Isernia to Milan Centrale train with Italo

Sun, May 17
+ Add return
Italo
Frecciarossa
Intercity
Regionale
Deutsche Bahn
2,000+ travel companies
Italo
Frecciarossa
Intercity
Regionale
Deutsche Bahn
2,000+ travel companies
QR-Code
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
rate4.9
42K ratings
Google Play
rate4.6
136K reviews

The cheapest and fastest trains from Isernia to Milan Centrale

Showing times and prices for May 17

Cheapest price

$70

Average price

$70

Fastest journey

13 h 22 m

Average duration

13 h 22 m

Trains per day

1

Distance

592 km

Cheap tickets

The best way to find a cheap train ticket from Isernia to Milan Centrale is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Isernia to Milan Centrale will cost around $70 if you buy it on the day, but the cheapest tickets can be found for only $70.

Fast trains

Of the 1 trains that leave Isernia for Milan Centrale on Sun, May 17, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.

On Sun, May 17 the direct trains cover the 592 km distance in an average of 13 h 22 m but if you time it right, some trains will get you there in just 13 h 22 m .

On Sun, May 17 the slowest trains will take 13 h 22 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

  • Intercity
    6:38 AM13h22
    Isernia
    8:00 PMMilan Centrale
    $701One-way
    0 transfers

Travel Information

Compare train, bus, and flight for Isernia to Milan Centrale

Omio recommends booking the bus as it is the most popular option from Isernia to Milan Centrale among Omio's users. If you are prioritising price take the bus with prices starting from $23. For those with little time consider booking a flight which can get you there in 1h 24m. The ticket price range depends on the travel mode: a bus costs an average of $23, and a flight costs an average of $33.

Distance: 367 miles (592 km)

Compare train with

Train
Most popular
Bus
Flight
Driving

$79

Average price

$49

Average price

Cheapest

$95

Average price

$210

Average price

(fuel + tolls)

7h 10m

Average total duration

6h 40m

Onboard

+

30m

Additional time*

12h 14m

Average total duration

11h 44m

Onboard

+

30m

Additional time*

4h 24m

Average total duration

Fastest

1h 24m

Onboard

+

3h 0m

Additional time*

7h 26m

Average total duration

(door-to-door)

Direct Options

Direct Options

Direct Options

Direct Options

The cheapest way to travel from Isernia to Milan Centrale is a bus with an average price of $49 (€39).

This is compared to other travel options from Isernia to Milan Centrale:

A bus is $30 (€25) less than a train for this route with tickets for a train from Isernia to Milan Centrale costing on average $79 (€64).

A bus is $46 (€37) less than a flight for this route with tickets for a flight from Isernia to Milan Centrale costing on average $95 (€77).

The fastest way to travel from Isernia to Milan Centrale is by flight with an average journey time of 1h 24m.

Other travel options to Milan Centrale take longer:

Train takes on average 6h 40m.

Bus takes on average 11h 44m.

It's helpful to compare your options as there are 3 ways to travel between Isernia and Milan Centrale including taking a train, bus, and flight.
We recommend using the bus as it is the most popular way to get from Isernia to Milan Centrale among Omio's users.
Take the train. On this route, it beats driving on both time and money.

The journey is about 46m faster (6h 40m by train vs 7h 26m by car) and roughly $130 (€105) cheaper once you factor in fuel and tolls ($79 (€64) vs $210 (€169)). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.

Driving is still worth considering if you want to stop along the way or need a car once you arrive.

Live departures

Isernia to Milan Centrale train times

The table below shows live departures for Isernia to Milan Centrale trains for tomorrow, Sunday, May 17. You can also manually refresh the results below to see updated train journeys.

Last updated at
ProviderDepartsDurationArrivesTransfers
Tickets
Intercity6:38 AM Isernia
13h22
8:00 PM Milan Centrale0 transfersDirect

This is the last train of the day.

Find all the dates and times for this journey

Compare prices and tickets Isernia to Milan Centrale by train, bus, or flight

Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Sun
May 17
Mon
May 18
Tue
May 19
Wed
May 20
Thu
May 21
Fri
May 22
Sat
May 23

Why should you book Isernia to Milan Centrale trains with Omio?

Italo as well as Frecciarossa, Intercity, Regionale and more offer trains services from Isernia to Milan Centrale.
Omio is the only official third party seller for Italo tickets.

Why book with Omio vs Italo?

  • Compare with other providers: On Omio, you can not only buy tickets for Italo, but also compare tickets for the likes of Frecciarossa, Intercity or Regionale to find the best option for your trip from Isernia to Milan Centrale.
  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Italo with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Isernia to Milan Centrale.

Journey information

Overview: Train from Isernia to Milan Centrale

ItalyItaly
ItalyItaly
Icon of train

Trains from Isernia to Milan Centrale run on average 7 times per day, taking around 6h 40m. Cheap train tickets for this journey start at $36 (€29) but you can travel from only $23 (€19) by bus.

The earliest train runs at 04:00, the last at 17:10. The fastest train covers the 367 miles (592 km) distance in 12h 15m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $23 (€19)
Distance
367 miles (592 km)
Average train duration
6h 40m
Cheapest ticket price
$36 (€29)
Trains per day
7
Fastest train
12h 15m
First train
4:00 AM
Last train
5:10 PM
Cheapest Month
Jun
Cheapest Day
Wed
High Season
Apr - Jun
Low Season
Jul - Sep
Busiest Day
Sat
Least Busy Day
Sat
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $23 (€19)

Train companies: Italo, Frecciarossa, Intercity, Regionale from Isernia to Milan Centrale trainsItalo, Frecciarossa, Intercity, Regionale trains will get you between Isernia and Milan Centrale from $23 (€19). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.

Italo

About
Italo is Italy’s private high-speed train service operated by Nuovo Trasporto Viaggiatori (NTV), connecting major cities such as Rome, Milan, Naples, Florence, Turin, Bologna, and Salerno. Its fleet includes the Italo AGV 575, capable of speeds up to 186 mph (300 km/h), and the eco-friendly Italo EVO, which reaches up to 150 mph (250 km/h). Passengers can choose from four classes — Smart, Comfort, Prima, and Club Executive — all offering modern amenities such as free Wi-Fi, power outlets, reclining leather seats, footrests, bathrooms, snack machines, and Italo Live entertainment with movies, music, and games. Italo offers three fare types — Low Cost, Economy, and Flex — providing different levels of price and flexibility. Popular routes include Rome–Milan, Rome–Florence, and Milan–Turin, making Italo a fast, comfortable, and convenient way to travel around Italy.
Luggage & cancellation policy
Luggage included
2 pieces of hand luggage (max 55x35x25cm) and 1 piece of luggage (max 75x53x30cm)
Luggage storage
Overhead racks and designated luggage areas between seats
Cancellation Policy
Cancellation possible according to ticket conditions
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Snack bar service available in most trains with drinks and light refreshments. Welcome service in Prima and Club Executive classes
Seat reservation
Included in Prima and Club Executive. Optional extra cost in Smart and Comfort
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for passengers with reduced mobility
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle. Guide dogs travel free
Quiet zone
Learn more about Italo

Frecciarossa

About
Step on board a Frecciarossa train and relax as you travel across Italy. Trenitalia’s Frecciarossa high-speed trains make around 200 connections across the country each day and are renowned for their comfort, speed, and reduced environmental impact. Reaching speeds of up to 186 mph (300 km/h), they connect major destinations such as Rome, Florence, Milan, Venice, and Naples quickly and efficiently. When booking your Frecciarossa journey, you can choose between four classes: Standard, Premium, Business, and Executive. While each class offers different levels of comfort, all provide free Wi-Fi access, power outlets, air conditioning, bathrooms, luggage storage, onboard entertainment, and restaurant and bar services. Ticket options include Super Economy, Economy, and Base, making it easy to find the right balance of comfort and price for your trip.
Luggage & cancellation policy
Average Duration
6h 14m
Cheapest Price
$112 (€91)
Frecciarossa frequency
5 a day
Luggage included
1 carry-on bag and 1 suitcase per passenger
Luggage storage
Overhead racks, dedicated luggage areas at carriage ends, under seats
Cancellation Policy
Refund policy depends on ticket type
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with full meals, bar service with snacks and beverages, at-seat service in Executive class
Seat reservation
Included in Executive class, optional fee for other classes
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible toilets, assistance service available
Pets
Small pets in carriers travel free, larger dogs require paid ticket and muzzle, service animals free
Quiet zone
Learn more about Frecciarossa

Intercity

About
Trenitalia Intercity is a high-speed train service operated by the Italian national railway company, Trenitalia. It operates throughout the country, with services running from early morning to late evening. The Intercity trains come in two types: the Intercity Plus, which is the fastest and most comfortable, and the Intercity, which is slightly slower but still offers a comfortable journey. Onboard facilities include air conditioning, power sockets, Wi-Fi, and a bar service. There are several ticket types available, including Standard, Super Economy, and Business. The most popular routes for Trenitalia Intercity are from Rome to Milan, Naples to Florence, and Turin to Venice.
Luggage & cancellation policy
Average Duration
12h 15m
Cheapest Price
$36 (€29)
Intercity frequency
2 a day
Luggage included
2 pieces of luggage up to 30kg total
Luggage storage
Overhead racks and designated luggage areas at end of carriages
Cancellation Policy
According to ticket conditions
Refund
Full refund provided
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with hot meals and snacks, trolley service in some trains. But do not count on the presence of a buffet car. So if having access to food and drink on the train is important to you, it’s best to bring your own refreshments onboard.
Seat reservation
Seat reservation included in ticket price for most routes
Toilets
USB plugs
Accessibility
Wheelchair spaces and accessible toilets available
Pets
Small pets in carriers allowed free, larger dogs require paid ticket
Quiet zone

Regionale

About
Regionale is the regional train service of national carrier Trenitalia connecting all of Italy. It is the most convinient way to travel to both big cities and the smallest villages all over the Italian country. The regional trains have different names depending on the region they serve, such as Treno Regionale Veloce (TRV) and Treno Regionale Lento (TRL). Treno Rock and Treno pop are the two new trains part of Trenitalia regionale fleet. Trenitalia Regionale offers a variety of ticket types, including single tickets (economy and standard), return tickets, and season tickets. Onboard facilities include free Wi-Fi, air conditioning, and power sockets. The most popular routes for Regionale are between Rome and Milan, Naples and Florence, and Turin and Venice.
Luggage & cancellation policy
Average Duration
5h 33m
Cheapest Price
$123 (€99)
Regionale frequency
4 a day
Luggage included
Free hand luggage allowance included in ticket price
Luggage storage
Overhead racks and designated luggage areas between seats
Cancellation Policy
According to ticket conditions
Refund
Full refund provided
Amenities on board the train
Wifi
Food sold onboard
Bar service available on some trains with snacks and beverages
Seat reservation
Seat reservation included in ticket price for most services
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for passengers with reduced mobility
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle
Quiet zone

FAQs: Trains from Isernia to Milan Centrale

Find answers to the most common questions about traveling from Isernia to Milan Centrale by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Milan Centrale, this guide helps you travel smarter and with confidence.

FAQs
Train ticket prices from Isernia to Milan Centrale can vary. The cheapest ticket starts at $36 (€29), while the average price is around $79 (€64).
The train from Isernia to Milan Centrale takes 12h 15m and runs 7 per day.
The first train from Isernia to Milan Centrale leaves at 4:00 AM.
The distance by train from Isernia to Milan Centrale is 367 miles (592 km).
The last train from Isernia to Milan Centrale leaves at 5:10 PM.
Yes, there is a high-speed train from Isernia to Milan Centrale.
There is no direct train service currently available from Isernia to Milan Centrale.
Unfortunately, there is no night train available from Isernia to Milan Centrale.
The cheapest way to get from Isernia to Milan Centrale is by bus, with a cost of around $23 (€19).
The train journey from Isernia to Milano Centrale offers varied scenery, featuring the picturesque landscapes of the Apennine Mountains, charming rural villages, and the lush countryside of northern Italy, providing a pleasant visual experience.
A day trip from Isernia to Milano Centrale is not feasible, as the journey duration is 12h 15m. However, there are 9 train trips per day available for this route.
Yes, you can take the train from Isernia to Milan Centrale.
Since both Isernia and Milan Centrale are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
Popular day trips by train from Milan Centrale include Como, Varenna, Bergamo, Verona, Turin.
We recommend using the bus as it is the most popular way to get from Isernia to Milan Centrale among Omio's users.
Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.
Yes, rail passes such as the Eurail Italy Pass and Interrail Italy Pass are valid on most trains operated by Trenitalia and Italo within Italy, including regional, intercity, and high-speed trains, though some restrictions and seat reservation fees may apply.
Italy uses the euro (EUR) as its currency. Travelers generally find it convenient to use cards for most payments, especially in cities and larger establishments, but carrying some cash is advisable for small shops, markets, and rural areas where card acceptance may be limited.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular train stations

Popular train stations from Isernia to Milan Centrale

Isernia
Milan
The major train station for departures in Isernia is Isernia. Find all the information you need to know about services, amenities and connections at Isernia for your trip from Isernia to Milan.
IserniaWifiLockersParkingDiningTaxisAccessibilityWCHotelLost and Found OfficeTicket OfficeBike ParkingInformation DeskLuggage Carts
Amenities at train station
WifiWifi
LockersLockers
ParkingParking
DiningDining
TaxisTaxis
AccessibilityAccessibility
WCWC
HotelHotel
Lost and Found OfficeLost and Found Office
Ticket OfficeTicket Office
Bike ParkingBike Parking
Information DeskInformation Desk
Luggage CartsLuggage Carts
information
address
Address
Piazza della Repubblica, 86170 Isernia IS, Italy
phone
Phone Number
ticketOfficeHours
Ticket Office Hours
  • 6:00 AM - 8:00 PM Monday - Sunday
platformCount
Number of platforms
2
Wifi
Wifi
  • Free
Parking
Parking
  • Parking is available 24/7 with access from Via Giovanni XXIII.
Dining
Dining
  • Pasta e Pizza
  • Ristorante da Adriano
Taxis
Taxis
  • Outside the main entrance.
Accessibility
Accessibility
  • Ramps.
WC
WC
  • €0.50
Hotel
Hotel
  • Grand Hotel Europa
  • Hotel Ristorante Sayonara
  • Hotel La Tequila
Lost and Found Office
Lost and Found Office
  • Located in the main hall
Information Desk
Information Desk
  • Located in the main hall
Luggage Carts
Luggage Carts
  • Free
Station Plan
  • Hall 1: main entrance, ticket office, and waiting area
  • Hall 2: platforms for regional trains
Public transit options for Isernia
  • Bus: Several local lines available
  • Train: Regional connections

Most popular train connections from Isernia

Train Isernia - Rome
Train Isernia - Naples

More options for your journey from Isernia to Milan Centrale

Here are some other resources that might have the information you need

Tickets and more information for trains to Isernia
Tickets and more information for trains to Milan Centrale

Most popular trains to and from Milan Centrale and Isernia

Train Naples - Milan Centrale
Train Nice - Milan Centrale
Train Bari - Milan Centrale
Train Paris Charles de Gaulle Airport - Milan Centrale
Train Munich - Milan Centrale
Train Berlin Hbf - Milan Centrale
Train Florence Santa Maria Novella - Milan Centrale
Train Rome Termini - Milan Centrale
Train Isernia - Florence
Train Palermo - Milan Centrale
Train Vienna - Milan Centrale
Train Verona - Milan Centrale
Train Salzburg - Milan Centrale
Train Isernia - Rome
Train Paris Gare de Lyon - Milan Centrale
Train Isernia - Naples
Train Hamburg Hbf - Milan Centrale
Train Venice - Milan Centrale
Train Munich Hbf - Milan Centrale
Train Isernia - Rome Leonardo da Vinci Fiumicino Airport
Train Rome - Milan Centrale
Train Isernia - Genoa
Train Bologna Centrale - Milan Centrale
Train Bologna - Milan Centrale
Train Turin - Milan Centrale
Train Paris Gare du Nord - Milan Centrale
Train Florence - Milan Centrale
HomeTrainsTrains in ItalyTrain Times to Milan CentraleIsernia to Milan Centrale train

The Omio App Makes Travel Planning Easy

We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.

ios-badge
android-badge
Hand With Phone