Travel Information
Compare train and bus for Isernia to Rome
Omio recommends booking the train as it is the most popular option from Isernia to Rome among Omio's users. If you are prioritising price, take the bus, with an average ticket price of CHF18 For those with little time, consider booking a train, which has an average total journey time of 3h 4m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.0 - 0.1kg. Average ticket prices depend on the travel mode: a bus costs an average of CHF18, while a train costs an average of CHF24.
Distance: 92 miles (149 km)
Compare train with
Most popular Train | Bus | Driving |
|---|---|---|
CHF24 Average price | CHF18 Average price Cheapest | CHF41 Average price (fuel + tolls) |
3h 4m Average total duration Fastest 2h 34m Onboard + 30m Additional time* | 3h 36m Average total duration 3h 6m Onboard + 30m Additional time* | 2h 26m Average total duration (door-to-door) |
0.0 - 0.1kg CO2 emissions Lowest | 0.1 - 0.4kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Isernia to Rome:
A bus is CHF6 less than a train for this route with tickets for a train from Isernia to Rome costing on average CHF24.
Other travel options to Rome take longer:
Bus takes on average 3h 36m.
Tickets start at around CHF24 compared to roughly CHF41 in fuel and tolls — a saving of about CHF17. The journey takes 2h 34m versus 2h 26m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Travel optionsfrom Isernia to Rome
How to get from Isernia to Rome by train, bus or flight.
Our recommendation
The best way to travel from Isernia to Rome is by taking a bus because it’s the best combination of price and speed.
FlixBus11:35 AM2h25Isernia, Piazza della Repubblica (F. Martino bus station)2:00 PMRoma, Autostazione TiburtinaCHF141One-way0 transfers
Cheapest
FlixBus11:35 AM2h25Isernia, Piazza della Repubblica (F. Martino bus station)2:00 PMRoma, Autostazione TiburtinaCHF141One-way0 transfers
Fastest
Regionale 233478:38 AM2h09Isernia station10:47 AMRome TerminiCHF141One-way0 transfers
Other options
Regionale 233416:35 AM2h18Isernia station8:53 AMRome TerminiCHF141One-way0 transfers
Regionale 233618:35 PM2h19Isernia station10:54 PMRome TerminiCHF141One-way0 transfers
Regionale 233513:03 PM2h24Isernia station5:27 PMRome TerminiCHF141One-way0 transfers
0598:25 AM2h25Isernia, Piazza della Repubblica (F. Martino bus station)10:50 AMRoma, Autostazione TiburtinaCHF161One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Isernia to Rome
Travel to Rome easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Isernia to Rome.

This is compared to other travel options from Isernia to Rome:
A bus is CHF6 less than a train for this route with tickets for a train from Isernia to Rome costing on average CHF24.
Other travel options to Rome take longer:
Bus takes on average 3h 36m.
- Around 8 trains per day.
- Around 2 buses per day.
However, we recommend checking specific travel dates for your route between Isernia and Rome as scheduled services by train and bus can vary by season or day of the week.
- Trains mostly depart from Isernia station and arrive in Rome Termini.
- Buses mostly depart from Isernia, Piazza della Repubblica (F. Martino bus station) and arrive in Roma, Autostazione Tiburtina.
- Travel with Marino Autolinee, FlixBus to go to Rome by bus.
- Travel with Frecciarossa, Intercity, Regionale to go to Rome by train.
- 1 direct buses per day with Marino Autolinee, FlixBus.
- 4 direct trains per day with Regionale.
Travelling from Isernia to Rome: related information
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