4.9
4.6
Travel Information
Compare train, bus, and flight for St. Louis, MO to Chicago, IL
Omio recommends booking the train as it is the most popular option from St. Louis, MO to Chicago, IL among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $70 For those with little time, consider booking a train, which has an average total journey time of 5h 41m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.4kg. Average ticket prices depend on the travel mode: a bus costs an average of $70, while a flight costs an average of $608.
Distance: 260 miles (419 km)
Compare train with
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$82 Average price | $70 Average price Cheapest | $608 Average price | $59 Average price (fuel + tolls) |
5h 41m Average total duration Fastest 5h 11m Onboard + 30m Additional time* | 7h 46m Average total duration 7h 16m Onboard + 30m Additional time* | 6h 31m Average total duration 4h 31m Onboard + 2h 0m Additional time* | 4h 21m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 0.4 - 1.0kg CO2 emissions | 1.3 - 2.5kg CO2 emissions | - CO2 emissions |
 Most popular train company |  Most popular bus company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from St. Louis, MO to Chicago, IL:
A bus is $12 less than a train for this route with tickets for a train from St. Louis, MO to Chicago, IL costing on average $82.
A bus is $537 less than a flight for this route with tickets for a flight from St. Louis, MO to Chicago, IL costing on average $608.
Other travel options to Chicago, IL take longer:
Flight takes on average 6h 31m.
Bus takes on average 7h 46m.
Tickets start at around $82 compared to roughly $59 in fuel and tolls — a saving of about $-22.87. The journey takes 5h 11m versus 4h 21m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Travel optionsfrom St. Louis, MO to Chicago, IL
How to get from St. Louis, MO to Chicago, IL by train, bus or flight.
Our recommendation
The best way to travel from St. Louis, MO to Chicago, IL is by taking a bus because it’s the best combination of price and speed.
- FlixBus2:30 PM6h05St. Louis, S 15th St (Civic center)8:35 PMChicago, Greyhound Bus Station$1041One-way0 transfers
Cheapest
- FlixBus2:30 PM6h05St. Louis, S 15th St (Civic center)8:35 PMChicago, Greyhound Bus Station$1041One-way0 transfers
Fastest
AA19265:00 AM1h26St. Louis Lambert International Airport6:26 AMO'Hare International Airport$3071One-way0 transfers
Other options
- 302 Lincoln Service6:35 AM5h05St. Louis Station, St. Louis, MO11:40 AMChicago Union Station, Chicago, IL$1101One-way0 transfers
- 318 Lincoln Service Missouri River Runner2:55 PM5h05St. Louis Station, St. Louis, MO8:00 PMChicago Union Station, Chicago, IL$1101One-way0 transfers
- 8359 Connecting Bus · 58 City Of New Orleans9:00 PM10h15St. Louis Station, St. Louis, MO7:15 AMChicago Union Station, Chicago, IL$1101One-way1 transfer
- FlixBus10:00 AM6h05St. Louis, S 15th St (Civic center)4:05 PMChicago, Greyhound Bus Station$1241One-way0 transfers
· 2:00 AM11h45St. Louis, S 15th St (Civic center)1:45 PMChicago, Union Station (Amtrak), IL$1491One-way1 transfer
- AA220811:31 AM1h28St. Louis Lambert International Airport12:59 PMO'Hare International Airport$3071One-way0 transfers
- AA19977:29 AM1h31St. Louis Lambert International Airport9:00 AMO'Hare International Airport$3071One-way0 transfers
AA64681:06 PM1h33St. Louis Lambert International Airport2:39 PMO'Hare International Airport$3071One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from St. Louis, MO to Chicago, IL
Travel to Chicago, IL easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from St. Louis, MO to Chicago, IL.
This is compared to other travel options from St. Louis, MO to Chicago, IL:
A bus is $12 less than a train for this route with tickets for a train from St. Louis, MO to Chicago, IL costing on average $82.
A bus is $537 less than a flight for this route with tickets for a flight from St. Louis, MO to Chicago, IL costing on average $608.
Other travel options to Chicago, IL take longer:
Flight takes on average 6h 31m.
Bus takes on average 7h 46m.
- Around 45 flights per day.
- Around 5 trains per day.
- Around 4 buses per day.
However, we recommend checking specific travel dates for your route between St. Louis, MO and Chicago, IL as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from St. Louis Lambert International Airport and arrive in O'Hare International Airport.
- Trains mostly depart from St. Louis Station, St. Louis, MO and arrive in Chicago Union Station, Chicago, IL.
- Buses mostly depart from St. Louis, S 15th St (Civic center) and arrive in Chicago, Greyhound Bus Station.
- Travel with FlixBus, Greyhound, Infobus to go to Chicago, IL by bus.
- Travel with American Airlines, United, Republic Airlines, skywest airlines, psa airlines to go to Chicago, IL by flight.
- Travel with Amtrak to go to Chicago, IL by train.
- 3 direct buses per day with FlixBus.
- 11 direct flights per day with American Airlines, United, Republic Airlines, skywest airlines.
- 5 direct trains per day with Amtrak.
Travelling from St. Louis, MO to Chicago, IL: related information
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