How to travel from St. Louis, MO to Chicago, IL

Sat, Jun 14
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Travel Information to Chicago, IL from St. Louis, MO

distanceDistance259 miles (418 km)
modeAvailable travel modesTrain, bus or flight
priceTicket price range$28 - $46
cheapestCheapest modeBus • $28 (€25) • 6 h 10 min
fastestFastest modeFlight • $46 (€42) • 1 h 16 min
carriersPopular travel companiesGreyhound, American Airlines or Amtrak

Take a train, bus or flight to travel 259 miles (418 km) from St. Louis, MO to Chicago, IL. The most popular travel companies which serve this journey are Greyhound, American Airlines or Amtrak among others. Travelers can even take a direct bus, flight or train from St. Louis, MO to Chicago, IL.

Travel options
from St. Louis, MO to Chicago, IL

How to get from St. Louis, MO to Chicago, IL by train, bus or flight.

Our recommendation
train

The best way to travel from St. Louis, MO to Chicago, IL is by taking a train because it’s the best combination of price and speed.

Amtrak306 Lincoln Service
05:40PM5h03
St. Louis Station, St. Louis, MO
10:43PMUnion Station, Chicago, IL
$441One-way
0 transfers
Cheapest
Amtrak306 Lincoln Service
05:40PM5h03
St. Louis Station, St. Louis, MO
10:43PMUnion Station, Chicago, IL
$441One-way
0 transfers
Fastest
American AirlinesAA439
06:00AM1h21
St. Louis Lambert International Airport, MO (STL)
07:21AMO'Hare International Airport, IL (ORD)
$4511One-way
0 transfers
Other options
Amtrak318 Lincoln Service Missouri River Runner
02:55PM5h05
St. Louis Station, St. Louis, MO
08:00PMUnion Station, Chicago, IL
$631One-way
0 transfers
Amtrak302 Lincoln Service
06:35AM5h05
St. Louis Station, St. Louis, MO
11:40AMUnion Station, Chicago, IL
$771One-way
0 transfers
Amtrak22 Texas Eagle
08:10AM5h34
St. Louis Station, St. Louis, MO
01:44PMUnion Station, Chicago, IL
$1051One-way
0 transfers
FlixBusFlixBus
09:45AM7h00
St. Louis, S 15th St (Civic center)
04:45PMChicago, Greyhound Bus Station
$681One-way
0 transfers
FlixBusFlixBus
04:00PM6h15
St. Louis, S 15th St (Civic center)
10:15PMChicago, Greyhound Bus Station
$681One-way
0 transfers
Greyhoundundefined · undefined
02:30AM11h45
St. Louis, S 15th St (Civic center)
02:15PMChicago, Union Station (Amtrak), IL
$1051One-way
1 transfer
American AirlinesAA2324
07:20AM1h23
St. Louis Lambert International Airport, MO (STL)
08:43AMO'Hare International Airport, IL (ORD)
$4511One-way
0 transfers

Find all the dates and times for this journey by train, bus, flight, and ferry .

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SNCF

All travel companies: Airlines, Train and Bus from St. Louis to Chicago

Travel between St. Louis and Chicago on Amtrak, FlixBus and American Airlines travel with Omio. When comparing schedules and tickets, we will also show you other options with multiple connections or other travel modes if they’re available.

Amtrak is the main travel company in the United States and operates medium and long-distance intercity services in 46 American states and 3 Canadian provinces. With over 300 Amtrak travel running daily, you can travel by travel across America and explore destinations near and far. Take the Acela travel for high-speed services connecting popular cities in the Northeast, the Coast Starlight to travel up and down the stunning West Coast or the Empire Builder to travel from Chicago to the Midwest and the Pacific Northwest among others. Amtrak offers different class options to suit any traveler’s budget with classes like Coach, Business, First and the Sleeper Class, where you can book a Roomette, Bedroom, and Bedroom suite among others for night travel. When you book your travel journey between St. Louis and Chicago, you can choose between ticket types like Saver, Value, Flexible, Business and Premium.

    FlixBus is one of Europe's leading low-cost travel companies, founded in Germany and offering long-distance travel services in Europe and the U. S. FlixBus also operates overnight travel on select routes throughout Europe. Standard amenities on FlixBus include free Wi-Fi, power outlets to charge your phone, tablet or laptop during long travel journeys, extra legroom, luggage space and toilets. You can even purchase snacks and drinks onboard. FlixBus offers only the Standard ticket for all its routes, which allows you to bring one carry-on luggage and one checked bag per person. Additional fees apply for extra luggage and specific seat reservations, such as if you want to book an Extra Seat, Table Seat or the Panorama Seat.

      American Airlines is one of the leading airlines in the USA and the world; they offer Main Cabin, Business and First Class tickets for your travel from St. Louis to Chicago.

        FAQs: Travel from St. Louis, MO to Chicago, IL

        FAQs: Travel to Chicago, IL easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from St. Louis, MO to Chicago, IL.
        FAQs
        HomeTravelTravel to USATravel to Chicago, ILHow to travel from St. Louis, MO to Chicago, IL

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