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The cheapest and fastest trains from Isernia to Milan Centrale
Showing times and prices for Feb 06
Cheapest price
$104
Average price
$157
Fastest journey
6 h
Average duration
6 h 11 m
Trains per day
27
Distance
592 km
Cheap tickets
The best way to find a cheap train ticket from Isernia to Milan Centrale is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Isernia to Milan Centrale will cost around $157 if you buy it on the day, but the cheapest tickets can be found for only $104.
Fast trains
It's difficult to get from Isernia to Milan Centrale without transferring at least once.
treno 23359 effettuato con bus CB713+
InterCityNotte 774 · InterCityNotte 75806:10PM12h55
Isernia station07:05AMMilan Centrale
$1041One-way
2 transfers
Regionale 5181+
Intercity 59007:10AM12h15
Isernia station07:25PMMilan Centrale
$1091One-way
1 transfer
treno 23341 effettuato con bus CB701+Intercity 588 · Intercity 60806:50AM10h55
Isernia station05:45PMMilan Centrale
$1141One-way
2 transfers
treno 23347 effettuato con bus CB703+
993208:50AM7h30
Isernia station04:20PMMilan Centrale
$1391One-way
1 transfer
treno 23347 effettuato con bus CB703+992808:50AM6h30
Isernia station03:20PMMilan Centrale
$1391One-way
1 transfer
treno 23351 effettuato con bus CB707+999203:15PM6h00
Isernia station09:15PMMilan Centrale
$1391One-way
1 transfer
treno 23341 effettuato con bus CB701+
FRECCIAROSSA 1000 962206:50AM6h08
Isernia station12:58PMMilan Centrale
$1471One-way
1 transfer
treno 23347 effettuato con bus CB703+FRECCIAROSSA 1000 963008:50AM6h08
Isernia station02:58PMMilan Centrale
$1471One-way
1 transfer
treno 23351 effettuato con bus CB707+FRECCIAROSSA 966003:15PM6h15
Isernia station09:30PMMilan Centrale
$1471One-way
1 transfer
Regionale 5179+FRECCIAROSSA 1000 962006:00AM6h24
Isernia station12:24PMMilan Centrale
$1431One-way
1 transfer
Travel Information
Compare train, bus, and flight for Isernia to Milan Centrale
Omio recommends booking the train as it is the most popular option from Isernia to Milan Centrale among Omio's users. If you are prioritising price take the flight with prices starting from €20. For those with little time consider booking a flight which can get you there in 1h 23m. The ticket price range depends on the travel mode: a flight costs an average of €20, and a train costs an average of €53.
Distance: 367 miles (592 km)
Compare train with
Most popular Train | Flight | Bus |
|---|---|---|
€98 Average price | €47 Average price Cheapest | €58 Average price |
7h 11m Average total duration 6h 41m Onboard + 30m Additional time* | 4h 23m Average total duration Fastest 1h 23m Onboard + 3h 0m Additional time* | 14h 28m Average total duration 13h 58m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Isernia to Milan Centrale train times
The table below shows live departures for Isernia to Milan Centrale trains for tomorrow, Friday, February 6. You can also manually refresh the results below to see updated train journeys.
Last updated at 11:14 PM
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| Regionale 5179+FRECCIAROSSA 1000 9620+9920 | 5:00 AM Isernia station | 7h20 | 12:20 PM Milan Centrale | 2 transfers | |
| Regionale 5179+FRECCIAROSSA 1000 9620+9976 | 5:00 AM Isernia station | 7h15 | 12:15 PM Milan Centrale | 2 transfers | |
| Regionale 5179+FRECCIAROSSA 1000 9620+9978 | On time 5:00 AM Isernia station | 8h15 | 1:15 PM Milan Centrale | 2 transfers | |
| Regionale 5179+FRECCIAROSSA 1000 9620 | 5:00 AM Isernia station | 6h24 | 11:24 AM Milan Centrale | 1 transfer | |
| treno 23341 effettuato con bus CB701+9976 | 5:50 AM Isernia station | 6h25 | 12:15 PM Milan Centrale | 1 transfer | |
| treno 23341 effettuato con bus CB701+FRECCIAROSSA 1000 9622 | 5:50 AM Isernia station | 6h08 | 11:58 AM Milan Centrale | 1 transfer | |
| treno 23341 effettuato con bus CB701+9920 | 5:50 AM Isernia station | 6h30 | 12:20 PM Milan Centrale | 1 transfer | |
| treno 23341 effettuato con bus CB701+9978 | On time 5:50 AM Isernia station | 7h25 | 1:15 PM Milan Centrale | 1 transfer | |
| treno 23341 effettuato con bus CB701+Intercity 588 · Intercity 608 | 5:50 AM Isernia station | 10h55 | 4:45 PM Milan Centrale | 2 transfers | |
| Regionale 5181+Intercity 590 | 6:10 AM Isernia station | 12h15 | 6:25 PM Milan Centrale | 1 transfer | |
| Regionale 5181+FRECCIAROSSA 1000 9628+9932 | 6:10 AM Isernia station | 9h10 | 3:20 PM Milan Centrale | 2 transfers | |
| Regionale 5181+FRECCIAROSSA 1000 9628+9928 | On time 6:10 AM Isernia station | 8h10 | 2:20 PM Milan Centrale | 2 transfers | |
| Regionale 5181+FRECCIAROSSA 1000 9628 | 6:10 AM Isernia station | 7h25 | 1:35 PM Milan Centrale | 1 transfer | |
| Regionale 5181+FRECCIAROSSA 1000 9628+9980 | 6:10 AM Isernia station | 8h05 | 2:15 PM Milan Centrale | 2 transfers | |
| treno 23347 effettuato con bus CB703+9932 | 7:50 AM Isernia station | 7h30 | 3:20 PM Milan Centrale | 1 transfer | |
| treno 23347 effettuato con bus CB703+9928 | On time 7:50 AM Isernia station | 6h30 | 2:20 PM Milan Centrale | 1 transfer | |
| treno 23347 effettuato con bus CB703+9980 | 7:50 AM Isernia station | 6h25 | 2:15 PM Milan Centrale | 1 transfer | |
| treno 23347 effettuato con bus CB703+FRECCIAROSSA 1000 9630 | 7:50 AM Isernia station | 6h08 | 1:58 PM Milan Centrale | 1 transfer | |
Regionale 5189+ FRECCIARGENTO 8314+9944 | 1:06 PM Isernia station | 7h39 | 8:45 PM Milan Centrale | 2 transfers | |
| Regionale 5189+FRECCIARGENTO 8314+FRECCIAROSSA 1000 9652 | 1:06 PM Isernia station | 6h24 | 7:30 PM Milan Centrale | 2 transfers | |
| Regionale 5189+FRECCIARGENTO 8314+9958 | 1:06 PM Isernia station | 7h14 | 8:20 PM Milan Centrale | 2 transfers | |
| Regionale 5189+FRECCIARGENTO 8314+9992 | 1:06 PM Isernia station | 7h09 | 8:15 PM Milan Centrale | 2 transfers | |
| treno 23351 effettuato con bus CB707+9994 | 2:15 PM Isernia station | 7h00 | 9:15 PM Milan Centrale | 1 transfer | |
| treno 23351 effettuato con bus CB707+9944 | 2:15 PM Isernia station | 6h30 | 8:45 PM Milan Centrale | 1 transfer | |
| treno 23351 effettuato con bus CB707+FRECCIAROSSA 9660 | 2:15 PM Isernia station | 6h15 | 8:30 PM Milan Centrale | 1 transfer | |
| treno 23351 effettuato con bus CB707+9992 | 2:15 PM Isernia station | 6h00 | 8:15 PM Milan Centrale | 1 transfer | |
| treno 23359 effettuato con bus CB713+InterCityNotte 774 · InterCityNotte 758 | 5:10 PM Isernia station | 12h55 | 6:05 AM Milan Centrale | 2 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Isernia to Milan Centrale by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Fri
Feb 06
Feb 06
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Why should you book Isernia to Milan Centrale trains with Omio?
Italo as well as Frecciarossa, Intercity, Intercity Notte, Regionale and more offer trains services from Isernia to Milan Centrale.
Omio is the only official third party seller for Italo tickets.
Why book with Omio vs Italo?
- Compare with other providers: On Omio, you can not only buy tickets for Italo, but also compare tickets for the likes of Frecciarossa, Intercity, Intercity Notte or Regionale to find the best option for your trip from Isernia to Milan Centrale.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Italo with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Isernia to Milan Centrale.
Why book with Omio over Raileurope?
- Official reseller: Italo tickets can only be bought on Omio or Italo's website as Omio is the only official third party seller for Italo tickets. Raileurope do not sell Italo tickets as they are not official sellers.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Isernia to Milan Centrale.
Journey information
Overview: Train from Isernia to Milan Centrale
ItalyItaly
Trains from Isernia to Milan Centrale run on average 7 times per day, taking around 6h 41m. Cheap train tickets for this journey start at $66 (€53) but you can travel from only $25 (€20) by flight.
The earliest train runs at 04:00, the last at 17:00. The fastest train covers the 367 miles (592 km) distance in 6h 14m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $25 (€20)
Distance 367 miles (592 km) |
Average train duration 6h 41m |
Cheapest ticket price $66 (€53) |
Trains per day 7 |
Fastest train 6h 14m |
First train 04:00 |
Last train 17:00 |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $25 (€20)
Train companies: Italo, Frecciarossa, Intercity, Intercity Notte, Regionale from Isernia to Milan Centrale trainsItalo, Frecciarossa, Intercity, Intercity Notte, Regionale trains will get you between Isernia and Milan Centrale from $25 (€20). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Italo
About
Italo is Italy’s private high-speed train service operated by Nuovo Trasporto Viaggiatori (NTV), connecting major cities such as Rome, Milan, Naples, Florence, Turin, Bologna, and Salerno. Its fleet includes the Italo AGV 575, capable of speeds up to 186 mph (300 km/h), and the eco-friendly Italo EVO, which reaches up to 150 mph (250 km/h). Passengers can choose from four classes — Smart, Comfort, Prima, and Club Executive — all offering modern amenities such as free Wi-Fi, power outlets, reclining leather seats, footrests, bathrooms, snack machines, and Italo Live entertainment with movies, music, and games. Italo offers three fare types — Low Cost, Economy, and Flex — providing different levels of price and flexibility. Popular routes include Rome–Milan, Rome–Florence, and Milan–Turin, making Italo a fast, comfortable, and convenient way to travel around Italy.
Luggage & cancellation policy
Luggage included
2 pieces of hand luggage (max 55x35x25cm) and 1 piece of luggage (max 75x53x30cm)
Luggage storage
Overhead racks and designated luggage areas between seats
Cancellation Policy
Cancellation possible according to ticket conditions
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Snack bar service available in most trains with drinks and light refreshments. Welcome service in Prima and Club Executive classes
Seat reservation
Included in Prima and Club Executive. Optional extra cost in Smart and Comfort
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for passengers with reduced mobility
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle. Guide dogs travel free
Quiet zone
Frecciarossa
About
Step on board a Frecciarossa train and relax as you travel across Italy. Trenitalia’s Frecciarossa high-speed trains make around 200 connections across the country each day and are renowned for their comfort, speed, and reduced environmental impact. Reaching speeds of up to 186 mph (300 km/h), they connect major destinations such as Rome, Florence, Milan, Venice, and Naples quickly and efficiently. When booking your Frecciarossa journey, you can choose between four classes: Standard, Premium, Business, and Executive. While each class offers different levels of comfort, all provide free Wi-Fi access, power outlets, air conditioning, bathrooms, luggage storage, onboard entertainment, and restaurant and bar services. Ticket options include Super Economy, Economy, and Base, making it easy to find the right balance of comfort and price for your trip.
Luggage & cancellation policy
Average Duration
6h 12m
Cheapest Price
$65 (€51)
Frecciarossa frequency
6 a day
Luggage included
1 carry-on bag and 1 suitcase per passenger
Luggage storage
Overhead racks, dedicated luggage areas at carriage ends, under seats
Cancellation Policy
Refund policy depends on ticket type
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with full meals, bar service with snacks and beverages, at-seat service in Executive class
Seat reservation
Included in Executive class, optional fee for other classes
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible toilets, assistance service available
Pets
Small pets in carriers travel free, larger dogs require paid ticket and muzzle, service animals free
Quiet zone
Intercity
About
Trenitalia Intercity is a high-speed train service operated by the Italian national railway company, Trenitalia. It operates throughout the country, with services running from early morning to late evening. The Intercity trains come in two types: the Intercity Plus, which is the fastest and most comfortable, and the Intercity, which is slightly slower but still offers a comfortable journey. Onboard facilities include air conditioning, power sockets, Wi-Fi, and a bar service. There are several ticket types available, including Standard, Super Economy, and Business. The most popular routes for Trenitalia Intercity are from Rome to Milan, Naples to Florence, and Turin to Venice.
Luggage & cancellation policy
Average Duration
10h 17m
Cheapest Price
$55 (€43)
Intercity frequency
2 a day
Luggage included
2 pieces of luggage up to 30kg total
Luggage storage
Overhead racks and designated luggage areas at end of carriages
Cancellation Policy
According to ticket conditions
Refund
Full refund provided
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with hot meals and snacks, trolley service in some trains. But do not count on the presence of a buffet car. So if having access to food and drink on the train is important to you, it’s best to bring your own refreshments onboard.
Seat reservation
Seat reservation included in ticket price for most routes
Toilets
USB plugs
Accessibility
Wheelchair spaces and accessible toilets available
Pets
Small pets in carriers allowed free, larger dogs require paid ticket
Quiet zone
Intercity Notte
About
Intercity Notte is an Italian train service operated by Trenitalia. It runs overnight services between major cities in Italy, making it a great option for travelers looking to save time and money. The Intercity Notte offers two types of trains: the Frecciarossa Notte and the Frecciargento Notte. The Frecciarossa Notte is the fastest train, with speeds of up to 300 km/h, while the Frecciargento Notte is slightly slower but still offers a comfortable journey. Both trains offer a range of onboard facilities, including comfortable seating, air conditioning, and Wi-Fi. Trenitalia offers a range of ticket types, including Standard, Comfort, and Business. Standard tickets are the most affordable, while Comfort and Business tickets offer additional benefits such as priority boarding and access to the lounge. The most popular routes for Intercity Notte are Rome to Milan, Rome to Venice, and Milan to Venice. These routes offer travelers the chance to explore some of Italy's most iconic cities in a convenient and comfortable way.
Luggage & cancellation policy
Average Duration
13h 5m
Cheapest Price
$76 (€60)
Intercity Notte frequency
2 a day
Luggage included
1 handbag and 1 suitcase included in ticket price
Luggage storage
Luggage racks above seats and at carriage ends
Cancellation Policy
Cancellation possible according to ticket type conditions
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with full dining service and bar
Seat reservation
Seat reservation included in ticket price
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for disabled passengers
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle. Guide dogs free.
Quiet zone
Regionale
About
Regionale is the regional train service of national carrier Trenitalia connecting all of Italy. It is the most convinient way to travel to both big cities and the smallest villages all over the Italian country. The regional trains have different names depending on the region they serve, such as Treno Regionale Veloce (TRV) and Treno Regionale Lento (TRL). Treno Rock and Treno pop are the two new trains part of Trenitalia regionale fleet. Trenitalia Regionale offers a variety of ticket types, including single tickets (economy and standard), return tickets, and season tickets. Onboard facilities include free Wi-Fi, air conditioning, and power sockets. The most popular routes for Regionale are between Rome and Milan, Naples and Florence, and Turin and Venice.
Luggage & cancellation policy
Average Duration
15h 18m
Cheapest Price
$191 (€152)
Regionale frequency
1 a day
Luggage included
Free hand luggage allowance included in ticket price
Luggage storage
Overhead racks and designated luggage areas between seats
Cancellation Policy
According to ticket conditions
Refund
Full refund provided
Amenities on board the train
Wifi
Food sold onboard
Bar service available on some trains with snacks and beverages
Seat reservation
Seat reservation included in ticket price for most services
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for passengers with reduced mobility
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle
Quiet zone
FAQs: Trains from Isernia to Milan Centrale
Find answers to the most common questions about traveling from Isernia to Milan Centrale by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Milan Centrale, this guide helps you travel smarter and with confidence.
Train ticket prices from Isernia to Milan Centrale can vary. The cheapest ticket starts at $66 (€53), while the average price is around $123 (€98).
The train from Isernia to Milan Centrale takes 6h 14m and runs 7 per day.
The distance by train from Isernia to Milan Centrale is 367 miles (592 km).
The first train from Isernia to Milan Centrale leaves at 4:00 AM.
The last train from Isernia to Milan Centrale leaves at 5:00 PM.
Yes, there is a high-speed train from Isernia to Milan Centrale.
There is no direct train service currently available from Isernia to Milan Centrale.
Yes, there is a night train from Isernia to Milan Centrale.
The cheapest way to get from Isernia to Milan Centrale is by flight, with a cost of around $25 (€20).
The train journey from Isernia to Milano Centrale offers varied scenery, featuring the picturesque landscapes of the Apennine Mountains, charming rural villages, and the lush countryside of northern Italy, providing a pleasant visual experience.
A day trip from Isernia to Milano Centrale is not feasible, as the journey duration is 6h 14m. However, there are 9 train trips per day available for this route.
Yes, you can take the train from Isernia to Milan Centrale.
popular train stations
Popular train stations from Isernia to Milan Centrale
Isernia
Milan
The major train station for departures in Isernia is Isernia. Find all the information you need to know about services, amenities and connections at Isernia for your trip from Isernia to Milan.
Amenities at train station
Wifi
Lockers
Parking
Dining
Taxis
Accessibility
WC
Hotel
Lost and Found Office
Ticket Office
Bike Parking
Information Desk
Luggage Cartsinformation
Ticket Office Hours
- 6:00 AM - 8:00 PM Monday - Sunday
Number of platforms
2Wifi
- Free
Parking
- Parking is available 24/7 with access from Via Giovanni XXIII.
Dining
- Pasta e Pizza
- Ristorante da Adriano
Taxis
- Outside the main entrance.
Accessibility
- Ramps.
WC
- €0.50
Hotel
- Grand Hotel Europa
- Hotel Ristorante Sayonara
- Hotel La Tequila
Lost and Found Office
- Located in the main hall
Information Desk
- Located in the main hall
Luggage Carts
- Free
Station Plan
- Hall 1: main entrance, ticket office, and waiting area
- Hall 2: platforms for regional trains
Public transit options for Isernia
- Bus: Several local lines available
- Train: Regional connections
The major train station for arrivals in Milan is Milano Centrale. Find all the information you need to know about services, amenities and connections at Milano Centrale for your journey to Milan from Isernia.
Amenities at train station
WifiLockersParkingDining
ATMTaxisAccessibilityWCHotelTicket OfficeBike Parking
Bike Rental
Car RentalInformation Deskinformation
Ticket Office Hours
- Mon - Sun: 05:50 - 22:20
Distance to city center
2 kmWifi
- Free WiFi in the station.
Lockers
- Provided by KiPoint and located on the ground floor, on the side of Piazza Luigi di Savoia. It is open every day from 06:00 to 23:00.
Dining
- Venchi
- Panzera Coffee
- Burger King
- Bar Motta
- Caffè Napoli
- VyTA Boulangerie
- Spontini
- Starbucks
- Dispensa Emilia
- McDonald's
- & many more
Accessibility
- Station is wheelchair accessible, has elevators and the Sala Blu, Trenitalia's office of assistance for disabled travelers, is next to Platform 4.
Hotel
- Glam Hotel Milano
- NYX MIlan
- iQ Hotel Milano
Ticket Office
- Mon - Sun: 05:50 - 22:20
Information Desk
- Located next to the ticket office on the ground floor in the shopping gallery.
Public transit options for Milano Centrale
- Metro lines: M2 (green), M3 (yellow)
- Tram lines: 1
- Bus lines: 5, 9, 10, 42, 81, 87, 152, 728, N26, NM2, NM3, Air Bus, Orio Shuttle
- Train lines: FR, FB, EC, Thello, XP2, R28, IC, ICN, RV, R, Regio, Italo
Most popular train connections from Isernia
More options for your journey from Isernia to Milan Centrale
Here are some other resources that might have the information you need
Most popular trains to and from Milan Centrale and Isernia
Most popular train connections to Milan Centrale
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