The cheapest and fastest trains from Isernia to Milan Centrale
Cheapest price
€57
Average price
€57
Fastest journey
13 h 22 m
Average duration
13 h 22 m
Trains per day
1
Distance
592 km
The best way to find a cheap train ticket from Isernia to Milan Centrale is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Isernia to Milan Centrale will cost around €57 if you buy it on the day, but the cheapest tickets can be found for only €57.
Of the 1 trains that leave Isernia for Milan Centrale on Sun, Aug 16, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Aug 16 the direct trains cover the 592 km distance in an average of 13 h 22 m but if you time it right, some trains will get you there in just 13 h 22 m .
On Sun, Aug 16 the slowest trains will take 13 h 22 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
6:38 AM13h22Isernia8:00 PMMilan Centrale€571One-way0 transfers
6:38 AM13h22Isernia8:00 PMMilan Centrale€571One-way0 transfers
Travel Information
Compare train, bus, and flight for Isernia to Milan Centrale
Omio recommends booking the bus as it is the most popular option from Isernia to Milan Centrale among Omio's users. If you are prioritising price take the bus with prices starting from €19. For those with little time consider booking a flight which can get you there in 1h 24m. The ticket price range depends on the travel mode: a bus costs an average of €19, and a flight costs an average of €27.
Distance: 367 miles (592 km)
Compare train with
| Train | Most popular Bus | Flight | Driving |
|---|---|---|---|
€64 Average price | €39 Average price Cheapest | €77 Average price | €169 Average price (fuel + tolls) |
7h 10m Average total duration 6h 40m Onboard + 30m Additional time* | 12h 14m Average total duration 11h 44m Onboard + 30m Additional time* | 4h 24m Average total duration Fastest 1h 24m Onboard + 3h 0m Additional time* | 7h 26m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Isernia to Milan Centrale:
A bus is €25 less than a train for this route with tickets for a train from Isernia to Milan Centrale costing on average €64.
A bus is €37 less than a flight for this route with tickets for a flight from Isernia to Milan Centrale costing on average €77.
Other travel options to Milan Centrale take longer:
Train takes on average 6h 40m.
Bus takes on average 11h 44m.
The journey is about 46m faster (6h 40m by train vs 7h 26m by car) and roughly €105 cheaper once you factor in fuel and tolls (€64 vs €169). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
Live departures
Isernia to Milan Centrale train times
The table below shows live departures for Isernia to Milan Centrale trains for today, Saturday, August 15. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
treno 23353 effettuato con bus CB709+ 8158 | 3:00 PM Isernia station | 8h45 | 11:45 PM Milan Centrale | 1 transfer | |
treno 23353 effettuato con bus CB709+ FRECCIAROSSA 9556 | 3:00 PM Isernia station | 7h30 | 10:30 PM Milan Centrale | 1 transfer | |
treno 23353 effettuato con bus CB709+ 9954 | 3:00 PM Isernia station | 8h00 | 11:00 PM Milan Centrale | 1 transfer | |
treno 23361 effettuato con bus CB715+ InterCityNotte 764+ Regionale TRENORD 2616 | 8:10 PM Isernia station | 11h25 | 7:35 AM Milan Centrale | 2 transfers | |
| Sunday, August 16 | |||||
![]() | 6:38 AM Isernia | 13h22 | 8:00 PM Milan Centrale | 0 transfersDirect | |
Find all the dates and times for this journey
Compare prices and tickets Isernia to Milan Centrale by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Aug 16
Aug 17
Aug 18
Aug 19
Aug 20
Aug 21
Aug 22
Why should you book Isernia to Milan Centrale trains with Omio?
Why book with Omio vs Italo?
- Compare with other providers: On Omio, you can not only buy tickets for Italo, but also compare tickets for the likes of Frecciarossa, Intercity or Regionale to find the best option for your trip from Isernia to Milan Centrale.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Italo with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Isernia to Milan Centrale.
Journey information
Overview: Train from Isernia to Milan Centrale
Trains from Isernia to Milan Centrale run on average 7 times per day, taking around 6h 40m. Cheap train tickets for this journey start at €29 but you can travel from only €19 by bus.
The earliest train runs at 04:00, the last at 17:10. The fastest train covers the 367 miles (592 km) distance in 12h 15m.
Distance 367 miles (592 km) |
Average train duration 6h 40m |
Cheapest ticket price €29 |
Trains per day 7 |
Fastest train 12h 15m |
First train 4:00 AM |
Last train 5:10 PM |
Cheapest Month Jun |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Jul - Sep |
Busiest Day Sat |
Least Busy Day Sat |
Train companies: Italo, Frecciarossa, Intercity, Regionale from Isernia to Milan Centrale trainsItalo, Frecciarossa, Intercity, Regionale trains will get you between Isernia and Milan Centrale from €19. With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Italo
Frecciarossa
Intercity
Regionale
FAQs: Trains from Isernia to Milan Centrale
Find answers to the most common questions about traveling from Isernia to Milan Centrale by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Milan Centrale, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Isernia to Milan Centrale
Most Isernia to Milan Centrale trains use the Isernia to Milano Centrale station pair. Use this guide to compare Isernia and Milan Centrale train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Getting to Isernia from Isernia city centre
Isernia train station facilities and services
Isernia has practical services for this route, including Wifi, Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Information Desk, and Luggage Carts.
Food and drink
Food options include: Pasta e Pizza, Ristorante da Adriano
Wi-Fi and ATMs
Free.
Tickets and information
Ticket office support is available at Isernia. Information desks are located in the main hall.
Luggage and lost property
Luggage storage is available at Isernia. Lost and found is available at the station.
Parking, taxis and toilets
Available at Isernia: Parking, Taxis, WC.
Bike and car services
Available at Isernia: Bike Parking.
Accessibility
Accessibility facilities are available at Isernia: Ramps.
Shops, hotels and contact
Nearby hotels include Grand Hotel Europa, Hotel Ristorante Sayonara, Hotel La Tequila.
Getting to Milano Centrale from Milan city centre
Milano Centrale is 2 km from Milan city centre. Public transport options include:
Milano Centrale train station facilities and services
Milano Centrale has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food and drink
Food options include: Venchi, Panzera Coffee, Burger King, Bar Motta, Caffè Napoli, VyTA Boulangerie, Spontini, Starbucks, Dispensa Emilia, McDonald's, & many more
Wi-Fi and ATMs
Free WiFi in the station. ATMs are there are ATMs in various locations around the station.
Tickets and information
The ticket office is open Mon - Sun: 05:50 - 22:20. Information desks are located next to the ticket office on the ground floor in the shopping gallery.
Luggage and lost property
Luggage storage is provided by KiPoint and located on the ground floor, on the side of Piazza Luigi di Savoia. It is open every day from 06:00 to 23:00.
Parking, taxis and toilets
Available at Milano Centrale: Parking, Taxis, WC.
Bike and car services
Available at Milano Centrale: Bike Parking, Bike Rental, Car Rental.
Accessibility
Accessibility facilities are available at Milano Centrale: Station is wheelchair accessible, has elevators and the Sala Blu, Trenitalia's office of assistance for disabled travelers, is next to Platform 4.
Shops, hotels and contact
Nearby hotels include Glam Hotel Milano, NYX MIlan, iQ Hotel Milano.
Most popular train connections from Isernia
More options for your journey from Isernia to Milan Centrale
Here are some other resources that might have the information you need




