How to travel from St. Louis, MO to Chicago, IL

Fri, Jul 19
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Travel Information to Chicago, IL from St. Louis, MO

distanceDistance259 miles (418 km)
modeAvailable travel modesTrain, bus or flight
priceTicket price range$31 - $229
cheapestCheapest modeTrain • $31 (€27) • 4 h 55 min
fastestFastest modeFlight • $229 (€198) • 1 h 15 min
carriersPopular travel companiesGreyhound, American Airlines or Amtrak

Take a train, bus or flight to travel 259 miles (418 km) between St. Louis, MO and Chicago, IL. The most popular travel companies which serve this route are Greyhound, American Airlines or Amtrak among others. Travelers can even take a direct bus, flight or train from St. Louis, MO to Chicago, IL.

Travel options
from St. Louis, MO to Chicago, IL

How to get from St. Louis, MO to Chicago, IL by train, bus or flight.

Our recommendation
bus

The best way to travel from St. Louis, MO to Chicago, IL is by taking a bus because it’s the best combination of price and speed.

Greyhound
12:50PM6h10
St. Louis, MO
07:00PMChicago, IL
$511One-way
0 transfers
Cheapest
Greyhound
12:50PM6h10
St. Louis, MO
07:00PMChicago, IL
$511One-way
0 transfers
Fastest
United
05:30PM1h25
St. Louis Lambert International Airport, MO (STL)
06:55PMO'Hare International Airport, IL (ORD)
$4141One-way
0 transfers
Other options
Amtrak
05:40PM5h03
St. Louis Station, St. Louis, MO
10:43PMUnion Station, Chicago, IL
$641One-way
0 transfers
Amtrak
02:55PM5h05
St. Louis Station, St. Louis, MO
08:00PMUnion Station, Chicago, IL
$921One-way
0 transfers
Amtrak
11:00PM10h15
St. Louis Station, St. Louis, MO
09:15AMUnion Station, Chicago, IL
$1671One-way
1 transfer
Greyhound
11:25PM5h55
St. Louis, MO
05:20AMChicago, IL
$701One-way
0 transfers
Greyhound
01:30PM9h10
St. Louis, MO
10:40PMChicago, IL
$771One-way
1 transfer
Greyhound
01:30PM9h25
St. Louis, MO
10:55PMChicago, IL
$771One-way
1 transfer
Republic Airlines
03:10PM1h31
St. Louis Lambert International Airport, MO (STL)
04:41PMO'Hare International Airport, IL (ORD)
$4141One-way
0 transfers

Find all the dates and times for this journey by train, bus, flight, and ferry .

Compare prices and tickets Prices for trains, buses and flights

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SNCF

All travel companies: Airlines, Train and Bus from St. Louis to Chicago

Travel between St. Louis and Chicago on Amtrak, FlixBus and American Airlines travel with Omio. When comparing schedules and tickets, we will also show you other options with multiple connections or other travel modes if they’re available.

Amtrak is the main travel company in the United States and operates medium and long-distance intercity services in 46 American states and 3 Canadian provinces. With over 300 Amtrak travel running daily, you can travel by travel across America and explore destinations near and far. Take the Acela travel for high-speed services connecting popular cities in the Northeast, the Coast Starlight to travel up and down the stunning West Coast or the Empire Builder to travel from Chicago to the Midwest and the Pacific Northwest among others. Amtrak offers different class options to suit any traveler’s budget with classes like Coach, Business, First and the Sleeper Class, where you can book a Roomette, Bedroom, and Bedroom suite among others for night travel. When you book your travel journey between St. Louis and Chicago, you can choose between ticket types like Saver, Value, Flexible, Business and Premium.

      American Airlines is one of the leading airlines in the USA and the world; they offer Main Cabin, Business and First Class tickets for your travel from St. Louis to Chicago.

        FAQs: Travel from St. Louis, MO to Chicago, IL

        FAQs: Travel to Chicago, IL easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from St. Louis, MO to Chicago, IL.
        FAQs

        There are 3 ways to get from St. Louis, MO to Chicago, IL: train, bus or flight.

        The cheapest way to go to Chicago, IL from St. Louis, MO is by taking a train, which costs on average $31 (€27).

        This is compared to other ways of getting from St. Louis, MO to Chicago, IL:

        A train is $3 (€2) less than a bus for this trip with tickets for a bus from St. Louis, MO to Chicago, IL costing on average $34 (€29).

        Taking a train costs $198 (€171) less than taking a flight, which average ticket prices of $229 (€198).

        The quickest way to travel to Chicago, IL from St. Louis, MO is by flight, which takes on average 1 h 15 min   compared to other travel options that take longer:

        Taking a bus requires on average 6 h 39 min of travel time.

        Taking a train requires on average 4 h 55 min of travel time.

        The St. Louis, MO to Chicago, IL distance is around 259 miles (418 km).

        The average frequency per day from St. Louis, MO to Chicago, IL is:

        • 2 buses a day.
        • 4 trains a day.

        However, we recommend checking specific travel dates for your trip from St. Louis, MO to Chicago, IL as scheduled services by train, bus or flight can vary by season or day of the week.

        These are the most popular departure and arrival points when traveling from St. Louis, MO to Chicago, IL:

          The following travel companies offer services from St. Louis, MO to Chicago, IL:

          • Greyhound or FlixBus can get you to Chicago, IL by bus. You can find a good deal for bus tickets with Greyhound from St. Louis, MO to Chicago, IL for $34 (€29) on Omio.
          • Travel with American Airlines, Sky West Airlines, United or Republic Airlines for flights to Chicago, IL. If you’re looking for a good deal on tickets, check for United St. Louis, MO to Chicago, IL tickets on Omio for $229 (€198).
          • Amtrak can take you to Chicago, IL by train. If searching for a good deal on trains, you can find tickets for Amtrak from St. Louis, MO to Chicago, IL for $31 (€27).

          Yes, there are direct services available from St. Louis, MO to Chicago, IL with the following travel companies:

          • Direct buses with Greyhound or FlixBus with 1 direct bus per day.
          • 4 direct trains per day with Amtrak.

          Direct services tend to save you time and add more convenience in getting you to Chicago, IL as you won't need to transfer at another stop in between, so it's worth paying attention to before booking your tickets to Chicago, IL from St. Louis, MO.

          Omio customers who travel from St. Louis, MO to Chicago, IL often also extend their vacation to go to San Francisco, CA, Indianapolis, IN, New York, NY, Milwaukee, WI or Champaign, IL. Omio can help you plan your trip by finding the best connections between Chicago, IL and these popular destinations at a great price.

          Most popular trains, buses and flights

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