The cheapest and fastest trains from Isernia to Milan Centrale
Cheapest price
$72
Average price
$86
Fastest journey
10 h 50 m
Average duration
13 h 10 m
Trains per day
5
Distance
592 km
The best way to find a cheap train ticket from Isernia to Milan Centrale is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Isernia to Milan Centrale will cost around $86 if you buy it on the day, but the cheapest tickets can be found for only $72.
Of the 5 trains that leave Isernia for Milan Centrale on Fri, Nov 07, 5 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Nov 07 the direct trains cover the 592 km distance in an average of 13 h 10 m but if you time it right, some trains will get you there in just 10 h 50 m .
On Fri, Nov 07 the slowest trains will take 15 h 49 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.










Travel Information
Compare train, bus, and flight for Isernia to Milan Centrale
Omio recommends booking the train as it is the most popular option from Isernia to Milan Centrale among Omio's users. If you are prioritising price take the bus with prices starting from €32. For those with little time consider booking a flight which can get you there in 1h 24m. The ticket price range depends on the travel mode: a bus costs an average of €32, and a train costs an average of €48.
Distance: 367 miles (592 km)
Compare train with
Most popular Train | Flight | Bus |
|---|---|---|
€75 Average price | €55 Average price | €52 Average price Cheapest |
7h 58m Average total duration 7h 28m Onboard + 30m Additional time* | 4h 24m Average total duration Fastest 1h 24m Onboard + 3h 0m Additional time* | 15h 43m Average total duration 15h 13m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Isernia to Milan Centrale train times
The table below shows live departures for Isernia to Milan Centrale trains for today, Thursday, November 6. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:16 AM Isernia | 14h14 | 7:30 PM Milan Centrale | 0 transfersDirect | |
![]() | 4:00 PM Isernia | 13h05 | 5:05 AM Milan Centrale | 0 transfersDirect | |
![]() | 5:19 PM Isernia | 13h13 | 6:32 AM Milan Centrale | 0 transfersDirect | |
| Friday, November 7 | |||||
![]() | 4:45 AM Isernia | 10h50 | 3:35 PM Milan Centrale | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Isernia to Milan Centrale by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Nov 07
Nov 08
Nov 09
Nov 10
Nov 11
Nov 12
Nov 13
Journey information
Overview: Train from Isernia to Milan Centrale
Trains from Isernia to Milan Centrale run on average 9 times per day, taking around 7h 28m. Cheap train tickets for this journey start at $59 (€48) but you can travel from only $34 (€28) by flight.
The earliest train runs at 03:00, the last at 16:00. The fastest train covers the 367 miles (592 km) distance in 6h 35m.
Distance 367 miles (592 km) |
Average train duration 7h 28m |
Cheapest ticket price $59 (€48) |
Trains per day 9 |
Fastest train 6h 35m |
First train 03:00 |
Last train 16:00 |
Train companies: Italo, Frecciarossa, Intercity, Intercity Notte, Regionale from Isernia to Milan Centrale trainsItalo, Frecciarossa, Intercity, Intercity Notte, Regionale trains will get you between Isernia and Milan Centrale from $34 (€28). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Italo
Frecciarossa
Intercity
Intercity Notte
Regionale
FAQs: Trains from Isernia to Milan Centrale
Find answers to the most common questions about traveling from Isernia to Milan Centrale by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Milan Centrale, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Isernia to Milan Centrale
- 6:00 AM - 8:00 PM Monday - Sunday
- Free
- Parking is available 24/7 with access from Via Giovanni XXIII.
- Pasta e Pizza
- Ristorante da Adriano
- Outside the main entrance.
- Ramps.
- €0.50
- Grand Hotel Europa
- Hotel Ristorante Sayonara
- Hotel La Tequila
- Located in the main hall
- Located in the main hall
- Free
- Hall 1: main entrance, ticket office, and waiting area
- Hall 2: platforms for regional trains
- Bus: Several local lines available
- Train: Regional connections
- Mon - Sun: 05:50 - 22:20
- Free WiFi in the station.
- Provided by KiPoint and located on the ground floor, on the side of Piazza Luigi di Savoia. It is open every day from 06:00 to 23:00.
- Venchi
- Panzera Coffee
- Burger King
- Bar Motta
- Caffè Napoli
- VyTA Boulangerie
- Spontini
- Starbucks
- Dispensa Emilia
- McDonald's
- & many more
- Station is wheelchair accessible, has elevators and the Sala Blu, Trenitalia's office of assistance for disabled travelers, is next to Platform 4.
- Glam Hotel Milano
- NYX MIlan
- iQ Hotel Milano
- Mon - Sun: 05:50 - 22:20
- Located next to the ticket office on the ground floor in the shopping gallery.
- Metro lines: M2 (green), M3 (yellow)
- Tram lines: 1
- Bus lines: 5, 9, 10, 42, 81, 87, 152, 728, N26, NM2, NM3, Air Bus, Orio Shuttle
- Train lines: FR, FB, EC, Thello, XP2, R28, IC, ICN, RV, R, Regio, Italo
Most popular train connections from Isernia
More options for your journey from Isernia to Milan Centrale
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