- Must visit
Pinacoteca di Brera
Milan’s premier art gallery, known for Italian masterpieces by Raphael, Caravaggio, and Mantegna in the historic Brera district.
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The cheapest and fastest trains from Isernia to Milan Centrale
Showing times and prices for Jul 02
Cheapest price
$58
Average price
$79
Fastest journey
12 h 15 m
Average duration
12 h 40 m
Trains per day
2
Distance
592 km
Cheap tickets
The best way to find a cheap train ticket from Isernia to Milan Centrale is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Isernia to Milan Centrale will cost around $79 if you buy it on the day, but the cheapest tickets can be found for only $58.
Fast trains
Of the 2 trains that leave Isernia for Milan Centrale on Thu, Jul 02, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Thu, Jul 02 the direct trains cover the 592 km distance in an average of 12 h 40 m but if you time it right, some trains will get you there in just 12 h 15 m .
On Thu, Jul 02 the slowest trains will take 13 h 5 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
6:10 AM12h15Isernia6:25 PMMilan Centrale$581One-way0 transfers
5:00 PM13h05Isernia6:05 AMMilan Centrale$991One-way0 transfers
- 6:10 AM12h15Isernia6:25 PMMilan Centrale$581One-way0 transfers
- 5:00 PM13h05Isernia6:05 AMMilan Centrale$991One-way0 transfers
Travel Information
Compare train, bus, and flight for Isernia to Milan Centrale
Omio recommends booking the bus as it is the most popular option from Isernia to Milan Centrale among Omio's users. If you are prioritising price take the bus with prices starting from $23. For those with little time consider booking a flight which can get you there in 1h 24m. The ticket price range depends on the travel mode: a bus costs an average of $23, and a flight costs an average of $33.
Distance: 367 miles (592 km)
Compare train with
| Train | Most popular Bus | Flight | Driving |
|---|---|---|---|
$78 Average price | $48 Average price Cheapest | $93 Average price | $206 Average price (fuel + tolls) |
7h 10m Average total duration 6h 40m Onboard + 30m Additional time* | 12h 14m Average total duration 11h 44m Onboard + 30m Additional time* | 4h 24m Average total duration Fastest 1h 24m Onboard + 3h 0m Additional time* | 7h 26m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Isernia to Milan Centrale is a bus with an average price of $48 (€39).
This is compared to other travel options from Isernia to Milan Centrale:
A bus is $30 (€25) less than a train for this route with tickets for a train from Isernia to Milan Centrale costing on average $78 (€64).
A bus is $45 (€37) less than a flight for this route with tickets for a flight from Isernia to Milan Centrale costing on average $93 (€77).
The fastest way to travel from Isernia to Milan Centrale is by flight with an average journey time of 1h 24m.
Other travel options to Milan Centrale take longer:
Train takes on average 6h 40m.
Bus takes on average 11h 44m.
It's helpful to compare your options as there are 3 ways to travel between Isernia and Milan Centrale including taking a train, bus, and flight.
We recommend using the bus as it is the most popular way to get from Isernia to Milan Centrale among Omio's users.
Take the train. On this route, it beats driving on both time and money.
The journey is about 46m faster (6h 40m by train vs 7h 26m by car) and roughly $128 (€105) cheaper once you factor in fuel and tolls ($78 (€64) vs $206 (€169)). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
Live departures
Isernia to Milan Centrale train times
The table below shows live departures for Isernia to Milan Centrale trains for today, Wednesday, July 1. You can also manually refresh the results below to see updated train journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 5:00 PM Isernia | 13h05 | 6:05 AM Milan Centrale | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Isernia to Milan Centrale by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Isernia to Milan Centrale trains with Omio?
Italo as well as Frecciarossa, Intercity, Regionale and more offer trains services from Isernia to Milan Centrale.
Omio is the only official third party seller for Italo tickets.
Why book with Omio vs Italo?
- Compare with other providers: On Omio, you can not only buy tickets for Italo, but also compare tickets for the likes of Frecciarossa, Intercity or Regionale to find the best option for your trip from Isernia to Milan Centrale.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Italo with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Isernia to Milan Centrale.
Journey information
Overview: Train from Isernia to Milan Centrale
ItalyItaly
Trains from Isernia to Milan Centrale run on average 7 times per day, taking around 6h 40m. Cheap train tickets for this journey start at $35 (€29) but you can travel from only $23 (€19) by bus.
The earliest train runs at 04:00, the last at 17:10. The fastest train covers the 367 miles (592 km) distance in 12h 15m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $23 (€19)
Distance 367 miles (592 km) |
Average train duration 6h 40m |
Cheapest ticket price $35 (€29) |
Trains per day 7 |
Fastest train 12h 15m |
First train 4:00 AM |
Last train 5:10 PM |
Cheapest Month Jun |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Jul - Sep |
Busiest Day Sat |
Least Busy Day Sat |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $23 (€19)
Train companies: Italo, Frecciarossa, Intercity, Regionale from Isernia to Milan Centrale trainsItalo, Frecciarossa, Intercity, Regionale trains will get you between Isernia and Milan Centrale from $23 (€19). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Italo
About
Italo is Italy’s private high-speed train service operated by Nuovo Trasporto Viaggiatori (NTV), connecting major cities such as Rome, Milan, Naples, Florence, Turin, Bologna, and Salerno. Its fleet includes the Italo AGV 575, capable of speeds up to 186 mph (300 km/h), and the eco-friendly Italo EVO, which reaches up to 150 mph (250 km/h). Passengers can choose from four classes — Smart, Comfort, Prima, and Club Executive — all offering modern amenities such as free Wi-Fi, power outlets, reclining leather seats, footrests, bathrooms, snack machines, and Italo Live entertainment with movies, music, and games. Italo offers three fare types — Low Cost, Economy, and Flex — providing different levels of price and flexibility. Popular routes include Rome–Milan, Rome–Florence, and Milan–Turin, making Italo a fast, comfortable, and convenient way to travel around Italy.
Luggage & cancellation policy
Luggage included
2 pieces of hand luggage (max 55x35x25cm) and 1 piece of luggage (max 75x53x30cm)
Luggage storage
Overhead racks and designated luggage areas between seats
Cancellation Policy
Cancellation possible according to ticket conditions
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Snack bar service available in most trains with drinks and light refreshments. Welcome service in Prima and Club Executive classes
Seat reservation
Included in Prima and Club Executive. Optional extra cost in Smart and Comfort
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for passengers with reduced mobility
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle. Guide dogs travel free
Quiet zone
Frecciarossa
About
Step on board a Frecciarossa train and relax as you travel across Italy. Trenitalia’s Frecciarossa high-speed trains make around 200 connections across the country each day and are renowned for their comfort, speed, and reduced environmental impact. Reaching speeds of up to 186 mph (300 km/h), they connect major destinations such as Rome, Florence, Milan, Venice, and Naples quickly and efficiently. When booking your Frecciarossa journey, you can choose between four classes: Standard, Premium, Business, and Executive. While each class offers different levels of comfort, all provide free Wi-Fi access, power outlets, air conditioning, bathrooms, luggage storage, onboard entertainment, and restaurant and bar services. Ticket options include Super Economy, Economy, and Base, making it easy to find the right balance of comfort and price for your trip.
Luggage & cancellation policy
Average Duration
6h 14m
Cheapest Price
$110 (€91)
Frecciarossa frequency
5 a day
Luggage included
1 carry-on bag and 1 suitcase per passenger
Luggage storage
Overhead racks, dedicated luggage areas at carriage ends, under seats
Cancellation Policy
Refund policy depends on ticket type
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with full meals, bar service with snacks and beverages, at-seat service in Executive class
Seat reservation
Included in Executive class, optional fee for other classes
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible toilets, assistance service available
Pets
Small pets in carriers travel free, larger dogs require paid ticket and muzzle, service animals free
Quiet zone
Intercity
About
Trenitalia Intercity is a high-speed train service operated by the Italian national railway company, Trenitalia. It operates throughout the country, with services running from early morning to late evening. The Intercity trains come in two types: the Intercity Plus, which is the fastest and most comfortable, and the Intercity, which is slightly slower but still offers a comfortable journey. Onboard facilities include air conditioning, power sockets, Wi-Fi, and a bar service. There are several ticket types available, including Standard, Super Economy, and Business. The most popular routes for Trenitalia Intercity are from Rome to Milan, Naples to Florence, and Turin to Venice.
Luggage & cancellation policy
Average Duration
12h 15m
Cheapest Price
$35 (€29)
Intercity frequency
2 a day
Luggage included
2 pieces of luggage up to 30kg total
Luggage storage
Overhead racks and designated luggage areas at end of carriages
Cancellation Policy
According to ticket conditions
Refund
Full refund provided
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with hot meals and snacks, trolley service in some trains. But do not count on the presence of a buffet car. So if having access to food and drink on the train is important to you, it’s best to bring your own refreshments onboard.
Seat reservation
Seat reservation included in ticket price for most routes
Toilets
USB plugs
Accessibility
Wheelchair spaces and accessible toilets available
Pets
Small pets in carriers allowed free, larger dogs require paid ticket
Quiet zone
Regionale
About
Regionale is the regional train service of national carrier Trenitalia connecting all of Italy. It is the most convinient way to travel to both big cities and the smallest villages all over the Italian country. The regional trains have different names depending on the region they serve, such as Treno Regionale Veloce (TRV) and Treno Regionale Lento (TRL). Treno Rock and Treno pop are the two new trains part of Trenitalia regionale fleet. Trenitalia Regionale offers a variety of ticket types, including single tickets (economy and standard), return tickets, and season tickets. Onboard facilities include free Wi-Fi, air conditioning, and power sockets. The most popular routes for Regionale are between Rome and Milan, Naples and Florence, and Turin and Venice.
Luggage & cancellation policy
Average Duration
5h 33m
Cheapest Price
$120 (€99)
Regionale frequency
4 a day
Luggage included
Free hand luggage allowance included in ticket price
Luggage storage
Overhead racks and designated luggage areas between seats
Cancellation Policy
According to ticket conditions
Refund
Full refund provided
Amenities on board the train
Wifi
Food sold onboard
Bar service available on some trains with snacks and beverages
Seat reservation
Seat reservation included in ticket price for most services
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for passengers with reduced mobility
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle
Quiet zone
Complete guide to Milano Centrale
Things to do in Milano Centrale
Discover the best of Milano Centrale — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Milano Centrale trip today.
- Recommended
Museo del Novecento
A major modern art museum facing Piazza del Duomo, with strong collections of 20th-century Italian art and excellent city views.
- Recommended
MUDEC - Museo delle Culture
A contemporary museum focused on world cultures, temporary exhibitions, design, and photography in the creative Tortona area.
- Must visit
Brera
Milan’s most atmospheric central district, loved for art, elegant streets, boutiques, and a classic old-city feel.
- Must visit
Navigli
The city’s famous canal area, popular for waterside walks, photography, and a lively atmosphere day and night.
- Must visit
Piazza del Duomo
Milan’s main square and natural starting point for sightseeing, framed by the cathedral and major historic buildings.
- Vegetarian
- Gluten-free
Risotto Alla Milanese
Milan’s signature saffron risotto, rich with butter and cheese, prized for its golden color and refined flavor.
Cotoletta Alla Milanese
A traditional breaded veal cutlet, fried until crisp; one of the city’s most iconic classic dishes.
- Gluten-free
Ossobuco
Braised veal shank, often served with risotto Alla Milanese; a hearty Lombard specialty known for deep, slow-cooked flavor.
Joia
Established fine dining restaurant famous for creative vegetarian cuisine and elegant tasting menus near Centrale access by metro.
Ratanà
Well-known Milan restaurant serving refined Lombard and Milanese cuisine in a stylish but relaxed setting.
Antica Trattoria Della Pesa
Historic trattoria celebrated for traditional Milanese dishes such as risotto, cotoletta, and ossobuco in a classic atmosphere.
Euro
Prices are high by Italian standards, especially near the station. Casual dining is manageable, but hotels and sit-down meals cost more.
Average meal costs
- Budget
- EUR 8-15 for pizza, panini, or takeaway.
- Mid-range
- EUR 20-35 per person at a standard restaurant.
- Fine dining
- EUR 70+ per person at upscale restaurants.
- Coffee
- EUR 1.50-3 for espresso or cappuccino.
Tipping culture
Service is often included or covered by coperto. Tipping is modest: round up or leave EUR 1-3 at cafes, 5-10% for very good restaurant service, and round up taxis.
ATM Milano Official App
Get the appOfficial public transport app
Prices
- Single ticket
- EUR 2.20
- Day pass
- EUR 7.60
To the city center
Milano Centrale, Milan -> Duomo di Milano, Milan
- Distance
- 3 km
- Travel time
- 10 min
- Validate your ticket before boarding and keep it until the end of the journey, as inspections are frequent.
- You can pay by contactless card directly on Milan metro gates and on many buses and trams, but carry a backup payment method.
FAQs: Trains from Isernia to Milan Centrale
Find answers to the most common questions about traveling from Isernia to Milan Centrale by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Milan Centrale, this guide helps you travel smarter and with confidence.
Train ticket prices from Isernia to Milan Centrale can vary. The cheapest ticket starts at $35 (€29), while the average price is around $78 (€64).
The train from Isernia to Milan Centrale takes 12h 15m and runs 7 per day.
The distance by train from Isernia to Milan Centrale is 367 miles (592 km).
The first train from Isernia to Milan Centrale leaves at 4:00 AM.
The last train from Isernia to Milan Centrale leaves at 5:10 PM.
Yes, there is a high-speed train from Isernia to Milan Centrale.
There is no direct train service currently available from Isernia to Milan Centrale.
Unfortunately, there is no night train available from Isernia to Milan Centrale.
The cheapest way to get from Isernia to Milan Centrale is by bus, with a cost of around $23 (€19).
The train journey from Isernia to Milano Centrale offers varied scenery, featuring the picturesque landscapes of the Apennine Mountains, charming rural villages, and the lush countryside of northern Italy, providing a pleasant visual experience.
A day trip from Isernia to Milano Centrale is not feasible, as the journey duration is 12h 15m. However, there are 9 train trips per day available for this route.
Yes, you can take the train from Isernia to Milan Centrale.
Since both Isernia and Milan Centrale are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
Popular day trips by train from Milan Centrale include Como, Varenna, Bergamo, Verona, Turin.
We recommend using the bus as it is the most popular way to get from Isernia to Milan Centrale among Omio's users.
Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.
Yes, rail passes such as the Eurail Italy Pass and Interrail Italy Pass are valid on most trains operated by Trenitalia and Italo within Italy, including regional, intercity, and high-speed trains, though some restrictions and seat reservation fees may apply.
Italy uses the euro (EUR) as its currency. Travelers generally find it convenient to use cards for most payments, especially in cities and larger establishments, but carrying some cash is advisable for small shops, markets, and rural areas where card acceptance may be limited.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular train stations
Popular train stations from Isernia to Milan Centrale
Most Isernia to Milan Centrale trains use the Isernia to Milano Centrale station pair. Use this guide to compare Isernia and Milan Centrale train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Departure train stations in Isernia
Arrival train stations in Milan
IserniaPiazza della Repubblica, 86170 Isernia IS, Italy+39 0865 4131
City-centre transport
Getting to Isernia from Isernia city centre
Bus31 · 1m · $4
Isernia train station facilities and services
Isernia has practical services for this route, including Wifi, Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Information Desk, and Luggage Carts.
Food and drink
Food options include: Pasta e Pizza, Ristorante da Adriano
Wi-Fi and ATMs
Free.
Tickets and information
Ticket office support is available at Isernia. Information desks are located in the main hall.
Luggage and lost property
Luggage storage is available at Isernia. Lost and found is available at the station.
Parking, taxis and toilets
Available at Isernia: Parking, Taxis, WC.
Bike and car services
Available at Isernia: Bike Parking.
Accessibility
Accessibility facilities are available at Isernia: Ramps.
Shops, hotels and contact
Nearby hotels include Grand Hotel Europa, Hotel Ristorante Sayonara, Hotel La Tequila.
Milano CentralePiazza Duca d'Aosta, 1, 20124 Milan, Italy+39 892021
City-centre transport
Getting to Milano Centrale from Milan city centre
Milano Centrale is 2 km from Milan city centre. Public transport options include:
TrainRe51 · 11m · $2 · every ~5 min
BusNm3 · 9m · $2 · every ~1 min
60 · 31m · $2 · every ~10 min
Tram9 · 27m · $2 · every ~16 min
Subway3 · 11m · $2 · every ~25 min
Milano Centrale train station facilities and services
Milano Centrale has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food and drink
Food options include: Venchi, Panzera Coffee, Burger King, Bar Motta, Caffè Napoli, VyTA Boulangerie, Spontini, Starbucks, Dispensa Emilia, McDonald's, & many more
Wi-Fi and ATMs
Free WiFi in the station. ATMs are there are ATMs in various locations around the station.
Tickets and information
The ticket office is open Mon - Sun: 05:50 - 22:20. Information desks are located next to the ticket office on the ground floor in the shopping gallery.
Luggage and lost property
Luggage storage is provided by KiPoint and located on the ground floor, on the side of Piazza Luigi di Savoia. It is open every day from 06:00 to 23:00.
Parking, taxis and toilets
Available at Milano Centrale: Parking, Taxis, WC.
Bike and car services
Available at Milano Centrale: Bike Parking, Bike Rental, Car Rental.
Accessibility
Accessibility facilities are available at Milano Centrale: Station is wheelchair accessible, has elevators and the Sala Blu, Trenitalia's office of assistance for disabled travelers, is next to Platform 4.
Shops, hotels and contact
Nearby hotels include Glam Hotel Milano, NYX MIlan, iQ Hotel Milano.
Most popular train connections from Isernia
More options for your journey from Isernia to Milan Centrale
Here are some other resources that might have the information you need
Most popular trains to and from Milan Centrale and Isernia
Most popular train connections to Milan Centrale
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