- Must visit
Uffizi Gallery
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
The best way to find a cheap train ticket from Salisbury, NC to Florence, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Salisbury, NC to Florence, SC will cost around $141 if you buy it on the day, but the cheapest tickets can be found for only $141.
It's difficult to get from Salisbury, NC to Florence, SC without transferring at least once.

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Take a train from Salisbury, NC to Florence, SC and enjoy the approximately 109 miles (176 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest train runs at 07:10, the last at 23:32.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Salisbury, NC to Florence, SC.
The table below shows live departures for Salisbury, NC to Florence, SC trains for tomorrow, Wednesday, November 4. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:28 AM Salisbury, NC | 10h24 | 5:52 PM Florence, SC | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Trains from Salisbury, NC to Florence, SC with Amtrak. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Florence, SC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence, SC trip today.
Celebrated art museum with Botticelli, Leonardo, and Michelangelo. A cornerstone visit for Renaissance painting and one of Florence’s defining experiences.
Museum centered on Michelangelo’s David, plus sculptures and paintings. Essential for seeing one of Florence’s most famous masterpieces up close.
Interactive museum inside the cathedral complex exploring Brunelleschi’s dome, tools, and original artworks. Ideal for understanding Florence’s cathedral story.
Grand civic square framed by Palazzo Vecchio and open-air sculptures. It is one of Florence’s key meeting points and a natural starting place for exploration.
Hilltop terrace with sweeping city views, especially at sunset. A classic Florence panorama and a rewarding walk or short bus ride from the center.
Large formal garden behind Pitti Palace with paths, fountains, and viewpoints. Excellent for a slower visit combining greenery, sculpture, and city vistas.
Pulled pork barbecue is a Pee Dee staple, slow-smoked until tender and served with the region's tangy vinegar-pepper sauce.
Smoked pork ribs are common at local barbecue joints, seasoned simply and cooked low and slow for deep smoke flavor.
Shrimp and grits is a South Carolina classic: local shrimp over creamy grits, often enriched with bacon, gravy, or butter.
Upscale downtown restaurant serving refined Southern dishes, steaks, seafood, and cocktails in a polished space.
Casual local favorite for Carolina barbecue, ribs, and classic Southern sides in a relaxed family setting.
Popular casual spot known for barbecue plates, pulled pork, and generous Southern comfort food portions.
Moderate by U.S. small-city standards. Hotels are usually cheaper than major tourist cities, while dining and car-based transport remain fairly typical for the region.
Tip 15-20% at restaurants. Round up or add 10-15% for taxis if service is good. Small change is fine at cafes.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Florence, SC.
Find answers to the most common questions about traveling from Salisbury, NC to Florence, SC by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

Most Salisbury, NC to Florence, SC trains use the Salisbury Amtrak Station to Florence Station station pair. Use this guide to compare Salisbury, NC and Florence, SC train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Salisbury Amtrak Station has practical services for this route, including Dining and Accessibility.
Food and drink options are available at Salisbury Amtrak Station.
Accessibility facilities are available at Salisbury Amtrak Station.
Florence Station has practical services for this route, including Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Information Desk, and Luggage Carts.
Food and drink options are available at Florence Station.
Ticket office support is available at Florence Station. Information desks are located in the main hall.
Luggage storage is available at Florence Station. Lost and found is available at the station.
Available at Florence Station: Parking, Taxis, WC.
Accessibility facilities are available at Florence Station: Elevators, ramps.
Nearby hotels include Aloft Florence, Hyatt Place Florence Downtown, Hotel Florence, Tapestry Collection by Hilton.
Check train stations information for Salisbury, NC and Florence, SC, including where trains depart and arrive on this route.