- Must visit
Vatican Museums
One of the world's great museum complexes, home to vast papal collections and the Sistine Chapel. A priority visit for art, history, and Renaissance masterpieces.
Cheapest price
$17
Average price
$28
Fastest journey
2 h 11 m
Average duration
2 h 19 m
Trains per day
15
Distance
149 km
The best way to find a cheap train ticket from Isernia to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Isernia to Rome will cost around $28 if you buy it on the day, but the cheapest tickets can be found for only $17.
Of the 15 trains that leave Isernia for Rome on Wed, Jul 08, 6 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Jul 08 the direct trains cover the 149 km distance in an average of 2 h 19 m but if you time it right, some trains will get you there in just 2 h 11 m .
On Wed, Jul 08 the slowest trains will take 2 h 28 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
Regionale 23351
Autobus RM113 · Regionale Veloce 12598
Regionale 23341
Regionale 23347
Autobus CB101 · Regionale 5826 · Regionale 12636
Regionale 23341
Regionale 23347
Regionale 23361
Regionale 23359
Regionale 23349Omio recommends booking the train as it is the most popular option from Isernia to Rome among Omio's users. If you are prioritising price take the train with prices starting from $16. For those with little time consider booking a bus which can get you there in 2h 22m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.0 - 0.1kg. The ticket price range depends on the travel mode: a train costs an average of $16, and a bus costs an average of $10.
Distance: 92 miles (149 km)
Most popular Train | Bus | Driving |
|---|---|---|
$17 Average price Cheapest | $18 Average price | $49 Average price (fuel + tolls) |
3h 28m Average total duration 2h 58m Onboard + 30m Additional time* | 2h 52m Average total duration Fastest 2h 22m Onboard + 30m Additional time* | 2h 26m Average total duration (door-to-door) |
0.0 - 0.1kg CO2 emissions Lowest | 0.1 - 0.4kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Isernia to Rome:
A train is $1 (€0.97) less than a bus for this route with tickets for a bus from Isernia to Rome costing on average $18 (€15).
Other travel options to Rome take longer:
Train takes on average 2h 58m.
Tickets start at around {cheapestPrice} compared to roughly {drivingPriceInCents} in fuel and tolls — a saving of about {savingsAmount}. The journey takes {durationInMinutes} versus {drivingDurationInMinutes} by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Direct services run with Regionale.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Isernia to Rome trains for today, Tuesday, July 7. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Regionale 23341 | 6:40 AM Isernia station | 2h11 | 8:51 AM Rome Tiburtina | 0 transfersDirect | |
Regionale 5181 · Regionale 5842 | 7:08 AM Isernia station | 3h10 | 10:18 AM Rome Termini | 1 transfer | |
Regionale 5181+ FRECCIAROSSA 8348 | 7:08 AM Isernia station | 3h05 | 10:13 AM Rome Termini | 1 transfer | |
Regionale 23347 | 8:38 AM Isernia station | 2h14 | 10:52 AM Rome Termini | 0 transfersDirect | |
Regionale 23349 | 1:28 PM Isernia station | 2h28 | 3:56 PM Rome Tiburtina | 0 transfersDirect | |
Regionale 5189+ FRECCIARGENTO 8314 | 2:06 PM Isernia station | 2h59 | 5:05 PM Rome Termini | 1 transfer | |
Regionale 23351 | 3:03 PM Isernia station | 2h31 | 5:34 PM Rome Termini | 0 transfersDirect | |
Autobus CB101 · Regionale 5826 · Regionale 12636 | 3:20 PM Isernia station | 5h00 | 8:20 PM Rome Termini | 2 transfers | |
Autobus CB101 · Regionale 5813+ FRECCIAROSSA 9592 | 3:20 PM Isernia station | 4h35 | 7:55 PM Rome Termini | 2 transfers | |
Regionale 5191 · Metropolitano 21461+ FRECCIAROSSA 8868 | 4:45 PM Isernia station | 3h31 | 8:16 PM Rome Termini | 2 transfers | |
Regionale 23359 | 6:00 PM Isernia station | 2h25 | 8:25 PM Rome Tiburtina | 0 transfersDirect | |
Autobus CB105 · Regionale 5812 · Regionale 12644 | 6:20 PM Isernia station | 4h21 | 10:41 PM Rome Termini | 2 transfers | |
Regionale 5199+ Intercity 704 | 7:01 PM Isernia station | 3h28 | 10:29 PM Rome Termini | 1 transfer | |
Regionale 23361 | 8:35 PM Isernia station | 2h19 | 10:54 PM Rome Termini | 0 transfersDirect | |
| Wednesday, July 8 | |||||
Autobus RM113 · Regionale Veloce 12598 | 4:50 AM Isernia station | 3h01 | 7:51 AM Rome Termini | 1 transfer | |
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Isernia to Rome run on average 9 times per day, taking around 2h 58m. Cheap train tickets for this journey start at $16 (€14) but you can travel from only $10 (€8) by bus.
There are 2 trains per day. The earliest train runs at 04:50, the last at 23:56. The fastest train covers the 92 miles (149 km) distance in 2h 7m.
Distance 92 miles (149 km) |
Average train duration 2h 58m |
Cheapest ticket price $16 (€14) |
Trains per day 9 |
Direct trains 2 |
Fastest train 2h 7m |
First train 4:50 AM |
Last train 11:56 PM |
Cheapest Month Jun |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Jan - Mar |
Busiest Day Sun |
Least Busy Day Mon |
Best time to book 49 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
One of the world's great museum complexes, home to vast papal collections and the Sistine Chapel. A priority visit for art, history, and Renaissance masterpieces.
A superb villa museum with Bernini sculptures and major paintings by Caravaggio, Raphael, and Titian. Timed entry is essential due to limited capacity.
The city's historic civic museums on Capitoline Hill, known for classical sculpture, ancient Roman art, and excellent views over the Forum.
A lively Baroque square with monumental fountains, elegant facades, and one of the most recognizable urban spaces in Rome.
A famous stairway and gathering point linking Piazza di Spagna with Trinita dei Monti, especially popular for photos and central city strolls.
A beloved neighborhood of narrow lanes, ivy-covered buildings, and lively Roman atmosphere, ideal for wandering day or night.
A classic Roman pasta with pecorino Romano, black pepper, and pasta water. It is one of the city’s most iconic dishes for its simplicity and bold flavor.
Traditional Roman pasta made with guanciale, egg yolk, pecorino Romano, and black pepper. It is a defining dish of Rome and is famously made without cream.
A beloved pasta sauce of tomato, guanciale, pecorino Romano, and chili. Though linked to Amatrice, it is deeply rooted in Roman trattoria cooking.
Rome’s best-known luxury fine-dining restaurant, famous for panoramic views, elegant service, and sophisticated Italian cuisine.
A historic restaurant near the Pantheon serving refined Roman classics with strong local identity. Well known for seasonal specialties and pasta.
A celebrated central Rome dining room known for Roman pasta, cured meats, and an exceptional wine list. Lively, polished, and very popular.
Moderate for Western Europe. Sights and central hotels cost more, but food, coffee, and transit can be good value.
Service is often included or modest. Locals may round up or leave EUR 1-2 at cafes; 5-10% is appreciated at restaurants for good service, not obligatory. Round up taxis.
Official public transport app
Rome Termini, Rome -> Piazza Venezia, Rome
Find answers to the most common questions about traveling from Isernia to Rome by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Isernia to Rome trains use the Isernia to Roma Termini station pair, with some services arriving at Roma Tiburtina. Use this guide to compare Isernia and Rome train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Isernia has practical services for this route, including Wifi, Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Information Desk, and Luggage Carts.
Food options include: Pasta e Pizza, Ristorante da Adriano
Free.
Ticket office support is available at Isernia. Information desks are located in the main hall.
Luggage storage is available at Isernia. Lost and found is available at the station.
Available at Isernia: Parking, Taxis, WC.
Available at Isernia: Bike Parking.
Accessibility facilities are available at Isernia: Ramps.
Nearby hotels include Grand Hotel Europa, Hotel Ristorante Sayonara, Hotel La Tequila.
Roma Termini is 1 km from Rome city centre. Public transport options include:
Roma Termini has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Car Rental, and Information Desk.
Food options include: Acafe, Moka Café, Roadhouse Grill, McDonald's, Gusto, Chef Express, Coop Minimarket, Mercato Centrale
Free WiFi in the station. ATMs are there are ATMs in various locations around the station.
The ticket office is open Mon - Sun: 06:30 - 22:00. Information desks are located near Platform 24.
Luggage storage is provided by KiPoint and located on Platform 24. Open every day from 06:00 to 23:00.
Available at Roma Termini: Parking, Taxis, WC.
Available at Roma Termini: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Termini: The Sala Blu, Trenitalia's office of assistance for disabled travelers, is located next to Platform 1.
Nearby hotels include Archi di Roma Guest House, Gemma di Roma, The Liberty Boutique Hotel.
Roma Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma Tiburtina has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Car Rental, and Information Desk.
Food options include: Rock n’ Coffee Roma, Arabian Kebab, Ingredienti, McDonald’s, Numb's Bakery Café
Free, limited Wi-Fi available in the station for 15 minutes. ATMs are located on the ground floor level.
The ticket office is open Mon - Sun: 06:35 - 20:20. Information desks are located inside the main terminal. .
Luggage storage is luggage lockers are located in the station lobby.
Available at Roma Tiburtina: Parking, Taxis, WC.
Available at Roma Tiburtina: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Tiburtina: Accessible facilities include elevators and escalators.
Nearby hotels include B&B Rome Tiburtina, B&B Alba Domus Roma, Hotel delle Province.
Gemelli is 5 km from Rome city centre. Public transport options include:
Gemelli has practical services for this route, including Parking, Dining, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Information Desk, and Luggage Carts.
Food and drink options are available at Gemelli.
Ticket office support is available at Gemelli. Information desks are located near the main entrance.
Available at Gemelli: Parking, Taxis, WC.
Available at Gemelli: Bike Parking.
Accessibility facilities are available at Gemelli: Ramps.
Nearby hotels include Courtyard Rome Central Park, Hotel Zone, Excel Roma Montemario.
Here are some other resources that might have the information you need