How to travel from St. Louis, MO to Milwaukee, WI

Wed, Sep 30
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Travel Information

Compare bus, train, and flight for St. Louis, MO to Milwaukee, WI

Omio recommends booking the flight as it is the most popular option from St. Louis, MO to Milwaukee, WI among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $81 For those with little time, consider booking a flight, which has an average total journey time of 5h 51m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.2 - 0.5kg. Average ticket prices depend on the travel mode: a bus costs an average of $81, while a flight costs an average of $617.

Distance: 327 miles (527 km)

Compare flight with

Most popular
Flight
Train
Bus
Driving

$617

Average price

$168

Average price

$81

Average price

Cheapest

$81

Average price

(fuel + tolls)

5h 51m

Average total duration

Fastest

3h 51m

Onboard

+

2h 0m

Additional time*

7h 19m

Average total duration

6h 49m

Onboard

+

30m

Additional time*

9h 21m

Average total duration

8h 51m

Onboard

+

30m

Additional time*

5h 17m

Average total duration

(door-to-door)

1.6 - 3.2kg

CO2 emissions

0.2 - 0.5kg

CO2 emissions

Lowest

0.5 - 1.3kg

CO2 emissions

-

CO2 emissions

United

Most popular airline

Amtrak

Most popular train company

FlixBus

Most popular bus company

Your own car or car rental

Direct Options

Direct Options

Direct Options

Direct Options

Additional time: Average total travel duration to departure point, security checks and transfers.

The cheapest way to travel from St. Louis, MO to Milwaukee, WI is a bus with an average price of $81.

This is compared to other travel options from St. Louis, MO to Milwaukee, WI:

A bus is $88 less than a train for this route with tickets for a train from St. Louis, MO to Milwaukee, WI costing on average $168.

A bus is $536 less than a flight for this route with tickets for a flight from St. Louis, MO to Milwaukee, WI costing on average $617.

The fastest way to travel from St. Louis, MO to Milwaukee, WI is by flight with an average journey time of 5h 51m.

Other travel options to Milwaukee, WI take longer:

Train takes on average 7h 19m.

Bus takes on average 9h 21m.

It's helpful to compare your options as there are 3 ways to travel between St. Louis, MO and Milwaukee, WI including taking a bus, train, and flight.
We recommend using the flight as it is the most popular way to get from St. Louis, MO to Milwaukee, WI among Omio's users.
Take the flight. It's the quicker way to make this trip, and the time saved usually justifies the slightly higher cost.

You'll arrive about 1h 26m sooner (3h 51m by flight vs 5h 17m by car). Tickets start at around $617 compared to roughly $81 in fuel and tolls — a bit more, but you get time back and avoid a long drive.

Driving makes more sense if you're travelling as a group, want flexibility on timing, or plan to stop en route.

Travel options
from St. Louis, MO to Milwaukee, WI

How to get from St. Louis, MO to Milwaukee, WI by train, bus or flight.

Our recommendation

bus

The best way to travel from St. Louis, MO to Milwaukee, WI is by taking a bus because it’s the best combination of price and speed.

  • Greyhound · ·
    2:00 AM15h00
    St. Louis, S 15th St (Civic center)
    5:00 PMMilwaukee, Intermodal Station
    $741One-way
    2 transfers

Cheapest

  • Greyhound · ·
    2:00 AM15h00
    St. Louis, S 15th St (Civic center)
    5:00 PMMilwaukee, Intermodal Station
    $741One-way
    2 transfers

Fastest

  • American AirlinesAA2818+envoy airAA4035
    11:01 AM3h15
    St. Louis Lambert International Airport
    2:16 PMGeneral Mitchell International Airport
    $4051One-way
    1 transfer

Other options

  • Greyhound · +FlixBusFlixBus
    2:00 AM16h25
    St. Louis, S 15th St (Civic center)
    6:25 PMMilwaukee, General Mitchell International Airport (Wisconsin Coach ORD-MKE Bus Stop), WI
    $741One-way
    2 transfers
  • FlixBusFlixBus+Greyhound
    2:30 PM9h20
    St. Louis, S 15th St (Civic center)
    11:50 PMMilwaukee, Intermodal Station
    $821One-way
    1 transfer
  • UnitedUA4517 · UA5933
    10:27 AM3h16
    St. Louis Lambert International Airport
    1:43 PMGeneral Mitchell International Airport
    $4051One-way
    1 transfer
  • UnitedUA2792 · UA5234
    8:00 AM3h30
    St. Louis Lambert International Airport
    11:30 AMGeneral Mitchell International Airport
    $4051One-way
    1 transfer
  • UnitedUA4395 · UA5668
    11:35 AM3h36
    St. Louis Lambert International Airport
    3:11 PMGeneral Mitchell International Airport
    $4051One-way
    1 transfer

Find all the dates and times for this journey by train, bus, flight, and ferry .

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FAQs: Travel from St. Louis, MO to Milwaukee, WI

Travel to Milwaukee, WI easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from St. Louis, MO to Milwaukee, WI.

FAQs
There are 3 options to travel between St. Louis, MO and Milwaukee, WI including taking a bus, train, and flight.
The cheapest way to travel from St. Louis, MO to Milwaukee, WI is a bus with an average price of $81.

This is compared to other travel options from St. Louis, MO to Milwaukee, WI:

A bus is $88 less than a train for this route with tickets for a train from St. Louis, MO to Milwaukee, WI costing on average $168.

A bus is $536 less than a flight for this route with tickets for a flight from St. Louis, MO to Milwaukee, WI costing on average $617.

The fastest way to travel from St. Louis, MO to Milwaukee, WI is by flight with an average journey time of 5h 51m.

Other travel options to Milwaukee, WI take longer:

Train takes on average 7h 19m.

Bus takes on average 9h 21m.

The distance from St. Louis, MO to Milwaukee, WI is approximately 327 miles (527 km).
The average frequency per day from St. Louis, MO to Milwaukee, WI is:
  • Around 52 flights per day.
  • Around 9 trains per day.
  • Around 6 buses per day.

However, we recommend checking specific travel dates for your route between St. Louis, MO and Milwaukee, WI as scheduled services by bus, train, and flight can vary by season or day of the week.

These are the most popular departure and arrival points from St. Louis, MO to Milwaukee, WI:
  • Flights mostly depart from St. Louis Lambert International Airport and arrive in General Mitchell International Airport.
  • Trains mostly depart from St. Louis Station, St. Louis, MO and arrive in Milwaukee Intermodal Station, Milwaukee, WI.
  • Buses mostly depart from St. Louis, S 15th St (Civic center) and arrive in Milwaukee, Intermodal Station.
If finding a good deal is your main consideration for your trip from St. Louis, MO to Milwaukee, WI, then we'll help you find the best value travel companies for you:
  • Travel with Greyhound, FlixBus to go to Milwaukee, WI by bus.
  • Travel with American Airlines, piedmont airlines, Republic Airlines, United, skywest airlines, psa airlines to go to Milwaukee, WI by flight.
  • Travel with Amtrak to go to Milwaukee, WI by train.
Omio customers who travel from St. Louis, MO to Milwaukee, WI often also extend their vacation to go to Chicago, IL, New York, NY, Denver, CO, Boston, MA, Minneapolis, MN. Omio can help you plan your trip by finding the best connections between Milwaukee, WI and these popular destinations at a great price.
Most travelers need at least three days in Milwaukee, WI to see the main sights at a comfortable pace. If you want day trips or a slower itinerary, consider adding extra time.
To fully experience Milwaukee, WI, it is recommended to spend 2 to 3 days. This allows time to explore its vibrant arts scene, enjoy local breweries, visit the Milwaukee Art Museum, and experience the historic Third Ward district.
HomeTravelTravel to USATravel to Milwaukee, WIHow to travel from St. Louis, MO to Milwaukee, WI

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