brindisi -> Brindisi Railway Station, Brindisi
Find answers to the most common questions about traveling from Siena to Brindisi by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brindisi, this guide helps you travel smarter and with confidence.

Most Siena to Brindisi buses use the Siena, Stazione FS (Piazzale Carlo Rosselli) to Brindisi, Via Giuseppe Maria Galanti (Istituto Professionale) station pair, with some services arriving at Brindisi. Use this guide to compare Siena and Brindisi bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need