How to travel from St. Louis, MO to Chicago
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How to get from St. Louis, MO to Chicago by train, bus or flight.
Our recommendation
The best way to travel from St. Louis, MO to Chicago is by taking a bus because it’s the best combination of price and speed.
Cheapest
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Travel Information to Chicago from St. Louis, MO
 | Distance | 259 miles (418 km) |
 | Available travel modes | Flight |
 | Fastest mode | Flight • $172 (€149) • 1 h 16 min |
 | Popular travel companies | United |
Take a flight to travel 259 miles (418 km) from St. Louis, MO to Chicago. United is the main travel company operating this route. Travelers can even take a direct flight from St. Louis, MO to Chicago.
More than 1,000 travel companies trust us to sell their tickets all in one place.
All travel companies: Airlines, Train and Bus from St. Louis, MO to Chicago
You can travel by train, bus or flight for as low as $23 (€20). When you search for schedules and tickets, Omio will show you the best route.
Amtrak is the main travel company in the United States and operates medium and long-distance intercity services in 46 American states and 3 Canadian provinces. With over 300 Amtrak travel running daily, you can travel by travel across America and explore destinations near and far. Take the Acela travel for high-speed services connecting popular cities in the Northeast, the Coast Starlight to travel up and down the stunning West Coast or the Empire Builder to travel from Chicago to the Midwest and the Pacific Northwest among others. Amtrak offers different class options to suit any traveler’s budget with classes like Coach, Business, First and the Sleeper Class, where you can book a Roomette, Bedroom, and Bedroom suite among others for night travel. When you book your travel journey to Chicago from St. Louis, MO, you can choose between ticket types like Saver, Value, Flexible, Business and Premium.
United Airlines is one of the USA’s leading airline and operates domestic and international routes. Economy, Premium Economy and Business are the ticket fares that the airline offers for your next travel between St. Louis, MO and Chicago.
- Cheapest Price: $157
FAQs: Travel from St. Louis, MO to Chicago
You can go from St. Louis, MO to Chicago by flight.
Traveling by flight is also the quickest way from St. Louis, MO to Chicago. It takes on average 1 h 16 min to travel this journey.
The St. Louis, MO to Chicago distance is around 259 miles (418 km).
These are the most popular departure and arrival points from St. Louis, MO to Chicago:
Let Omio help you find the best company to travel with from St. Louis, MO to Chicago:
- You can take a flight from St. Louis, MO to Chicago with United. Cheap tickets can be found for $172 (€149) with United from St. Louis, MO to Chicago.
Yes, there is a direct service from St. Louis, MO to Chicago:
- You'll find direct flights with Republic Airlines, American Airlines or United.
Direct services to Chicago tend to save you time and add more convenience as you won't need to transfer at another stop in between, so it's worth paying attention to before booking tickets for your trip.
Travelling from St. Louis, MO to Chicago: related information
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